CAS No. 77191-36-7
| CAS Number | 77191-36-7 | |
|---|---|---|
| Molecular Formula |
C14H18N2O2 |
|
| Molecular Weight (MW) | 246.3 | |
| SMILES | CC1=C(C(=CC=C1)C)NC(=O)CN2CCCC2=O |
Nefiracetam is a cognitive enhancer and neuronal system enhancer that targets GABAergic, cholinergic, and monoaminergic systems. It potentiates nicotinic acetylcholine receptor responses and activates voltage-gated calcium channels, thereby enhancing intracellular calcium signaling and neurotransmitter release. These actions contribute to improved synaptic plasticity, facilitation of long-term potentiation, and neuroprotective activity in neuronal injury models. [1][2]
|
Concentration
Volume
Mass
|
|---|
| Solvent | Solubility & Note |
|---|---|
| DMSO |
49 mg/mL
(198.94 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Ethanol | 49 mg/mL |
| Water | 3 mg/mL |
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
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