CAS No. 635318-11-5

Batch: Purity:99.94
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pomaglumetad (LY404039) Chemical Structure
Chemical Structure
Check the pomaglumetad (LY404039) product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.

Chemical Information

CAS Number 635318-11-5
Molecular Formula

C7H9NO6S
Molecular Weight (MW) 235.22
SMILES C1C(C2C(C2S1(=O)=O)C(=O)O)(C(=O)O)N

Ordering Information

Biological Activity

Pomaglumetad (LY404039) is a selective group II metabotropic glutamate receptor agonist targeting human mGlu2 (Ki = 149 nM) and mGlu3 (Ki = 92 nM). It exhibits over 100-fold selectivity over ionotropic glutamate receptors and glutamate transporters. By inhibiting forskolin-stimulated cAMP formation, pomaglumetad suppresses excitatory neurotransmission and attenuates phencyclidine-induced hyperlocomotion in preclinical animal models. [1]

How to Prepare Stock Solution?

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Solubility

Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
Solvent Solubility & Note
5%TFA 3.06 mg/mL
DMSO 0.5 mg/mL (2.12 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO.)
Water Insoluble
FAQ
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
  • Preheat media/saline to 37°C.
  • Mix rapidly (pipette/vortex) upon addition.
  • For complex mixes, always add the aqueous phase last.
  • Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).

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Note: Technical data last updated: Sep 1, 2026.