CAS No. 136790-76-6

Batch: Purity:99.02
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Lubiprostone Chemical Structure
Chemical Structure
Check the Lubiprostone product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.

Chemical Information

CAS Number 136790-76-6
Molecular Formula

C20H32F2O5
Molecular Weight (MW) 390.46
SMILES CCCCC(C1(CCC2C(O1)CC(=O)C2CCCCCCC(=O)O)O)(F)F

Biological Activity

Lubiprostone is a bicyclic prostaglandin E1 derivative that acts as a selective activator of ClC-2 chloride channels. Activation of apical ClC-2 channels in gastrointestinal epithelial cells stimulates chloride-rich fluid secretion directly into the intestinal lumen. This localized fluid secretion softens stool, accelerates intestinal transit, and promotes gastrointestinal motility while helping to restore epithelial mucosal barrier function.

How to Prepare Stock Solution?

Concentration Volume Mass
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Solubility

Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
Solvent Solubility & Note
DMSO 78 mg/mL (199.76 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.)
Ethanol 78 mg/mL
Water Insoluble
FAQ
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
  • Preheat media/saline to 37°C.
  • Mix rapidly (pipette/vortex) upon addition.
  • For complex mixes, always add the aqueous phase last.
  • Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).

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Note: Technical data last updated: Sep 1, 2026.