CAS No. 152520-56-4

Batch: Purity:99.86
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Nebivolol hydrochloride (R-65824) Chemical Structure
Chemical Structure
Check the Nebivolol hydrochloride (R-65824) product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.

Chemical Information

IUPAC Name (1S)-1-[(2R)-6-fluoro-3,4-dihydro-2H-chromen-2-yl]-2-[[(2S)-2-[(2S)-6-fluoro-3,4-dihydro-2H-chromen-2-yl]-2-hydroxyethyl]amino]ethanol;hydrochloride
CAS Number 152520-56-4
Molecular Formula

C22H25F2NO4.HCl
Molecular Weight (MW) 441.9
SMILES C1CC2=C(C=CC(=C2)F)OC1C(CNCC(C3CCC4=C(O3)C=CC(=C4)F)O)O.Cl
InChIKey JWEXHQAEWHKGCW-BIISKSHESA-N

Biological Activity

Nebivolol hydrochloride is a selective β1-adrenoceptor antagonist that additionally stimulates endothelial nitric oxide release. By blocking β1-adrenergic receptors, the compound inhibits sympathetic signaling in cardiovascular tissues. Concurrently, it enhances endothelial nitric oxide synthase activity, elevating nitric oxide bioactivity to induce vasodilation and suppress vascular smooth muscle cell proliferation in cellular assays.

How to Prepare Stock Solution?

Concentration Volume Mass
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Solubility

Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
Solvent Solubility & Note
DMSO 88 mg/mL (199.14 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.)
Water Insoluble
Ethanol Insoluble
FAQ
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
  • Preheat media/saline to 37°C.
  • Mix rapidly (pipette/vortex) upon addition.
  • For complex mixes, always add the aqueous phase last.
  • Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).

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Note: Technical data last updated: Sep 1, 2026.