CAS No. 862507-23-1

Batch: Purity:99.75
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Ralimetinib (LY2228820) dimesylate Chemical Structure
Chemical Structure
Check the Ralimetinib (LY2228820) dimesylate product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.

Chemical Information

IUPAC Name 5-[2-tert-butyl-4-(4-fluorophenyl)-1H-imidazol-5-yl]-3-(2,2-dimethylpropyl)imidazo[4,5-b]pyridin-2-amine;methanesulfonic acid
CAS Number 862507-23-1
Molecular Formula

C24H29FN6.2CH4O3S
Molecular Weight (MW) 612.74
SMILES CC(C)(C)CN1C2=C(C=CC(=N2)C3=C(N=C(N3)C(C)(C)C)C4=CC=C(C=C4)F)N=C1N.CS(=O)(=O)O.CS(=O)(=O)O
InChIKey NARMJPIBAXVUIE-UHFFFAOYSA-N

Biological Activity

Ralimetinib dimesylate is a potent and selective p38 MAPK inhibitor, targeting p38α MAPK and p38β MAPK. By inhibiting p38 MAPK, it blocks the phosphorylation of downstream substrates such as MAPKAPK2 and HSP27, suppressing p38 MAPK signaling pathways. This inhibition impairs cytokine production and reduces tumor growth and cell survival across various preclinical cancer models. [1]

How to Prepare Stock Solution?

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Solubility

Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
Solvent Solubility & Note
Water 123 mg/mL
DMSO 35 mg/mL (57.12 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.)
Ethanol 3 mg/mL
FAQ
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
  • Preheat media/saline to 37°C.
  • Mix rapidly (pipette/vortex) upon addition.
  • For complex mixes, always add the aqueous phase last.
  • Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
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Reference

[1] Campbell VT, et al. Mol Cancer Ther. 2014;13(5):1259-69.

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Note: Technical data last updated: Sep 1, 2026.