CAS No. 59-92-7
| IUPAC Name | (2S)-2-amino-3-(3,4-dihydroxyphenyl)propanoic acid | |
|---|---|---|
| CAS Number | 59-92-7 | |
| Molecular Formula |
C9H11NO4 |
|
| Molecular Weight (MW) | 197.19 | |
| SMILES | C1=CC(=C(C=C1CC(C(=O)O)N)O)O | |
| InChIKey | WTDRDQBEARUVNC-LURJTMIESA-N |
Levodopa (L-DOPA) is a metabolic precursor of dopamine, norepinephrine, and epinephrine that acts as a central dopaminergic receptor agonist following metabolic conversion. Upon crossing the blood-brain barrier, levodopa is decarboxylated to dopamine by aromatic L-amino acid decarboxylase (DOPA decarboxylase). The generated dopamine stimulates postsynaptic dopamine receptors, restoring dopaminergic neurotransmission in depleted brain regions and enhancing downstream dopamine signaling pathways.
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Concentration
Volume
Mass
|
|---|
| Solvent | Solubility & Note |
|---|---|
| 5%TFA | 6.03 mg/mL |
| DMSO |
Insoluble
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO.) |
| Water | Insoluble |
| 5%TFA | 3 mg/mL |
| DMSO |
Insoluble
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO.) |
| Water | Insoluble |
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Pre-aliquoted for Longevity: Solid-state aliquots offer significantly longer shelf life compared to stock solutions, ensuring maximum stability for every use.
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