CAS No. 57149-07-2
| CAS Number | 57149-07-2 | |
|---|---|---|
| Molecular Formula |
C24H28N2O3 |
|
| Molecular Weight (MW) | 392.49 | |
| SMILES | COC1=CC=CC=C1N2CCN(CC2)CC(COC3=CC=CC4=CC=CC=C43)O |
Naftopidil is a selective α1-adrenergic receptor antagonist with affinity for α1A-adrenoceptors (Ki 3.7 nM), α1B-adrenoceptors (Ki 20 nM), and α1D-adrenoceptors (Ki 1.2 nM). By inhibiting α1-adrenergic receptor activation, it suppresses norepinephrine-induced intracellular calcium mobilization and downstream signaling pathways. Consequently, naftopidil relaxes vascular and prostatic smooth muscle tissues by inhibiting adrenergic-mediated contractile responses.
|
Concentration
Volume
Mass
|
|---|
| Solvent | Solubility & Note |
|---|---|
| DMSO |
17 mg/mL
(43.31 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Water | Insoluble |
| Ethanol | Insoluble |
| DMSO |
17 mg/mL
(43.31 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Water | Insoluble |
| Ethanol | Insoluble |
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
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