CAS No. 22373-78-0

Batch: Purity:97
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Sodium Monensin (NSC 343257) Chemical Structure
Chemical Structure
Check the Sodium Monensin (NSC 343257) product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.

Chemical Information

IUPAC Name sodium (2S,3R,4S)-4-[(2S,5R,7S,8R,9S)-2-[(2R,5S)-5-ethyl-5-[(2R,3S,5R)-5-[(2S,3S,5R,6R)-6-hydroxy-6-(hydroxymethyl)-3,5-dimethyloxan-2-yl]-3-methyloxolan-2-yl]oxolan-2-yl]-7-hydroxy-2,8-dimethyl-1,10-dioxaspiro[4.5]decan-9-yl]-3-methoxy-2-methylpentanoate
CAS Number 22373-78-0
Molecular Formula

C36H61NaO11
Molecular Weight (MW) 692.85
SMILES CCC1(CCC(O1)C2(CCC3(O2)CC(C(C(O3)C(C)C(C(C)C(=O)[O-])OC)C)O)C)C4C(CC(O4)C5C(CC(C(O5)(CO)O)C)C)C.[Na+]
InChIKey XOIQMTLWECTKJL-FBZUZRIGSA-M

Ordering Information

Biological Activity

Sodium Monensin (NSC 343257) is a naturally derived polyether ionophore antibiotic that functions as a selective Na+/H+ antiporter to disrupt intracellular ion gradients. By disturbing transmembrane electrochemical homeostasis and vesicular Golgi apparatus transport, it effectively inhibits cell proliferation and downregulates androgen receptor signaling pathways, ultimately promoting cell cycle arrest and inducing apoptosis in human cancer cell lines. [1]

How to Prepare Stock Solution?

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Solubility

Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
Solvent Solubility & Note
Ethanol 100 mg/mL
DMSO Insoluble
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO.)
Water Insoluble
FAQ
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
  • Preheat media/saline to 37°C.
  • Mix rapidly (pipette/vortex) upon addition.
  • For complex mixes, always add the aqueous phase last.
  • Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).

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Note: Technical data last updated: Sep 1, 2026.