CAS No. 862507-23-1
Batch:
Purity:99.75
Chemical Structure
Check the
Ralimetinib (LY2228820) dimesylate
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
| IUPAC Name | 5-[2-tert-butyl-4-(4-fluorophenyl)-1H-imidazol-5-yl]-3-(2,2-dimethylpropyl)imidazo[4,5-b]pyridin-2-amine;methanesulfonic acid | |
|---|---|---|
| CAS Number | 862507-23-1 | |
| Molecular Formula |
C24H29FN6.2CH4O3S |
|
| Molecular Weight (MW) | 612.74 | |
| SMILES | CC(C)(C)CN1C2=C(C=CC(=N2)C3=C(N=C(N3)C(C)(C)C)C4=CC=C(C=C4)F)N=C1N.CS(=O)(=O)O.CS(=O)(=O)O | |
| InChIKey | NARMJPIBAXVUIE-UHFFFAOYSA-N |
Ralimetinib dimesylate is a potent and selective p38 MAPK inhibitor, targeting p38α MAPK and p38β MAPK. By inhibiting p38 MAPK, it blocks the phosphorylation of downstream substrates such as MAPKAPK2 and HSP27, suppressing p38 MAPK signaling pathways. This inhibition impairs cytokine production and reduces tumor growth and cell survival across various preclinical cancer models. [1]
|
Concentration
Volume
Mass
|
|---|
Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| Water | 123 mg/mL |
| DMSO |
35 mg/mL
(57.12 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Ethanol | 3 mg/mL |
| Water | 100 mg/mL |
| Ethanol | 20 mg/mL |
| DMSO |
4 mg/mL
(6.52 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO.) |
| DMSO |
100 mg/mL
(163.2 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Water | 100 mg/mL |
| Ethanol | 7 mg/mL |
| DMSO |
100 mg/mL
(163.2 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Water | 100 mg/mL |
| Ethanol | 5 mg/mL |
| DMSO |
100 mg/mL
(163.2 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Water | 100 mg/mL |
| Ethanol | 100 mg/mL |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Pre-aliquoted for Longevity: Solid-state aliquots offer significantly longer shelf life compared to stock solutions, ensuring maximum stability for every use.
Looking for a specific aliquot size? Reach out to your local sales representative or contact us at orders@selleckchem.com.
- Ralimetinib (LY2228820) dimesylate Clinical Trials
- Ralimetinib (LY2228820) dimesylate Solubility in DMSO
- Ralimetinib (LY2228820) dimesylate Stock Solution
- Ralimetinib (LY2228820) dimesylate Storage
- Ralimetinib (LY2228820) dimesylate Stability
- Ralimetinib (LY2228820) dimesylate Molecular Weight
- Ralimetinib (LY2228820) dimesylate SMILES
- Ralimetinib (LY2228820) dimesylate Chemical Structure (2D and 3D)
- Ralimetinib (LY2228820) dimesylate SDS｜MSDS
Note: Technical data last updated: Sep 1, 2026.