CAS No. 336113-53-2

Batch: Purity:99.92
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Ispinesib (SB-715992) Chemical Structure
Chemical Structure
Check the Ispinesib (SB-715992) product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.

Chemical Information

IUPAC Name N-(3-aminopropyl)-N-[(1R)-1-(3-benzyl-7-chloro-4-oxoquinazolin-2-yl)-2-methylpropyl]-4-methylbenzamide
CAS Number 336113-53-2
Molecular Formula

C30H33ClN4O2
Molecular Weight (MW) 517.06
SMILES CC1=CC=C(C=C1)C(=O)N(CCCN)C(C2=NC3=C(C=CC(=C3)Cl)C(=O)N2CC4=CC=CC=C4)C(C)C
InChIKey QJZRFPJCWMNVAV-HHHXNRCGSA-N

Ordering Information

Biological Activity

Ispinesib (SB-715992) is a potent and selective inhibitor of kinesin spindle protein (KSP/Eg5) with a Ki ofand an IC50 of. By inhibiting KSP ATPase activity, it disrupts bipolar mitotic spindle assembly, triggering cell cycle arrest in the M phase and inducing apoptotic cell death across various cancer cell lines. In vivo, ispinesib exhibits broad antitumor activity in human tumor xenograft models.

How to Prepare Stock Solution?

Concentration Volume Mass
1 mg 5 mg 10 mg
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Solubility

Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
Solvent Solubility & Note
DMSO 103 mg/mL (199.2 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.)
Ethanol 103 mg/mL
Water Insoluble
FAQ
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
  • Preheat media/saline to 37°C.
  • Mix rapidly (pipette/vortex) upon addition.
  • For complex mixes, always add the aqueous phase last.
  • Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).

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Note: Technical data last updated: Sep 1, 2026.