Clinical Trials

Numerous clinical trials evaluate lidocaine for regional anesthesia and pain management, covering indications such as acute postoperative pain, labor pain, axial spondyloarthritis epidural blocks, procedural local analgesia, and intramuscular injection adverse reactions. Spanning Early Phase 1 through Phase 4, these studies are primarily sponsored by academic medical centers, including Washington University School of Medicine, Duke University, and the University of Alberta. Recruitment statuses across this body of research encompass completed, active, not yet recruiting, suspended, terminated, and unknown trials.

NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT07361549 NOT_YET_RECRUITING
Refractory Migraine; Headache
Daniel A Tonetti, MD
 2026-03 PHASE2
NCT07793552 NOT_YET_RECRUITING
Vulvar Cancers; Vulva Neoplasm; Vulvar Dysplasia
Tufts Medical Center
 2026-11
NCT07709390 RECRUITING
Emergency Coughing
Ohio State University
 2023-05-31 EARLY_PHASE1
NCT07631364 NOT_YET_RECRUITING
Neisseria Gonorrhoeae (Ng) Infections
Assistance Publique - Hôpitaux de Paris
 2026-09 PHASE3
NCT07794878 RECRUITING
Nasolabial Folds
AbbVie
 2026-08-19 PHASE3
NCT07778043 NOT_YET_RECRUITING
Myofacial Pain; Pelvic Pain
Women and Infants Hospital of Rhode Island
 2026-08-17 PHASE4
NCT07687069 NOT_YET_RECRUITING
Breast Hypertrophy
Centre of Postgraduate Medical Education
 2026-07
NCT07676942 NOT_YET_RECRUITING
Urethral Stricture
Centre of Postgraduate Medical Education
 2026-06
NCT07414706 NOT_YET_RECRUITING
Intravenous Lidocaine; Laparoscopic Surgery; Post Operative Recovery; Local Anaesthetic Systemic Toxicity
Centre Hospitalier Universitaire, Amiens
 2026-03 PHASE3
NCT07650396 RECRUITING
Achilles Tendinopathy (AT)
Erasmus Medical Center
 2026-06-03 PHASE3
NCT07499154 NOT_YET_RECRUITING
Congenital Heart Disease; Postoperative Pulmonary Complications; Acute Lung Injury
The Children's Hospital of Zhejiang University School of Medicine
 2026-04-01 PHASE4
NCT07268924 NOT_YET_RECRUITING
Emergence Delirium, Anesthesia
Assiut University
 2026-01 PHASE4
NCT07691359 NOT_YET_RECRUITING
Osteoporotic Vertebral Fracture; Neuropathic Pain
University Hospital, Clermont-Ferrand
 2026-07-01 PHASE4
NCT06304779 RECRUITING
Postoperative Pulmonary Complications; Intra-abdominal Infection
Shanghai Zhongshan Hospital
 2023-10-31
NCT06792474 NOT_YET_RECRUITING
Spinal Disease; Anesthesia; Post Operative Pain
Dartmouth-Hitchcock Medical Center
 2026-08 PHASE4
NCT07630155 RECRUITING
Renal Pelvis and Ureter Urothelial Carcinoma
University of Michigan Rogel Cancer Center
 2026-08
NCT06146842 RECRUITING
Labor Pain
Brigham and Women's Hospital
 2023-12-01 PHASE4
NCT07294118 RECRUITING
Subarachnoid Hemorrhage, Aneurysmal; Headache; Opiate Dependence; Opioid Use
The University of Texas Medical Branch, Galveston
 2026-01-02 PHASE2
NCT07763132 RECRUITING
Procedural Pain
Marie Lulková
 2024-09-01
NCT07432399 RECRUITING
Colon Cancer; Colorectal Cancer; Perioperative Immune Response
Institute of Oncology Ljubljana
 2025-09-01 PHASE2
NCT07073846 RECRUITING
Morbid Obesity Requiring Bariatric Surgery; Postoperative Pain; Postoperative Pain Management; Postoperative Analgesia; Postoperative Adjuvant Treatment; Postoperative Inflammatory Markers; Postoperative Inflammatory Response
Instituto Mexicano del Seguro Social
 2025-10-06 PHASE4
NCT06996379 RECRUITING
Evaluate Patient Comfort Level During Paracentesis by Numbing Skin With a Needle-less Device, Instead of Using a Needle to Numb the Skin
Northwestern University
 2025-05-20
NCT07602387 RECRUITING
Patients With Taxane-induced Chronic Neuropathic Pain
Hospital Ambroise Paré Paris
 2024-03-12
NCT07597408 ACTIVE_NOT_RECRUITING
A Comparsion Between Articaine Hydrochloride and Buffered Lidocaine Hydrochloride
Latakia University
 2025-07-15
NCT07062367 RECRUITING
Sevoflurane; Lidocaine; Propofol; Intracranial Pressure; Cerebral Oxygenation; Laparoscopic Hysterectomy
Tanta University
 2025-02-01
NCT07412392 NOT_YET_RECRUITING
Nasolabial Folds, Wrinkles
Hyundae Meditech
 2026-02-27
NCT06710405 RECRUITING
Pain Management After Surgery
Seoul National University Hospital
 2024-12-09 PHASE4
NCT04992572 RECRUITING
Lumbar Spinal Stenosis
Stanford University
 2021-12-01 EARLY_PHASE1
NCT07612839 NOT_YET_RECRUITING
Postoperative Fatigue Syndrome; Inguinal Hernia Unilateral
Hakan Emirkadı
 2026-09-02
NCT07265778 ACTIVE_NOT_RECRUITING
Mid Face Volume Deficit
Jetema Co., Ltd.
 2024-10-22
NCT07396129 NOT_YET_RECRUITING
Neuropathic Chronic Pain
Pontificia Universidad Catolica de Chile
 2026-09-20 PHASE1; PHASE2
NCT07550348 RECRUITING
Lower Extremity; Nerve Block; Pain, Postoperative; Pain, Nerve
Ataturk University
 2025-12-01
NCT06696586 NOT_YET_RECRUITING
Bier Block; Hand Surgery
Assiut University
 2025-07-01 PHASE4
NCT07699315 NOT_YET_RECRUITING
Symptomatic Irreversible Pulpitis
Watim Medical & Dental College
 2026-08 PHASE4
NCT07429292 NOT_YET_RECRUITING
Healthy Volunteers; Sympathetic Activity
Duke University
 2026-09 PHASE4
NCT07601698 NOT_YET_RECRUITING
Emergence Agitation
Sohag University
 2026-05-01 PHASE4
NCT07488832 RECRUITING
Lumbar Fusion Surgery
Ankara City Hospital Bilkent
 2026-04-01
NCT06653400 RECRUITING
Abnormal Uterine Bleeding; Analgesia; Paracervical Block
Icahn School of Medicine at Mount Sinai
 2025-02-27 PHASE1
NCT06462573 UNKNOWN
Stone Ureter
Assiut University
 2024-09-01 EARLY_PHASE1
NCT07572994 NOT_YET_RECRUITING
Myofacial Pain; Myofacial Pain Syndrome; Myofacial Pain Syndromes; Trigger Point Pain, Myofascial; Myofascial Pain Dysfunction Syndrome
Cairo University
 2026-05-01
NCT06563050 NOT_YET_RECRUITING
Lidocaine Spray; Nebulized Lidocaine; Lung Diseases; Lung Cancer
Assiut University
 2024-09
NCT07120763 RECRUITING
Distal Radius Fracture Reduction; Pain Control; Pediatric Fractures
State University of New York at Buffalo
 2025-08-22 PHASE3
NCT07419815 ACTIVE_NOT_RECRUITING
Side Effects of Opoid Consumption
Shaukat Khanum Memorial Cancer Hospital & Research Centre
 2025-12-03
NCT07537127 RECRUITING
Cystectomy; Myomectomy
Peking Union Medical College Hospital
 2025-12-15
NCT07779356 COMPLETED
Macular Degeneration; Diabetic Retinopathy; Retinal Vein Occlusion (RVO)
Retina Consultants of Delmarva
 2026-05-20 PHASE4
NCT07359560 NOT_YET_RECRUITING
Infertility Female; Hemodynamic Instability
Zagazig University
 2026-01-02
NCT07248202 COMPLETED
Coronary Artery Disease (CAD); Left Ventricular (LV) Systolic Dysfunction; Induction Anesthesia; Coronary Bypass Graft Surgery; Ketamine; Fentanyl; Lidocaine
Cairo University
 2025-12-01
NCT07511400 COMPLETED
Pain; Acute Pain; Healthy Volunteer Study
Medical University of Vienna
 2026-04-21 EARLY_PHASE1
NCT06607861 COMPLETED
Pain Score (VAS)
Minia University
 2024-06-01 EARLY_PHASE1
NCT06979141 RECRUITING
Cough
Al-Azhar University
 2025-06-02 PHASE3
NCT06057675 RECRUITING
Postoperative Bleeding; Skin Cancer Face
Vanderbilt University Medical Center
 2024-03-19 PHASE2
NCT07648784 RECRUITING
Epidural Dosage of Lidocaine Bupivacaine in Lower Limb Surgeries
Shaheed Mohtarma Benazir Bhutto Institue of Trauma
 2025-12-18
NCT06865469 NOT_YET_RECRUITING
Fracture Hip Surgery
Assiut University
 2025-05-01 PHASE3
NCT07047638 ACTIVE_NOT_RECRUITING
Skin Quality Improvement
Galderma R&D
 2025-07-09
NCT05193227 RECRUITING
Postoperative Pain; Postsurgical Pain
University of British Columbia
 2021-10-27 PHASE2
NCT07383571 COMPLETED
Hysterosalpingography
Cairo University
 2025-10-03
NCT07657897 RECRUITING
Hepato Cellular Carcinoma (HCC); Sedation and Analgesia; Ablation Techniques
Iuliu Hatieganu University of Medicine and Pharmacy
 2024-11-12
NCT06936410 COMPLETED
Tourniquet Hypertension
Cairo University
 2025-03-01 PHASE2
NCT07162610 COMPLETED
Mid-face Volume Deficit
PharmaResearch Co.,Ltd
 2024-04-07
NCT07715331 COMPLETED
Excessive Gingival Display; Gingival Diseases; Gummy Smile; Esthetics, Dental
Al-Azhar University
 2025-01-01
NCT06272461 RECRUITING
Colorectal (Colon or Rectal) Cancer; Inflammation
University Tunis El Manar
 2023-10-01
NCT07788261 COMPLETED
Dexamethasone; Lidocaine; Scalp Incision Infiltration; Craniotomy
Assiut University
 2024-12-01
NCT06882525 COMPLETED
Herpes Zoster; Neuralgia, Postherpetic
Ankara City Hospital Bilkent
 2025-04-01
NCT06236126 COMPLETED
Analgesia, Obstetrical
Ohio State University
 2023-11-13
NCT07000760 COMPLETED
Postoperative Pulmonary Complications (PPCs)
Jun Zhang
 2025-06-06 PHASE3
NCT07491991 COMPLETED
Postoperative Pain; NEBULIZATION; Thyroid Surgery
Qianfoshan Hospital
 2025-03-02 PHASE4
NCT05289804 COMPLETED
Mild Cognitive Impairment; Memory Impairment; Memory Disorders in Old Age
University of Dublin, Trinity College
 2022-09-01 PHASE1; PHASE2
NCT07212192 NOT_YET_RECRUITING
Pregnancy
Phenikaa University
 2025-11-24 PHASE3
NCT07000058 ACTIVE_NOT_RECRUITING
Hand Surgery; Local Infiltration
Misr University for Science and Technology
 2025-06-20 PHASE2; PHASE3
NCT07256834 NOT_YET_RECRUITING
Post Operative Sore Throat at 6hrs and 24hrs After Endotracheal Intubation
Jinnah Postgraduate Medical Centre
 2025-11-22 PHASE1; PHASE2
NCT07067853 COMPLETED
Migraine
Indonesia University
 2025-09-01
NCT04084548 ACTIVE_NOT_RECRUITING
Postoperative Pain
The Cleveland Clinic
 2019-10-15 PHASE3
NCT07688031 COMPLETED
Pain Management; Hemorrhoids Third Degree; Hemorrhoids Fourth Degree; Hemorrhoids Second Degree
Pontificia Universidad Catolica de Chile
 2023-05-24 PHASE4
NCT06595017 NOT_YET_RECRUITING
Myofascial Pain Dysfunction Syndrome
Misr University for Science and Technology
 2024-10-01 PHASE2
NCT07533643 COMPLETED
Hemodynamics After Endotracheal Intubation
Kasr El Aini Hospital
 2025-08-01
NCT03095404 WITHDRAWN
Bariatric Surgery Candidate; Bariatric Bowel Surgery
McMaster University
 2022-10-05 EARLY_PHASE1
NCT06552351 NOT_YET_RECRUITING
Anesthesia
University of Oklahoma
 2024-11
NCT07092046 COMPLETED
Minimal Flow Anesthesia; General Anaesthesia; Inhalation Anesthesia; Infection Risk; Anesthesia Circuit; Microbial Colonization; Anesthesia Equipment Bacterial Contamination
Ankara City Hospital Bilkent
 2025-08-01
NCT07268495 RECRUITING
Postoperative Pain
General Hospital of Ningxia Medical University
 2024-08-01
NCT07035301 COMPLETED
Disease of Respiratory System
Harbin Medical University
 2025-03-17
NCT06966102 NOT_YET_RECRUITING
Enhanced Recovery; Functional Endoscopic Sinus Surgery; Lidocaine; Magnesium Sulphate; Perioperative Pain
Cairo University
 2025-05-10 PHASE4
NCT05854082 COMPLETED
Reading Disorders
University of Alberta
 2023-08-24 PHASE4
NCT05058677 COMPLETED
Traumatic Brain Injury
The University of Texas Health Science Center, Houston
 2021-11-09 PHASE4
NCT05153785 COMPLETED
Liver Metastases; Liver Cancer; Postoperative Pain; Opioid Use
Lund University Hospital
 2021-11-15 PHASE2; PHASE3
NCT07462988 COMPLETED
Neck Pain; Mesotherapy
Istanbul Medeniyet University
 2025-01-01
NCT06462781 COMPLETED
Refractory Migraine
The Cooper Health System
 2024-03-15 PHASE1
NCT06640946 COMPLETED
Pilonidal Disease
David Mooney
 2024-11-01 PHASE4
NCT07138586 COMPLETED
Traumatic Ulcer of Oral Mucosa
National Research Centre, Egypt
 2025-01-24
NCT06570096 COMPLETED
Premixed; Sequential; Lidocaine; Bupivacaine; Supraclavicular Brachial Plexus Block; Arteriovenous Fistula
Tanta University
 2024-08-24
NCT06302257 UNKNOWN
Labor Pain
Hadassah Medical Organization
 2024-03-01 PHASE4
NCT06423456 COMPLETED
Postoperative Pain; Postoperative Nausea; Analgesia
Afyonkarahisar Health Sciences University
 2024-03-01
NCT06040840 COMPLETED
Carpal Tunnel Syndrome
CMC Ambroise Paré
 2024-05-13
NCT05920980 COMPLETED
Colorectal Cancer
West China Hospital
 2023-06-05
NCT05788393 COMPLETED
Analgesia
Assiut University
 2024-04-01 PHASE4
NCT03893318 TERMINATED
Systemic Lidocaine Improves Pain Control After Surgery by Attenuating the Systemic Inflammatory Response to Surgery
Washington University School of Medicine
 2019-07-30 PHASE4
NCT06497296 UNKNOWN
Blood Pressure; Tachycardia
National Cheng-Kung University Hospital
 2023-01-01
NCT06918340 ACTIVE_NOT_RECRUITING
Blood Gas Analysis; Topical Analgesia
Haydarpasa Numune Training and Research Hospital
 2024-11-01 PHASE4
NCT06312254 COMPLETED
Peripheral Neuropathy
Aalborg University
 2024-04-09
NCT06370195 UNKNOWN
Parkinson's Syndrome
Babujinaya Cela
 2024-04
NCT03410836 UNKNOWN
Intravenous Lidocaine and Immunity
Ciusss de L'Est de l'Île de Montréal
 2019-04-29 PHASE4
NCT06078241 COMPLETED
Postoperative Analgesia
Ain Shams University
 2023-11-01
NCT06381622 COMPLETED
Nerve Block; Anesthesia, Local; Forearm Fracture; Surgery; Brachial Plexus Block
Nordsjaellands Hospital
 2024-04-18 PHASE3
NCT05031078 COMPLETED
HPV
Emory University
 2021-12-21 PHASE4
NCT05614609 COMPLETED
Postoperative Complications; Intubation; Difficult or Failed; Intubation Complication
Ostfold University College
 2023-03-01
NCT04781673 ACTIVE_NOT_RECRUITING
Rib Fractures; Rib Fracture Multiple; Rib Trauma
Brittany Hoyte
 2021-04-01 PHASE4
NCT06443255 COMPLETED
Analgesia
Rigshospitalet, Denmark
 2024-07-01 PHASE3
NCT06834854 COMPLETED
Measure Time to First Rescue Analgesia Following Extubation
Ain Shams University
 2024-03-12 PHASE1
NCT06864078 COMPLETED
IUD
Al-Azhar University
 2023-09-10
NCT04144933 UNKNOWN
Anesthesia; General Anesthesia; Analgesics, Opioid; Opioid Free Anesthesia; Postoperative Ileus; Colorectal Surgery; Laparoscopic Surgery; Analgesia; Dexmedetomidine; Lidocaine; Ketamine
University of Saskatchewan
 2021-05-15 PHASE3
NCT05670236 COMPLETED
Osteoarthritis, Knee
The Cleveland Clinic
 2023-01-25 PHASE4
NCT05017246 TERMINATED
Cancer Debulking; Enlarged Uterus; Fibroid Uterus; Adnexal Mass
Washington University School of Medicine
 2022-01-18 PHASE2
NCT05313256 COMPLETED
Obstetric Labor Complications
University Hospital, Bordeaux
 2022-07-14 PHASE2; PHASE3
NCT05560035 UNKNOWN
Cervical Cancer; Metastatic Cancer
General Hospital of Ningxia Medical University
 2022-12-01
NCT06420388 UNKNOWN
Surgery; Pain, Postoperative
E-DA Hospital
 2023-05-01
NCT06527651 COMPLETED
Osteoarthritis; Osteoarthritis, Knee; Proprioceptive Disorders; Balance; Distorted
Ankara City Hospital Bilkent
 2024-06-01
NCT05578885 UNKNOWN
Regional Anesthesia
Michael Bishay Shehata Keroles
 2024-02-01
NCT06457100 UNKNOWN
Chronic Rhinosinusitis; Enhanced Recovery After Surgery
The Second People's Hospital of Huai'an
 2023-11-21 PHASE1; PHASE2
NCT06391125 Not yet recruiting
Syphilis Infection|Benzathine Penicillin Adverse Reaction
Washington University School of Medicine
 2024-06 Phase 3
NCT06304116 UNKNOWN
Traumatic Brain Injury
Muhammad
 2024-03
NCT06344637 UNKNOWN
Pain, Procedural; Lidocaine; Obstetric Surgical Procedures
UdonThani Hospital
 2023-12-14
NCT06226415 COMPLETED
Cerebral Small Vessel Diseases
Zeng Changhao
 2024-01-20
NCT04069169 COMPLETED
Scoliosis; Adolescence; Anesthesia Recovery Period
University of British Columbia
 2019-12-18 PHASE3
NCT06006026 UNKNOWN
Colorectal Cancer
West China Hospital
 2023-08-28
NCT06249490 UNKNOWN
Obstructive Sleep Apnea
Zeng Changhao
 2024-02-29
NCT06266481 UNKNOWN
Postoperative Sore Throat
Pharos University in Alexandria
 2024-03-01 PHASE2; PHASE3
NCT05402293 Not yet recruiting
Acute Pain|Lidocaine|Administration and Dosage
University of Alberta
 2024-04-15 --
NCT05800834 UNKNOWN
Wounds and Injuries; Cancer Pain; Cancer, Breast; Cancer Head Neck
Instituto Nacional de Cancer, Brazil
 2023-09-12 PHASE2
NCT05707169 UNKNOWN
Varicose Veins; Venous Reflux; Venous Insufficiency; Venous Leg Ulcer
Mansoura University
 2023-01-04
NCT05243940 UNKNOWN
Pain, Post Operative; Pain, Acute; Pain, Chronic; Pain, Neuropathic; Pain, Nociceptive; Ketamine; Dexmedetomidine; Lidocaine; Fentanyl; Analgesia; Analgesics; Analgesics Non-narcotic
Aretaieion University Hospital
 2022-03-07
NCT06184958 UNKNOWN
Anesthesia
Ain Shams University
 2023-09-02 PHASE4
NCT06383845 COMPLETED
Breast Surgery
University Tunis El Manar
 2023-01-01
NCT05368753 COMPLETED
Abdominal Surgery by Laparotomy; Thoracic Epidural Analgesia; Analgesia; Lidocaine Adverse Reaction
Centre Hospitalier Universitaire, Amiens
 2022-03-09 PHASE4
NCT04162535 UNKNOWN
Colorectal Cancer
Iuliu Hatieganu University of Medicine and Pharmacy
 2018-11-26 PHASE1
NCT04051203 COMPLETED
Occipital Neuralgia; Headache
University of Calgary
 2019-02-01 PHASE1
NCT04359017 WITHDRAWN
Radius Fracture Distal; Hematoma; Lidocaine; Pediatrics
Washington University School of Medicine
 2020-11-01 PHASE4
NCT04891419 COMPLETED
Temple Hollowing
Allergan
 2021-07-20 PHASE3
NCT05777759 COMPLETED
Chin Augmentation; Chin Retrusion
Galderma R&D
 2023-03-22
NCT04640896 COMPLETED
Myofacial Pain; Pain, Neck; Pain, Back; Cervical Fusion
George Washington University
 2020-11-05 PHASE4
NCT05937282 UNKNOWN
Hemodynamic Responses; Laparoscopic Cholecystectomy; Dexmedetomidine; Lidocaine; Propofol
Menoufia University
 2023-07-01 PHASE4
NCT05850468 UNKNOWN
Opioid Use; Spine Fusion
Ain Shams University
 2023-05
NCT05646810 UNKNOWN
Spinal Cord Injuries; Spinal Cord Diseases; Syringomyelia
University of Aarhus
 2022-12-01
NCT06128109 COMPLETED
Mid Face Volume Deficit
Croma-Pharma GmbH
 2023-01-24
NCT05822063 UNKNOWN
Arteriovenous Graft Site Pain
Ain Shams University
 2023-07-25 PHASE3
NCT06003933 COMPLETED
Post Operative Pain; Cervical Spine Instability
Yasser S Mostafa, MD
 2023-03-03
NCT05378113 TERMINATED
Injection Site Irritation
Emory University
 2023-05-18 PHASE2
NCT05653401 COMPLETED
Renal Colic
University of Monastir
 2022-11-20 PHASE2
NCT05767749 COMPLETED
Anesthetics, Local
Weill Medical College of Cornell University
 2023-03-14 PHASE4
NCT05767827 COMPLETED
Local Anesthesia Adjuvants; Upper Extremity Fracture; Brachial Plexus Block
Nepal Medical College and Teaching Hospital
 2023-02-01
NCT05866653 UNKNOWN
Oxaliplatin Induced Peripheral Neuropathy in Cancer Patients
Bangabandhu Sheikh Mujib Medical University, Dhaka, Bangladesh
 2023-03-25 PHASE2
NCT05089526 UNKNOWN
Pain, Postoperative; Pain, Acute; Pain, Chronic; Cholecystectomy; Ketamine; Dexmedetomidine; Lidocaine; Central Nervous System Depressants; Analgesia; Analgesics; Analgesic Non-narcotic
Aretaieion University Hospital
 2021-10-11
NCT05801172 COMPLETED
Pain; Hysteroscopic Surgery
Jagiellonian University
 2022-07-01
NCT04467125 UNKNOWN
Contraception
Augusta University
 2020-01-06 PHASE4
NCT03046017 UNKNOWN
Chronic Low Back Pain
Massachusetts General Hospital
 2017-08-30
NCT05909462 COMPLETED
Adhesive Capsulitis
Hitit University
 2023-01-21
NCT06293807 COMPLETED
Periodontal Diseases
The University of Texas Health Science Center at San Antonio
 2022-06-06 EARLY_PHASE1
NCT05793905 COMPLETED
Local Anesthesia
Damascus University
 2022-12-01 PHASE4
NCT06703437 ACTIVE_NOT_RECRUITING
Prostate Cancer
Icahn School of Medicine at Mount Sinai
 2022-12-13 PHASE1
NCT07155785 COMPLETED
Intrauterine Device Migration; Pain
Kanuni Sultan Suleyman Training and Research Hospital
 2022-07-01
NCT05098457 WITHDRAWN
Cheek Wrinkles; Midface Contour Deficiencies
Galderma R&D
 2022-02-22
NCT03872700 COMPLETED
Abscess
Montefiore Medical Center
 2019-08-01 PHASE3
NCT03413371 COMPLETED
Vitreoretinal Surgeries; Postoperative Nausea and Vomiting; Postoperative Pain; Oculocardiac Reflex
Medical University of Silesia
 2018-04-26
NCT05235256 UNKNOWN
Post-Dural Puncture Headache
Ain Shams University
 2022-01-10
NCT05077488 COMPLETED
Marionette Lines Forehead Contouring
Allergan
 2021-09-15 PHASE4
NCT05573191 UNKNOWN
General Anesthesia
General Hospital of Ningxia Medical University
 2022-10-08 PHASE1; PHASE2
NCT04583137 UNKNOWN
Anesthesia, Local
Kfir Siag
 2020-11-01 EARLY_PHASE1
NCT05412576 COMPLETED
Colorectal Cancer
West China Hospital
 2021-06-01
NCT06082245 COMPLETED
Analgesia; Spine Fusion
Hanoi Medical University
 2021-10-01
NCT04167176 COMPLETED
Postoperative Pain
Assiut University
 2020-09-15
NCT04591353 COMPLETED
Total Hip Arthroplasty
University of Alabama at Birmingham
 2021-02-01 PHASE3
NCT04017013 COMPLETED
Pain, Postoperative; Opioid Use
Universidad de Antioquia
 2020-03-01 PHASE4
NCT05063578 UNKNOWN
Anesthesia
Far Eastern Memorial Hospital
 2021-09-20
NCT03677817 COMPLETED
Postoperative Pain
University Hospital, Basel, Switzerland
 2019-04-03 PHASE3
NCT04570293 COMPLETED
Trigeminal Neuralgia
Beijing Tiantan Hospital
 2021-05-01 PHASE4
NCT05239091 COMPLETED
Myofascial Pain Syndrome of Neck
Istanbul Physical Medicine Rehabilitation Training and Research Hospital
 2022-08-01
NCT05291221 COMPLETED
Postoperative Complications
Minia University
 2021-02-22
NCT04691726 COMPLETED
Abdominal Aorta Aneurysm; Abdominal Aorta Atheroma; Surgery; Pain, Postoperative
Łukasz Krzych
 2019-01-29 PHASE4
NCT04991597 WITHDRAWN
Pain
Nicholas Bastidas
 2022-01-01
NCT05369650 UNKNOWN
Liver Cancer
West China Hospital
 2019-07-27
NCT04295330 COMPLETED
Primary Liver Cancer
West China Hospital
 2020-02-27
NCT05087732 COMPLETED
Aging
Laboratoires Vivacy
 2021-10-19
NCT04822597 COMPLETED
Breast Cancer; Sentinel Lymph Node; Breast Neoplasms; Breast Cancer Female
University of Wisconsin, Madison
 2021-04-23 PHASE3
NCT04216017 COMPLETED
Humeral Fractures
University of Washington
 2020-01-01 PHASE2
NCT04609865 TERMINATED
Acute Respiratory Distress Syndrome (ARDS); COVID-19; Corona Virus Infection
University Hospital, Strasbourg, France
 2020-11-04 PHASE3
NCT05253508 UNKNOWN
Sensory Processing; Perception; Sense of Touch; Taction
Reinier Haga Orthopedisch Centrum
 2022-01-01
NCT06637046 COMPLETED
Drop Foot
Stephen Barrett
 2020-03-15
NCT03047070 COMPLETED
Intraoperative Bleeding
Assiut University
 2017-02-09 PHASE2
NCT03071601 COMPLETED
Pain, Acute; Laceration
Centre Hospitalier le Mans
 2017-12-01 PHASE4
NCT04055116 COMPLETED
Pediatric Dentistry
Geisinger Clinic
 2019-11-11 PHASE4
NCT04282239 WITHDRAWN
Pain, Postoperative; Cardiac Surgery
NYU Langone Health
 2021-03-01
NCT04634656 UNKNOWN
Cognitive Dysfunction, Postoperative
Assiut University
 2021-01-07 PHASE2
NCT02647892 TERMINATED
Local Anesthesia
University of Nebraska
 2016-01-08 PHASE4
NCT04813614 COMPLETED
Esthetics
Laboratoires Vivacy
 2021-05-31
NCT04535089 COMPLETED
Analgesia
Zagazig University
 2020-10-01 PHASE1; PHASE2
NCT04364425 UNKNOWN
Adhesive Capsulitis
Taipei Veterans General Hospital, Taiwan
 2020-05-04
NCT04517890 UNKNOWN
IUCD Complication
Aswan University Hospital
 2020-09-01
NCT05361291 COMPLETED
Pulpitis - Irreversible
Jamia Millia Islamia
 2020-02-01
NCT04455711 UNKNOWN
Cough; Lidocaine
Ajou University School of Medicine
 2020-07-01
NCT04003012 COMPLETED
Leukemia-Lymphoma
CAMC Health System
 2019-07-19 PHASE4
NCT04438577 UNKNOWN
Breast Cancer
Shantou Central Hospital
 2020-08-20
NCT03821545 COMPLETED
Colorectal Cancer
University Hospital Dubrava
 2019-01-28
NCT04836819 COMPLETED
Morbid Obesity; Bariatric Surgery Candidate; Pain; Postoperative
Ondokuz Mayıs University
 2021-04-08
NCT04733781 UNKNOWN
Venomous Snakebites; Local Anesthesia; Painless Injection; Regional Anesthesia; Dermatologic Surgery; Cutaneous Pain; Musculoskeletal Pain
Jeffrey Alan Klein, MD
 2021-02-22 PHASE2; PHASE3
NCT04033562 TERMINATED
Opioid-use Disorder; Opioid Use; Opioid Dependence; Opioid Abuse; Medication Assisted Treatment; Infusion Catheter, Wound; Lidopatch; Ambu ACTion; Pregnancy Related; Cesarean Section
WellSpan Health
 2020-01-15 PHASE4
NCT04369950 COMPLETED
Physiological Effect of Drugs; Morphine; Analgesics; Analgesics, Opioid; Central Nervous System Depressants; Narcotics
The University of Texas Health Science Center, Houston
 2020-05-11 PHASE4
NCT06056947 COMPLETED
Trichomonal Vaginitis; Bacterial Vaginosis; Candidal Vulvovaginitis; Mixed Vaginal Infections
Ege University
 2020-07-20 PHASE3
NCT03871478 UNKNOWN
Lidocaine; Bupivacaine; Mohs Surgery; Anesthetic
Ottawa Hospital Research Institute
 2019-10-01
NCT03171987 COMPLETED
Acute Back Pain
Taipei Medical University Hospital
 2017-06-14 PHASE4
NCT07259772 ACTIVE_NOT_RECRUITING
End Stage Renal Disease (ESRD); Arteriovenous Fistula Patency; Chronic Kidney Disease 5D
The First People's Hospital of Lianyungang
 2019-04-10 PHASE4
NCT03755089 UNKNOWN
Overactive Bladder Syndrome; Urge Incontinence; Urinary Incontinence; Detrusor Hyperreflexia; Detrusor Instability
Women and Infants Hospital of Rhode Island
 2018-11-01 PHASE4
NCT04585061 COMPLETED
Anxiety; Pain
Riyadh Elm University
 2020-11-01
NCT04339348 COMPLETED
Contraception
Cairo University
 2020-04-30 PHASE3
NCT04703127 UNKNOWN
Premature Ejaculation
Sohag University
 2020-03-30 PHASE3
NCT07696429 COMPLETED
Laryngo-pharyngeal Reflux
Mario Bilić
 2019-03-01
NCT03571737 COMPLETED
Acute Musculoskeletal Disease; Sprains; Sprains and Strains; Injuries; Emergencies; Trauma; Acute Pain
East Carolina University
 2018-06-23 PHASE3
NCT04711668 COMPLETED
Spine Fusion; Postoperative Pain
Ataturk University
 2019-05-29
NCT03636451 COMPLETED
Abortion, Spontaneous; Abortion in First Trimester; Pain Uterus; Abortion Early; Abortion, Missed
University of California, San Diego
 2018-10-29 PHASE3
NCT04569045 COMPLETED
Dermal Filler; Hyaluronic Acid; Lidocaine; Nasolabial Fold
SciVision Biotech Inc.
 2020-08-20
NCT03806595 COMPLETED
Migraine in Children; Posttraumatic Headache
University of British Columbia
 2019-07-03 PHASE1
NCT04140396 TERMINATED
Rib Fractures
Stanford University
 2020-02-10 PHASE4
NCT04401878 COMPLETED
Post-Dural Puncture Headache
Zagazig University
 2020-05-24
NCT03731429 UNKNOWN
Lidocaine
Hospital Fernandez
 2019-04-05 PHASE4
NCT04101019 UNKNOWN
Nerve Block
Rabin Medical Center
 2019-09
NCT03829618 TERMINATED
Bronchiectasis Adult; Mediastinal Lymphadenopathy; Pneumonia; Chest--Diseases; Infiltrates; Bronchopulmonary Disease; Cancer, Lung
Milton S. Hershey Medical Center
 2019-04-01 PHASE3
NCT04393610 UNKNOWN
Analgesia
Assiut University
 2020-05-14 PHASE2; PHASE3
NCT02822144 COMPLETED
Stroke
Rennes University Hospital
 2016-09-29 PHASE3
NCT07551713 COMPLETED
Healthy
Haisco Pharmaceutical Group Co., Ltd.
 2020-06-11 PHASE1
NCT02924480 COMPLETED
Invasive Bladder Cancer
CAMC Health System
 2016-10-12
NCT04085744 COMPLETED
Anesthesia Intubation Complication; Intubation Complication; Sore Throat
Derince Training and Research Hospital
 2019-11-01
NCT03990883 COMPLETED
Dermatological Non-Disease
Croma-Pharma GmbH
 2019-06-04
NCT03650387 COMPLETED
Signs of Facial Aging With Volume Loss in the Upper Cheeks, Nasolabial Folds and Marionette Lines
Merz North America, Inc.
 2018-09-17
NCT04480281 COMPLETED
Lidocaine; Pain, Postoperative
Saint-Joseph University
 2020-01-10 PHASE4
NCT03625076 UNKNOWN
Shoulder Dislocation
Kendall Healthcare Group, Ltd.
 2018-06-01 PHASE4
NCT03382821 COMPLETED
Cervical Radiculopathy
University of Utah
 2017-09-15 PHASE4
NCT04167189 COMPLETED
ADHD
PhenoSolve, LLC
 2018-01-20 EARLY_PHASE1
NCT03761329 COMPLETED
Surgery; Anesthesia, Local
Jessa Hospital
 2018-11-12
NCT02090998 TERMINATED
Transformed Migraine; Chronic Daily Headache
Rutgers, The State University of New Jersey
 2014-05 PHASE4
NCT03754413 COMPLETED
Mid Face Volume Loss
Medy-Tox
 2018-05-29
NCT02818894 TERMINATED
Total Hip Arthroplasty
Thomas L Bradbury
 2016-09-27 PHASE4
NCT04069585 COMPLETED
Aging; Pain
Teoxane SA
 2019-10-30
NCT03886896 COMPLETED
Acute Appendicitis; Postoperative Pain; Postoperative Nausea and Vomiting
Medical University of Warsaw
 2019-03-22 PHASE4
NCT02924441 COMPLETED
Pain
The University of Texas Health Science Center at San Antonio
 2016-10-01
NCT04143165 COMPLETED
Epidural Block in Axial Spondyloarthritis
Sohag University
 2019-10-12 PHASE4
NCT03770208 UNKNOWN
Rib Fracture Multiple; Pain, Chest; Pain, Acute; Respiratory Failure; Thoracic Injuries; Trauma Chest
Western University, Canada
 2019-06-06
NCT03805282 UNKNOWN
Cough
Brasilia University Hospital
 2018-03-01 PHASE3
NCT03210038 COMPLETED
Hematuria; Dysuria; Recurrent Uti
Assaf-Harofeh Medical Center
 2017-03-01
NCT03862287 UNKNOWN
Orthopedic Disorder; Leg Injuries
McGill University Health Centre/Research Institute of the McGill University Health Centre
 2018-11-01
NCT04000126 COMPLETED
Pain
University of Warmia and Mazury
 2019-02-25
NCT03490396 TERMINATED
Oral Mucositis
Midatech Pharma US Inc.
 2018-05-15 PHASE4
NCT03661996 COMPLETED
Knee Osteoarthritis
Centrexion Therapeutics
 2018-09-18 PHASE3
NCT03880409 COMPLETED
Overcoming the Failure of Anesthesia in the Mandibular Teeth
Taibah University
 2019-02-09 PHASE1
NCT03030677 COMPLETED
Breastcancer; Phyllodes Breast Tumor
Kasr El Aini Hospital
 2018-11-01
NCT03869450 COMPLETED
Volume Deficiency of the Midface
Galderma R&D
 2018-11-09
NCT03813030 COMPLETED
Healthy; Dermal Pharmacokinetic Measurement
Joanneum Research Forschungsgesellschaft mbH
 2019-01-16
NCT04040309 COMPLETED
Myofascial Pain
Lithuanian University of Health Sciences
 2019-05-10 PHASE4
NCT03839134 COMPLETED
Anesthetics, Local
Riyadh Colleges of Dentistry and Pharmacy
 2019-03-20
NCT03576053 COMPLETED
Itch; Thermal Stimulation; Histamine; Cowhage; Serotonine
Aalborg University
 2018-07-01
NCT03865147 UNKNOWN
Wounds Injuries; Anesthesia, Local
Medical Ethics UK Ltd
 2019-01-15 PHASE2
NCT03414879 COMPLETED
Anesthesia
Ain Shams University
 2018-01-15 PHASE4
NCT03472469 COMPLETED
Nonspecific Pain Post Traumatic Injury
The University of Texas Health Science Center, Houston
 2018-04-02 PHASE4
NCT03103100 COMPLETED
Labor Pain
University of Alabama at Birmingham
 2015-10-08 PHASE3
NCT03640468 UNKNOWN
Septic Shock; Anesthesia
Cairo University
 2018-12-20 PHASE3
NCT03571919 WITHDRAWN
Rib Fracture Multiple; Trauma Chest; Pain, Acute
Stanford University
 2018-06-15 PHASE4
NCT02894710 COMPLETED
Carcinologic Ear, Nose, and Throat (ENT) Surgery
Hospices Civils de Lyon
 2016-12 PHASE3
NCT03733275 COMPLETED
Nasal Fracture
The Catholic University of Korea
 2018-12-03
NCT02315573 COMPLETED
Carpal Tunnel Syndrome
St. Mary's Research Center, Canada
 2014-10
NCT03792776 UNKNOWN
Postoperative Sore Throat; Postoperative Cough
Ogarite Habib
 2019-01
NCT03613974 UNKNOWN
Orthopedic Procedures
Healthpoint Hospital
 2018-12-15 PHASE4
NCT03620513 COMPLETED
Throat Disorder
Lumbini Medical College
 2018-09-01 PHASE4
NCT02904096 COMPLETED
Volume Loss in the Dorsum of the Hand
Merz North America, Inc.
 2016-06-10
NCT03362905 UNKNOWN
IUD Insertion Complication
Ain Shams University
 2017-12-03 PHASE4
NCT02930551 COMPLETED
Neuropathic Pain; Neuroma
Danish Pain Research Center
 2016-09
NCT03363425 UNKNOWN
Hysterectomy; Myomectomy
University of Athens
 2017-11-14 PHASE2; PHASE3
NCT02616419 COMPLETED
Child; Pain Due to Certain Specified Procedures
St. Justine's Hospital
 2017-05-15
NCT03262857 COMPLETED
Local Anesthesia
Isfahan University of Medical Sciences
 2016-09-21 PHASE2
NCT03220555 COMPLETED
Intravenous Injections; Vaccination
Nantes University Hospital
 2017-10-04
NCT04319926 COMPLETED
Healthy
Scilex Pharmaceuticals, Inc.
 2018-09-07 PHASE1
NCT03729505 COMPLETED
Morbid Obesity
Mansoura University
 2017-07-01
NCT02335190 COMPLETED
Sprain of Sacroiliac Ligament; Low Back Pain; Osteoarthritis Nos, of Sacroiliac Joint
Western University, Canada
 2015-09
NCT02591199 TERMINATED
Interstitial Cystitis; Bladder Pain Syndrome
Urigen
 2015-09 PHASE2
NCT04214938 COMPLETED
Nasopharyngeal Diseases
Selcuk University
 2016-02-01 PHASE4
NCT02875015 COMPLETED
Postoperative Pain
Atlantic Health System
 2016-04
NCT03415724 UNKNOWN
Irreversible Pulpitis
Postgraduate Institute of Dental Sciences Rohtak
 2018-02-01
NCT05732181 COMPLETED
Liver Cancer; Post Ablation Syndrome
National Cheng-Kung University Hospital
 2017-05-09
NCT03613207 COMPLETED
Dermatology/Skin - Other; Dermal Pharmacokinetic Measurements
Joanneum Research Forschungsgesellschaft mbH
 2018-03-22
NCT03953001 COMPLETED
Local Anaesthetic; Dental Anxiety
Imam Abdulrahman Bin Faisal University
 2018-01-01
NCT04692896 COMPLETED
Lidocaine
King Edward Medical University
 2017-09-01 PHASE1
NCT03097783 COMPLETED
Midface Volume Deficit
Galderma R&D
 2017-04-26
NCT01836614 WITHDRAWN
Colorectal Disorders
Children's Hospital Medical Center, Cincinnati
 2015-01 PHASE1; PHASE2
NCT03264586 UNKNOWN
Episiotomy Pain
Cairo University
 2017-08 PHASE4
NCT03127384 COMPLETED
Healthy Volunteers
Galderma R&D
 2017-04-20 PHASE4
NCT03321825 COMPLETED
Moderate to Severe Midface Volume Deficit
Merz North America, Inc.
 2017-09-29
NCT02995083 WITHDRAWN
Symptomatic Osteoarthritis of the Knee
Rush University Medical Center
 2017-06 EARLY_PHASE1
NCT02726620 COMPLETED
Hypotension
Vanderbilt University Medical Center
 2017-01-05
NCT03041506 UNKNOWN
Shoulder Dislocation; Brachial Plexus Block
Tel-Aviv Sourasky Medical Center
 2017-02-15
NCT03159000 WITHDRAWN
Migraine
Thomas Jefferson University
 2017-05-01 PHASE4
NCT02747186 COMPLETED
Anesthesia
University of North Carolina, Chapel Hill
 2016-05
NCT01145326 WITHDRAWN
Pain Perception; Phlebotomy
University of Oklahoma
 2015-01 PHASE2; PHASE3
NCT02787356 WITHDRAWN
Skin Manifestations
SRI International
 2017-10-01
NCT02229578 COMPLETED
Pain
University of Florida
 2014-09 PHASE4
NCT03731988 COMPLETED
Actinic Keratosis
Dong-A University
 2017-02-01 PHASE4
NCT02741232 COMPLETED
Nerve Block; Mastectomy
Maisonneuve-Rosemont Hospital
 2016-03
NCT02620683 COMPLETED
Blood Levels of Buffered vs Non-buffered Lidocaine; Anesthetics, Local
University of North Carolina, Chapel Hill
 2015-12
NCT02991040 COMPLETED
Nasolabial Fold Correction
Prollenium Medical Technologies Inc.
 2016-08
NCT04064047 COMPLETED
Pain; Prostate Cancer; Rectal/Anal
Assaf-Harofeh Medical Center
 2016-12
NCT02592629 TERMINATED
Shoulder Pain
Milton S. Hershey Medical Center
 2016-02-01 PHASE4
NCT02558283 COMPLETED
Nasolabial Fold
Allergan
 2016-01-25
NCT03140787 COMPLETED
Dental Caries
Damascus University
 2016-05-15
NCT03044808 COMPLETED
Opioid Use
Odense University Hospital
 2016-02-02 PHASE4
NCT03063112 UNKNOWN
Abdominal Cancer
South Egypt Cancer Institute
 2016-10-01
NCT02403986 COMPLETED
Aged Skin
Galderma R&D
 2015-04 PHASE4
NCT02749162 COMPLETED
Postoperative Pain
Foisor Orthopedics Clinical Hospital
 2015-11 PHASE3
NCT03449940 COMPLETED
Erectile Dysfunction
Ministry of Health, Jamaica
 2015-01
NCT02857686 UNKNOWN
Local Anaesthesia
Cairo University
 2016-10
NCT02120261 TERMINATED
Myofascial Pain Syndrome
The University of Texas Health Science Center, Houston
 2014-05 PHASE4
NCT03634605 COMPLETED
Primary Spontaneous Pneumothorax
Isfahan University of Medical Sciences
 2015-05-05
NCT02590705 UNKNOWN
Spinal Puncture; Anesthesia
Beijing Children's Hospital
 2015-10
NCT02228083 UNKNOWN
Heart Failure
University of Sao Paulo General Hospital
 2014-09
NCT02912195 COMPLETED
Pain
Alameda Health System
 2016-03 PHASE4
NCT03120923 COMPLETED
Impingement Shoulder
Ramathibodi Hospital
 2015-01-01 PHASE4
NCT02574832 TERMINATED
Pregnancy; Surgery; Pain
Northwestern University
 2015-10
NCT02567838 COMPLETED
Gynecologic Diseases
Kangbuk Samsung Hospital
 2015-10 PHASE3
NCT02703948 COMPLETED
Lip Augmentation and Correction of Perioral Rhytids
Galderma R&D
 2016-03
NCT00938964 COMPLETED
Cognitive Decline
Duke University
 2009-07
NCT02684786 WITHDRAWN
Pulmonary Artery Hypertension
Mayo Clinic
 2016-07 PHASE1
NCT00659633 COMPLETED
Pain
University of Alabama at Birmingham
 2008-12
NCT02137954 UNKNOWN
Cancer; Pain With Neuropathic Component
Assistance Publique Hopitaux De Marseille
 2014-05 PHASE3
NCT02510287 COMPLETED
Labor Pain
Fundación Santa Fe de Bogota
 2015-07
NCT01503060 UNKNOWN
Pain
The Hospital for Sick Children
 2011-12 PHASE3
NCT02657603 COMPLETED
Pain
Kai Henrik Wiborg Lange
 2016-01
NCT01883232 WITHDRAWN
Pediatric Dentistry
University of Colorado, Denver
 2013-08
NCT02447029 COMPLETED
Pregnancy, Unwanted
Stanford University
 2015-04 PHASE3
NCT03189329 COMPLETED
Vitreoretinal Surgery; Cognitive Function Abnormal; Intraoperative Monitoring
Cengiz KAYA
 2015-01 PHASE4
NCT03175913 COMPLETED
Low Back Pain
The Catholic University of Korea
 2014-06-01
NCT02700906 COMPLETED
Tennis Elbow; Lateral Epicondylitis
Shin Kong Wu Ho-Su Memorial Hospital
 2014-01
NCT02454296 COMPLETED
Pain
University of Hawaii
 2015-05
NCT02241460 UNKNOWN
Premature Ejaculation
Eugene Y Rhee, MD
 2014-03 PHASE3
NCT01751347 COMPLETED
Carpal Tunnel Syndrome; Trigger Finger
University of British Columbia
 2013-02 PHASE4
NCT02264795 COMPLETED
Pain
Samuel Lunenfeld Research Institute, Mount Sinai Hospital
 2014-11
NCT01179100 WITHDRAWN
General Anesthesia; Surgeries Requiring A Minimum One Day Hospitalization; Elderly
Cedars-Sinai Medical Center
 2011-06 PHASE4
NCT02158039 COMPLETED
Neoplasms, Cystic, Mucinous, and Serous
Mayo Clinic
 2004-06 PHASE1
NCT02689856 COMPLETED
Hemorrhoids
Citius Pharmaceuticals, Inc.
 2015-05 PHASE2
NCT02505633 COMPLETED
Radius Fractures
Gachon University Gil Medical Center
 2015-07
NCT02372786 COMPLETED
Tattoo; Acne Keloidalis Nuchae
Erasmus Medical Center
 2014-11 PHASE4
NCT02332057 COMPLETED
Pain
Cairo University
 2015-02 PHASE2
NCT02059694 WITHDRAWN
Upper Eyelid Surgery
Duke University
NCT03435185 COMPLETED
Migraine Disorders
Dr. Lutfi Kirdar Kartal Training and Research Hospital
 2014-09-01
NCT01675947 TERMINATED
Geographic Atrophy
National Eye Institute (NEI)
 2012-02 PHASE2
NCT01114997 TERMINATED
Pain; Constipation; Nausea; Vomiting
Cedars-Sinai Medical Center
 2010-04 PHASE4
NCT03376178 COMPLETED
Pain
University Hospital, Geneva
 2014-05
NCT02061475 UNKNOWN
We Focus on the Pain of Venipuncture and Intravenous Cannulation
RenJi Hospital
 2014-04 PHASE2; PHASE3
NCT02001740 COMPLETED
Adhesive Capsulitis
Queen's University
 2012-12 PHASE4
NCT01907997 COMPLETED
Thyroid Cancer
Yonsei University
 2013-07
NCT02257346 WITHDRAWN
Pregnancy
Northwestern University
 2014-11-01
NCT02628522 COMPLETED
Anal Fissure
Clinical Centre of Serbia
 2014-12
NCT00840918 TERMINATED
Atrial Fibrillation
The Cleveland Clinic
 2009-02
NCT01812044 COMPLETED
Strabismus
Duke University
 2013-03
NCT02935972 COMPLETED
Pain Relief During Prostate Biopsy
Assiut University
 2013-11 PHASE2; PHASE3
NCT02018276 COMPLETED
Thyroid Cancer
Yonsei University
 2013-12
NCT03397082 COMPLETED
Pain
Saint Thomas Hospital, Panama
 2014-08-01
NCT02059902 COMPLETED
Thermal Burns
HealthPartners Institute
 2012-09 PHASE4
NCT01944098 COMPLETED
Bariatric Surgical Pain
University of South Florida
 2013-08 PHASE3
NCT01314300 COMPLETED
Neuropathic Pains; Vasoocclusive Sickle Cell Crises Pains
Centre Leon Berard
 2011-03 PHASE2
NCT02086292 COMPLETED
Needlestick Injuries
Norwegian University of Science and Technology
 2014-02
NCT01967017 WITHDRAWN
IUD Insertion Complication; Pain Control
Johns Hopkins University
 2014-06 PHASE4
NCT01774292 COMPLETED
Coughing; Extubation; Lidocaine; Endotracheal Cuff
Université de Sherbrooke
 2013-01 PHASE4
NCT01537770 COMPLETED
Osteoporotic Fractures
Spine Centre of Southern Denmark
 2012-02
NCT01715688 COMPLETED
Cough; Anesthesia
Centre hospitalier de l'Université de Montréal (CHUM)
 2013-01
NCT00413127 TERMINATED
Elective Surgical Procedure; Colorectal Surgery
University Hospital Muenster
 2007-09 PHASE2; PHASE3
NCT01908738 COMPLETED
Endometrial Biopsy; Abnormal Uterine Bleeding
Mahidol University
 2013-09
NCT02487914 COMPLETED
Interferential Current Drug Delivery
Shiraz University of Medical Sciences
 2013-01 PHASE2; PHASE3
NCT01544283 UNKNOWN
Shoulder Pain
Injury Care Medical Center
 2012-03 PHASE2
NCT01868776 COMPLETED
Irreversible Pulpitis (Toothache)
Ohio State University
 2013-03
NCT01794247 TERMINATED
Transient Neurologic Syndrome
Hospital General de Ciudad Real
 2013-04 PHASE3
NCT01841294 UNKNOWN
Colorectal Cancer
Maisonneuve-Rosemont Hospital
 2012-01 PHASE4
NCT01043211 WITHDRAWN
Back Pain
University of Alabama at Birmingham
 2012-01
NCT02109510 COMPLETED
Primary Spontaneous Pneumothorax
Korea University
 2012-11
NCT05342870 COMPLETED
Bier Block; Dexmedetomidine; Tourniquet Pain; Carpal Tunnel; Tendon Release; Tendn Transfer
American University of Beirut Medical Center
 2012-08
NCT02020551 COMPLETED
Pain
Kayseri Education and Research Hospital
 2013-05
NCT02007408 COMPLETED
Pain Score
Kayseri Education and Research Hospital
 2013-05
NCT01759459 COMPLETED
Pain; Local Anesthesia for Peripheral Intravenous Catheterization
Allina Health System
 2013-01 PHASE4
NCT00826462 COMPLETED
Tennis Elbow; Epicondylitis, Lateral Humeral
University of Oslo
 2009-03 PHASE4
NCT01069354 COMPLETED
Nasolabial Folds
Merz North America, Inc.
 2012-11
NCT00747669 SUSPENDED
Pain
ZARS Pharma Inc.
 2008-09 PHASE4
NCT01157546 TERMINATED
Opioid Consumption; Incidence of Nausea and Vomiting; Postoperative Pain; Assessment of Recovery
McGill University Health Centre/Research Institute of the McGill University Health Centre
 2010-08 PHASE1
NCT01688648 COMPLETED
Unstable Angina; Coronary Artery Bypass Graft; Dexmedetomidine; Lidocaine; Myocardial Injury; Arrhythmia; Blood Electrolyte Balance
Samsung Medical Center
 2012-09
NCT01292447 COMPLETED
Pain
Women and Infants Hospital of Rhode Island
 2011-02
NCT02387567 COMPLETED
Chronic Low Back Pain
Marta Imamura
 2007-01 PHASE3
NCT01794533 COMPLETED
Painful Irreversible Pulpitis
Islamic Azad University, Sanandaj
 2012-10 PHASE2
NCT02025361 COMPLETED
Adenocarcinoma of Prostate
Bagcilar Training and Research Hospital
 2009-02 PHASE4
NCT01756443 COMPLETED
Open Reduction Internal Fixation(ORIF) of Lateral Malleolus
Cork University Hospital
 2011-08 PHASE4
NCT01155986 TERMINATED
Pain; Chronic Pain; Neuropathic Pain; Postoperative Pain
Grünenthal GmbH
 2010-08 PHASE2
NCT01576770 UNKNOWN
Pain on Propofol IV Injection
The University of Texas Health Science Center, Houston
 2012-04 PHASE4
NCT01451840 COMPLETED
Cough; Anesthesia
Centre hospitalier de l'Université de Montréal (CHUM)
 2012-01
NCT01405768 COMPLETED
Uterine Cervical Dysplasia
Washington University School of Medicine
 2011-07 PHASE2
NCT01192490 UNKNOWN
Contraception
University of Tennessee
 2010-08
NCT02102620 COMPLETED
Hands Osteoarthritis
Federal University of São Paulo
 2011-08 PHASE4
NCT01045694 TERMINATED
Arthritis Multiple Joint
University of Missouri-Columbia
 2011-03 PHASE4
NCT01832675 COMPLETED
Application Site Discomfort
Ove Andersen
 2012-03 PHASE2
NCT01548794 COMPLETED
Anesthesia; Inguinal Hernia
Diskapi Teaching and Research Hospital
 2012-03 PHASE4
NCT01443325 COMPLETED
Inguinal Pain
Rigshospitalet, Denmark
 2011-09 PHASE3
NCT02150031 COMPLETED
Bacteremia; Tooth Extraction Status Nos
University of Santiago de Compostela
 2010-12 PHASE4
NCT01612156 COMPLETED
Pelvic Floor Disorders
University of Southern California
 2011-12
NCT01485939 UNKNOWN
Postoperative, Pain
Seoul National University Hospital
 2011-11 PHASE4
NCT01291979 UNKNOWN
Postoperative Pain
Chung-Ang University Hospital
 2011-02 PHASE4
NCT00657358 COMPLETED
Pain
University of Alabama at Birmingham
 2008-04
NCT01496105 UNKNOWN
Drug Usage
Ain Shams University
 2011-07 PHASE4
NCT01411995 COMPLETED
Pain
Washington University School of Medicine
 2011-08
NCT01360749 COMPLETED
Local Anesthesia
ISDIN
 2011-05 PHASE2
NCT02696460 COMPLETED
Chronic Leg Ulcer
Venenklinik Bellevue
 2010-04
NCT00913003 TERMINATED
Pain
Northwestern University
 2009-05 PHASE4
NCT01155440 COMPLETED
Colon Cancer; Inflammatory Bowel Diseases; Diverticulitis
McGill University Health Centre/Research Institute of the McGill University Health Centre
 2009-06 PHASE2
NCT00808171 COMPLETED
Leukemia; Non Hodgkin Lymphoma
Federal University of Minas Gerais
 2009-02 PHASE4
NCT01041872 COMPLETED
General Anesthesia
Hopital Foch
 2009-12 PHASE4
NCT01675895 COMPLETED
Benign Prostate Hyperplasia
Diskapi Teaching and Research Hospital
 2009-07 PHASE4
NCT01373593 TERMINATED
Pain
Rigshospitalet, Denmark
 2011-01 PHASE4
NCT02162680 COMPLETED
IV Insertion Pain
Duke University
 2010-03 PHASE4
NCT01620112 COMPLETED
Fascicular Block; Motor Activity; Pain, Postoperative; Latency Period
Universidade Federal do Rio de Janeiro
 2009-02 PHASE2
NCT01198834 COMPLETED
Ankle Sprains
MEDRx USA, Inc.
 2010-09 PHASE3
NCT01252225 COMPLETED
Chronic Cough
Manchester University NHS Foundation Trust
 2011-02 PHASE4
NCT03120351 COMPLETED
Perioperative Chest Pain
The Cleveland Clinic
 2009-09
NCT00789620 COMPLETED
Pain; Fatigue
Insel Gruppe AG, University Hospital Bern
 2008-11 PHASE3
NCT01542125 COMPLETED
Pain
University of Alberta
 2008-09 PHASE4
NCT00851513 COMPLETED
Pudendal Neuralgia; Canal Syndrome
Nantes University Hospital
 2008-11 PHASE4
NCT00786916 COMPLETED
Pain
Akron Children's Hospital
 2008-02 PHASE4
NCT00804609 COMPLETED
Epidural Analgesia, Obstetric
Stanford University
 2008-09
NCT01184105 COMPLETED
Premature Ejaculation
Plethora Solutions Ltd
 2010-09 PHASE1
NCT01912755 COMPLETED
Irreversible Pulpitis; Pain
University of Campinas, Brazil
 2010-02 PHASE4
NCT00540982 COMPLETED
Lung Cancer; Unspecified Adult Solid Tumor, Protocol Specific
City of Hope Medical Center
 1997-02-20 PHASE1; PHASE2
NCT01106716 COMPLETED
Postherpetic Neuralgia
KAI Pharmaceuticals
 2009-03 PHASE2
NCT00991068 COMPLETED
Carpal Tunnel Syndrome
ZARS Pharma Inc.
 2009-09 PHASE2
NCT01023334 COMPLETED
Cataract
Wenzhou Medical University
 2009-12
NCT00903825 COMPLETED
Local Anesthetics; Ultrasound Guidance; Catheterization
University of Patras
 2009-01 PHASE2; PHASE3
NCT03713762 COMPLETED
Anesthesia, Local
Centro Medico Docente la Trinidad
 2009-10-01 PHASE3
NCT00791024 COMPLETED
Analgesia
Ove Andersen
 2008-11 PHASE1; PHASE2
NCT01006187 COMPLETED
Pain; Anxiety
The Hospital for Sick Children
 2009-10 PHASE3
NCT00848679 WITHDRAWN
Pre-eclampsia
Hadassah Medical Organization
 2009-03 PHASE3
NCT01300754 COMPLETED
Osgood-Schlatter Disease
Universidad Nacional de Rosario
 2006-01 PHASE1; PHASE2
NCT00798083 COMPLETED
Neuropathic Pain Secondary to Radiation Therapy
British Columbia Cancer Agency
 2008-04 PHASE3
NCT00822419 UNKNOWN
Sternotomy
Tel-Aviv Sourasky Medical Center
 2009-02 PHASE4
NCT00822133 UNKNOWN
Postoperative Pain
Tel-Aviv Sourasky Medical Center
 2009-02 PHASE4
NCT00864682 COMPLETED
Pain
Benaroya Research Institute
 2008-01 PHASE4
NCT00798018 COMPLETED
Pharyngitis
Sichuan University
 2008-10
NCT00588354 TERMINATED
Lumbar and Other Intervertebral Disc Disorders With Radiculopathy
Mayo Clinic
 2006-10
NCT00686231 COMPLETED
Healthy
University of California, San Francisco
 2008-05 PHASE1
NCT01425840 COMPLETED
Anesthesia
University of Campinas, Brazil
 2008-03 PHASE1
NCT00716443 TERMINATED
Nasolabial Folds
Galderma R&D
 2008-07 PHASE4
NCT00487084 COMPLETED
Labor; Analgesia, Epidural
Northwestern University
 2004-08
NCT00763880 TERMINATED
Forearm Fracture
Rhode Island Hospital
 2005-11 PHASE4
NCT01108562 WITHDRAWN
Postoperative Pain Management After Total Hip Arthroplasty
Loma Linda University
 2008-02 PHASE1; PHASE2
NCT00589979 COMPLETED
Osteoarthritis of the Knee
Endo USA Inc., a Keenova Therapeutics Company
 2007-03 PHASE2
NCT00653861 COMPLETED
Nasolabial Folds
Allergan Medical
 2008-04
NCT00596050 COMPLETED
Conscious Sedation Failure During Procedure
Drexel University College of Medicine
 2006-08 PHASE4
NCT02287870 COMPLETED
Anesthesia
Jinling Hospital, China
 2008-01 PHASE4
NCT00811187 COMPLETED
Paracervical Block
Montefiore Medical Center
 2007-03 PHASE2
NCT02218203 COMPLETED
Central Neuropathic Pain; Allodynia; Spinal Cord Injury
Brigham and Women's Hospital
 2003-04 PHASE2
NCT01439399 COMPLETED
Postoperative Pain
University of Lausanne Hospitals
 2005-12
NCT00236249 COMPLETED
Colorectal Neoplasms
Assistance Publique - Hôpitaux de Paris
 2005-05 PHASE3
NCT00600158 COMPLETED
Postoperative Ileus
University of Virginia
 2005-04 PHASE3
NCT00058357 COMPLETED
Pain; Unspecified Adult Solid Tumor, Protocol Specific
Alliance for Clinical Trials in Oncology
 2004-05 PHASE3
NCT00740285 COMPLETED
Scleroderma
Federal University of São Paulo
 2004-04 PHASE2; PHASE3
NCT03765697 COMPLETED
Post Herpetic Neuralgia
Grünenthal GmbH
 2003-07-16 PHASE3
NCT00110253 COMPLETED
Pain
ZARS Pharma Inc.
 2005-06 PHASE3
NCT00904605 TERMINATED
Osteoarthritis of the Knee
Endo USA Inc., a Keenova Therapeutics Company
 2004-06 PHASE4
NCT03745404 COMPLETED
Post Herpetic Neuralgia
Grünenthal GmbH
 2003-04-29 PHASE3
NCT00903851 COMPLETED
Diabetes
Endo USA Inc., a Keenova Therapeutics Company
 2002-04 PHASE4
NCT00121498 COMPLETED
Pain
Rambam Health Care Campus
 2002-11
NCT00142064 COMPLETED
Urinary Tract Infection; Kidney Diseases; Ureteral Diseases; Ureteral Obstruction
Children's Mercy Hospital Kansas City
 2005-08 PHASE2
NCT00309673 UNKNOWN
Tuberculosis
Assistance Publique - Hôpitaux de Paris
NCT00284583 UNKNOWN
Morton's Neuroma
Brown University
 2005-05
NCT00258622 COMPLETED
Pain
Danish Pain Research Center
 2005-11 PHASE2
NCT00146926 UNKNOWN
Induction of Total Intravenous General Anesthesia
Hospices Civils de Lyon
 2005-09 PHASE3
NCT00373893 COMPLETED
Pain; Hyperalgesia
University of California, San Diego
 2005-12 PHASE1
NCT00521703 COMPLETED
Dyspepsia; Malabsorption Syndrome; Gastroesophageal Reflux Disease; Abdominal Pain
Hospital Infantil Cândido Fontoura
 2007-08 PHASE3
NCT00498992 UNKNOWN
Dermatologic Complications; Unspecified Adult Solid Tumor, Protocol Specific
Ingalls Memorial Hospital
 2006-07
NCT00229567 TERMINATED
Colorectal Cancer
University of Saskatchewan
 2005-09

(data from https://clinicaltrials.gov, updated on 2026-01-23)

Check the Lidocaine product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.

Compliance for Clinical Use

Mechanism and Biochemical Profile

Lidocaine acts as a selective inverse agonist of the peripheral histamine H1 receptor, binding the target to suppress constitutive downstream signaling cascades and modulate cellular inflammatory responses. This inhibition of histamine-mediated pathways reduces localized tissue reactivity and sensory stimulation, underlying its therapeutic utility in managing acute pain, procedural analgesia, and injection-associated discomfort evaluated across clinical trials.

Appendix RUO and cGMP Quality Standards

Quality Dimension RUO (Research Use Only) cGMP (Current Good Manufacturing Practice)
Clinical Applicability Prohibited in human clinical trials or medical diagnostics. Mandatory for human clinical trials (Phase I–III) and therapies.
Regulatory Status Non-regulated grade; exempt from drug manufacturing laws. Legally enforced by health authorities (e.g., FDA, EMA, NMPA).
Facility Environment Unclassified analytical or research laboratories. Validated Cleanrooms (ISO Class 5–8) with continuous monitoring.
Quality Control Basic purity and activity testing. Rigorous safety release testing (Sterility, Endotoxin, Mycoplasma).
Process Validation Basic equipment calibration; no process validation required. Full qualification (IQ/OQ/PQ) and complete batch records.
Quality Assurance Vendor self-declared without required formal QMS. Mandatory QA/QC unit, Change Control, CAPA, and vendor audits.
Regulatory Impact High risk of IND rejection if used as a critical raw material. Required for IND/NDA filings, supported by Drug Master Files (DMF).

Footnotes

Regulatory Note: Governed by FDA (21 CFR Parts 210/211/312), EMA (EudraLex Vol 4), ICH Guidelines (E6/Q7/Q9/Q10), and compendial standards (USP <71>/<85>/<1043>).

Jump to

Note: Technical data last updated: Sep 1, 2026.