Clinical Trials

Numerous clinical trials evaluate the therapeutic application of ivermectin from early phase 1 through phase 4, focusing primarily on parasitic and dermatological diseases—including scabies, strongyloidiasis, pediculosis capitis, lymphatic filariasis, onchocerciasis, demodicidosis, and rosacea—alongside investigations in COVID-19. Sponsored by prominent academic and public health institutes such as the University of Oxford, Swiss Tropical and Public Health Institute, and Washington University School of Medicine, these studies range in status from completed trials to active, recruiting, and upcoming pediatric efficacy trials.

NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT04351347 RECRUITING
COVID
Tanta University
 2020-06-16 PHASE2; PHASE3
NCT03553615 WITHDRAWN
Atopic Dermatitis
Stanford University
 2030-12-01 PHASE2
NCT07145736 RECRUITING
Onchocerciasis; Ascaris Lumbricoides Infection; Trichuris Trichiura; Infection; Hookworm Infections; Scabies
Kirby Institute
 2025-08-04 PHASE4
NCT07487805 NOT_YET_RECRUITING
Solid Tumor, Adult
University of Florida
 2026-09 PHASE2
NCT04108897 ACTIVE_NOT_RECRUITING
Rosacea
Johns Hopkins University
 2019-09-17 EARLY_PHASE1
NCT07707817 RECRUITING
Onchocerciasis (River Blindness); Schistosomiasis; Soil Transmitted Helminth (STH) Infections; Lymphatic Filariasis
Uwemedimo Friday Ekpo
 2026-07-01
NCT06918665 SUSPENDED
Scabies
Murdoch Childrens Research Institute
 2026-07 PHASE1
NCT07159373 NOT_YET_RECRUITING
Lymphatic Filariasis; Scabies; Strongyloidiasis
Medicines Development for Global Health
 2026-03 PHASE3
NCT07661316 NOT_YET_RECRUITING
Trichuriasis; Strongyloidiasis; Ascariasis; Hookworm Infection; Soil-Transmitted Helminthiasis
Mundo Sano Foundation
 2026-11-01 PHASE3
NCT07396714 NOT_YET_RECRUITING
Warts
Assiut University
 2026-02-01 EARLY_PHASE1
NCT05041907 RECRUITING
COVID-19
University of Oxford
 2021-09-30 PHASE2
NCT07657143 NOT_YET_RECRUITING
Survival of Flies Developing in Faecal Samples
London School of Hygiene and Tropical Medicine
 2026-07 PHASE4
NCT05318469 RECRUITING
Anatomic Stage IV Breast Cancer AJCC v8; Metastatic Triple-Negative Breast Carcinoma
Yuan Yuan
 2023-10-13 PHASE1; PHASE2
NCT05180461 ACTIVE_NOT_RECRUITING
Onchocerciasis
Drugs for Neglected Diseases
 2021-08-30 PHASE2
NCT06070116 ACTIVE_NOT_RECRUITING
Onchocercal Subcutaneous Nodule; Onchocerciasis; Onchocerciasis, Ocular; Onchocerca Infection; Tropical Disease
Washington University School of Medicine
 2024-04-05 PHASE2
NCT07795567 COMPLETED
Rosacea
Sun Pharmaceutical Industries, Inc.
 2025-12-09 PHASE1
NCT07710638 ACTIVE_NOT_RECRUITING
Plane Warts
Al-Azhar University
 2026-06-01 PHASE2
NCT05500326 ACTIVE_NOT_RECRUITING
Scabies; Itch; Scabies
Murdoch Childrens Research Institute
 2025-06-24 PHASE2
NCT06896929 NOT_YET_RECRUITING
Scabies
Children Hospital and Institute of Child Health, Lahore
 2025-05-01 PHASE2
NCT06282315 RECRUITING
Soil-Transmitted Helminths
Insud Pharma
 2025-09-01 PHASE3
NCT07045493 ENROLLING_BY_INVITATION
Soil Transmitted Helminth (STH) Infections
International Centre for Diarrhoeal Disease Research, Bangladesh
 2025-07-10 PHASE2
NCT02735707 RECRUITING
Community-acquired Pneumonia, Influenza, COVID-19
UMC Utrecht
 2016-04-11 PHASE3
NCT06265870 RECRUITING
Eosinophilia
Prince of Songkla University
 2024-05-01
NCT06404333 COMPLETED
Scabies
University of Oxford
 2025-02-25 PHASE2
NCT04332068 COMPLETED
Scabies
University of Oxford
 2023-11-18 PHASE2
NCT06033352 COMPLETED
Rosacea
Insel Gruppe AG, University Hospital Bern
 2023-09-12 PHASE2
NCT04410406 COMPLETED
Lymphatic Filariasis
Washington University School of Medicine
 2020-08-20 PHASE3
NCT06404333 Not yet recruiting
Scabies
University of Oxford|Fundação de Medicina Tropical Dr. Heitor Vieira Dourado|Fundação de Dermatologia Tropical e Venereologia Alfredo da Matta (FUAM)|University of Basel|ClinSearch
 2024-10-01 Phase 2
NCT04311671 COMPLETED
Onchocerciasis
Medicines Development for Global Health
 2021-05-03 PHASE3
NCT06373835 COMPLETED
Strongyloides Stercoralis Infection; Strongyloidiasis
Swiss Tropical & Public Health Institute
 2024-05-20 PHASE2
NCT06184399 COMPLETED
Trichuriasis; Ascariasis; Hookworm Infections
Jennifer Keiser
 2024-06-05 PHASE2
NCT03876262 ACTIVE_NOT_RECRUITING
Onchocerciasis
Medicines Development for Global Health
 2021-05-03 PHASE3
NCT06557603 COMPLETED
Rosacea
Humanis Saglık Anonim Sirketi
 2024-03-06 PHASE1
NCT05500326 Not yet recruiting
Scabies; Itch|Scabies
Murdoch Childrens Research Institute|Burnet Institute|Lao Tropical and Public Health Institute
 2024-06 Phase 2
NCT05946642 UNKNOWN
Malaria
Malaria Consortium
 2023-07-15 PHASE3
NCT06373835 Not yet recruiting
Strongyloides Stercoralis Infection|Strongyloidiasis
Swiss Tropical & Public Health Institute|National Institute of Public Health Vientiane Laos
 2024-05-01 Phase 2
NCT04885530 COMPLETED
Covid19
Susanna Naggie, MD
 2021-06-08 PHASE3
NCT04966702 COMPLETED
Malaria
Barcelona Institute for Global Health
 2022-03-17 PHASE3
NCT06332872 UNKNOWN
Pediculus Capitis Infestation; Permethrin Adverse Reaction; Dimethicone Adverse Reaction; Permethrin Allergy; Dimethicone Allergy; Ivermectin; School-age Children
Phramongkutklao College of Medicine and Hospital
 2023-12-15 PHASE4
NCT06251739 COMPLETED
Post-kala-azar Dermal Leishmaniasis
International Centre for Diarrhoeal Disease Research, Bangladesh
 2023-10-30 EARLY_PHASE1
NCT04275999 COMPLETED
Rosacea
Wake Forest University Health Sciences
 2021-04-16 PHASE2
NCT06332872 Active not recruiting
Pediculus Capitis Infestation|Permethrin Adverse Reaction|Dimethicone Adverse Reaction|Permethrin Allergy|Dimethicone Allergy|Ivermectin|School-age Children
Phramongkutklao College of Medicine and Hospital
 2023-12-15 Phase 4
NCT06037876 COMPLETED
Trichuriasis
Jennifer Keiser
 2023-10-09 PHASE3
NCT04049851 COMPLETED
Onchocerciasis, Ocular; Loiasis
Center for Research on Filariasis and Other Tropical Diseases, Cameroon
 2022-04-07 PHASE2
NCT05124691 TERMINATED
Helminthes; Infestation, Intestinal
Barcelona Institute for Global Health
 2022-01-20 PHASE2; PHASE3
NCT05269030 UNKNOWN
Parosmia
Menoufia University
 2022-07 PHASE2
NCT04844905 UNKNOWN
Malaria,Falciparum; Neglected Tropical Diseases; Strongyloidiasis; Lymphatic Filariasis; Scabies; Hook Worm; Soil Transmitted Helminths
London School of Hygiene and Tropical Medicine
 2021-05-03 PHASE3
NCT05819983 COMPLETED
Scabies
Universitas Padjadjaran
 2023-01-25 PHASE4
NCT05605925 UNKNOWN
Malaria
Makerere University
 2022-08-04 PHASE4
NCT05477810 COMPLETED
Bioequivalence
University Children's Hospital Basel
 2022-09-13 EARLY_PHASE1
NCT04510194 COMPLETED
Covid19; SARS-CoV Infection
University of Minnesota
 2021-01-01 PHASE3
NCT04959786 UNKNOWN
COVID-19 Pneumonia
Mansoura University
 2021-04-01 PHASE2; PHASE3
NCT05305560 COMPLETED
COVID-19
MedinCell S.A
 2022-03-25 PHASE2
NCT05930002 COMPLETED
COVID-19
Ain Shams University
 2021-07-21
NCT05643820 COMPLETED
Pediculosis
Combined Military Hospital Abbottabad
 2022-03-01 PHASE1
NCT05894538 COMPLETED
Covid19
Susanna Naggie, MD
 2022-02-16 PHASE3
NCT04848688 COMPLETED
Strongyloides Stercoralis Infection
Jennifer Keiser
 2022-02-05 PHASE3
NCT04447235 TERMINATED
Cancer; COVID; Coronavirus Infection
Instituto do Cancer do Estado de São Paulo
 2020-07-23 PHASE2
NCT05283954 WITHDRAWN
SARS-CoV2 Infection; COVID-19
Oriol Mitja
 2022-05-01 PHASE2; PHASE3
NCT07286604 COMPLETED
Post Kala Azar Dermal Leishmaniasis
International Centre for Diarrhoeal Disease Research, Bangladesh
 2022-03-02 EARLY_PHASE1
NCT05155527 UNKNOWN
COVID-19
Mahidol University
 2022-02-10 PHASE2
NCT05231603 TERMINATED
COVID-19
Clinical Research Centre, Malaysia
 2022-02-16 PHASE3
NCT05213585 UNKNOWN
The Focus of the Study is to Assess the Effectiveness of Topical Ivermectin on Eliminating Eyelash Sleeves
Helm Vision Group
 2021-08-24 PHASE1
NCT04482686 COMPLETED
COVID; Covid-19; Corona Virus Infection; Coronavirus Infection; Coronavirus-19; SARS-CoV2; SARS-CoV Infection
ProgenaBiome
 2020-12-09 PHASE1
NCT04951362 UNKNOWN
Anosmia
South Valley University
 2021-04-20 PHASE2; PHASE3
NCT04392427 UNKNOWN
COVID; Drug Effect
Mansoura University
 2020-10 PHASE3
NCT05040724 UNKNOWN
To Assess the Reduction in the Viral Load of SARS-CoV-2 in Patients Receiving Ivermectin Compared to Those Receiving Standard Care
Raincy Montfermeil Hospital Group
 2021-05-28 PHASE3
NCT03690453 COMPLETED
Healthy
University of Oxford
 2019-02-04 PHASE4
NCT05736861 COMPLETED
Covid19
Susanna Naggie, MD
 2021-06-08 PHASE3
NCT04188301 COMPLETED
Onchocerciasis
Washington University School of Medicine
 2019-12-06 PHASE2
NCT05060666 UNKNOWN
Covid19
Infectopharm Arzneimittel GmbH
 2021-11 PHASE3
NCT04703608 UNKNOWN
Covid-19
London School of Hygiene and Tropical Medicine
 2021-01-22 PHASE3
NCT05246072 COMPLETED
COVID-19
Ain Shams University
 2021-11-01 PHASE4
NCT03570814 COMPLETED
Trachoma; Lymphatic Filariases
London School of Hygiene and Tropical Medicine
 2021-12-01 PHASE4
NCT02841215 COMPLETED
Gale; Severe Forms of Scabies; Oral Parasitic Drug; Ivermectin
Assistance Publique - Hôpitaux de Paris
 2017-10-11 PHASE3
NCT06259383 COMPLETED
Clinical Syndrome
Prince of Songkla University
 2018-01-01 PHASE3
NCT04944082 UNKNOWN
Covid19
Assiut University
 2021-07-01 PHASE4
NCT04729140 UNKNOWN
Covid19
Max Health, Subsero Health
 2020-12-28 PHASE4
NCT02407782 COMPLETED
Scabies
University Hospital, Bordeaux
 2016-01-19 PHASE3
NCT04602507 TERMINATED
Covid19; Severe Acute Respiratory Syndrome
CES University
 2020-12-10 PHASE2
NCT05076253 COMPLETED
Safety; SARS-CoV2 Infection; Ivermectin Poisoning; Effect of Drug
Bangkok Metropolitan Administration Medical College and Vajira Hospital
 2021-09-01 PHASE1; PHASE2
NCT04891250 WITHDRAWN
SARS-CoV-2; Ivermectin
Centre for Infectious Disease Research in Zambia
 2021-10 PHASE4
NCT05362513 COMPLETED
Scabies
Combined Military Hospital Abbottabad
 2021-06-01 PHASE1
NCT04920942 COMPLETED
COVID-19
Clinical Research Centre, Malaysia
 2021-05-31 PHASE3
NCT04703205 UNKNOWN
Covid19
Kitasato University
 2020-09-16 PHASE2
NCT04894721 COMPLETED
Covid19
Ministry of Public Health, Argentina
 2021-06-01 PHASE2; PHASE3
NCT04726969 COMPLETED
Trichuriasis; Ascariasis; Hookworm Infections
Jennifer Keiser
 2021-06-15 PHASE3
NCT04937569 UNKNOWN
Covid19
Assiut University
 2021-07-01 PHASE3
NCT04886362 UNKNOWN
COVID-19 Pneumonia
Ayudas Diagnosticas Sura S.A.S
 2021-07 PHASE2; PHASE3
NCT05085665 COMPLETED
Loiasis
Washington University School of Medicine
 2021-07-30 PHASE4
NCT04700423 COMPLETED
Trichuriasis; Ascariasis; Hookworm Infections; Helminthes; Infestation, Intestinal
Jennifer Keiser
 2021-03-01 PHASE2; PHASE3
NCT04472585 UNKNOWN
Coronavirus Infection; COVID; Sars-CoV2
Sohaib Ashraf
 2020-11-14 PHASE1; PHASE2
NCT05993143 TERMINATED
COVID-19; SARS-CoV-2
Insud Pharma
 2021-01-18 PHASE3
NCT04836299 UNKNOWN
Covid19
Universidad Mayor de San Simón
 2021-05-08 PHASE2
NCT04768179 UNKNOWN
Covid19
Makerere University
 2021-02-19 PHASE2; PHASE3
NCT04530474 WITHDRAWN
Covid19
Temple University
 2021-04-01 PHASE3
NCT04438850 TERMINATED
Covid19
IRCCS Sacro Cuore Don Calabria di Negrar
 2020-07-31 PHASE2
NCT04435587 UNKNOWN
Asymptomatic Infections; SARS-CoV2 Infection
Mahidol University
 2020-07-13 PHASE4
NCT04681053 UNKNOWN
COVID-19
Mansoura University
 2021-02-25 PHASE3
NCT04056325 COMPLETED
Strongyloides Stercoralis Infection
Jennifer Keiser
 2019-11-27 PHASE2; PHASE3
NCT04834115 UNKNOWN
Covid19; Coronavirus Infection
Universidad Nacional de Asunción
 2020-11-17 PHASE3
NCT04635943 COMPLETED
Covid19; Coronavirus Infection; SARS-CoV Infection
Universidad Peruana Cayetano Heredia
 2020-08-29 PHASE2
NCT04712279 UNKNOWN
Covid19
Corpometria Institute
 2021-01-25 PHASE2; PHASE3
NCT04779047 UNKNOWN
Covid19; Pneumonia
October 6 University
 2020-10-01 PHASE4
NCT04632706 COMPLETED
Covid19
MedinCell S.A
 2020-09-22 PHASE1
NCT05749653 COMPLETED
Onchocerciasis; Epilepsy
Universiteit Antwerpen
 2017-03-01
NCT04854460 COMPLETED
Healthy
Genuine Research Center, Egypt
 2021-01-28 PHASE1
NCT04673214 COMPLETED
Covid19
Gilberto Cruz Arteaga
 2020-12-16 PHASE3
NCT04529525 COMPLETED
Covid19
Instituto de Cardiología de Corrientes
 2020-08-19 PHASE2; PHASE3
NCT04716569 UNKNOWN
Covid19
South Valley University
 2021-01-20 PHASE2; PHASE3
NCT04723459 UNKNOWN
Covid-19
South Valley University
 2021-01-23
NCT04746365 COMPLETED
Covid19
Elaraby Hospital
 2020-12-06 PHASE4
NCT04407507 COMPLETED
COVID-19
Investigacion Biomedica para el Desarrollo de Farmacos S.A. de C.V.
 2020-07-01 PHASE2
NCT04374019 TERMINATED
COVID; Sars-CoV2
Susanne Arnold
 2020-05-01 PHASE2
NCT05082753 COMPLETED
Anthelmintic Agent
Humanis Saglık Anonim Sirketi
 2020-11-19 PHASE1
NCT04405843 COMPLETED
COVID-19
Centro de Estudios en Infectogía Pediatrica
 2020-07-14 PHASE2; PHASE3
NCT04784481 COMPLETED
Covid19; SARS (Severe Acute Respiratory Syndrome)
Ministry of Public Health, Argentina
 2020-09-20 PHASE1; PHASE2
NCT04701710 COMPLETED
Covid19; SARS (Severe Acute Respiratory Syndrome)
Maria de los Angeles Peral de Bruno
 2020-10-15 PHASE1; PHASE2
NCT04431466 TERMINATED
Coronavirus Infection
Universidade Federal de Sao Carlos
 2020-07-01 PHASE2
NCT04527211 UNKNOWN
Covid19; Healthcare Worker Patient Transmission
Javeriana University
 2020-09-07 PHASE3
NCT03967054 COMPLETED
Malaria
Brian Foy
 2019-07-13 PHASE3
NCT04391127 COMPLETED
COVID-19
Centenario Hospital Miguel Hidalgo
 2020-05-04 PHASE3
NCT04551755 UNKNOWN
Covid19
Bangladesh Medical Research Council (BMRC)
 2020-09 PHASE2
NCT04403555 COMPLETED
COVID
Tanta University
 2020-06-01 PHASE2; PHASE3
NCT04407130 COMPLETED
COVID-19 Patients
International Centre for Diarrhoeal Disease Research, Bangladesh
 2020-06-16 PHASE2
NCT04360356 UNKNOWN
COVID-19
Tanta University
 2020-05 PHASE2; PHASE3
NCT04510233 UNKNOWN
Covid19
Tanta University
 2020-09 PHASE2
NCT04591600 COMPLETED
Covid19
Alkarkh Health Directorate-Baghdad
 2020-07-01 PHASE1; PHASE2
NCT04429711 UNKNOWN
COVID-19
Sheba Medical Center
 2020-05-12
NCT04381884 COMPLETED
COVID-19 Drug Treatment
Laboratorio Elea Phoenix S.A.
 2020-05-18 PHASE2
NCT03432442 COMPLETED
Dengue Hemorrhagic Fever
Mahidol University
 2018-09-04 PHASE2
NCT04390022 COMPLETED
Covid-19; Coronavirus Infection; SARS-CoV-2 Infection
Clinica Universidad de Navarra, Universidad de Navarra
 2020-07-31 PHASE2
NCT04668469 COMPLETED
Covid19
Benha University
 2020-06-08
NCT04384458 UNKNOWN
Coronavirus Infections
Nucleo De Pesquisa E Desenvolvimento De Medicamentos Da Universidade Federal Do Ceara
 2020-07-20
NCT04646109 COMPLETED
COVID-19
Afyonkarahisar Health Sciences University
 2020-05-11 PHASE3
NCT04446104 COMPLETED
Covid-19
National University Hospital, Singapore
 2020-05-13 PHASE3
NCT04523831 COMPLETED
Covid19
Dhaka Medical College
 2020-06-01 PHASE3
NCT04106726 COMPLETED
Facial Rosacea
Zydus Worldwide DMCC
 2019-10-17 PHASE3
NCT04445311 UNKNOWN
COVID
Zagazig University
 2020-05-31 PHASE2; PHASE3
NCT04373824 UNKNOWN
COVID
Max Healthcare Insititute Limited
 2020-04-25
NCT04422561 COMPLETED
COVID
Zagazig University
 2020-05-31 PHASE2; PHASE3
NCT04425707 UNKNOWN
Covid19
Ministry of Health and Population, Egypt
 2020-06-09
NCT04392713 UNKNOWN
COVID
Combined Military Hospital, Pakistan
 2020-04-15
NCT04739410 COMPLETED
Covid19
FMH College of Medicine and Dentistry
 2020-05-01 PHASE4
NCT04343092 COMPLETED
COVID 19
University of Baghdad
 2020-04-18 PHASE1
NCT04399746 COMPLETED
COVID
Instituto de Seguridad y Servicios Sociales de los Trabajadores del Estado
 2020-03-15
NCT03527732 COMPLETED
Trichuriasis
Jennifer Keiser
 2018-09-09 PHASE2; PHASE3
NCT04041453 COMPLETED
Trichuris Infection; Helminthiasis
Alejandro Krolewiecki
 2019-10-09 PHASE2
NCT03576313 COMPLETED
Malaria
London School of Hygiene and Tropical Medicine
 2018-08-11 PHASE3
NCT03036059 COMPLETED
Lymphatic Filariasis; Helminth Infection
Noguchi Memorial Institute for Medical Research
 2017-05-19 PHASE4
NCT03517462 COMPLETED
Onchocerciasis
Washington University School of Medicine
 2018-08-06
NCT02806414 COMPLETED
Rosacea
University of California, San Diego
 2016-07 PHASE1; PHASE2
NCT03852303 COMPLETED
Epilepsy
Universiteit Antwerpen
 2017-10-01 PHASE4
NCT03578679 COMPLETED
Pediculoses
Institut de Recherche pour le Developpement
 2018-07-11
NCT03676140 COMPLETED
Trachoma; Yaws; Lymphatic Filariases; Scabies; Strongyloidiasis
Lihir Medical Centre
 2018-10-01 PHASE3
NCT03664063 COMPLETED
Lymphatic Filariasis; Yaws; Trauma
Lihir Medical Centre
 2018-09-01 PHASE2
NCT02974049 COMPLETED
Lymphatic Filariasis
University Hospitals Cleveland Medical Center
 2015-01
NCT03074435 COMPLETED
Malaria
Institut de Recherche pour le Developpement
 2016-07 PHASE3
NCT01570504 COMPLETED
Strongyloidiasis
Centro per le Malattie Tropicali
 2013-03 PHASE3
NCT02078024 COMPLETED
Onchocerciasis
University Hospitals Cleveland Medical Center
 2014-06 PHASE3
NCT03717558 WITHDRAWN
Healthy Volunteers
Pierre Fabre Dermatology
 2018-04-30 PHASE1
NCT03459794 COMPLETED
Ivermectin
University of Georgia
 2018-02-12 EARLY_PHASE1
NCT03301649 COMPLETED
Head Lice
Actavis Inc.
 2017-10-07 PHASE3
NCT03075891 COMPLETED
Rosacea
Galderma R&D
 2017-07-05 PHASE4
NCT03052998 COMPLETED
Ivermectin; Onchocerciasis; Epilepsy
Robert Colebunders
 2017-10-01 PHASE4
NCT03236168 COMPLETED
Scabies; Head Lice
London School of Hygiene and Tropical Medicine
 2017-08-01 PHASE3
NCT03337490 COMPLETED
Head Lice
Mayne Pharma International Pty Ltd
 2017-10-02 PHASE3
NCT05198947 COMPLETED
Scabies
B.P. Koirala Institute of Health Sciences
 2017-01
NCT01975441 COMPLETED
Lymphatic Filariasis
University Hospitals Cleveland Medical Center
 2014-05 PHASE2
NCT03177993 COMPLETED
Lymphatic Filariases; Scabies; Impetigo; Soil Transmitted Helminths
Washington University School of Medicine
 2017-07-13
NCT03286101 COMPLETED
Pediculosis Capitis
United Laboratories
 2017-09-14 PHASE2
NCT02775617 COMPLETED
Scabies; Yaws; Impetigo
London School of Hygiene and Tropical Medicine
 2016-07 PHASE4
NCT03257943 COMPLETED
Lice; Head Lice
Sun Pharmaceutical Industries, Inc.
 2017-03-20 PHASE1
NCT02899936 COMPLETED
Lymphatic Filariasis
Washington University School of Medicine
 2016-07
NCT02795117 COMPLETED
Rosacea
Padagis LLC
 2016-05 PHASE3
NCT02568098 COMPLETED
Drug Combination; Pharmacokinetics; Healthy
University of Oxford
 2015-10 PHASE1
NCT03173742 COMPLETED
Helminthiasis
Insud Pharma
 2016-03 PHASE1
NCT02963324 COMPLETED
Malaria
University Hospital, Basel, Switzerland
 2016-11 PHASE1
NCT02840461 COMPLETED
Moderate to Severe Papulopustular Rosacea
Actavis Inc.
 2016-06 PHASE3
NCT02616250 COMPLETED
Rosacea
Galderma R&D
 2015-12 PHASE4
NCT02511353 COMPLETED
Malaria
Liverpool School of Tropical Medicine
 2015-07 PHASE2
NCT02845713 COMPLETED
Wuchereria Bancrofti Infection
University Hospitals Cleveland Medical Center
 2016-04-17 PHASE1
NCT02045069 UNKNOWN
Dengue Fever
Mahidol University
 2014-02 PHASE2; PHASE3
NCT02036229 UNKNOWN
Demodicidosis; Rosacea
Rabin Medical Center
 2014-02 PHASE3
NCT02509481 COMPLETED
Malaria; Lymphatic Filariasis
Colorado State University
 2015-06 PHASE2; PHASE3
NCT03238131 COMPLETED
Onchocerciasis
University Hospitals Cleveland Medical Center
 2012-04 PHASE3
NCT02046200 COMPLETED
Alcohol Use Disorder
University of California, Los Angeles
 2014-02 PHASE1; PHASE2
NCT03605758 TERMINATED
Strongyloides Stercoralis Infection; Strongyloidiasis
Albert Einstein College of Medicine
 2012-05 PHASE3
NCT02236403 COMPLETED
Chronic Blepharitis
Universidad Nacional de Colombia
 2014-10 PHASE3
NCT01903057 WITHDRAWN
Trachoma; Lymphatic Filariasis
Emory University
 2014-02 PHASE4
NCT01493947 COMPLETED
Papulopustular Rosacea
Galderma R&D
 2012-04 PHASE3
NCT01593722 COMPLETED
Loiasis
National Institute of Allergy and Infectious Diseases (NIAID)
 2012-04 PHASE4
NCT01603251 COMPLETED
Malaria
London School of Hygiene and Tropical Medicine
 2013-01 PHASE1; PHASE2
NCT01308268 UNKNOWN
Helminthiasis; Strongyloides Stercoralis Infection
Universidad Nacional de Salta
 2010-12
NCT00790998 COMPLETED
Onchocerciasis
Medicines Development for Global Health
 2009-04 PHASE3
NCT01213576 TERMINATED
Lymphatic Filariasis
London School of Hygiene and Tropical Medicine
 2009-01
NCT00817713 TERMINATED
HIV Infections; Helminthiasis
Swiss Tropical & Public Health Institute
 2009-01
NCT01068158 COMPLETED
Head Lice
Topaz Pharmaceuticals Inc
 2010-03 PHASE3
NCT01066585 COMPLETED
Head Lice
Topaz Pharmaceuticals Inc
 2010-03 PHASE3
NCT00765024 COMPLETED
Chronic Strongyloidiasis
Mahidol University
 2008-07 PHASE3
NCT01586169 COMPLETED
Parasitic Diseases; Bacterial Diseases
Centre d'Appui à la lutte contre la Maladie
 2010-02
NCT00994422 COMPLETED
Head Lice
Topaz Pharmaceuticals Inc
 2009-10 PHASE2
NCT00300768 COMPLETED
Onchocerciasis
Medicines Development for Global Health
 2006-09-06 PHASE2
NCT00988533 COMPLETED
Head Lice
Topaz Pharmaceuticals Inc
 2009-09 PHASE1
NCT01050452 COMPLETED
Parasitic Diseases
DBL -Institute for Health Research and Development
 2007-10
NCT00857948 COMPLETED
Pediculus Humanus Capitis (Head Lice)
Topaz Pharmaceuticals Inc
 2009-03 PHASE2
NCT02784743 COMPLETED
Lymphatic Filariasis
Centre d'Appui à la lutte contre la Maladie
 2001-05 PHASE4
NCT00339417 COMPLETED
Lymphatic Filariasis
National Institute of Allergy and Infectious Diseases (NIAID)
 2006-02-22 PHASE2
NCT00604084 COMPLETED
Scabies
Edward Via Virginia College of Osteopathic Medicine
 2007-05
NCT01050517 COMPLETED
Parasitic Diseases
DBL -Institute for Health Research and Development
 2007-10
NCT00921219 COMPLETED
Healthy
Johnson & Johnson Consumer and Personal Products Worldwide
 2005-09 PHASE1
NCT00921154 COMPLETED
Healthy
Johnson & Johnson Consumer and Personal Products Worldwide
 2005-03 PHASE1
NCT00921674 COMPLETED
Healthy
Johnson & Johnson Consumer and Personal Products Worldwide
 2005-02 PHASE1
NCT00819520 COMPLETED
Lice Infestations
Johnson & Johnson Consumer and Personal Products Worldwide
 2004-02 PHASE3
NCT00207753 COMPLETED
Ascariasis; Trichuriasis; Hookworm Infection; Strongyloidiasis; Pediculosis
Centers for Disease Control and Prevention
 2005-02
NCT00262418 COMPLETED
Scabies
University Ghent
 2004-07 PHASE2
NCT00215280 COMPLETED
Mansonelliasis; Pruritus; Lymphoedema; Abdominal Pains
DBL -Institute for Health Research and Development
 2005-11

(data from https://clinicaltrials.gov, updated on 2021-03-10)

Check the Ivermectin product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.

Compliance for Clinical Use

Mechanism and Biochemical Profile

Ivermectin selectively binds to and activates glutamate-gated chloride channels while acting as a positive allosteric effector of P2X4 and α7 nicotinic acetylcholine receptors. By increasing membrane permeability to chloride ions, this influx leads to neuronal hyperpolarization and neuromuscular paralysis, effectively eradicating infectious organisms in clinical trial indications such as scabies, strongyloidiasis, and onchocerciasis.

Appendix RUO and cGMP Quality Standards

Quality Dimension RUO (Research Use Only) cGMP (Current Good Manufacturing Practice)
Clinical Applicability Prohibited in human clinical trials or medical diagnostics. Mandatory for human clinical trials (Phase I–III) and therapies.
Regulatory Status Non-regulated grade; exempt from drug manufacturing laws. Legally enforced by health authorities (e.g., FDA, EMA, NMPA).
Facility Environment Unclassified analytical or research laboratories. Validated Cleanrooms (ISO Class 5–8) with continuous monitoring.
Quality Control Basic purity and activity testing. Rigorous safety release testing (Sterility, Endotoxin, Mycoplasma).
Process Validation Basic equipment calibration; no process validation required. Full qualification (IQ/OQ/PQ) and complete batch records.
Quality Assurance Vendor self-declared without required formal QMS. Mandatory QA/QC unit, Change Control, CAPA, and vendor audits.
Regulatory Impact High risk of IND rejection if used as a critical raw material. Required for IND/NDA filings, supported by Drug Master Files (DMF).

Footnotes

Regulatory Note: Governed by FDA (21 CFR Parts 210/211/312), EMA (EudraLex Vol 4), ICH Guidelines (E6/Q7/Q9/Q10), and compendial standards (USP <71>/<85>/<1043>).

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Note: Technical data last updated: Sep 1, 2026.