Mercaptopurine has been evaluated in numerous clinical trials focusing primarily on hematologic malignancies, including pediatric and adult acute lymphoblastic leukemia and lymphoblastic lymphoma, alongside adverse events such as oral mucositis. Spanning early to late clinical phases, these investigations are led by academic institutions, hospital networks, cooperative groups, and corporate sponsors. Recruitment statuses across these studies range from active and recruiting to completed or withdrawn, underscoring the ongoing characterization of this antileukemic agent.
| NCT Number | Recruitment | Conditions | Sponsor/Collaborators | Start Date | Phases |
|---|---|---|---|---|---|
| NCT07072585 | NOT_YET_RECRUITING | Stage II T Lymphoblastic Leukemia/Lymphoma; Stage III T Lymphoblastic Leukemia/Lymphoma; Stage IV T Lymphoblastic Leukemia/Lymphoma; T Acute Lymphoblastic Leukemia; T Lymphoblastic Lymphoma |
Children's Oncology Group |
2026-08-28 | PHASE2; PHASE3 |
| NCT07716735 | NOT_YET_RECRUITING | Advanced Kidney Carcinoma; Advanced Renal Cell Carcinoma; Hereditary Leiomyomatosis and Renal Cell Carcinoma; Metastatic Kidney Carcinoma; Metastatic Renal Cell Carcinoma; Skin Leiomyoma; Stage III Renal Cell Cancer AJCC v8; Stage IV Renal Cell Cancer AJCC v8; Uterine Corpus Leiomyoma |
Jonsson Comprehensive Cancer Center |
2026-12-01 | PHASE1 |
| NCT06099366 | RECRUITING | Lymphoblastic Leukemia in Children |
Hee Young Ju |
2024-03-05 | PHASE2 |
| NCT03959085 | RECRUITING | B Acute Lymphoblastic Leukemia; B Lymphoblastic Lymphoma; Central Nervous System Leukemia; Mixed Phenotype Acute Leukemia; Testicular Leukemia |
Children's Oncology Group |
2019-10-31 | PHASE3 |
| NCT07636564 | NOT_YET_RECRUITING | Acute Leukemia of Ambiguous Lineage; B Acute Lymphoblastic Leukemia; B Acute Lymphoblastic Leukemia, Philadelphia Chromosome Negative; T Acute Lymphoblastic Leukemia |
SWOG Cancer Research Network |
2026-10-14 | PHASE2 |
| NCT07431060 | RECRUITING | Langerhans Cell Histiocytosis (LCH) |
West China Second University Hospital |
2026-02-13 | |
| NCT06124157 | RECRUITING | B Acute Lymphoblastic Leukemia |
National Cancer Institute (NCI) |
2025-05-30 | PHASE2 |
| NCT07227584 | RECRUITING | Acute Lymphoblastic Leukemia; Philadelphia Chromosome-Negative Lymphoblastic Leukemia; Acute Lymphoblastic Leukemia (ALL); Leukemia |
Dana-Farber Cancer Institute |
2026-04-03 | PHASE2 |
| NCT04043494 | RECRUITING | Lymphoblastic Lymphoma, Childhood |
University Hospital Muenster |
2019-08-23 | PHASE3 |
| NCT06336395 | RECRUITING | B Lymphoblastic Leukemia |
National University Hospital, Singapore |
2020-03-04 | PHASE2 |
| NCT06918431 | RECRUITING | B Acute Lymphoblastic Leukemia, Philadelphia Chromosome Negative; Lymphoblastic Lymphoma |
City of Hope Medical Center |
2025-10-10 | PHASE2 |
| NCT06317662 | RECRUITING | Acute Leukemia of Ambiguous Lineage; B Acute Lymphoblastic Leukemia |
National Cancer Institute (NCI) |
2025-06-05 | PHASE2 |
| NCT05848687 | RECRUITING | Lymphoblastic Leukemia |
Tanja Andrea Gruber |
2023-11-03 | PHASE1; PHASE2 |
| NCT03643276 | RECRUITING | Acute Lymphoblastic Leukemia, Pediatric |
Martin Schrappe |
2018-07-15 | PHASE3 |
| NCT04546399 | RECRUITING | Down Syndrome; Recurrent B Acute Lymphoblastic Leukemia |
National Cancer Institute (NCI) |
2020-12-17 | PHASE2 |
| NCT07643103 | NOT_YET_RECRUITING | Ph- Acute Lymphoblastic Leukemia (Ph-ALL) |
Institute of Hematology & Blood Diseases Hospital, China |
2026-06-12 | PHASE2 |
| NCT06533748 | RECRUITING | Acute Lymphoblastic Leukemia; Lymphoblastic Lymphoma |
St. Jude Children's Research Hospital |
2025-01-23 | PHASE2 |
| NCT03286634 | ACTIVE_NOT_RECRUITING | Down Syndrome; Acute Lymphoblastic Leukemia; Childhood Cancer |
National Hospital Organization Nagoya Medical Center |
2017-04-18 | PHASE2 |
| NCT04747912 | RECRUITING | Lymphoblastic Leukemia; Acute Lymphoblastic Leukemia; ph+ Acute Lymphoblastic Leukemia |
University of Chicago |
2021-03-02 | PHASE2 |
| NCT07462299 | NOT_YET_RECRUITING | Childhood Acute Lymphoblastic Leukemia |
The Children's Hospital of Zhejiang University School of Medicine |
2026-02-20 | |
| NCT05645718 | RECRUITING | Leukemia |
M.D. Anderson Cancer Center |
2023-07-14 | PHASE2 |
| NCT01371630 | RECRUITING | B Acute Lymphoblastic Leukemia With t(9;22)(q34.1;q11.2); BCR-ABL1; B Acute Lymphoblastic Leukemia, Philadelphia Chromosome Negative; Burkitt-Like Lymphoma With 11q Aberration; High Grade B-Cell Lymphoma With MYC and BCL2 and/or BCL6 Rearrangements; High Grade B-Cell Lymphoma, Not Otherwise Specified; Recurrent B Acute Lymphoblastic Leukemia; Recurrent Burkitt Lymphoma; Refractory B Acute Lymphoblastic Leukemia; Refractory Burkitt Lymphoma |
M.D. Anderson Cancer Center |
2011-08-26 | PHASE1; PHASE2 |
| NCT05660473 | RECRUITING | Precursor Cell Lymphoblastic Leukemia-Lymphoma |
Institute of Hematology & Blood Diseases Hospital, China |
2022-08-01 | PHASE2 |
| NCT06390319 | RECRUITING | T-cell Acute Lymphoblastic Leukemia; T-cell Lymphoma; Mixed Phenotype Acute Leukemia |
St. Jude Children's Research Hospital |
2024-12-27 | PHASE2 |
| NCT03914625 | ACTIVE_NOT_RECRUITING | B Acute Lymphoblastic Leukemia; B Lymphoblastic Lymphoma; Down Syndrome |
National Cancer Institute (NCI) |
2019-07-03 | PHASE3 |
| NCT05157971 | ACTIVE_NOT_RECRUITING | B Acute Lymphoblastic Leukemia; Ph-Like Acute Lymphoblastic Leukemia |
City of Hope Medical Center |
2022-03-17 | PHASE1 |
| NCT05303792 | ACTIVE_NOT_RECRUITING | B Acute Lymphoblastic Leukemia; B Lymphoblastic Lymphoma |
Alliance for Clinical Trials in Oncology |
2023-06-09 | PHASE2 |
| NCT06639958 | SUSPENDED | Acute Lymphoblastic Leukemia; Childhood Acute Lymphoblastic Leukemia |
Children's Oncology Group |
2024-12-04 | |
| NCT03150693 | RECRUITING | B Acute Lymphoblastic Leukemia |
Alliance for Clinical Trials in Oncology |
2017-09-20 | PHASE3 |
| NCT05681260 | RECRUITING | T-cell Lymphoblastic Lymphoma |
Children's Cancer Group, China |
2023-02-06 | PHASE3 |
| NCT04216524 | RECRUITING | Blastic Plasmacytoid Dendritic Cell Neoplasm |
M.D. Anderson Cancer Center |
2020-05-29 | PHASE2 |
| NCT06387121 | RECRUITING | Precursor Cell Lymphoblastic Leukemia-Lymphoma |
Institute of Hematology & Blood Diseases Hospital, China |
2024-04-02 | PHASE2 |
| NCT03020030 | ACTIVE_NOT_RECRUITING | Acute Lymphoblastic Leukemia, Pediatric |
Dana-Farber Cancer Institute |
2017-03-03 | PHASE3 |
| NCT02877303 | RECRUITING | B Acute Lymphoblastic Leukemia; B Lymphoblastic Lymphoma |
M.D. Anderson Cancer Center |
2016-11-01 | PHASE2 |
| NCT00501826 | RECRUITING | T Acute Lymphoblastic Leukemia; T Lymphoblastic Lymphoma |
M.D. Anderson Cancer Center |
2007-07-11 | PHASE2 |
| NCT03117751 | ACTIVE_NOT_RECRUITING | Acute Lymphoblastic Leukemia; Acute Lymphoblastic Lymphoma |
St. Jude Children's Research Hospital |
2017-03-29 | PHASE2; PHASE3 |
| NCT06210750 | WITHDRAWN | T Acute Lymphoblastic Leukemia; T Lymphoblastic Lymphoma |
National Cancer Institute (NCI) |
2024-08-09 | PHASE2 |
| NCT03571321 | RECRUITING | Acute Lymphoblastic Leukemia; ALL, Childhood; ALL |
University of Chicago |
2019-05-28 | PHASE1 |
| NCT01920737 | ACTIVE_NOT_RECRUITING | Leukemia |
Memorial Sloan Kettering Cancer Center |
2013-08-07 | PHASE2 |
| NCT02205762 | ACTIVE_NOT_RECRUITING | Langerhans Cell Histiocytosis |
North American Consortium for Histiocytosis |
2016-11-02 | PHASE2; PHASE3 |
| NCT03007147 | ACTIVE_NOT_RECRUITING | Acute Lymphoblastic Leukemia; B Acute Lymphoblastic Leukemia; Mixed Phenotype Acute Leukemia; T Acute Lymphoblastic Leukemia |
Children's Oncology Group |
2017-08-08 | PHASE3 |
| NCT04440267 | RECRUITING | Acute Leukemia of Ambiguous Lineage |
Institute of Hematology & Blood Diseases Hospital, China |
2020-07-08 | PHASE2 |
| NCT02723994 | COMPLETED | Leukemia |
Incyte Corporation |
2016-09-30 | PHASE2 |
| NCT06199557 | RECRUITING | Acute Myeloid Leukemia, Adult; Myelodysplastic Syndromes, Adult |
Haukeland University Hospital |
2024-05-23 | PHASE1; PHASE2 |
| NCT06279767 | UNKNOWN | Glioblastoma; Cancer; Temozolomide |
The First Affiliated Hospital with Nanjing Medical University |
2022-07-01 | PHASE1; PHASE2 |
| NCT02688140 | COMPLETED | Acute Promyelocytic Leukemia |
Technische Universität Dresden |
2016-06 | PHASE3 |
| NCT05276284 | COMPLETED | Solid Tumor, Adult; Metastatic Cancer |
Kristoffer Rohrberg |
2022-09-01 | PHASE1; PHASE2 |
| NCT02881086 | COMPLETED | Acute Lymphoblastic Leukemia; Lymphoblastic Lymphoma |
Goethe University |
2016-08 | PHASE3 |
| NCT05506332 | RECRUITING | Acute Myeloid Leukemia, in Relapse; Acute Myeloid Leukemia Refractory |
University Hospital, Antwerp |
2022-07-15 | PHASE1 |
| NCT05032183 | TERMINATED | Recurrent Adult Lymphoblastic Lymphoma; Recurrent B Acute Lymphoblastic Leukemia; Recurrent T Acute Lymphoblastic Leukemia; Refractory B Acute Lymphoblastic Leukemia; Refractory Lymphoblastic Lymphoma; Refractory T Acute Lymphoblastic Leukemia |
M.D. Anderson Cancer Center |
2022-02-17 | PHASE1; PHASE2 |
| NCT02303821 | COMPLETED | Acute Lymphoblastic Leukemia (ALL) |
Amgen |
2015-02-16 | PHASE1 |
| NCT05192889 | ACTIVE_NOT_RECRUITING | Refractory Acute Lymphoblastic Leukemia; Relapsed Acute Lymphoblastic Leukemia |
St. Jude Children's Research Hospital |
2022-08-25 | PHASE1; PHASE2 |
| NCT02845882 | ACTIVE_NOT_RECRUITING | Lymphoblastic Lymphoma |
Children's Cancer Group, China |
2016-01 | PHASE3 |
| NCT04773366 | UNKNOWN | Langerhans Cell Histiocytosis |
Shanghai Children's Medical Center |
2018-07-01 | PHASE3 |
| NCT02003222 | ACTIVE_NOT_RECRUITING | Acute Lymphoblastic Leukemia; B Acute Lymphoblastic Leukemia, Philadelphia Chromosome Negative |
National Cancer Institute (NCI) |
2014-05-19 | PHASE3 |
| NCT04228393 | UNKNOWN | Acute Lymphoblastic Leukemia, Pediatric |
Wei Zhao |
2020-02-01 | PHASE2; PHASE3 |
| NCT02883049 | COMPLETED | B Acute Lymphoblastic Leukemia; B Acute Lymphoblastic Leukemia, BCR-ABL1-Like; Central Nervous System Leukemia; Testicular Leukemia |
National Cancer Institute (NCI) |
2012-02-29 | PHASE3 |
| NCT03384654 | COMPLETED | Precursor Cell Lymphoblastic Leukemia-Lymphoma |
Janssen Research & Development, LLC |
2018-05-14 | PHASE2 |
| NCT02143414 | ACTIVE_NOT_RECRUITING | Acute Lymphoblastic Leukemia; B Acute Lymphoblastic Leukemia; B Acute Lymphoblastic Leukemia With t(9;22)(q34.1;q11.2); BCR-ABL1; Recurrent Acute Lymphoblastic Leukemia; Refractory Acute Lymphoblastic Leukemia |
National Cancer Institute (NCI) |
2015-06-30 | PHASE2 |
| NCT02553460 | ACTIVE_NOT_RECRUITING | Acute Lymphoblastic Leukemia |
St. Jude Children's Research Hospital |
2016-01-29 | PHASE1; PHASE2 |
| NCT02910245 | UNKNOWN | Colitis, Ulcerative |
Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA) |
2016-11 | PHASE3 |
| NCT02523976 | COMPLETED | Acute,Leukemia, Lymphoid |
Institute of Hematology & Blood Diseases Hospital, China |
2015-08-01 | PHASE2 |
| NCT01117441 | COMPLETED | Leukemia |
University Hospital Schleswig-Holstein |
2010-06 | PHASE3 |
| NCT03920813 | UNKNOWN | Acute Lymphoblastic Leukemia |
Shandong University |
2015-01 | PHASE4 |
| NCT02200978 | COMPLETED | Childhood Acute Promyelocytic Leukemia |
South China Children's Leukemia Group |
2011-09 | PHASE4 |
| NCT01700946 | COMPLETED | Recurrent B-Cell Childhood Acute Lymphoblastic Leukemia; Recurrent Childhood B-Lymphoblastic Lymphoma |
St. Jude Children's Research Hospital |
2013-04-15 | PHASE2 |
| NCT02101853 | ACTIVE_NOT_RECRUITING | Recurrent B Acute Lymphoblastic Leukemia |
National Cancer Institute (NCI) |
2014-12-17 | PHASE3 |
| NCT02852694 | COMPLETED | Crohn's Disease |
PIBD-Net |
2017-02-28 | PHASE4 |
| NCT02177071 | COMPLETED | Crohn's Disease |
Groupe d'Etude Therapeutique des Affections Inflammatoires Digestives |
2015-10-09 | PHASE4 |
| NCT03564704 | UNKNOWN | Leukemia; Leukemia, Acute; Adult Lymphoblastic Lymphoma; Leukemia, Lymphoblastic; Leukemia, T Cell; Adult Acute Lymphoblastic Leukemia; Lymphoblastic Lymphoma; Lymphoblastic Leukemia |
Nanfang Hospital, Southern Medical University |
2016-02-14 | PHASE2; PHASE3 |
| NCT03518112 | TERMINATED | Philadelphia Chromosome Negative; Recurrent B Acute Lymphoblastic Leukemia; Refractory B Acute Lymphoblastic Leukemia |
M.D. Anderson Cancer Center |
2018-04-18 | PHASE2 |
| NCT01451515 | COMPLETED | Lymphoblastic Lymphoma |
St. Jude Children's Research Hospital |
2012-05-25 | PHASE2 |
| NCT03760003 | COMPLETED | Ulcerative Colitis |
Abivax S.A. |
2019-08-13 | PHASE2 |
| NCT04770922 | Completed | Acute Lymphoblastic Leukemia Pediatric|Adverse Drug Event |
Cipherome Inc.|Stanford University |
2021-02-23 | -- |
| NCT02420717 | TERMINATED | Recurrent B Acute Lymphoblastic Leukemia; Recurrent Ph-Like Acute Lymphoblastic Leukemia; Refractory B Acute Lymphoblastic Leukemia; Refractory Ph-Like Acute Lymphoblastic Leukemia |
M.D. Anderson Cancer Center |
2015-07-15 | PHASE2 |
| NCT00550992 | UNKNOWN | Leukemia |
Dutch Childhood Oncology Group |
2006-01 | |
| NCT02611492 | UNKNOWN | Philadelphia Chromosome Positive Adult Acute Lymphoblastic Leukemia |
Assistance Publique - Hôpitaux de Paris |
2016-04 | PHASE3 |
| NCT02828358 | COMPLETED | Acute Leukemia of Ambiguous Lineage; B Acute Lymphoblastic Leukemia; Mixed Phenotype Acute Leukemia |
National Cancer Institute (NCI) |
2017-04-01 | PHASE2 |
| NCT00549848 | COMPLETED | Acute Lymphoblastic Leukemia |
St. Jude Children's Research Hospital |
2007-10-29 | PHASE3 |
| NCT02776605 | UNKNOWN | ALL |
PETHEMA Foundation |
2016-06 | PHASE2 |
| NCT03553238 | UNKNOWN | Leukemia, Acute; Leukemia, T Cell; Leukemia, Lymphoblastic |
Nanfang Hospital, Southern Medical University |
2016-02-14 | PHASE2; PHASE3 |
| NCT02046694 | COMPLETED | Acute Lymphoblastic Leukemia (ALL) |
Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins |
2014-01-06 | EARLY_PHASE1 |
| NCT03488225 | TERMINATED | Acute Lymphoblastic Leukemia in Remission; B Acute Lymphoblastic Leukemia; B Acute Lymphoblastic Leukemia, Philadelphia Chromosome Negative |
M.D. Anderson Cancer Center |
2018-03-28 | PHASE2 |
| NCT02112916 | ACTIVE_NOT_RECRUITING | Adult T Acute Lymphoblastic Leukemia; Ann Arbor Stage II Adult Lymphoblastic Lymphoma; Ann Arbor Stage II Childhood Lymphoblastic Lymphoma; Ann Arbor Stage III Adult Lymphoblastic Lymphoma; Ann Arbor Stage III Childhood Lymphoblastic Lymphoma; Ann Arbor Stage IV Adult Lymphoblastic Lymphoma; Ann Arbor Stage IV Childhood Lymphoblastic Lymphoma; Childhood T Acute Lymphoblastic Leukemia |
National Cancer Institute (NCI) |
2014-10-04 | PHASE3 |
| NCT02912676 | COMPLETED | Acute Lymphoblastic Leukemia; Lymphoblastic Lymphoma |
Kjeld Schmiegelow |
2016-10 | PHASE1; PHASE2 |
| NCT02036489 | COMPLETED | Acute Lymphobkastic Leukemia |
PETHEMA Foundation |
2008-01 | PHASE4 |
| NCT01228331 | COMPLETED | Leukemia |
Universitätsklinikum Hamburg-Eppendorf |
2010-10 | PHASE2; PHASE3 |
| NCT01503632 | COMPLETED | Acute Lymphoblastic Leukemia |
Children's Oncology Group |
2012-02-21 | PHASE3 |
| NCT01190930 | COMPLETED | Acute Lymphoblastic Leukemia; Adult B Lymphoblastic Lymphoma; Ann Arbor Stage I B Lymphoblastic Lymphoma; Ann Arbor Stage II B Lymphoblastic Lymphoma; Childhood B Acute Lymphoblastic Leukemia; Childhood B Acute Lymphoblastic Leukemia With t(9;22)(q34.1;q11.2); BCR-ABL1; Childhood B Lymphoblastic Lymphoma; Down Syndrome; Hypodiploid B Acute Lymphoblastic Leukemia; Philadelphia Chromosome Positive |
Children's Oncology Group |
2010-08-11 | PHASE3 |
| NCT03370601 | TERMINATED | Inflammatory Bowel Diseases |
University Hospital, Lille |
2017-01-03 | |
| NCT02660762 | UNKNOWN | Leukaemia,Lymphoblastic |
Sun Yat-sen University |
2016-01 | PHASE2 |
| NCT03022747 | UNKNOWN | Lymphoblastic Leukemia, Acute, Childhood |
Vastra Gotaland Region |
2017-01 | PHASE2 |
| NCT00707083 | COMPLETED | Leukemia |
Prince of Wales Hospital, Shatin, Hong Kong |
2008-05-01 | PHASE3 |
| NCT02894645 | UNKNOWN | Acute Lymphoblastic Leukemia (ALL) |
National University Hospital, Singapore |
2008-10 | PHASE4 |
| NCT01906671 | UNKNOWN | Acute Lymphoblastic Leukemia; 6-mercaptopurine Therapy |
Kjeld Schmiegelow |
2013-06 | PHASE4 |
| NCT00866749 | COMPLETED | Lymphoblastic Leukemia; Lymphoblastic Lymphoma |
M.D. Anderson Cancer Center |
2006-09-12 | PHASE2 |
| NCT02518750 | TERMINATED | Acute Lymphoblastic Leukemia; Lymphoma, Non-Hodgkin's; Leukemia, T-Cell; Leukemia, B-Cell |
St. Jude Children's Research Hospital |
2016-11-23 | PHASE2 |
| NCT02578511 | WITHDRAWN | Acute Lymphoblastic Leukemia in Complete Remission; Lymphoblastic Lymphoma in Complete Remission; Mixed Phenotype Acute Leukemia in Complete Remission |
Ehab L Atallah |
2017-06-29 | PHASE1 |
| NCT02413047 | TERMINATED | Inflammatory Bowel Disease; Ulcerative Colitis; Crohn's Disease |
Indiana University |
2015-05 | |
| NCT01256398 | COMPLETED | Acute Lymphoblastic Leukemia; Adult B Acute Lymphoblastic Leukemia With t(9;22)(q34.1;q11.2); BCR-ABL1 |
National Cancer Institute (NCI) |
2010-12-14 | PHASE2 |
| NCT01156883 | COMPLETED | Leukemia |
Gruppo Italiano Malattie EMatologiche dell'Adulto |
2010-04 | |
| NCT00408005 | COMPLETED | T Acute Lymphoblastic Leukemia; T Lymphoblastic Lymphoma |
National Cancer Institute (NCI) |
2007-01-30 | PHASE3 |
| NCT00557193 | COMPLETED | Acute Lymphoblastic Leukemia; Acute Undifferentiated Leukemia; Childhood T Acute Lymphoblastic Leukemia |
Children's Oncology Group |
2008-01-15 | PHASE3 |
| NCT02419469 | TERMINATED | Leukemia; Precursor-B Acute Lymphoblastic Leukemia; Lymphoblastic Lymphoma; Lymphoma |
M.D. Anderson Cancer Center |
2015-11-13 | PHASE2 |
| NCT00551460 | COMPLETED | Leukemia |
SWOG Cancer Research Network |
2007-11-15 | PHASE2 |
| NCT03022747 | Unknown status | Lymphoblastic Leukemia Acute Childhood |
Vastra Gotaland Region |
2017-01 | Phase 2 |
| NCT02419755 | TERMINATED | Mixed Lineage Acute Leukemia; Acute Myeloid Leukemia; Acute Lymphoid Leukemia |
St. Jude Children's Research Hospital |
2015-04-14 | PHASE2 |
| NCT02141100 | WITHDRAWN | Non-Hodgkin Lymphoma |
Kjeld Schmiegelow |
2014-07 | PHASE1; PHASE2 |
| NCT02228772 | COMPLETED | Acute Lymphoblastic Leukemia; Lymphoblastic Lymphoma; B-cell Adult Acute Lymphoblastic Leukemia; T-cell Adult Acute Lymphoblastic Leukemia |
Massachusetts General Hospital |
2014-12 | PHASE1 |
| NCT00558519 | COMPLETED | Leukemia |
Alliance for Clinical Trials in Oncology |
2008-03-12 | PHASE2 |
| NCT00186875 | COMPLETED | Acute Lymphoblastic Leukemia; Lymphoma, Lymphoblastic |
St. Jude Children's Research Hospital |
2003-11 | PHASE2 |
| NCT01629628 | UNKNOWN | Crohn Disease |
Tel-Aviv Sourasky Medical Center |
2012-07 | PHASE3 |
| NCT00816049 | COMPLETED | Acute Lymphoblastic Leukemia |
Rigshospitalet, Denmark |
2009-01 | PHASE3 |
| NCT00381680 | COMPLETED | B-cell Childhood Acute Lymphoblastic Leukemia; L1 Childhood Acute Lymphoblastic Leukemia; L2 Childhood Acute Lymphoblastic Leukemia; Intermediate Risk Recurrent Childhood Acute Lymphoblastic Leukemia |
Children's Oncology Group |
2007-03 | PHASE3 |
| NCT00866918 | COMPLETED | Childhood Acute Promyelocytic Leukemia With PML-RARA; Myeloid Neoplasm |
Children's Oncology Group |
2009-03-09 | PHASE3 |
| NCT00526175 | COMPLETED | Acute Lymphoblastic Leukemia |
PETHEMA Foundation |
2001-06 | PHASE4 |
| NCT00720109 | COMPLETED | Acute Lymphoblastic Leukemia; Adult B Acute Lymphoblastic Leukemia With t(9;22)(q34.1;q11.2); BCR-ABL1; Childhood B Acute Lymphoblastic Leukemia With t(9;22)(q34.1;q11.2); BCR-ABL1 |
National Cancer Institute (NCI) |
2008-07-14 | PHASE2; PHASE3 |
| NCT01432145 | COMPLETED | Breast Cancer; Ovarian Cancer |
University of Oxford |
2011-05 | PHASE2 |
| NCT00973752 | COMPLETED | Acute Lymphoblastic Leukemia |
Massachusetts General Hospital |
2009-08 | PHASE2 |
| NCT00400946 | COMPLETED | Drug/Agent Toxicity by Tissue/Organ; Leukemia |
Dana-Farber Cancer Institute |
2005-04 | PHASE3 |
| NCT00866307 | COMPLETED | Acute Lymphoblastic Leukemia; Adult B Acute Lymphoblastic Leukemia; Childhood B Acute Lymphoblastic Leukemia |
Children's Oncology Group |
2009-02-23 | PHASE1 |
| NCT00458848 | COMPLETED | Leukemia |
Gruppo Italiano Malattie EMatologiche dell'Adulto |
2004-10 | PHASE2 |
| NCT00103285 | COMPLETED | Acute Lymphoblastic Leukemia; Childhood B Acute Lymphoblastic Leukemia |
Children's Oncology Group |
2005-04-11 | PHASE3 |
| NCT00492856 | COMPLETED | Leukemia |
SWOG Cancer Research Network |
2007-06-01 | PHASE3 |
| NCT00846703 | UNKNOWN | Acute Lymphoblastic Leukemia |
Sun Yat-sen University |
2008-07 | PHASE4 |
| NCT00096135 | COMPLETED | Leukemia |
Children's Oncology Group |
2004-11 | |
| NCT00476190 | COMPLETED | Acute Lymphoblastic Leukemia |
Dana-Farber Cancer Institute |
2007-04 | PHASE2 |
| NCT01005758 | UNKNOWN | Leukemia |
Ohio State University Comprehensive Cancer Center |
2009-01 | PHASE2 |
| NCT01094613 | TERMINATED | Crohn's Disease |
Teva GTC |
2010-11 | PHASE1; PHASE2 |
| NCT01358253 | COMPLETED | Acute Lymphoblastic Leukemia |
Ruijin Hospital |
2010-12 | PHASE4 |
| NCT00853008 | COMPLETED | Acute Lymphoblastic Leukemia |
PETHEMA Foundation |
2003-01 | PHASE4 |
| NCT01697020 | COMPLETED | Acute Lymphoblastic Leukemia |
Nova Laboratories Limited |
2012-09 | PHASE1 |
| NCT00262925 | TERMINATED | Recurrent Adult Acute Lymphoblastic Leukemia |
National Cancer Institute (NCI) |
2006-06 | PHASE2 |
| NCT00482833 | COMPLETED | Leukemia |
Gruppo Italiano Malattie EMatologiche dell'Adulto |
2007-08 | PHASE3 |
| NCT01433432 | WITHDRAWN | Crohn's Disease |
Teva GTC |
2011-10 | PHASE2 |
| NCT00408278 | COMPLETED | Acute Promyelocytic Leukemia |
PETHEMA Foundation |
2005-07 | PHASE4 |
| NCT00430118 | COMPLETED | Leukemia |
University Hospital Schleswig-Holstein |
2000-07 | PHASE3 |
| NCT00521950 | COMPLETED | Inflammatory Bowel Diseases; Crohn Disease; Ulcerative Colitis |
ZonMw: The Netherlands Organisation for Health Research and Development |
2007-09 | |
| NCT00184041 | COMPLETED | Acute Lymphoblastic Leukemia |
University of Southern California |
2004-07 | PHASE2 |
| NCT00002766 | COMPLETED | Leukemia; Lymphoma |
Memorial Sloan Kettering Cancer Center |
1996-03 | PHASE3 |
| NCT00198991 | COMPLETED | Adult Acute Lymphocytic Leukemia |
Goethe University |
2003-04 | PHASE4 |
| NCT00198978 | COMPLETED | Adult Acute Lymphocytic Leukemia |
Goethe University |
2003-01 | PHASE4 |
| NCT00131053 | UNKNOWN | Lymphoblastic Leukemia, Acute |
Japan Adult Leukemia Study Group |
2002-09 | PHASE2 |
| NCT00514982 | WITHDRAWN | Hermanski-Pudlak Syndrome; Colitis; Cytokines; Lymphocytes; Drug Evaluation |
National Institute of Allergy and Infectious Diseases (NIAID) |
2007-08-07 | PHASE2 |
| NCT00131027 | UNKNOWN | Lymphoblastic Leukemia, Acute |
Japan Adult Leukemia Study Group |
2002-09 | PHASE3 |
| NCT00671034 | COMPLETED | Acute Lymphoblastic Leukemia; Adult B Acute Lymphoblastic Leukemia; Childhood B Acute Lymphoblastic Leukemia |
Children's Oncology Group |
2008-07-21 | PHASE3 |
| NCT00075725 | COMPLETED | Acute Lymphoblastic Leukemia; Adult B Acute Lymphoblastic Leukemia; Childhood B Acute Lymphoblastic Leukemia |
Children's Oncology Group |
2003-12-29 | PHASE3 |
| NCT00109837 | COMPLETED | Leukemia |
SWOG Cancer Research Network |
2005-04 | PHASE2 |
| NCT00137111 | COMPLETED | Lymphoblastic Leukemia, Acute |
St. Jude Children's Research Hospital |
2000-07-08 | PHASE3 |
| NCT00059839 | COMPLETED | Lymphoma |
Children's Oncology Group |
2003-11 | PHASE3 |
| NCT00275106 | TERMINATED | Lymphoma |
Children's Cancer and Leukaemia Group |
2004-09 | PHASE3 |
| NCT00199017 | COMPLETED | Lymphoma, Lymphoblastic |
Johann Wolfgang Goethe University Hospital |
2004-04 | PHASE4 |
| NCT00199004 | COMPLETED | Adult Acute Lymphocytic Leukemia |
Johann Wolfgang Goethe University Hospital |
2004-04 | PHASE4 |
| NCT00774982 | COMPLETED | Crohns Disease |
Teva GTC |
2008-12 | PHASE1 |
| NCT00548431 | COMPLETED | Leukemia, Lymphocytic, Acute |
Rigshospitalet, Denmark |
2007-12 | PHASE2 |
| NCT00003650 | COMPLETED | Lymphoma |
UNICANCER |
1997-02 | PHASE3 |
| NCT00136435 | COMPLETED | Acute Lymphoblastic Leukemia |
Dana-Farber Cancer Institute |
2002-06 | PHASE2 |
| NCT00176462 | COMPLETED | Acute Lymphocytic Leukemia |
Rutgers, The State University of New Jersey |
2001-02 | PHASE2 |
| NCT00004228 | COMPLETED | Lymphoma |
Children's Oncology Group |
2000-06 | PHASE3 |
| NCT00136084 | COMPLETED | Leukemia, Myelocytic, Acute |
St. Jude Children's Research Hospital |
2002-08 | PHASE3 |
| NCT00003728 | UNKNOWN | Leukemia; Lymphoma |
European Organisation for Research and Treatment of Cancer - EORTC |
1998-12 | PHASE3 |
| NCT00061945 | COMPLETED | Acute Undifferentiated Leukemia; B-cell Adult Acute Lymphoblastic Leukemia; B-cell Childhood Acute Lymphoblastic Leukemia; L1 Adult Acute Lymphoblastic Leukemia; L1 Childhood Acute Lymphoblastic Leukemia; L2 Adult Acute Lymphoblastic Leukemia; L2 Childhood Acute Lymphoblastic Leukemia; Philadelphia Chromosome Negative Adult Precursor Acute Lymphoblastic Leukemia; Philadelphia Chromosome Positive Adult Precursor Acute Lymphoblastic Leukemia; Philadelphia Chromosome Positive Childhood Precursor Acute Lymphoblastic Leukemia; T-cell Adult Acute Lymphoblastic Leukemia; T-cell Childhood Acute Lymphoblastic Leukemia; Untreated Adult Acute Lymphoblastic Leukemia; Untreated Childhood Acute Lymphoblastic Leukemia |
National Cancer Institute (NCI) |
2003-06 | PHASE1; PHASE2 |
| NCT00276601 | COMPLETED | Leukemia |
Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins |
2004-10 | PHASE2 |
| NCT00962767 | COMPLETED | Leukemia, Myelocytic, Acute |
Wyeth is now a wholly owned subsidiary of Pfizer |
2002-05 | PHASE3 |
| NCT00005945 | COMPLETED | Leukemia |
Children's Oncology Group |
2000-06 | PHASE3 |
| NCT00764907 | UNKNOWN | Leukemia |
University Hospital, Motol |
2002-11 | PHASE3 |
| NCT00002756 | COMPLETED | Leukemia |
Children's Oncology Group |
1996-06 | PHASE2 |
| NCT00465933 | COMPLETED | Acute Promyelocytic Leukemia |
PETHEMA Foundation |
1999-03 | PHASE4 |
| NCT00005585 | COMPLETED | Leukemia |
Children's Oncology Group |
2000-04 | PHASE3 |
| NCT00016302 | COMPLETED | T-cell Childhood Acute Lymphoblastic Leukemia; Untreated Childhood Acute Lymphoblastic Leukemia |
National Cancer Institute (NCI) |
2001-04 | |
| NCT00494897 | COMPLETED | Acute Lymphoblastic Leukemia |
PETHEMA Foundation |
1996-06 | PHASE4 |
| NCT00002744 | COMPLETED | Leukemia |
Children's Oncology Group |
1996-05 | PHASE3 |
| NCT00002514 | COMPLETED | Leukemia |
Eastern Cooperative Oncology Group |
1993-05-07 | PHASE3 |
| NCT00003934 | COMPLETED | Adult Acute Myeloid Leukemia With t(15;17)(q22;q12); Adult Acute Promyelocytic Leukemia (M3); Childhood Acute Promyelocytic Leukemia (M3); Untreated Adult Acute Myeloid Leukemia; Untreated Childhood Acute Myeloid Leukemia and Other Myeloid Malignancies |
National Cancer Institute (NCI) |
1999-06 | PHASE3 |
| NCT00022737 | COMPLETED | Childhood Acute Lymphoblastic Leukemia in Remission; Recurrent Childhood Acute Lymphoblastic Leukemia |
National Cancer Institute (NCI) |
2002-10 | PHASE3 |
| NCT00089349 | COMPLETED | Recurrent Childhood Acute Lymphoblastic Leukemia |
National Cancer Institute (NCI) |
2004-07 | PHASE2 |
| NCT00187057 | COMPLETED | Ataxia-Telangiectasia |
St. Jude Children's Research Hospital |
2002-09 | |
| NCT00613457 | COMPLETED | Leukemia |
Associazione Italiana Ematologia Oncologia Pediatrica |
2000-09 | PHASE3 |
| NCT00002812 | COMPLETED | Leukemia |
Children's Oncology Group |
1996-09 | PHASE3 |
| NCT00015873 | COMPLETED | Leukemia |
Dutch Childhood Oncology Group |
1999-05 | PHASE3 |
| NCT00005603 | COMPLETED | Leukemia |
Children's Oncology Group |
2000-03 | PHASE3 |
| NCT00005596 | COMPLETED | Leukemia |
Children's Oncology Group |
2000-04 | PHASE3 |
| NCT00526305 | COMPLETED | Acute Lymphoblastic Leukemia |
PETHEMA Foundation |
2000-01 | PHASE4 |
| NCT00022126 | COMPLETED | Leukemia |
Children's Oncology Group |
2002-11 | PHASE2 |
| NCT00002704 | COMPLETED | Leukemia |
National Cancer Institute (NCI) |
1996-01 | PHASE2 |
| NCT00187122 | COMPLETED | Lymphoblastic Lymphoma |
St. Jude Children's Research Hospital |
1993-03 | |
| NCT00002700 | COMPLETED | Leukemia; Lymphoma |
European Organisation for Research and Treatment of Cancer - EORTC |
1995-08 | PHASE3 |
| NCT00003700 | COMPLETED | Leukemia |
Alliance for Clinical Trials in Oncology |
1999-01 | PHASE2 |
| NCT00648336 | COMPLETED | Healthy |
Mylan Pharmaceuticals Inc |
2003-11 | PHASE1 |
| NCT00187083 | COMPLETED | Acute Lymphoblastic Leukemia |
St. Jude Children's Research Hospital |
1997-02 | PHASE3 |
| NCT00199056 | COMPLETED | Adult Acute Lymphocytic Leukemia |
Goethe University |
1999-10 | PHASE4 |
| NCT00199095 | COMPLETED | Adult Acute Lymphocytic Leukemia |
Goethe University |
1997-02 | PHASE4 |
| NCT00003671 | COMPLETED | Leukemia |
Children's Oncology Group |
1998-12 | PHASE2 |
| NCT00003783 | COMPLETED | Leukemia |
Children's Oncology Group |
1999-03 | PHASE2 |
| NCT00602134 | COMPLETED | Acute Lymphoblastic Leukemia |
Roxane Laboratories |
2002-11 | |
| NCT00187005 | TERMINATED | Acute Lymphoblastic Leukemia |
St. Jude Children's Research Hospital |
1998-07 | PHASE3 |
| NCT00002665 | COMPLETED | Leukemia; Neutropenia; Thrombocytopenia |
SWOG Cancer Research Network |
1995-07 | PHASE2 |
| NCT01230983 | COMPLETED | Cardiac Toxicity; Leukemia; Lymphoma |
Children's Oncology Group |
1996-06 | PHASE3 |
| NCT00002618 | COMPLETED | Lymphoma |
Children's Oncology Group |
1994-12 | PHASE3 |
| NCT00002785 | COMPLETED | Leukemia |
Children's Oncology Group |
1996-07 | PHASE2 |
| NCT00199069 | COMPLETED | Adult Acute Lymphocytic Leukemia |
Goethe University |
1993-04 | PHASE4 |
| NCT00002531 | UNKNOWN | Leukemia |
Johann Wolfgang Goethe University Hospital |
1993-01 | PHASE2 |
| NCT00343369 | UNKNOWN | Leukemia |
Universitätsklinikum Hamburg-Eppendorf |
2003-01 | |
| NCT00003437 | UNKNOWN | Leukemia |
Medical Research Council |
1997-01 | PHASE3 |
| NCT00047268 | UNKNOWN | Leukemia; Myelodysplastic/Myeloproliferative Neoplasms |
European Working Group of MDS in Childhood |
1998-07 | PHASE3 |
| NCT00004688 | COMPLETED | Anaplastic Astrocytoma; Anaplastic Oligodendroglioma; Mixed Gliomas; Glioblastoma Multiforme; Recurrent Brain Tumor |
Emory University |
1996-08 | PHASE2 |
| NCT00003423 | UNKNOWN | Lymphoma |
United Kingdom Children's Cancer Study Group |
1995-05 | PHASE3 |
| NCT00019409 | WITHDRAWN | Leukemia |
National Institutes of Health Clinical Center (CC) |
1999-10 | PHASE3 |
| NCT00287170 | COMPLETED | Crohn's Disease |
Teva GTC |
2006-07 | PHASE1; PHASE2 |
| NCT00002701 | UNKNOWN | Leukemia |
European Organisation for Research and Treatment of Cancer - EORTC |
1995-10 | PHASE3 |
| NCT00018954 | COMPLETED | Leukemia; Lymphoma |
National Institutes of Health Clinical Center (CC) |
1992-10 | PHASE2 |
(data from https://clinicaltrials.gov, updated on 2026-07-30)
Check the
Mercaptopurine (6-MP)
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
Mechanism and Biochemical Profile
Appendix RUO and cGMP Quality Standards
| Quality Dimension | RUO (Research Use Only) | cGMP (Current Good Manufacturing Practice) |
|---|---|---|
| Clinical Applicability | Prohibited in human clinical trials or medical diagnostics. | Mandatory for human clinical trials (Phase I–III) and therapies. |
| Regulatory Status | Non-regulated grade; exempt from drug manufacturing laws. | Legally enforced by health authorities (e.g., FDA, EMA, NMPA). |
| Facility Environment | Unclassified analytical or research laboratories. | Validated Cleanrooms (ISO Class 5–8) with continuous monitoring. |
| Quality Control | Basic purity and activity testing. | Rigorous safety release testing (Sterility, Endotoxin, Mycoplasma). |
| Process Validation | Basic equipment calibration; no process validation required. | Full qualification (IQ/OQ/PQ) and complete batch records. |
| Quality Assurance | Vendor self-declared without required formal QMS. | Mandatory QA/QC unit, Change Control, CAPA, and vendor audits. |
| Regulatory Impact | High risk of IND rejection if used as a critical raw material. | Required for IND/NDA filings, supported by Drug Master Files (DMF). |
Footnotes
Regulatory Note: Governed by FDA (21 CFR Parts 210/211/312), EMA (EudraLex Vol 4), ICH Guidelines (E6/Q7/Q9/Q10), and compendial standards (USP <71>/<85>/<1043>).
- Mercaptopurine (6-MP) Solubility in DMSO
- Mercaptopurine (6-MP) Stock Solution
- Mercaptopurine (6-MP) Storage
- Mercaptopurine (6-MP) Stability
- Mercaptopurine (6-MP) Molecular Weight
- Mercaptopurine (6-MP) SMILES
- Mercaptopurine (6-MP) CAS Number
- Mercaptopurine (6-MP) Chemical Structure (2D and 3D)
- Mercaptopurine (6-MP) SDS｜MSDS
Note: Technical data last updated: Sep 1, 2026.