CAS No. 89226-75-5
Batch:
Purity:99.57
Chemical Structure
Check the
Manidipine 2HCl
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
Chemical Information
| IUPAC Name | 5-O-[2-(4-benzhydrylpiperazin-1-yl)ethyl] 3-O-methyl 2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate;dihydrochloride | |
|---|---|---|
| CAS Number | 89226-75-5 | |
| Molecular Formula |
C35H38N4O6.2HCl |
|
| Molecular Weight (MW) | 683.62 | |
| SMILES | CC1=C(C(C(=C(N1)C)C(=O)OCCN2CCN(CC2)C(C3=CC=CC=C3)C4=CC=CC=C4)C5=CC(=CC=C5)[N+](=O)[O-])C(=O)OC.Cl.Cl | |
| InChIKey | JINNGBXKBDUGQT-UHFFFAOYSA-N |
Biological Activity
Manidipine 2HCl is a lipophilic, third-generation dihydropyridine calcium channel blocker that acts as a potent inhibitor of voltage-gated calcium channels. By blocking voltage-dependent inward calcium currents in vascular smooth muscle cells, it reduces intracellular calcium levels and induces systemic vasodilation. Furthermore, manidipine suppresses vascular smooth muscle cell proliferation and DNA synthesis while promoting glycosaminoglycan synthesis.
How to Prepare Stock Solution?
|
Concentration
Volume
Mass
|
|---|
Solubility
Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| DMSO |
100 mg/mL
(146.28 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Water | Insoluble |
| Ethanol | Insoluble |
| DMSO |
137 mg/mL
(200.4 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Water | Insoluble |
| Ethanol | Insoluble |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Pre-aliquoted for Longevity: Solid-state aliquots offer longer shelf life compared to stock solutions.
Looking for a specific aliquot size? Contact your local sales representative or orders@selleckchem.com.
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Note: Technical data last updated: Sep 1, 2026.