CAS No. 10347-81-6
| IUPAC Name | N-methyl-3-(1-tetracyclo[6.6.2.02,7.09,14]hexadeca-2,4,6,9,11,13-hexaenyl)propan-1-amine;hydrochloride | |
|---|---|---|
| CAS Number | 10347-81-6 | |
| Molecular Formula |
C20H23N.HCl |
|
| Molecular Weight (MW) | 313.86 | |
| SMILES | CNCCCC12CCC(C3=CC=CC=C31)C4=CC=CC=C24.Cl | |
| InChIKey | NZDMFGKECODQRY-UHFFFAOYSA-N |
Maprotiline HCl is a tetracyclic antidepressant that functions as a selective norepinephrine reuptake inhibitor. By selectively blocking the norepinephrine transporter at presynaptic nerve terminals, Maprotiline HCl prevents the reuptake of norepinephrine into neurons. This inhibition enhances noradrenergic neurotransmission by increasing extracellular norepinephrine concentration in central adrenergic synapses, thereby modulating downstream adrenergic signaling pathways. [1]
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Concentration
Volume
Mass
|
|---|
| Solvent | Solubility & Note |
|---|---|
| DMSO |
62 mg/mL
(197.54 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Ethanol | 52 mg/mL |
| Water | Insoluble |
| DMSO |
63 mg/mL
(200.72 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Ethanol | 24 mg/mL |
| Water | Insoluble |
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
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