CAS No. 70476-82-3
| IUPAC Name | 1,4-dihydroxy-5,8-bis[2-(2-hydroxyethylamino)ethylamino]anthracene-9,10-dione;dihydrochloride | |
|---|---|---|
| CAS Number | 70476-82-3 | |
| Molecular Formula |
C22H29ClN4O6.2HCl |
|
| Molecular Weight (MW) | 517.4 | |
| SMILES | C1=CC(=C2C(=C1NCCNCCO)C(=O)C3=C(C=CC(=C3C2=O)O)O)NCCNCCO.Cl.Cl | |
| InChIKey | ZAHQPTJLOCWVPG-UHFFFAOYSA-N |
Mitoxantrone Dihydrochloride (NSC 301739) is a synthetic anthracenedione antineoplastic agent that acts as a potent inhibitor of type II topoisomerase and intercalates into DNA. By intercalating into deoxyribonucleic acid and interfering with topoisomerase II activity, it disrupts DNA re-ligation, leading to double-strand DNA breaks and inhibition of RNA synthesis. These downstream DNA damage responses disrupt cellular proliferation and trigger apoptotic pathways in cancer cells. [1]
| Solvent | Solubility & Note |
|---|---|
| DMSO |
104 mg/mL
(201.0 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Water | 104 mg/mL |
| Ethanol | Insoluble |
| DMSO |
100 mg/mL
(193.27 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Water | 92 mg/mL |
| Ethanol | Insoluble |
| DMSO |
100 mg/mL
(193.27 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Water | 100 mg/mL |
| Ethanol | Insoluble |
| DMSO |
100 mg/mL
(193.27 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Water | 100 mg/mL |
| Ethanol | Insoluble |
| DMSO |
100 mg/mL
(193.27 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Water | 100 mg/mL |
| Ethanol | Insoluble |
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
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- Mitoxantrone Dihydrochloride (NSC 301739) Clinical Trials
- Mitoxantrone Dihydrochloride (NSC 301739) Solubility in DMSO
- Mitoxantrone Dihydrochloride (NSC 301739) Storage
- Mitoxantrone Dihydrochloride (NSC 301739) Stability
- Mitoxantrone Dihydrochloride (NSC 301739) Molecular Weight
- Mitoxantrone Dihydrochloride (NSC 301739) SMILES
- Mitoxantrone Dihydrochloride (NSC 301739) Chemical Structure (2D and 3D)
- Mitoxantrone Dihydrochloride (NSC 301739) SDS｜MSDS