CAS No. 28002-70-2 ,1405-10-3

Batch: Purity:97
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Neomycin sulfate Chemical Structure
Chemical Structure
Check the Neomycin sulfate product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.

Chemical Information

IUPAC Name (2R,3S,4R,5R,6R)-5-amino-2-(aminomethyl)-6-[(1R,2R,3S,4R,6S)-4,6-diamino-2-[(2S,3R,4S,5R)-4-[(2R,3R,4R,5S,6S)-3-amino-6-(aminomethyl)-4,5-dihydroxyoxan-2-yl]oxy-3-hydroxy-5-(hydroxymethyl)oxolan-2-yl]oxy-3-hydroxycyclohexyl]oxyoxane-3,4-diol;sulfuric acid
CAS Number 28002-70-2 ,1405-10-3
Molecular Formula

C23H46N6O13.H2SO4
Molecular Weight (MW) 712.72
SMILES C1C(C(C(C(C1N)OC2C(C(C(C(O2)CN)O)O)N)OC3C(C(C(O3)CO)OC4C(C(C(C(O4)CN)O)O)N)O)O)N.OS(=O)(=O)O
InChIKey OIXVKQDWLFHVGR-WQDIDPJDSA-N

Biological Activity

Neomycin sulfate is an aminoglycoside antibiotic that targets the 16S rRNA within the bacterial 30S ribosomal subunit. By binding to the ribosomal A site, it induces mRNA misreading and disrupts protein synthesis, leading to the accumulation of defective proteins. This mechanism exerts potent bactericidal activity against a broad spectrum of Gram-positive and Gram-negative bacteria, including Staphylococcus aureus and Escherichia coli. [1][2]

How to Prepare Stock Solution?

Concentration Volume Mass
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Solubility

Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
Solvent Solubility & Note
Water 100 mg/mL
DMSO Insoluble
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO.)
Ethanol Insoluble
FAQ
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
  • Preheat media/saline to 37°C.
  • Mix rapidly (pipette/vortex) upon addition.
  • For complex mixes, always add the aqueous phase last.
  • Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
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Reference

[1] Moazed D, et al. Nature. 1987;327(6121):389-94.

[2] Vicens Q, et al. Structure. 2001;9(8):647-58.

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Note: Technical data last updated: Sep 1, 2026.