CAS No. 388082-77-7
Batch:
Purity:99.98
Chemical Structure
Check the
Lapatinib Ditosylate
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
| IUPAC Name | N-[3-chloro-4-[(3-fluorophenyl)methoxy]phenyl]-6-[5-[(2-methylsulfonylethylamino)methyl]furan-2-yl]quinazolin-4-amine;bis(4-methylbenzenesulfonic acid) | |
|---|---|---|
| CAS Number | 388082-77-7 | |
| Molecular Formula |
C29H26ClFN4O4S.2C7H8O3S |
|
| Molecular Weight (MW) | 925.46 | |
| SMILES | CC1=CC=C(C=C1)S(=O)(=O)O.CC1=CC=C(C=C1)S(=O)(=O)O.CS(=O)(=O)CCNCC1=CC=C(O1)C2=CC3=C(C=C2)N=CN=C3NC4=CC(=C(C=C4)OCC5=CC(=CC=C5)F)Cl | |
| InChIKey | UWYXLGUQQFPJRI-UHFFFAOYSA-N |
Lapatinib Ditosylate is a dual tyrosine kinase inhibitor targeting EGFR and ErbB2. It blocks receptor autophosphorylation and downstream MAPK/ERK and PI3K/AKT signaling pathways, leading to cell cycle arrest and inhibition of tumor cell proliferation in EGFR- and ErbB2-overexpressing cancer cells. Lapatinib exhibits high selectivity over other protein kinases such as VEGFR-2 and c-Raf-1. [1]
|
Concentration
Volume
Mass
|
|---|
Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| DMSO |
186 mg/mL
(200.98 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Water | Insoluble |
| Ethanol | Insoluble |
| DMSO |
100 mg/mL
(108.05 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Water | Insoluble |
| Ethanol | Insoluble |
| DMSO |
100 mg/mL
(108.05 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Water | Insoluble |
| Ethanol | Insoluble |
| DMSO |
185 mg/mL
(199.9 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Water | Insoluble |
| Ethanol | Insoluble |
| DMSO |
100 mg/mL
(108.05 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Water | Insoluble |
| Ethanol | Insoluble |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Pre-aliquoted for Longevity: Solid-state aliquots offer significantly longer shelf life compared to stock solutions, ensuring maximum stability for every use.
Looking for a specific aliquot size? Reach out to your local sales representative or contact us at orders@selleckchem.com.
- Lapatinib Ditosylate Clinical Trials
- Lapatinib Ditosylate Solubility in DMSO
- Lapatinib Ditosylate Stock Solution
- Lapatinib Ditosylate Storage
- Lapatinib Ditosylate Stability
- Lapatinib Ditosylate Molecular Weight
- Lapatinib Ditosylate SMILES
- Lapatinib Ditosylate Chemical Structure (2D and 3D)
- Lapatinib Ditosylate SDS｜MSDS
Note: Technical data last updated: Sep 1, 2026.