CAS No. 21829-25-4
| IUPAC Name | dimethyl 2,6-dimethyl-4-(2-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate | |
|---|---|---|
| CAS Number | 21829-25-4 | |
| Molecular Formula |
C17H18N2O6 |
|
| Molecular Weight (MW) | 346.33 | |
| SMILES | CC1=C(C(C(=C(N1)C)C(=O)OC)C2=CC=CC=C2[N+](=O)[O-])C(=O)OC | |
| InChIKey | HYIMSNHJOBLJNT-UHFFFAOYSA-N |
Nifedipine is a dihydropyridine calcium channel blocker that targets L-type voltage-gated calcium channels. By inhibiting transmembrane calcium influx into vascular smooth muscle cells, nifedipine suppresses intracellular calcium elevation. This inhibition disrupts calcium-dependent excitation-contraction coupling, leading to smooth muscle relaxation and potent vasodilation. Downstream, the reduced intracellular calcium signaling attenuates vascular tone and decreases peripheral resistance. [1]
| Solvent | Solubility & Note |
|---|---|
| DMSO |
69 mg/mL
(199.23 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Ethanol | 15 mg/mL |
| Water | Insoluble |
| DMSO |
69 mg/mL
(199.23 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Ethanol | 17 mg/mL |
| Water | Insoluble |
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
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