CAS No. 478-01-3

Batch: Purity:99.43
Check CoA
Nobiletin Chemical Structure
Chemical Structure
Check the Nobiletin product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.

Chemical Information

IUPAC Name 2-(3,4-dimethoxyphenyl)-5,6,7,8-tetramethoxychromen-4-one
CAS Number 478-01-3
Molecular Formula

C21H22O8
Molecular Weight (MW) 402.39
InChIKey MRIAQLRQZPPODS-UHFFFAOYSA-N

Ordering Information

Biological Activity

Nobiletin is a citrus polymethoxyflavone and dietary flavonoid that exhibits anti-inflammatory, neuroprotective, and antitumor activities. It acts through the modulation of cell signaling cascades, suppressing the NF-kB, MAPK, and AKT/mTOR pathways. Downstream, nobiletin inhibits the expression of pro-inflammatory cytokines and matrix metalloproteinases, thereby suppressing tumor proliferation, invasion, and inflammatory responses in preclinical models. [1]

How to Prepare Stock Solution?

Concentration Volume Mass
🧮 Molarity Calculator

Solubility

Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
Solvent Solubility & Note
DMSO 80 mg/mL (198.81 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.)
Ethanol 3 mg/mL
Water Insoluble
FAQ
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
  • Preheat media/saline to 37°C.
  • Mix rapidly (pipette/vortex) upon addition.
  • For complex mixes, always add the aqueous phase last.
  • Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).

Jump to

Note: Technical data last updated: Sep 1, 2026.