CAS No. 847559-80-2

Batch: Purity:99.86
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NVP-BEP800 Chemical Structure
Chemical Structure
Check the NVP-BEP800 product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.

Chemical Information

IUPAC Name 2-amino-4-[2,4-dichloro-5-(2-pyrrolidin-1-ylethoxy)phenyl]-N-ethylthieno[2,3-d]pyrimidine-6-carboxamide
CAS Number 847559-80-2
Molecular Formula

C21H23Cl2N5O2S
Molecular Weight (MW) 480.41
SMILES CCNC(=O)C1=CC2=C(N=C(N=C2S1)N)C3=CC(=C(C=C3Cl)Cl)OCCN4CCCC4
InChIKey WJUNQSYQHHIVFX-UHFFFAOYSA-N

Ordering Information

Biological Activity

NVP-BEP800 is a synthetic, orally bioavailable HSP90 inhibitor with an IC50 ofand exhibits over 70-fold selectivity against Grp94 and Trap-1. It binds to the NH2-terminal ATP-binding pocket of HSP90, disrupting chaperone function and inducing degradation of oncogenic client proteins. This inhibition leads to cell cycle arrest, apoptosis, and potent antiproliferative activity across multiple tumor cell lines. [1]

How to Prepare Stock Solution?

Concentration Volume Mass
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Solubility

Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
Solvent Solubility & Note
Ethanol 15 mg/mL
DMSO Insoluble
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO.)
Water Insoluble
FAQ
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
  • Preheat media/saline to 37°C.
  • Mix rapidly (pipette/vortex) upon addition.
  • For complex mixes, always add the aqueous phase last.
  • Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).

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Note: Technical data last updated: Sep 1, 2026.