Clinical Trials

Numerous clinical trials, ranging from Early Phase 1 to Phase 4, evaluate melatonin across diverse conditions, including preoperative anxiety, schizophrenia, fatigue, glucose metabolism disorders, and pregnancy complications such as fetal growth retardation. Supported by academic, medical, and corporate sponsors, these active, completed, and upcoming studies encompass protocols investigating interventions such as preoperative anxiety management and antenatal maternal supplementation.

NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT07542756 RECRUITING
Insomnia; Insomnia Disorder; Chronic Insomnia; Chronic Insomnia Disorder
University of Pennsylvania
 2026-05-01 PHASE4
NCT05502900 RECRUITING
Uveal Melanoma; Uveal Melanoma, Posterior, Medium/Large Size; Eye Cancer, Intraocular Melanoma
Gustav Stalhammar
 2022-10-02 PHASE3
NCT07334197 NOT_YET_RECRUITING
Ppm, Cardiomyopathy
Tanta University
 2026-12-20
NCT00262470 ACTIVE_NOT_RECRUITING
Tachycardia; Chronic Orthostatic Intolerance
Satish R. Raj
 1997-04 PHASE1; PHASE2
NCT07695246 RECRUITING
Insomnia; Aging; Sleep Disorders
The University of Hong Kong
 2026-08-01
NCT07418554 NOT_YET_RECRUITING
Post-traumatic Stress Disorder (PTSD); Current Significant Sleep Disturbances
University Hospital, Strasbourg, France
 2027-01-01 PHASE3
NCT06062953 RECRUITING
Psychiatric Disorders; Insomnia
Lone Baandrup
 2023-09-18 PHASE2; PHASE3
NCT07576764 NOT_YET_RECRUITING
Anorexia Nervosa; Sleep Disorders in Children
Assistance Publique Hopitaux De Marseille
 2026-09-01 PHASE3
NCT07120880 RECRUITING
Major Depressive Disorder (MDD) With Insomnia
Assistance Publique - Hôpitaux de Paris
 2026-01-28 PHASE3
NCT07221968 NOT_YET_RECRUITING
CSWS; Developmental and/or Epileptic Encephalopathies; Electrical Status Epilepticus in Sleep
Hugo W. Moser Research Institute at Kennedy Krieger, Inc.
 2026-07-01 PHASE2
NCT05701969 RECRUITING
Sleep Disorders, Circadian Rhythm
University of Virginia
 2022-05-30 EARLY_PHASE1
NCT07472075 RECRUITING
Bipolar Affective Disorder
Lars Vedel Kessing
 2026-05-08 PHASE2
NCT03879707 WITHDRAWN
Pain After TJA
Stanford University
 2025-06 EARLY_PHASE1
NCT06768749 RECRUITING
Sleep Problems; Depressive Disorder and Anxiety Disorders
University of Redlands
 2025-02-28
NCT06380491 RECRUITING
Obstructive Sleep Apnea of Adult
Instituto Nacional de Ciencias Medicas y Nutricion Salvador Zubiran
 2023-06-22 PHASE4
NCT07495605 NOT_YET_RECRUITING
Intensity of Postoperative Pain, Bacterial Load Reduction and Periapical MMP-9 Levels in Patients With Necrotic Pulp
Cairo University
 2026-03-22
NCT03438526 RECRUITING
Hypoactive Delirium
University Hospital, Basel, Switzerland
 2022-01-03 PHASE4
NCT07096635 NOT_YET_RECRUITING
Pain Relief After Arthroscopic Anterior Cruciate Ligament Reconstruction
Assiut University
 2025-10-01
NCT06252571 RECRUITING
Idiopathic Hypersomnia
University Hospital, Strasbourg, France
 2024-09-07 PHASE2
NCT05617833 RECRUITING
Intraventricular Hemorrhage of Prematurity
Johns Hopkins University
 2024-04-30 PHASE1
NCT06826755 RECRUITING
Perimenopause; Hypertension
Mayo Clinic
 2025-05-23
NCT07036796 RECRUITING
Diabetic Peripheral Neuropathy; Diabetic Neuropathy; Diabetic Peripheral Neuropathy in Type 2 Diabetic Patients
Ain Shams University
 2025-07-04 PHASE2
NCT07345715 RECRUITING
Oral Melatonin; Nebulized Dexmedetomidine; Emergence Agitation; Children; Adenotonsillectomy
Tanta University
 2025-07-01
NCT07336277 RECRUITING
Orthopedic Trauma; Sleep Quality
Emory University
 2026-06-02 PHASE3
NCT05084196 RECRUITING
Acute Kidney Injury; Adverse Drug Event
Rutgers, The State University of New Jersey
 2023-06-05 PHASE3
NCT07344467 RECRUITING
Oral; Melatonin; Pregabalin; Postoperative Pain; Anxiety; Spine Surgery
Tanta University
 2026-01-17
NCT07369284 NOT_YET_RECRUITING
Gestational Diabetes
Obstetrics & Gynecology Hospital of Fudan University
 2026-02 PHASE2
NCT05358834 RECRUITING
Pregnant Women
Brigham and Women's Hospital
 2023-01-01
NCT05651347 RECRUITING
Fetal Growth Retardation; Stillbirth and Fetal Death; Pregnancy Preterm
Monash University
 2019-05-29 PHASE3
NCT07617922 RECRUITING
Ureteral Stent-Related Symptoms; Ureteral Calculi; Lower Urinary Tract Symptoms
Beni-Suef University
 2026-05-07 PHASE2
NCT07062757 ENROLLING_BY_INVITATION
Dentofacial Deformities; Edema; Pain
Bezmialem Vakif University
 2025-03-30
NCT05541276 RECRUITING
Emergence Delirium
Arash Afshari
 2025-01-21 PHASE3
NCT05474846 RECRUITING
Sleep; Fatigue; Anxiety; Cancer; Depression
M.D. Anderson Cancer Center
 2022-11-21 PHASE2; PHASE3
NCT07553143 NOT_YET_RECRUITING
Laparoscopic Cholecystectomy; Postoperative Quality of Recovery; Preoperative Anxiety; Postoperative Sleep Quality; Opioid Consumption, Postoperative; PONV in Laparoscopic Cholocystectomies
Armed Forces Medical Institute Bangladesh
 2026-05-01
NCT07046429 RECRUITING
Hepatic Encephalopathy; Covert Hepatic Encephalopathy; Cirrhosis; Sleep Disturbances and Insomnia
Weill Medical College of Cornell University
 2025-08-05
NCT07652801 NOT_YET_RECRUITING
HIE - Hypoxic - Ischemic Encephalopathy
University of Child Health Sciences and Children's Hospital, Lahore
 2026-07-01 PHASE3
NCT05713877 RECRUITING
Delirium
Ciusss de L'Est de l'Île de Montréal
 2023-02-01 PHASE2
NCT07743255 ENROLLING_BY_INVITATION
Migraine Disorders
Nishtar Medical University
 2026-06-10
NCT06226025 RECRUITING
Bipolar Disorder; Delayed Sleep-Wake Phase Disorder
Leslie Swanson
 2024-08-13 PHASE2
NCT06859957 RECRUITING
Chronic Low-back Pain (cLBP)
Bart Koes
 2025-04-11 PHASE3
NCT07549295 ENROLLING_BY_INVITATION
Fetal Growth Restriction (FGR)
Xinhua Hospital, Shanghai Jiao Tong University School of Medicine
 2023-01-01 PHASE1
NCT07732725 NOT_YET_RECRUITING
Sleep Disturbance
Benha University
 2026-08-04 EARLY_PHASE1
NCT04831398 ACTIVE_NOT_RECRUITING
Healthy
University of Oklahoma
 2023-01-01 PHASE4
NCT07721324 NOT_YET_RECRUITING
Therapy; Treatment
Ain Shams University
 2026-07-21 PHASE2; PHASE3
NCT07610876 RECRUITING
Dental Implants; Immediate Implant Placement; Osseointegration
Suez Canal University
 2025-08-11
NCT06768580 RECRUITING
Oral Melatonin; Lidocaine Infusion; Postoperative Delirium; Elderly Patients; Total Hip Arthroplasty
Tanta University
 2025-01-15
NCT06093477 RECRUITING
Juvenile; Scoliosis; Scoliosis Idiopathic; Scoliosis; Adolescence; Scoliosis;Congenital; Kyphosis; Spondylolisthesis; Pectus Surgery; Hip Surgery
Stanford University
 2024-05-30
NCT07651514 RECRUITING
Poor Sleep Quality; Leg Cramps, Nocturnal
StudySetGo
 2026-06-10
NCT07349459 NOT_YET_RECRUITING
Melatonin; Breast Cancer Patients Diagnosed; Vitamin D Concentration; Doxorubicin
Tanta University
 2026-04-30
NCT07375693 ENROLLING_BY_INVITATION
Parkinson Disease
Bangladesh Medical University
 2026-02-17 PHASE2
NCT07735806 COMPLETED
Impacted Mandibular Third Molar
Kafrelsheikh University
 2024-07-22
NCT07514507 NOT_YET_RECRUITING
Sleep Disorders
IRCCS Fondazione Stella Maris
 2026-05
NCT06382610 COMPLETED
Sleep
University of Redlands
 2024-05-19
NCT07138443 COMPLETED
Stress; Mental Stress
Baylor University
 2025-08-01
NCT07554716 RECRUITING
Hospitalised Patients With Enteral Nutrition
Fundación Pública Andaluza para la Investigación de Málaga en Biomedicina y Salud
 2025-10-10
NCT07374536 ACTIVE_NOT_RECRUITING
Impact Molar
Suez Canal University
 2025-09-01
NCT07316582 ENROLLING_BY_INVITATION
Periodontitis Stage II
Al-Azhar University
 2025-11-01 PHASE4
NCT07336095 NOT_YET_RECRUITING
Emergence Delirium, Anesthesia; Child; Anxiety; Midazolam Premedication; Melatonin Bioavailability; Tonsillectomy
Ain Shams University
 2026-03-01 PHASE3
NCT07036367 RECRUITING
Cataract Surgery Anesthesia
Al-Azhar University
 2025-09-01 PHASE4
NCT07305350 ACTIVE_NOT_RECRUITING
Hypoxic Ischaemic Encephalopathy (HIE)
University of Child Health Sciences and Children's Hospital, Lahore
 2025-12-10 PHASE2
NCT07375342 RECRUITING
Post Tonsillectomy Emergence Agitation
Benha University
 2025-12-10
NCT07003243 NOT_YET_RECRUITING
Immediate Implant Placement; Melatonin Production
University of Baghdad
 2025-05-26 PHASE1
NCT07173699 ACTIVE_NOT_RECRUITING
Postoperative Pain After Endodontic Treatment
Ataturk University
 2025-09-01
NCT07669766 COMPLETED
Sleep
Nutraland USA, Inc.
 2026-01-13
NCT06935292 NOT_YET_RECRUITING
Tracheal Intubation Morbidity; Laryngoscopy; Hemodynamic Response
Tanta University
 2025-04 PHASE2; PHASE3
NCT07442162 ENROLLING_BY_INVITATION
Crying
Al-Hadba university
 2026-02-23 PHASE1; PHASE2
NCT06476392 COMPLETED
Back Pain Lower Back Chronic; Insomnia
Odense University Hospital
 2024-12-11 PHASE3
NCT07307677 RECRUITING
PCOS(Insulin Resistant)
Mst.Sumyara Khatun
 2025-03-11
NCT07380568 COMPLETED
Pain Management; Pain After Surgery; Cesarean Section Pain
Benha University
 2025-10-10
NCT07067307 NOT_YET_RECRUITING
Breast Cancer
Mansoura University
 2025-07 PHASE1; PHASE2
NCT06404112 COMPLETED
Long COVID; Long COVID-19; Sleep Disturbance
Duke University
 2024-07-31 PHASE2
NCT03540485 TERMINATED
Sclerosis, Multiple; Autoimmune Diseases of the Nervous System; Nervous System Diseases; Autoimmune Diseases
Fundación Pública Andaluza para la gestión de la Investigación en Sevilla
 2019-11-29 PHASE1; PHASE2
NCT04547439 RECRUITING
Diabetes Mellitus; Diabetic Retinopathy
University of Illinois at Chicago
 2021-02-03 PHASE2
NCT06156059 UNKNOWN
Septic Shock; Stroke Hemorrhagic; Strokes Thrombotic; Cardiac Arrest
Hospital San Carlos, Madrid
 2025-02-01 PHASE4
NCT05247125 RECRUITING
Ischemic Stroke, Acute; Sleep Disorders, Circadian Rhythm
Federal State Budgetary Institution, V. A. Almazov Federal North-West Medical Research Centre, of the Ministry of Health
 2022-03-01 PHASE4
NCT07475156 COMPLETED
Post Operative Delerium
Ain Shams University
 2025-08-01 PHASE4
NCT07605767 COMPLETED
Periodontal Disease; Melatonin
Liaquat College of Medicine and Dentistry
 2025-11-03 PHASE4
NCT04631341 NOT_YET_RECRUITING
Cardiovascular Diseases
RenJi Hospital
 2021-01-01
NCT06846086 RECRUITING
Cardiomyopathies
Tanta University
 2025-02-20 PHASE3
NCT07318974 ACTIVE_NOT_RECRUITING
ICS
Benha University
 2025-09-10 PHASE2
NCT06801379 UNKNOWN
Insomnia
Woolcock Institute of Medical Research
 2025-07-01 EARLY_PHASE1
NCT07095270 COMPLETED
Circadian Disruption
Icahn School of Medicine at Mount Sinai
 2025-07-07
NCT06777342 NOT_YET_RECRUITING
Delirium - Postoperative; Sleep Problems; CABG; Valve Surgery
Yan Fuxia
 2025-02-01
NCT06404086 COMPLETED
Long COVID; Long COVID-19; Hypersomnia; Sleep Disturbance
Duke University
 2024-07-31 PHASE2
NCT07169383 ENROLLING_BY_INVITATION
Melasma (Facial Melasma)
Hina Malik
 2025-06-28 PHASE2
NCT01628029 ACTIVE_NOT_RECRUITING
Hematopoietic and Lymphoid Cell Neoplasm; Malignant Solid Neoplasm; Sleep Disorder
M.D. Anderson Cancer Center
 2014-01-15 PHASE2
NCT06696378 UNKNOWN
Female Breast Cancer; Older Adults; Exercise Trainning Progrmam
University of Valladolid
 2025-01-15
NCT06802913 RECRUITING
Insomnia
Woolcock Institute of Medical Research
 2025-07-01 EARLY_PHASE1
NCT06949904 RECRUITING
Pneumonia Childhood
Mian Muhammad Hassan Ahmed
 2025-05 PHASE1; PHASE2
NCT07592442 COMPLETED
Type 1 Diabetes (T1D)
Ain Shams University
 2024-11-24
NCT07034560 ACTIVE_NOT_RECRUITING
Melasma; Treatment Outcome; Recurrence
Thammasat University
 2024-11-12 PHASE4
NCT03954899 RECRUITING
Mild Cognitive Impairment; Cognitive Decline; Healthy Aging
Natalie Denburg
 2019-11-12
NCT06236932 RECRUITING
Obesity; Type2diabetes; Lipodystrophy; Infections; Obesity Associated Disorder
Federico II University
 2023-12-29
NCT04791943 COMPLETED
Pain, Postoperative; Narcotic Use
Montefiore Medical Center
 2021-11-16 PHASE2
NCT06012175 COMPLETED
Osteoarthritis, Knee
Xiangya Hospital of Central South University
 2023-11-02
NCT06996171 RECRUITING
Primary Insomnia
CMH Kharian Medical College
 2025-05-05
NCT07162272 COMPLETED
Dental Anxiety; Children
Ain Shams University
 2025-06-25 PHASE4
NCT06821425 COMPLETED
Periodontal Disease, AVDC Stage 3
Ain Shams University
 2025-01-01 PHASE4
NCT07192835 COMPLETED
Healthy; Dietary Bioavailability; Plant Extracts; Phenolic Compounds; Melatonin
Universidad Miguel Hernandez de Elche
 2025-03-01
NCT07103564 COMPLETED
Dental Implants; Osteoprotegerin; Melatonin
Hams Hamed Abdelrahman
 2024-07-01
NCT03785158 COMPLETED
Post-operative Delirium; Major Non-cardiac Surgery
McMaster University
 2021-09-14
NCT06872944 COMPLETED
Pain Score (VAS) at 24 h Postoperatively
Cairo University
 2025-03-21 EARLY_PHASE1
NCT06838104 ACTIVE_NOT_RECRUITING
Schizophrenia Disorders; Psychotic Disorder
Lahore General Hospital
 2024-12-05
NCT06429059 COMPLETED
Amyotrophic Lateral Sclerosis ALS
Duke University
 2024-06-12 PHASE2
NCT06809751 NOT_YET_RECRUITING
Central Serous Chorioretinopathy; Melatonin; Ocular Diseases; Visual Acuity; Macula Abnormality
Mohsen Pourazizi
 2025-02-01 PHASE2; PHASE3
NCT07385768 COMPLETED
Sleep Disturbance; Circadian Rhythm Sleep Disorders; Intensive Care Unit Patients
Ataturk University
 2024-08-01
NCT07550751 COMPLETED
Clinical Trial
Aswan University Hospital
 2024-08-01 PHASE4
NCT04335968 COMPLETED
Orthopedic Surgery
Assistance Publique - Hôpitaux de Paris
 2021-01-23 PHASE3
NCT06355687 UNKNOWN
Anesthesia
Ain Shams University
 2024-04
NCT06894108 COMPLETED
Sleep
Nutraceuticals Research Institute
 2024-10-01
NCT06617351 NOT_YET_RECRUITING
Cell Migration; Cell Invasion; Exercise Recovery
University of Central Florida
 2024-10-01
NCT06910345 COMPLETED
Urological Surgery
Atlas University
 2024-02-25
NCT05857046 UNKNOWN
Stroke, Acute Ischemic; Strokes Thrombotic
Coordinación de Investigación en Salud, Mexico
 2024-03-01 PHASE3
NCT04932096 COMPLETED
Traumatic Brain Injury; Critical Illness; Sleep
Oregon Health and Science University
 2023-01-02 PHASE2
NCT06509191 RECRUITING
Delirium
Sultan Qaboos University
 2024-09-30 PHASE2; PHASE3
NCT06997263 COMPLETED
Anxiety; Postoperative Pain; Anesthesia
Benha University
 2024-01-15
NCT05439876 COMPLETED
Epilepsy in Children
National Taiwan University Hospital
 2022-07-18 PHASE2; PHASE3
NCT07090720 COMPLETED
Melatonin; Left Ventricular Function; Neonates; Persistent Pulmonary Hypertension
Tanta University
 2023-01-01
NCT05440734 TERMINATED
Insomnia
Douglas Mental Health University Institute
 2022-06-17
NCT04233112 ACTIVE_NOT_RECRUITING
Osteopenia
Duquesne University
 2020-05-26 EARLY_PHASE1
NCT05728892 UNKNOWN
Postoperative Pain
Ain Shams University
 2023-01-25
NCT06405204 UNKNOWN
IVF
Beni-Suef University
 2024-06-30 PHASE3
NCT06685679 COMPLETED
Neonatal Diseases and Abnormalities; Neonatal Mortality; Pulmonary Arterial Hypertension; Pulmonary Arterial Hypertension, Children
Ain Shams University
 2024-05-15 PHASE3
NCT07568873 COMPLETED
Stress Response of Endotracheal Intubation and Surgical Field Clarity in FESS
Zagazig University
 2024-01-25
NCT06237556 UNKNOWN
Melatonin; Anxiety; Sleep Quality; Coronary Artery Bypass Graft
Ain Shams University
 2024-02-01
NCT05829148 UNKNOWN
Endoscopic Sinus Surgery
Egymedicalpedia
 2023-05-01 EARLY_PHASE1
NCT06076668 UNKNOWN
Dexmedetomidine; Melatonin; Delirium
Tanta University
 2023-10-16
NCT05759429 COMPLETED
Obesity
Istituto Auxologico Italiano
 2021-04-29
NCT04521972 Not yet recruiting
Pregnancy Related|Labor; Poor|Uterine Contractions Weak
Michigan State University|McLaren Health Care
 2024-10-01 Not Applicable
NCT05971485 COMPLETED
Preterm Neonate Analgesia
Ain Shams University
 2022-08-20 PHASE2
NCT05454683 UNKNOWN
Chronic Fatigue Syndrome; Myalgic Encephalomyelitis
Laboratorios Viñas, S.A.
 2022-09-05
NCT06372561 UNKNOWN
Dental Caries in Children; Vital Pulp Therapy
Suez Canal University
 2023-05-20
NCT07769164 COMPLETED
Sleep Disturbance; Sleep Quality
Cannabis Science Innovations, LLC
 2023-12-01
NCT06390267 Not yet recruiting
Acute Stress Reaction|Cognitive Performance
Spark Biomedical Inc.|Battelle Memorial Institute
 2024-08 Not Applicable
NCT06533033 UNKNOWN
Oral Lichen Planus
Hams Hamed Abdelrahman
 2024-01-01
NCT03490864 COMPLETED
Improving Cardiometabolic Outcomes in Adults
Northwestern University
 2018-05-16
NCT06736821 COMPLETED
Bone Healing
rehab soliman
 2024-01-09
NCT06343805 Not yet recruiting
Primary Myelofibrosis|Post-Essential Thrombocythemia Myelofibrosis|Post-Polycythemia Vera Myelofibrosis|PMF|PPV-MF|PET-MF
Ajax Therapeutics Inc.
 2024-07-15 Phase 1
NCT05536596 UNKNOWN
Retrognathism; Prognathism; Orthognathic Surgery; Neurosensory Disorder
Universitat Internacional de Catalunya
 2022-09-30 PHASE2; PHASE3
NCT05716906 ACTIVE_NOT_RECRUITING
Autism Spectrum Disorder
Massachusetts General Hospital
 2023-01-11
NCT03490825 COMPLETED
Improving Cardiometabolic Outcomes in Older Adults
Northwestern University
 2018-03-01
NCT06898463 COMPLETED
Postoperative Sleep Disturbances
Konya City Hospital
 2022-09-19 PHASE4
NCT06031961 UNKNOWN
Anesthesia
Al-Azhar University
 2023-09-10
NCT05906563 UNKNOWN
Bone Loss in Jaw
Amira ragab
 2022-12-14 PHASE2
NCT05483231 UNKNOWN
Very Low Birth Weight Infant
Children's Hospital of Fudan University
 2023-12-01
NCT06215573 COMPLETED
Sleep
University of Exeter
 2023-12-04
NCT07600528 COMPLETED
Sleep Disturbance; Sleep Quality
OmniSolutions Laboratory Holdings Limited
 2024-04-15
NCT04795336 COMPLETED
Osteo Arthritis Knee
NYU Langone Health
 2021-07-12 PHASE1
NCT04318067 UNKNOWN
Attention Deficit Hyperactivity Disorder; Sleep Disorder
Allan Hvolby
 2020-09-01 PHASE4
NCT06236191 UNKNOWN
Insomnia; Neurodevelopmental Disorders
KK Women's and Children's Hospital
 2023-07-24
NCT03708341 UNKNOWN
Sleep Deprivation; Intensive Care Psychosis
Saint-Joseph University
 2018-11-15 PHASE3
NCT05307770 TERMINATED
Rapid Eye Movement Sleep Behavior Disorder; Parkinson Disease
Mayo Clinic
 2022-05-01
NCT05740969 UNKNOWN
Actinic Keratoses
Ismail Gögenur
 2023-02-01 PHASE2
NCT05680584 UNKNOWN
Effect of Drug; Anxiety
Minia University
 2023-02-01 PHASE1
NCT06096558 UNKNOWN
Peritoneal Dialysis
National Nutrition and Food Technology Institute
 2023-10-20
NCT05378932 COMPLETED
Hypohidrotic Ectodermal Dysplasia
Assistance Publique - Hôpitaux de Paris
 2022-06-10
NCT07343947 COMPLETED
Infertility; Infertility (IVF Patients); Infertile Women Undergoing IVF or ICSI
University of Sao Paulo General Hospital
 2022-01-31
NCT05042700 UNKNOWN
Low Anterior Resection Syndrome
Ismail Gögenur
 2021-10-13 PHASE2
NCT05699876 UNKNOWN
Anxiety, Preoperarative
All India Institute of Medical Sciences
 2023-01-15
NCT04810975 COMPLETED
Musculoskeletal Diseases
Duquesne University
 2022-02-07
NCT03945955 COMPLETED
Sleep Quality; DNA Damage Repair Deficiency; Oxidative Stress
University of British Columbia
 2022-06-01 PHASE4
NCT06103188 COMPLETED
Anxiety; Preoperative Anxiety
University of Jordan
 2023-10-02 PHASE3
NCT06191523 COMPLETED
Sepsis Newborn
Universitas Sebelas Maret
 2023-04-27
NCT06146712 COMPLETED
Sleep
Asutra
 2023-08-07
NCT05459272 UNKNOWN
Sleep Disorders
Uriach Consumer Healthcare
 2022-07-10
NCT05766436 UNKNOWN
Anxiety Acute; Emergence Agitation
nada moahmed aboelrouse
 2023-03-15
NCT05319301 COMPLETED
Oxytocin Deficiency; Hypopituitarism; Hypothalamic Obesity; Pituitary Dysfunction; Central Diabetes Insipidus; Social Isolation
Fundació Institut de Recerca de l'Hospital de la Santa Creu i Sant Pau
 2022-04-01
NCT06868745 COMPLETED
Glaucoma; Sleep Disturbance; Circadian Rhythm; Melatonin; Actigraphy
University of Sao Paulo
 2022-05-04
NCT06816277 COMPLETED
Periimplantitis
Universidad Complutense de Madrid
 2020-09-01
NCT05640934 COMPLETED
Delirium in Old Age
Menoufia University
 2022-12-10 PHASE2
NCT05552586 UNKNOWN
Coronary Artery Bypass Grafting; Coronary Artery Disease
Ain Shams University
 2022-10
NCT04522960 UNKNOWN
Alzheimer Disease
Universitair Ziekenhuis Brussel
 2020-10-20
NCT04878198 COMPLETED
Physical Exercise; Sleep Disturbance; Autism Spectrum Disorder; Melatonin Deficiency
Education University of Hong Kong
 2022-12-02
NCT06724432 COMPLETED
Postoperative Pain; Oxidative Stress Response
University of Parma
 2021-06-01
NCT05419466 COMPLETED
Melatonin Bioavailability
Larena SAS
 2023-03-14
NCT05349188 COMPLETED
Sleep Disturbance
Northwell Health
 2022-05-11 PHASE1
NCT05382923 UNKNOWN
Circadian Rhythm Sleep Disorder, Jet Lag Type
University of Arizona
 2021-07-10
NCT03826563 COMPLETED
Psychosis; Sleep
Children's Hospital of Philadelphia
 2019-01-18
NCT05570526 UNKNOWN
Hemodialysis Complication; Oxidative Stress; Inflammation
Ain Shams University
 2022-12-01 PHASE3
NCT06053385 COMPLETED
Sleep
University of Redlands
 2022-02-09
NCT05670444 COMPLETED
Influenza -Like Illness
Hôpital Universitaire Sahloul
 2023-01-02 PHASE1
NCT03843008 WITHDRAWN
Stroke, Acute; Ischemic Stroke
University of Florida
 2022-04
NCT05285124 UNKNOWN
Disorder of Consciousness
First Affiliated Hospital of Zhejiang University
 2021-07-01
NCT05654415 UNKNOWN
Epilepsy
IRCCS National Neurological Institute "C. Mondino" Foundation
 2021-09-01
NCT05256173 UNKNOWN
Epilepsy，Cognition
Xijing Hospital
 2022-02-01
NCT04530097 UNKNOWN
NSCLC and Theropy
Shanghai 10th People's Hospital
 2021-01-01
NCT04784754 WITHDRAWN
COVID-19
State University of New York at Buffalo
 2021-04-01 PHASE2
NCT05122130 UNKNOWN
Wound Heal
Salma Nabil
 2021-11-20 PHASE2
NCT04421339 COMPLETED
Huntington Disease
The University of Texas Health Science Center, Houston
 2021-01-22
NCT04665453 COMPLETED
Electroencephalography; Child; Dexmedetomidine; Melatonin; Sleep; Epilepsy
University Medical Centre Ljubljana
 2020-09-01
NCT04531748 WITHDRAWN
Covid19
Reena Mehra, MD
 2021-12 PHASE2
NCT04233502 WITHDRAWN
Autism Spectrum Disorder
Neurim Pharmaceuticals Ltd.
 2020-09 PHASE3
NCT05034809 UNKNOWN
Dengue Fever With Warning Signs
Ilocos Training and Regional Medical Center
 2021-10-20 PHASE2
NCT04530539 COMPLETED
Covid19; SARS-CoV Infection
Lancaster General Hospital
 2020-10-05
NCT03498131 COMPLETED
Relapsing Remitting Multiple Sclerosis
Providence Health & Services
 2018-05-09 EARLY_PHASE1
NCT04474483 TERMINATED
COVID-19
State University of New York at Buffalo
 2020-11-06 PHASE2
NCT03464084 COMPLETED
Glucose; Circadian Rhythm; Melatonin; Genes; Light
Brigham and Women's Hospital
 2018-02-17
NCT05593731 COMPLETED
Patients With Missing Teeth
Misr University for Science and Technology
 2021-12-10 PHASE2
NCT04287543 WITHDRAWN
Parkinson Disease
Instituto Mexicano del Seguro Social
 2021-05 PHASE2; PHASE3
NCT04325191 UNKNOWN
Cardiovascular Risk Factor
University of Delaware
 2020-03-12
NCT05236504 UNKNOWN
Sleep Hygiene; Sleep Disturbance
Bettery S.A.
 2021-11-28
NCT05224167 UNKNOWN
Preoperative Anxiety
Mongi Slim Hospital
 2022-03-01
NCT05223010 COMPLETED
Emergence Agitation
Menoufia University
 2022-01-30 PHASE4
NCT04864509 UNKNOWN
Osteoporosis, Postmenopausal
University of Aarhus
 2021-05-01 PHASE4
NCT03557229 UNKNOWN
Oxidative Stress; Septic Shock
American British Cowdray Medical Center
 2018-07-23 PHASE3
NCT06125353 COMPLETED
Breast Cancer
Harokopio University
 2022-01-01
NCT05141344 COMPLETED
Postoperative Pain
Cairo University
 2021-12-15 PHASE1
NCT05221151 COMPLETED
Anxiety
Menoufia University
 2022-01-30 PHASE4
NCT02415309 COMPLETED
Anxiety
United States Naval Medical Center, San Diego
 2016-07 PHASE3
NCT04959825 COMPLETED
Postoperative Pain
Cairo University
 2021-07-15 EARLY_PHASE1
NCT05976451 COMPLETED
Gingival Recession Types One(RT1)
Ain Shams University
 2020-10-01
NCT04908605 COMPLETED
Agitation
Ain Shams University
 2021-06-15 PHASE4
NCT02642640 COMPLETED
Glucose; Circadian Rhythm; Melatonin; Genes
Brigham and Women's Hospital
 2016-11
NCT03968939 COMPLETED
Primary Total Hip Arthroplasty; Primary Total Knee Arthroplasty
James A. Keeney
 2019-10-01 PHASE4
NCT03804177 UNKNOWN
Immediate Dental Implant
Cairo University
 2019-02-10 PHASE4
NCT05332717 COMPLETED
Arthroplasty; Replacement; Knee; Sleep Initiation and Maintenance Disorders
Hospital for Special Surgery, New York
 2022-01-10
NCT05870358 COMPLETED
Diabetes Mellitus; Periodontitis; Melatonin; Matrix Metalloproteinases
Yağmur Saraç Gül
 2021-02-18 PHASE4
NCT05033639 COMPLETED
Necrotizing Enterocolitis
Ilocos Training and Regional Medical Center
 2021-03-01 PHASE1; PHASE2
NCT03806816 UNKNOWN
Hypoxic-Ischemic Encephalopathy; Cell Damage; Asphyxia Perinatal
University Hospital of Ferrara
 2018-12-13
NCT04788979 UNKNOWN
Periodontal Diseases
University of Baghdad
 2021-04-01 PHASE1; PHASE2
NCT04590742 UNKNOWN
Sleep Disturbance; Total Joint Arthroplasty
Rothman Institute Orthopaedics
 2018-02-27
NCT03715465 COMPLETED
Delayed Sleep Phase Syndrome
University of Michigan
 2019-02-15 PHASE3
NCT02333149 WITHDRAWN
Attention Deficit/Hyperactivity Disorder; Initial Insomnia
University of Alberta
 2019-01-01 PHASE3
NCT03730194 COMPLETED
Autism Spectrum Disorder; Attention Deficit Hyperactivity Disorder; Sleep Disturbance
University of Nebraska
 2019-05-31
NCT04872712 COMPLETED
Insomnia
Indonesia University
 2021-05-04
NCT02282241 WITHDRAWN
Delirium
University of British Columbia
 2016-02 PHASE4
NCT03831165 COMPLETED
Genital Herpes
University of Sao Paulo General Hospital
 2015-09-02 PHASE4
NCT03779243 COMPLETED
Sleep Disturbance; Trauma
Stanford University
 2019-01-07
NCT03848533 UNKNOWN
PreDiabetes
University of Guadalajara
 2019-08-22 PHASE2
NCT03241004 TERMINATED
Anesthesia
Englewood Hospital and Medical Center
 2017-07-07
NCT04802785 UNKNOWN
Air Travel
Dinara Zhumanbayeva
 2021-06 PHASE2; PHASE3
NCT03725267 TERMINATED
Acute Kidney Injury; Melatonin; Polymyxin B Adverse Reaction
Hospital de Clinicas de Porto Alegre
 2018-10-01 PHASE2
NCT03478306 COMPLETED
Diabetic Retinopathy; Melatonin; Circadian Dysrhythmia; Circadian Rhythm Sleep Disorder, Unspecified Type
Glostrup University Hospital, Copenhagen
 2018-03-27 PHASE3
NCT02332928 TERMINATED
Breast Cancer - Female
Virginia Commonwealth University
 2015-03-25 PHASE3
NCT03966235 UNKNOWN
Coronary Artery Calcification
Chinese PLA General Hospital
 2019-06-01 PHASE4
NCT01863446 COMPLETED
Pregnancy
Brigham and Women's Hospital
 2013-05
NCT02681887 UNKNOWN
Obesity; Prediabetic State
Brigham and Women's Hospital
 2016-09 PHASE3
NCT05596617 COMPLETED
Severe Covid-19
Hospital San Carlos, Madrid
 2020-04-22
NCT03859934 COMPLETED
Metabolic Disease; Insulin Sensitivity; Glucose Metabolism Disorders (Including Diabetes Mellitus); Type 2 Diabetes Mellitus; Blood Pressure; Inflammation
University of Aarhus
 2019-09-26 PHASE1
NCT03524937 COMPLETED
Mechanically Ventilated Patients
Assistance Publique - Hôpitaux de Paris
 2019-02-01 PHASE2; PHASE3
NCT02454855 TERMINATED
Cancer
Centre Jean Perrin
 2015-07 PHASE3
NCT04424875 COMPLETED
Impacted Third Molar Tooth
Fayoum University
 2020-07-01 PHASE3
NCT02386319 COMPLETED
Anxiety
Herlev Hospital
 2016-08 PHASE3
NCT04193501 UNKNOWN
Irritable Bowel Syndrome
Sanjay Gandhi Postgraduate Institute of Medical Sciences
 2020-02-01 PHASE3
NCT03716583 COMPLETED
Radiation Dermatitis; Radiation Dermatitis Acute; Breast Cancer
Dennis Bregner Zetner
 2019-04-30 PHASE2
NCT03689998 COMPLETED
Immediate Dental Implant
Cairo University
 2019-09-30 PHASE4
NCT04278677 UNKNOWN
Sleep Disturbance
Rothman Institute Orthopaedics
 2020-03
NCT02487082 TERMINATED
Autism Spectrum Disorder
Stony Brook University
 2015-06 PHASE2
NCT04625179 COMPLETED
Edentulous; Alveolar Process, Atrophy
Hams Hamed Abdelrahman
 2019-12-03
NCT05759416 COMPLETED
Chronic Periodontitis
Al-Azhar University
 2020-04-01 PHASE4
NCT04570254 COMPLETED
Pneumonia, Viral; Covid19; ARDS; Oxidative Stress
Unidad Temporal COVID-19 en Centro Citibanamex
 2020-08-19
NCT03255642 COMPLETED
REM Sleep Behavior Disorder
Kyung Hee University Hospital at Gangdong
 2017-11-09
NCT04035889 COMPLETED
Multiple Sclerosis
University of California, San Francisco
 2019-09-23
NCT04470297 UNKNOWN
Covid19; Lung Injury
Associação Fundo de Incentivo à Pesquisa
 2020-09 PHASE2
NCT05236907 COMPLETED
Delirium, Anesthesia Emergence; Delirium
University of Baghdad
 2020-07-01
NCT04353128 COMPLETED
Covid19; SARS-CoV 2; Coronavirus Infection
Instituto de Investigación Hospital Universitario La Paz
 2020-04-20 PHASE2; PHASE3
NCT02536417 COMPLETED
Delirium
Fraser Health
 2016-06-29 PHASE3
NCT04251845 UNKNOWN
Oral Leukoplakia
Postgraduate Institute of Dental Sciences Rohtak
 2020-02-01
NCT04785183 COMPLETED
Newborn Morbidity; Oxidative Stress; Pre-Term; Melatonin Deficiency
Azienda Ospedaliera Universitaria Policlinico "G. Martino"
 2019-01-01
NCT02506777 UNKNOWN
Breast Cancer
N.N. Petrov National Medical Research Center of Oncology
 2015-07 PHASE2
NCT02506790 UNKNOWN
Breast Cancer
N.N. Petrov National Medical Research Center of Oncology
 2015-07 PHASE2
NCT04409522 UNKNOWN
COVID-19
Mohammad Sadegh Bagheri Baghdasht
 2020-05-12
NCT04229719 UNKNOWN
Alveolar Bone Loss
University of Baghdad
 2019-11-01 PHASE3
NCT04336566 COMPLETED
Chronic Kidney Diseases
University of Oklahoma
 2019-07-01
NCT02691897 UNKNOWN
Diabetes Mellitus
Shiraz University of Medical Sciences
 2019-07 EARLY_PHASE1
NCT03894683 UNKNOWN
Heart Failure With Reduced Ejection Fraction
Isfahan University of Medical Sciences
 2018-11-30 PHASE2
NCT04189666 COMPLETED
Delirium
Ain Shams University
 2019-11-18 PHASE1; PHASE2
NCT03590197 COMPLETED
Generalized Epilepsy
All India Institute of Medical Sciences, Bhubaneswar
 2018-08-06 PHASE4
NCT04187807 UNKNOWN
Delirium in Old Age
Universidad Autonoma de San Luis Potosí
 2019-10-10
NCT03692026 UNKNOWN
Immediate Dental Implant
Cairo University
 2018-10 PHASE4
NCT02639741 COMPLETED
Postoperative Pain
Cukurova University
 2014-11 PHASE4
NCT03656484 COMPLETED
Chronic Periodontitis
Concordia Dent Srl
 2019-01-15 PHASE2
NCT04304807 COMPLETED
Preterm Infant; Feeding Intolerance; Necrotizing Enterocolitis
Ain Shams University
 2018-12-24 PHASE4
NCT03597529 COMPLETED
Migraine
Amy Gelfand
 2017-09-25 PHASE2
NCT03150797 TERMINATED
Migraine
Amy Gelfand
 2017-08-02 PHASE2
NCT02789592 UNKNOWN
REM Sleep Behavior Disorder; Parkinson Disease
Seoul National University Hospital
 2016-07 PHASE2
NCT03966950 UNKNOWN
Melatonin; Cognitive Dysfunction; Postoperative Complications; Prostate Hyperplasia
University of Sao Paulo
 2017-06-26
NCT03764020 UNKNOWN
Elevated Blood Pressure
Tehran University of Medical Sciences
 2019-06-01 PHASE3
NCT03117725 UNKNOWN
Infertility, Female
Bundang CHA Hospital
 2017-05-12
NCT04067791 COMPLETED
Healthy
Pharmavite LLC
 2019-08-01 PHASE1
NCT03953066 COMPLETED
Indications for Care in Pregnancy; Labor; and Delivery
Samsun Education and Research Hospital
 2019-06-12
NCT03951025 COMPLETED
Biological Availability
Technological Centre of Nutrition and Health, Spain
 2019-06-05 PHASE2
NCT03461042 COMPLETED
Chronic Insomnia
Translational Research Center for Medical Innovation, Kobe, Hyogo, Japan
 2018-02-06 PHASE4
NCT03788733 UNKNOWN
Sleep Disorders, Circadian Rhythm
Universidad de Murcia
 2018-12-14
NCT03348982 UNKNOWN
Physical Activity; Sleep Apnea; Autism Spectrum Disorder
The Hong Kong Polytechnic University
 2018-01
NCT02319265 WITHDRAWN
Sepsis
University of Aberdeen
 2017-04 PHASE1; PHASE2
NCT04019899 COMPLETED
Female Infertility
Lo.Li.Pharma s.r.l
 2018-05-02
NCT02963181 TERMINATED
Hypotension, Orthostatic; Hypertension; Autonomic Nervous System Diseases
London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's
 2018-03-01 EARLY_PHASE1
NCT03659760 COMPLETED
Cranial Nerve Diseases
Diskapi Yildirim Beyazit Education and Research Hospital
 2018-09-03
NCT03062839 UNKNOWN
Attention Deficit Hyperactivity Disorder
Hospital Israelita Albert Einstein
 2017-09-01 PHASE3
NCT03204877 COMPLETED
Glucose Metabolism Disorders
University of Aarhus
 2017-08-22 PHASE1; PHASE2
NCT03688464 WITHDRAWN
Atopic Dermatitis
University of Nebraska
 2019-02-02 EARLY_PHASE1
NCT02251041 COMPLETED
Reperfusion Injury
Universitaire Ziekenhuizen KU Leuven
 2014-09 PHASE2
NCT03492970 COMPLETED
Smith Magenis Syndrome
Hôpital le Vinatier
 2018-03-07
NCT03258294 UNKNOWN
Parkinson's Disease
KIMJisun
 2016-01-13 PHASE4
NCT03588676 COMPLETED
Intermittent Hypoxia
Robert L. Owens
 2018-01-10
NCT03833570 COMPLETED
Oral Mucositis (Ulcerative) Due to Radiation
Hams Hamed Abdelrahman
 2018-01-12 PHASE2
NCT03732963 COMPLETED
Monitored Anaesthesia Care; Loco-regional Chronic Subdural Hematoma Evacuation
Cairo University
 2018-09-05 PHASE1
NCT04352062 COMPLETED
Melatonin Deficiency
Medical University of Lodz
 2011-01-09
NCT02615340 UNKNOWN
Delirium
Mount Sinai Hospital, Canada
 2017-10-12 PHASE2
NCT03492736 TERMINATED
Obstructive Sleep Apnea
Naomi Deacon
 2018-04-01 EARLY_PHASE1
NCT03631901 COMPLETED
Febrile Seizures
Tanta University
 2017-04-01 PHASE4
NCT04137627 COMPLETED
Oral Squamous Cell Carcinoma; Neoadjuvant Chemotherapy
Indonesia University
 2017-07-04 PHASE3
NCT02732288 TERMINATED
Disorders of Consciousness
Rockefeller University
 2016-05
NCT01993251 COMPLETED
Sleep Disorders
Hospices Civils de Lyon
 2014-06 PHASE2
NCT03419767 UNKNOWN
Carotid Stenosis
Peking Union Medical College Hospital
 2017-08-01 PHASE4
NCT04392063 COMPLETED
Cerebral Palsy; Melatonin; Growth; Children, Only
Ain Shams University
 2016-06
NCT02903901 WITHDRAWN
Delirium
Loyola University
 2015-06 PHASE4
NCT04013464 COMPLETED
Depressive Disorder, Major
Peking University Sixth Hospital
 2016-05-01
NCT00506259 COMPLETED
Developmental Delay Disorders; Chromosome Deletion; Mental Retardation; Sleep Disorders, Circadian Rhythm; Self Injurious Behavior
National Human Genome Research Institute (NHGRI)
 2007-07-17 PHASE1
NCT04034771 COMPLETED
TBI (Traumatic Brain Injury)
Cairo University
 2018-01-01 PHASE3
NCT02395783 TERMINATED
Premature Birth
Assistance Publique - Hôpitaux de Paris
 2015-03 PHASE2; PHASE3
NCT02883790 TERMINATED
Breast Cancer; Lung Cancer; Colon Cancer
Helsinn Healthcare SA
 2015-10
NCT03013790 UNKNOWN
Delirium; Melatonin
MICE Trial Group
 2016-12 PHASE4
NCT02836743 UNKNOWN
REM Sleep Behavior Disorder
Seoul National University Hospital
 2016-01 PHASE4
NCT02631148 TERMINATED
Obesity; Prediabetic State
Brigham and Women's Hospital
 2016-01 PHASE2
NCT02630004 COMPLETED
Oral Mucositis
Spherium Biomed
 2015-11 PHASE1; PHASE2
NCT01858155 COMPLETED
Relapsed Malignant Solid Tumor
C17 Council
 2013-05 PHASE1
NCT01904786 WITHDRAWN
Newborn Hypoxic Ischemic Encephalopathy
St. Louis University
 2014-04 PHASE1
NCT02654314 TERMINATED
Delirium
Yale University
 2016-07 PHASE3
NCT02484300 COMPLETED
Obstructive Sleep Apnea
University of California, San Diego
 2015-07
NCT03156205 COMPLETED
Critically Ill Adult Patients in Intensive Care Units
Yonsei University
 2017-03-02
NCT02195661 COMPLETED
Epilepsy; Electroencephalogram; Children; Sedation
University of Cape Town
 2014-04 PHASE3
NCT02451293 COMPLETED
Depression; Acute Coronary Syndrome
Zealand University Hospital
 2016-01-18 PHASE2; PHASE3
NCT02889432 UNKNOWN
Dentofacial Deformities
The University of Hong Kong
 2016-06 PHASE2
NCT02962037 UNKNOWN
Delayed Sleep Phase Syndrome
Lilach Kemer
 2016-11 PHASE4
NCT02993588 UNKNOWN
In Vitro Fertilization; Poor Ovarian Response
Assiut University
 2016-12 PHASE2; PHASE3
NCT03153917 COMPLETED
Shift-Work Sleep Disorder
Hospices Civils de Lyon
 2017-06-02
NCT03514732 COMPLETED
Sleep Disorder (Healthy Volunteers)
Sanofi
 2017-03-17 PHASE1
NCT03000777 COMPLETED
Fatigue Syndrome, Chronic; Myalgic Encephalomyelitis
Laboratorios Viñas, S.A.
 2016-02
NCT02824770 UNKNOWN
Sleep Deprivation
Eskisehir Osmangazi University
 2017-01-01
NCT02374567 TERMINATED
Dementia; Depression; Schizophrenia; Psychosomatic Disorders; Anxiety Disorders
Hannover Medical School
 2015-01 PHASE3
NCT03368430 COMPLETED
Periodontal Diseases
Mansoura University
 2016-07-04 PHASE4
NCT03115034 COMPLETED
Carotid Stenosis
Peking Union Medical College Hospital
 2016-06-01 PHASE4
NCT01566474 COMPLETED
Barrett's Esophagus
Aragon Institute of Health Sciences
 2012-04 PHASE3
NCT02936674 COMPLETED
Melatonin
VA Palo Alto Health Care System
 2016-10
NCT02500017 TERMINATED
Night-eating Syndrome
Yale University
 2015-09-24
NCT01700959 COMPLETED
Cancer Malignancies
St. Jude Children's Research Hospital
 2013-02-06 PHASE3
NCT01874847 UNKNOWN
Post-concussion Syndrome; Post-concussive Symptoms; Traumatic Brain Injury; Concussion; Children
University of Calgary
 2013-09 PHASE2; PHASE3
NCT00668707 COMPLETED
Non Small Cell Lung Cancer
The Canadian College of Naturopathic Medicine
 2007-09 PHASE3
NCT02486796 TERMINATED
Quality of Life
Midwestern Regional Medical Center
 2016-02-19 PHASE1; PHASE2
NCT03295162 COMPLETED
Neonatal Sepsis
Mohamed Hussein Metwally
 2015-11-26 PHASE1; PHASE2
NCT02768077 UNKNOWN
Parkinson's Disease
Kuhnil Pharmaceutical Co., Ltd.
 2016-01 PHASE4
NCT03066518 COMPLETED
Sleep Disorders; Dementia
Hospital Universitario Dr. Jose E. Gonzalez
 2016-01-15 PHASE4
NCT02691702 COMPLETED
Healthy Adult Subjects; Healthy Elderly Subjects
Biogen
 2016-03-28 PHASE1
NCT02597231 COMPLETED
Delirium
Scripps Health
 2015-11 PHASE1; PHASE2
NCT03121521 COMPLETED
Hepatopathy
Medical University of Lodz
 2012-09-01 PHASE4
NCT04005222 COMPLETED
Anterior Segment Ischemia (Diagnosis)
Beytepe Murat Erdi Eker State Hospital
 2014-05 EARLY_PHASE1
NCT02644590 UNKNOWN
Diabetes Mellitus, Type 1; Hypertension
Sheba Medical Center
 2016-02 EARLY_PHASE1
NCT01965522 COMPLETED
Early Stage Breast Cancer
Juravinski Cancer Center
 2013-10 PHASE2
NCT02845778 UNKNOWN
Pharmacokinetics of Melatonin
Khon Kaen University
 2016-05 PHASE1; PHASE2
NCT01598259 TERMINATED
Burns
Shriners Hospitals for Children
 2014-05 PHASE2
NCT01172171 COMPLETED
Acute Myocardial Infarction; Ischemia-reperfusion Injury
Herlev Hospital
 2013-06 PHASE2
NCT02424071 COMPLETED
Recovery From Bariatric Surgery
Sheba Medical Center
 2015-07 PHASE4
NCT02200172 COMPLETED
Cancer
Bruyère Health Research Institute.
 2014-12 PHASE2
NCT02344316 COMPLETED
Migraine in Adolescents
Amy Gelfand
 2015-05 PHASE2
NCT00640094 TERMINATED
Acute Myocardial Infarction
Alberto Domínguez Rodríguez
 2013-05 PHASE2
NCT02588742 TERMINATED
Delirium
Yonsei University
 2015-02-02
NCT02431728 COMPLETED
Substance Withdrawal Syndrome
Duquesne University
 2015-05 PHASE1; PHASE2
NCT02663570 UNKNOWN
Polycystic Ovary Syndrome
Catholic University of the Sacred Heart
 2015-06
NCT02190838 TERMINATED
Melanoma
N.N. Petrov National Medical Research Center of Oncology
 2014-04 PHASE2
NCT00691444 TERMINATED
Blindness
Oregon Health and Science University
 2002-09
NCT02430298 COMPLETED
Head and Neck Cancer
Khon Kaen University
 2013-07 PHASE2
NCT02604095 COMPLETED
Acanthosis Nigricans; Obesity
Shanghai 10th People's Hospital
 2014-05
NCT02359448 UNKNOWN
Parkinson's Disease; Nocturia
University College, London
 2015-04 PHASE2
NCT02099331 WITHDRAWN
Atrial Fibrillation
Johns Hopkins University
 2014-09 PHASE2
NCT02747628 COMPLETED
Postoperative Pain Relief
Ain Shams University
 2013-04 PHASE4
NCT02591238 COMPLETED
Smoking; Vascular System Injuries
Peking Union Medical College Hospital
 2015-06 PHASE4
NCT00795236 TERMINATED
Sleep Disorder; Blindness
Oregon Health and Science University
 2009-11
NCT00688935 TERMINATED
Blindness
Oregon Health and Science University
 2005-01
NCT04684199 COMPLETED
Dyspepsia
Children's Mercy Hospital Kansas City
 2014-08
NCT02767102 COMPLETED
Bioavailability
University of Milan
 2014-07
NCT01617070 COMPLETED
Phenylketonuria (PKU)
University of Southern California
 2012-05 PHASE4
NCT01695070 COMPLETED
Fetal Growth Retardation
Monash University
 2012-09 PHASE4
NCT01705639 COMPLETED
Diabetes; Glucose Tolerance
University of Helsinki
 2012-11 PHASE3
NCT02195271 UNKNOWN
Analgesia Disorder; Pain
Hospital de Clinicas de Porto Alegre
 2014-03 PHASE2
NCT05511740 COMPLETED
Cervical Cancer; Radiotherapy Side Effect
Indonesia University
 2010-01
NCT01690000 COMPLETED
Osteoporosis
University of Aarhus
 2012-11
NCT01923974 COMPLETED
Analgesia; Antihyperalgesia
Lars Peter Holst Andersen
 2013-08 PHASE2; PHASE3
NCT01431092 COMPLETED
Schizophrenia; Schizoaffective Disorder; Bipolar Affective Disorder
Lone Baandrup
 2011-10 PHASE4
NCT00625742 TERMINATED
Advanced Cancer; Cachexia
M.D. Anderson Cancer Center
 2008-02
NCT00965575 COMPLETED
Epilepsy
Children's Hospital Medical Center, Cincinnati
 2011-06 PHASE2
NCT01863277 UNKNOWN
Acute Ischemic Stroke
Wolfson Medical Center
 2013-07 PHASE4
NCT01741389 COMPLETED
Spinal Cord Injured, Tetraplegia
University of Oslo
 2012-12 PHASE1
NCT01586039 COMPLETED
Non-visual Photoreception
Brigham and Women's Hospital
 2012-08
NCT01903681 COMPLETED
Sleep Problems
Neurim Pharmaceuticals Ltd.
 2013-03 PHASE1
NCT02224937 COMPLETED
Solar Skin Damage
Zealand University Hospital
 2013-12 PHASE1
NCT01279876 COMPLETED
Multiple Sclerosis, Relapsing-Remitting
Tehran University of Medical Sciences
 2010-10 PHASE2
NCT01858909 UNKNOWN
Severe Sepsis; Septic Shock
Aragon Institute of Health Sciences
 2013-05 PHASE3
NCT01860716 UNKNOWN
Evidence of Liver Transplantation
Aragon Institute of Health Sciences
 2013-05 PHASE3
NCT01267604 WITHDRAWN
Infertility
AGUNCO Obstetrics and Gynecology Centre
 2010-12 PHASE4
NCT00988078 UNKNOWN
Polycystic Ovary Syndrome
Federal University of São Paulo
 2011-07
NCT02265822 COMPLETED
Premedication; Anaesthesia
Azienda Ospedaliera Universitaria Policlinico "G. Martino"
 2012-09 PHASE4
NCT01114360 COMPLETED
Hypertension
Emory University
 2010-03 PHASE2
NCT01114373 COMPLETED
Hypertension
Emory University
 2010-06 PHASE2
NCT00950885 COMPLETED
Delayed Sleep Phase Disorder; Jet-lag; Shift-work Disorder
Brigham and Women's Hospital
 2009-09
NCT01575678 UNKNOWN
Nocturnal Enuresis
University of Aarhus
 2012-01 PHASE2
NCT01780883 COMPLETED
Childhood Autism
Rennes University Hospital
 2013-02 PHASE2
NCT01505465 COMPLETED
Postoperative Pain; Delirium; Confusion; Sleep
Hospital for Special Surgery, New York
 2012-02
NCT01724424 COMPLETED
Sepsis
University of Aberdeen
 2012-06 PHASE1
NCT01873430 COMPLETED
Sunburn
Herlev Hospital
 2013-05 PHASE1
NCT01593774 COMPLETED
Schizophrenia
Guilan University of Medical Sciences
 2012-05 PHASE2
NCT00925899 COMPLETED
Cancer; Fatigue
Bispebjerg Hospital
 2009-10 PHASE2; PHASE3
NCT01198938 COMPLETED
Cardiac Surgery
University Health Network, Toronto
 2010-08
NCT01340417 COMPLETED
Pregnancy Preterm
Assistance Publique - Hôpitaux de Paris
 2011-04
NCT01355523 TERMINATED
Breast Cancer; Depression
Melissa Voigt Hansen
 2011-07 PHASE2; PHASE3
NCT02876770 TERMINATED
Motor Activity
kais
 2012-12 EARLY_PHASE1
NCT03505411 COMPLETED
Antioxidants; Oxidative Stress; Inflammation; Lipid Peroxidation
Nicolaus Copernicus University
 2010-01-15
NCT00513357 COMPLETED
Gastrointestinal Cancer; Lung Cancer
M.D. Anderson Cancer Center
 2006-06 PHASE3
NCT01718678 COMPLETED
Fatigue
Isfahan University of Medical Sciences
 2012-05 PHASE2
NCT01572805 COMPLETED
Post Partum Haemorrhage in Patients Undergoing Cesarean Section
Qazvin University Of Medical Sciences
 2012-02 PHASE1; PHASE2
NCT01038921 COMPLETED
Metabolic Syndrome
Emory University
 2009-07 PHASE2
NCT01370486 WITHDRAWN
Lennox-Gastaut Syndrome
Institution de Lavigny
 2011-08 PHASE4
NCT02107079 COMPLETED
Pharmacokinetics of Melatonin
Utrecht University
 2012-01
NCT00834886 COMPLETED
Delayed Sleep Phase Syndrome
University of Bergen
 2008-10 PHASE4
NCT01486615 COMPLETED
Anxiety
B.P. Koirala Institute of Health Sciences
 2011-10 PHASE4
NCT01269671 WITHDRAWN
Functional Abdominal Pain; Irritable Bowel Syndrome; Functional Dyspepsia
Medical College of Wisconsin
 2011-01 PHASE1
NCT01115127 COMPLETED
Pre-menopausal Irregular Cycles and Bleedings
University of Messina
 2010-03 PHASE2; PHASE3
NCT01357031 COMPLETED
Migraine
Hospital Israelita Albert Einstein
 2010-05 PHASE3
NCT01706627 COMPLETED
Advanced Stage Cancer
Khon Kaen University
 2007-08 PHASE2; PHASE3
NCT00867451 COMPLETED
Attention Deficit Hyperactivity Disorder
Children's Hospital Medical Center, Cincinnati
 2010-01 PHASE1; PHASE2
NCT01280734 COMPLETED
Postural Instability
Neurim Pharmaceuticals Ltd.
 2011-01 PHASE4
NCT00649961 COMPLETED
Premature Birth; Brain Injury
Imperial College London
 2010-05 PHASE2
NCT01528202 COMPLETED
Sleep
Northumbria University
 2010-04
NCT00507546 COMPLETED
Insomnia; Spinal Cord Injury; Tetraplegia; Sleep Disorders
US Department of Veterans Affairs
 2007-07 PHASE4
NCT00749814 UNKNOWN
Sleep Disorders
Tel-Aviv Sourasky Medical Center
 2008-10 PHASE4
NCT00512070 COMPLETED
Schizophrenia; Schizoaffective Disorder; Bipolar Disorder; Obesity; Metabolic Syndrome
Seattle Institute for Biomedical and Clinical Research
 2007-07
NCT01033565 TERMINATED
Sleep Disorder
University of Nebraska
 2010-03-04 PHASE4
NCT00238108 COMPLETED
Sleep Disorders; Hypertension
Brigham and Women's Hospital
 2005-10 PHASE2
NCT01152580 COMPLETED
Osteoporosis; Osteopenia
Duquesne University
 2008-09 PHASE1
NCT01064544 COMPLETED
Sleep Problems
Meander Medical Center
 2010-03 PHASE3
NCT00927030 COMPLETED
Autistic Disorder; Insomnia
Vanderbilt University
 2008-01 PHASE1
NCT00790478 TERMINATED
Ulcerative Colitis
Emory University
 2009-01 PHASE2
NCT00387179 UNKNOWN
Sleep Disorders, Circadian Rhythm
National Heart, Lung, and Blood Institute (NHLBI)
 2006-10
NCT00869869 WITHDRAWN
Heart Failure; Sleep Disorders
Brigham and Women's Hospital
 2009-03 PHASE2
NCT00675181 COMPLETED
Vasospastic Syndrome
University Hospital, Basel, Switzerland
 2008-05
NCT00388661 COMPLETED
Sleep Problems; Haemodialysis
Meander Medical Center
 2007-04 PHASE3
NCT00849511 COMPLETED
Migraine
Nordlandssykehuset HF
 2009-02 PHASE2
NCT01805089 COMPLETED
Breast Cancer
Dana-Farber Cancer Institute
 2006-10 EARLY_PHASE1
NCT00691574 TERMINATED
Chromosome Disorders
Oregon Health and Science University
 1998-09
NCT00705003 COMPLETED
Major Depressive Disorder
Massachusetts General Hospital
 2008-05 PHASE2
NCT00506064 TERMINATED
Breast Cancer
M.D. Anderson Cancer Center
 2004-02 PHASE1
NCT00444249 TERMINATED
Macular Degeneration
The Ludwig Boltzmann Institute of Retinology and Biomicroscopic Laser Surgery
 2007-03
NCT00315926 COMPLETED
Aortic Aneurysm
University Hospital, Gentofte, Copenhagen
 2007-01 PHASE2; PHASE3
NCT02156271 COMPLETED
Insomnia
Duke University
 2007-07 PHASE4
NCT00230737 COMPLETED
Sleep Initiation and Maintenance Disorders
Nalaka Gooneratne
 2004-10 PHASE2
NCT00692094 TERMINATED
Blindness
Oregon Health and Science University
 2004-08
NCT00972075 COMPLETED
Non-24 Hour Sleep-Wake Disorder; Blindness
Neurim Pharmaceuticals Ltd.
 2006-02 PHASE2
NCT00404456 COMPLETED
Hemodialysis; Peritoneal Dialysis; Sleep Problems
Meander Medical Center
 2005-04 PHASE3
NCT00113906 COMPLETED
Postoperative Complications; Fatigue; Dyssomnias
University Hospital, Gentofte, Copenhagen
 2005-03 PHASE2; PHASE3
NCT00097474 COMPLETED
Jet Lag
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
 2004-12-21 PHASE2
NCT00869128 COMPLETED
Diabetes Mellitus, Type 2; Insomnia
Neurim Pharmaceuticals Ltd.
 1995-11 PHASE2
NCT00915616 WITHDRAWN
Gastroesophageal Reflux Disease
Mansoura University
 PHASE3
NCT00544791 UNKNOWN
Mild Cognitive Impairment (MCI)
Assaf-Harofeh Medical Center
 2007-10 PHASE2
NCT00261183 UNKNOWN
Benzodiazepines
Tel-Aviv Sourasky Medical Center
 2004-12 PHASE3
NCT01325389 UNKNOWN
Perimenopause
AGUNCO Obstetrics and Gynecology Centre
NCT00564590 UNKNOWN
Gastroesophageal Reflux Disease
Rabin Medical Center
 2008-10 PHASE1; PHASE2
NCT00288262 TERMINATED
Hot Flashes
Scripps Health
 2004-06 PHASE1; PHASE2
NCT00282061 UNKNOWN
Delayed Sleep Phase Syndrome
Sheba Medical Center
 PHASE1
NCT00000171 COMPLETED
Alzheimer Disease; Dyssomnias
National Institute on Aging (NIA)
 PHASE3

(data from https://clinicaltrials.gov, updated on 2026-06-05)

Check the Melatonin product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.

Compliance for Clinical Use

Mechanism and Biochemical Profile

As a melatonin receptor agonist and selective ATF-6 inhibitor, melatonin downregulates COX-2 expression and modulates signaling cascades to enhance mitophagy while maintaining the cellular homeostasis of autophagy and apoptosis. This biochemical modulation attenuates cellular oxidative stress and systemic inflammatory responses, providing a therapeutic rationale for its clinical evaluation in conditions such as preoperative anxiety, psychiatric disorders, and fatigue.

Appendix RUO and cGMP Quality Standards

Quality Dimension RUO (Research Use Only) cGMP (Current Good Manufacturing Practice)
Clinical Applicability Prohibited in human clinical trials or medical diagnostics. Mandatory for human clinical trials (Phase I–III) and therapies.
Regulatory Status Non-regulated grade; exempt from drug manufacturing laws. Legally enforced by health authorities (e.g., FDA, EMA, NMPA).
Facility Environment Unclassified analytical or research laboratories. Validated Cleanrooms (ISO Class 5–8) with continuous monitoring.
Quality Control Basic purity and activity testing. Rigorous safety release testing (Sterility, Endotoxin, Mycoplasma).
Process Validation Basic equipment calibration; no process validation required. Full qualification (IQ/OQ/PQ) and complete batch records.
Quality Assurance Vendor self-declared without required formal QMS. Mandatory QA/QC unit, Change Control, CAPA, and vendor audits.
Regulatory Impact High risk of IND rejection if used as a critical raw material. Required for IND/NDA filings, supported by Drug Master Files (DMF).

Footnotes

Regulatory Note: Governed by FDA (21 CFR Parts 210/211/312), EMA (EudraLex Vol 4), ICH Guidelines (E6/Q7/Q9/Q10), and compendial standards (USP <71>/<85>/<1043>).

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Note: Technical data last updated: Sep 1, 2026.