CAS No. 852475-26-4
Batch:
Purity:99.51
Chemical Structure
Check the
MC1568
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
Chemical Information
| IUPAC Name | (E)-3-[4-[(E)-3-(3-fluorophenyl)-3-oxoprop-1-enyl]-1-methylpyrrol-2-yl]-N-hydroxyprop-2-enamide | |
|---|---|---|
| CAS Number | 852475-26-4 | |
| Molecular Formula |
C17H15FN2O3 |
|
| Molecular Weight (MW) | 314.31 | |
| SMILES | CN1C=C(C=C1C=CC(=O)NO)C=CC(=O)C2=CC(=CC=C2)F | |
| InChIKey | QRDAPCMJAOQZSU-KQQUZDAGSA-N |
Biological Activity
MC1568 is a selective class II histone deacetylase (HDAC) inhibitor that selectively targets class II HDACs over class I HDACs. By inhibiting class II HDAC activity, MC1568 interrupts HDAC-mediated transcriptional repression and regulates myocyte enhancer factor 2 (MEF2) signaling pathways. This inhibition impairs cell differentiation and myogenesis while suppressing proliferation in specific cancer cell lines, making MC1568 a useful chemical probe for dissecting class II HDAC functions. [1]
How to Prepare Stock Solution?
|
Concentration
Volume
Mass
|
|---|
Solubility
Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| DMSO |
22 mg/mL
(69.99 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Water | Insoluble |
| Ethanol | Insoluble |
| DMSO |
13 mg/mL
(41.36 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Water | Insoluble |
| Ethanol | Insoluble |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Pre-aliquoted for Longevity: Solid-state aliquots offer longer shelf life compared to stock solutions.
Looking for a specific aliquot size? Contact your local sales representative or orders@selleckchem.com.
Reference
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Note: Technical data last updated: Sep 1, 2026.