Irinotecan is currently evaluated across numerous clinical trials spanning Early Phase 1 through Phase 4, sponsored by academic medical centers, university hospitals, and biopharmaceutical entities across recruiting, completed, suspended, and not yet recruiting statuses. Clinical investigations focus primarily on gastrointestinal and thoracic malignancies—notably metastatic colorectal cancer, small cell lung carcinoma, gastric cancer, esophageal squamous cell carcinoma, and pancreatic adenocarcinoma. Promising protocols explore novel liposomal formulations and combination regimens alongside targeted therapeutics and chemotherapy to overcome treatment resistance in advanced solid tumors and peritoneal metastases.
| NCT Number | Recruitment | Conditions | Sponsor/Collaborators | Start Date | Phases |
|---|---|---|---|---|---|
| NCT06365008 | NOT_YET_RECRUITING | Unresectable/Metastatic Gastric Cancer |
Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University |
2026-06 | PHASE2 |
| NCT07521605 | NOT_YET_RECRUITING | Rectal Cancer Patients |
Guangdong Provincial People's Hospital |
2026-05-20 | PHASE2 |
| NCT07381764 | NOT_YET_RECRUITING | Metastatic Colorectal Cancer (CRC) |
Gruppo Oncologico Italia Meridionale |
2026-03-30 | PHASE2 |
| NCT07549321 | RECRUITING | High-Risk Neuroblastoma |
Renaissance Pharma Ltd. |
2026-03-30 | PHASE2; PHASE3 |
| NCT07585279 | NOT_YET_RECRUITING | Metastatic Colorectal Cancer (CRC); Liposomal Irinotecan; Second-Line |
Hebei Medical University Fourth Hospital |
2026-05-20 | PHASE2; PHASE3 |
| NCT06401330 | RECRUITING | Stage I Mixed Cell Type Kidney Wilms Tumor; Stage II Mixed Cell Type Kidney Wilms Tumor; Stage III Mixed Cell Type Kidney Wilms Tumor; Stage IV Mixed Cell Type Kidney Wilms Tumor |
Children's Oncology Group |
2025-04-15 | PHASE3 |
| NCT07782346 | NOT_YET_RECRUITING | Advanced Solid Malignancies |
National Health Research Institutes, Taiwan |
2026-10-01 | PHASE1 |
| NCT01042379 | RECRUITING | Breast Neoplasms; Breast Cancer; Breast Tumors; Angiosarcoma; TNBC - Triple-Negative Breast Cancer; HER2-positive Breast Cancer; HER2-negative Breast Cancer; Hormone Receptor Positive Tumor; Hormone Receptor Negative Tumor; Early-stage Breast Cancer; Locally Advanced Breast Cancer |
QuantumLeap Healthcare Collaborative |
2010-03-01 | PHASE2 |
| NCT06958328 | RECRUITING | Locally Advanced Unresectable Pancreatic Ductal Adenocarcinoma; Stage II Pancreatic Cancer AJCC v8; Stage III Pancreatic Cancer AJCC v8; Stage IV Pancreatic Cancer AJCC v8 |
NRG Oncology |
2025-08-21 | PHASE3 |
| NCT07662031 | NOT_YET_RECRUITING | Colorectal Cancer; Metastatic Colorectal Cancer |
Washington University School of Medicine |
2026-08-31 | PHASE2 |
| NCT07141771 | NOT_YET_RECRUITING | SCLC, Extensive Stage |
Cancer Institute and Hospital, Chinese Academy of Medical Sciences |
2025-12-31 | PHASE1; PHASE2 |
| NCT05719558 | RECRUITING | Advanced Solid Tumors |
Astellas Pharma Global Development, Inc. |
2023-03-13 | PHASE1 |
| NCT01356290 | RECRUITING | Medulloblastoma Recurrent; Ependymoma Recurrent; ATRT Recurrent; Rare CNS Tumor Recurrent |
Medical University of Vienna |
2014-04 | PHASE2 |
| NCT07183865 | RECRUITING | Locally Recurrent Rectal Cancer |
Fudan University |
2025-03-09 | PHASE2 |
| NCT06607185 | ACTIVE_NOT_RECRUITING | Pancreatic Ductal Adenocarcinoma; Non-small Cell Lung Cancer; Colorectal Cancer; Advanced Solid Tumor; Metastatic Solid Tumor |
Eli Lilly and Company |
2024-10-21 | PHASE1 |
| NCT06998940 | RECRUITING | Locally Advanced Pancreatic Adenocarcinoma; Metastatic Pancreatic Adenocarcinoma; Stage III Pancreatic Cancer AJCC v8; Stage IV Pancreatic Cancer AJCC v8; Unresectable Pancreatic Adenocarcinoma |
SWOG Cancer Research Network |
2026-05-13 | PHASE3 |
| NCT07795346 | NOT_YET_RECRUITING | Advanced Gastric or Gastroesophageal Junction Adenocarcinoma |
Antengene Biologics Limited |
2026-09-01 | PHASE3 |
| NCT07683949 | ENROLLING_BY_INVITATION | Advanced Colorectal Cancer (Part 1) |
Seoul National University Bundang Hospital |
2026-06-15 | PHASE1; PHASE2 |
| NCT06528496 | RECRUITING | High-risk Neuroblastoma; Neuroblastoma; Childhood Neuroblastoma |
Memorial Sloan Kettering Cancer Center |
2024-07-22 | PHASE2 |
| NCT07790380 | NOT_YET_RECRUITING | Locally Advanced, Recurrent or Metastatic ESCC Patients Who Have Failed Prior PD-1/PD-L1 Inhibitors Combined With Platinum-based Chemotherapy |
Jiangsu HengRui Medicine Co., Ltd. |
2026-10-10 | PHASE3 |
| NCT06586515 | RECRUITING | Pancreatic Ductal Adenocarcinoma; Non-small Cell Lung Cancer; Colorectal Cancer |
Eli Lilly and Company |
2024-09-12 | PHASE1 |
| NCT04199026 | RECRUITING | Metastatic Sarcoma; Recurrent Sarcoma; Resectable Sarcoma |
M.D. Anderson Cancer Center |
2025-02-25 | |
| NCT06963502 | NOT_YET_RECRUITING | Advanced Solid Tumors; Colorectal Cancer; Non-Small Cell Lung Cancer |
Jiangsu Hansoh Pharmaceutical Co., Ltd. |
2025-05-30 | PHASE1 |
| NCT04340141 | ACTIVE_NOT_RECRUITING | Pancreatic Adenosquamous Carcinoma; Resectable Pancreatic Adenocarcinoma; Stage I Pancreatic Cancer AJCC v8; Stage II Pancreatic Cancer AJCC v8; Stage III Pancreatic Cancer AJCC v8 |
Alliance for Clinical Trials in Oncology |
2020-10-13 | PHASE3 |
| NCT07391566 | NOT_YET_RECRUITING | Metastatic Colorectal Cancer (mCRC) |
Luye Pharma Group Ltd. |
2026-03-31 | PHASE1; PHASE2 |
| NCT07417735 | NOT_YET_RECRUITING | Locally Advanced/Metastatic/Recurrent ESCC |
CSPC Megalith Biopharmaceutical Co.,Ltd. |
2026-03-18 | PHASE3 |
| NCT06662786 | RECRUITING | Colorectal Neoplasms |
Janssen Research & Development, LLC |
2024-10-18 | PHASE3 |
| NCT07606599 | RECRUITING | Biliary Tract Cancer |
Sichuan Baili Pharmaceutical Co., Ltd. |
2026-07-07 | PHASE3 |
| NCT06450041 | RECRUITING | Neuroblastoma |
New Approaches to Neuroblastoma Therapy Consortium |
2024-12-16 | PHASE2 |
| NCT05677490 | RECRUITING | Advanced Esophageal Adenocarcinoma; Advanced Gastric Adenocarcinoma; Advanced Gastroesophageal Junction Adenocarcinoma; Clinical Stage III Esophageal Adenocarcinoma AJCC v8; Clinical Stage III Gastric Cancer AJCC v8; Clinical Stage III Gastroesophageal Junction Adenocarcinoma AJCC v8; Clinical Stage IV Esophageal Adenocarcinoma AJCC v8; Clinical Stage IV Gastric Cancer AJCC v8; Clinical Stage IV Gastroesophageal Junction Adenocarcinoma AJCC v8; Metastatic Esophageal Adenocarcinoma; Metastatic Gastric Adenocarcinoma; Metastatic Gastroesophageal Junction Adenocarcinoma; Unresectable Esophageal Adenocarcinoma; Unresectable Gastric Adenocarcinoma; Unresectable Gastroesophageal Junction Adenocarcinoma |
Alliance for Clinical Trials in Oncology |
2023-01-31 | PHASE3 |
| NCT07238283 | RECRUITING | First-line Treatment of Metastatic Pancreatic Cancer |
Jiangsu HengRui Medicine Co., Ltd. |
2025-12-02 | PHASE3 |
| NCT07784413 | NOT_YET_RECRUITING | Gastric Cancer Peritoneal Metastasis (GCPM) |
Zhejiang Cancer Hospital |
2026-09-01 | PHASE2 |
| NCT02885753 | RECRUITING | Colorectal Neoplasms |
Federation Francophone de Cancerologie Digestive |
2016-12 | PHASE3 |
| NCT06459180 | ACTIVE_NOT_RECRUITING | Cervical Cancer |
Merck Sharp & Dohme LLC |
2024-07-24 | PHASE3 |
| NCT06995872 | RECRUITING | Neuroblastoma |
National Cancer Institute (NCI) |
2025-10-21 | PHASE1 |
| NCT05365581 | RECRUITING | Gastric Adenocarcinoma; Gastroesophageal Junction (GEJ) Adenocarcinoma; Pancreatic Adenocarcinoma |
Astellas Pharma Global Development, Inc. |
2022-06-07 | PHASE1 |
| NCT06733038 | RECRUITING | Colorectal Cancer |
Gruppo Oncologico del Nord-Ovest |
2024-11-15 | PHASE3 |
| NCT06381154 | ACTIVE_NOT_RECRUITING | Locally Advanced Pancreatic Adenocarcinoma; Metastatic Pancreatic Adenocarcinoma; Stage II Pancreatic Cancer AJCC v8; Stage III Pancreatic Cancer AJCC v8; Stage IV Pancreatic Cancer AJCC v8; Unresectable Pancreatic Adenocarcinoma |
Mayo Clinic |
2024-12-06 | PHASE2 |
| NCT04901741 | NOT_YET_RECRUITING | Metastatic Pancreatic Cancer |
TME Pharma AG |
2026-01 | PHASE2 |
| NCT06757244 | RECRUITING | Pancreas Neoplasms |
Hopital Foch |
2025-02-18 | PHASE2 |
| NCT05694715 | RECRUITING | Metastatic Solid Tumor; BRCA1 Mutation; BRCA2 Mutation; ATM Gene Mutation; PALB2 Gene Mutation |
University of California, San Francisco |
2023-05-23 | PHASE1 |
| NCT07457775 | NOT_YET_RECRUITING | Soft Tissue Sarcoma (Excluding GIST) |
Second Affiliated Hospital, Zhejiang University, School of Medicine |
2026-03-31 | PHASE2 |
| NCT06771622 | ACTIVE_NOT_RECRUITING | Solid Cancer |
FBD Biologics Limited |
2025-03-13 | PHASE1; PHASE2 |
| NCT07258147 | NOT_YET_RECRUITING | Lung Cancer (SCLC) |
Sichuan University |
2026-10-31 | PHASE2 |
| NCT07314385 | NOT_YET_RECRUITING | Pancreatic Adenocarcinoma Metastatic; Liver Metastasis |
National Taiwan University Hospital |
2026-01-01 | PHASE1 |
| NCT06692491 | NOT_YET_RECRUITING | Rare Tumour |
Peking University Shenzhen Hospital |
2025-01-01 | PHASE2 |
| NCT07705919 | NOT_YET_RECRUITING | Borderline Resectable Pancreatic Ductal Adenocarcinoma |
Ohio State University Comprehensive Cancer Center |
2026-09-01 | PHASE1; PHASE2 |
| NCT07059338 | NOT_YET_RECRUITING | HER2 Positive; Colorectal Cancer (CRC) |
Sun Yat-sen University |
2025-07-11 | PHASE2 |
| NCT06750094 | RECRUITING | Colorectal Neoplasms |
Janssen Research & Development, LLC |
2024-12-12 | PHASE3 |
| NCT07340151 | RECRUITING | Adenocarcinoma of the Pancreas |
The University of Texas Health Science Center at San Antonio |
2026-03-02 | |
| NCT04150640 | RECRUITING | Esophageal Adenocarcinoma; Gastric Adenocarcinoma |
University of Wisconsin, Madison |
2020-07-13 | PHASE2 |
| NCT06749691 | RECRUITING | Small Cell Lung Cancer Extensive Stage |
Second Affiliated Hospital, Zhejiang University, School of Medicine |
2024-12-28 | PHASE2 |
| NCT05652686 | RECRUITING | Small Cell Lung Cancer (SCLC); Large Cell Neuroendocrine Cancer (LCNEC); Neuroendocrine Prostate Cancer (NEPC); Gastroenteropancreatic Neuroendocrine Carcinoma (GEP-NEC); Neuroendocrine Carcinomas (NEC); Extrapulmonary Neuroendocrine Carcinoma (EP-NEC) |
Phanes Therapeutics |
2023-09-05 | PHASE1; PHASE2 |
| NCT05062889 | SUSPENDED | Stage II Colon Cancer; Stage III Colon Cancer; HER2-positive Colon Cancer; RAS Wild-type Colon Cancer |
Gruppo Oncologico del Nord-Ovest |
2023-05-17 | PHASE2 |
| NCT06555003 | RECRUITING | Liver Neoplasm; Colorectal Cancer Metastatic |
Tehran University of Medical Sciences |
2025-01-20 | PHASE3 |
| NCT07474727 | RECRUITING | Colorectal Cancer |
Multitude Therapeutics Inc. |
2026-04-29 | PHASE2 |
| NCT06766019 | ACTIVE_NOT_RECRUITING | Pancreatic Cancer |
The First Affiliated Hospital with Nanjing Medical University |
2024-10-16 | PHASE2 |
| NCT05722327 | ACTIVE_NOT_RECRUITING | Colon Cancer; Colorectal Cancer |
M.D. Anderson Cancer Center |
2023-12-06 | PHASE1 |
| NCT06578052 | RECRUITING | Pancreatic Cancer |
Junjie Hang |
2024-08-28 | |
| NCT06846346 | RECRUITING | Metastatic Esophageal Adenocarcinoma; Advanced Esophageal Adenocarcinoma; Metastatic Gastric Adenocarcinoma; Advanced Gastric Adenocarcinoma |
UNICANCER |
2025-11-20 | PHASE2 |
| NCT05592626 | RECRUITING | Advanced Solid Tumors; Genital Neoplasm, Female; Urogenital Neoplasms; Lung Neoplasm; Neoplasms by Site; Papillomavirus Infection; Epstein-Barr Virus Infections; Carcinoma; Neoplasms; Vulvar Neoplasms; Vulvar Diseases; Abdominal Neoplasm; NSCLC (Non-small Cell Lung Cancer); Colorectal Cancer |
Marengo Therapeutics, Inc. |
2023-01-04 | PHASE1; PHASE2 |
| NCT06680622 | ACTIVE_NOT_RECRUITING | Metastatic Gastro-esophageal Adenocarcinoma |
Institut für Klinische Krebsforschung IKF GmbH at Krankenhaus Nordwest |
2025-03-03 | PHASE2 |
| NCT07309185 | RECRUITING | Stomach Neoplasms |
Shandong Tumor Hospital |
2024-07-24 | PHASE2 |
| NCT07363408 | NOT_YET_RECRUITING | Advanced Microsatellite Stable Colorectal Carcinoma; Metastatic Microsatellite Stable Colorectal Carcinoma; Stage III Colorectal Cancer AJCC v8; Stage IV Colorectal Cancer AJCC v8 |
City of Hope Medical Center |
2026-12-01 | PHASE1 |
| NCT04322318 | RECRUITING | Anaplastic Kidney Wilms Tumor; Recurrent Kidney Wilms Tumor; Stage II Kidney Wilms Tumor; Stage III Kidney Wilms Tumor; Stage IV Kidney Wilms Tumor |
Children's Oncology Group |
2020-10-19 | PHASE2 |
| NCT03977233 | RECRUITING | Pancreatic Ductal Adenocarcinoma (PDAC); Cancer of Pancreas; Pancreatic Cancer, Adult; Pancreas Adenocarcinoma; Pancreatic Neoplasms; Pancreatic Cancer Non-resectable; Pancreatic Cancer Resectable |
UNC Lineberger Comprehensive Cancer Center |
2019-06-12 | PHASE2 |
| NCT07134205 | NOT_YET_RECRUITING | Metastatic Colorectal Cancer (mCRC) |
Shanghai JMT-Bio Inc. |
2025-10-01 | PHASE3 |
| NCT07570914 | NOT_YET_RECRUITING | Colorectal Cancer Liver Metastases (CRLM); Colorectal Cancer; Liver Metastasis |
Tianjin Medical University Cancer Institute and Hospital |
2026-05-30 | PHASE2 |
| NCT05391126 | RECRUITING | Colorectal Cancer; Pancreatic Cancer |
Reema A. Patel |
2022-09-28 | |
| NCT05999994 | RECRUITING | Neoplasms; Child; Adolescent |
Eli Lilly and Company |
2020-01-22 | PHASE2 |
| NCT06954246 | RECRUITING | Small Cell Lung Cancer Extensive Stage |
Qilu Pharmaceutical Co., Ltd. |
2025-06-04 | PHASE3 |
| NCT06332950 | NOT_YET_RECRUITING | Extensive-stage Small-cell Lung Cancer |
Baohui Han |
2024-04-01 | PHASE1; PHASE2 |
| NCT06648525 | NOT_YET_RECRUITING | Intrahepatic Cholangiocarcinoma (Icc) |
Harbin Medical University |
2024-10 | PHASE2 |
| NCT03533582 | ACTIVE_NOT_RECRUITING | Childhood Hepatocellular Carcinoma; Childhood Malignant Liver Neoplasm; Fibrolamellar Carcinoma; Hepatoblastoma; Hepatocellular Malignant Neoplasm, Not Otherwise Specified |
Children's Oncology Group |
2018-05-24 | PHASE3 |
| NCT01837862 | ACTIVE_NOT_RECRUITING | Pilomyxoid Astrocytoma; Pilocytic Astrocytoma; Glioma, Astrocytic; Optic Nerve Glioma; Pleomorphic Xanthoastrocytoma; Glioblastoma Multiforme; Anaplastic Astrocytoma; Gliosarcoma; Diffuse Intrinsic Pontine Glioma; DIPG; Low-grade Glioma; Brainstem Glioma |
Julie Krystal |
2013-10-22 | PHASE1; PHASE2 |
| NCT04205968 | RECRUITING | Metastatic Small Intestinal Adenocarcinoma; Stage III Small Intestinal Adenocarcinoma AJCC v8; Stage IIIA Small Intestinal Adenocarcinoma AJCC v8; Stage IIIB Small Intestinal Adenocarcinoma AJCC v8; Stage IV Small Intestinal Adenocarcinoma AJCC v8 |
SWOG Cancer Research Network |
2020-06-01 | PHASE2 |
| NCT07229846 | NOT_YET_RECRUITING | Colorectal Cancer |
Yanqiao Zhang |
2026-02 | PHASE2 |
| NCT05255666 | WITHDRAWN | Triple Negative Breast Cancer; Brain Metastases |
Washington University School of Medicine |
2023-07-31 | PHASE2 |
| NCT04927780 | ACTIVE_NOT_RECRUITING | Pancreatic Cancer; Pancreatic Ductal Adenocarcinoma; Resectable Pancreatic Adenocarcinoma |
Erasmus Medical Center |
2021-09-07 | PHASE3 |
| NCT06013618 | RECRUITING | Neuroblastoma |
Sun Yat-Sen University Cancer Center |
2023-06-19 | PHASE2 |
| NCT06820762 | NOT_YET_RECRUITING | SCLC |
The Second Affiliated Hospital of Dalian Medical University |
2025-02-28 | PHASE2 |
| NCT07014540 | NOT_YET_RECRUITING | Neuroendocrine Carcinomas (NEC) |
Beijing GoBroad Hospital |
2025-06-20 | PHASE4 |
| NCT06006273 | RECRUITING | Refractory Solid Tumors |
M.D. Anderson Cancer Center |
2023-08-16 | PHASE1 |
| NCT06763029 | RECRUITING | Colorectal Cancer Metastatic |
Fudan University |
2025-02-26 | PHASE2 |
| NCT06194734 | RECRUITING | Esophageal Squamous Cell Carcinoma |
Beijing Konruns Pharmaceutical Co., Ltd. |
2024-02-05 | PHASE3 |
| NCT06714357 | RECRUITING | Colorectal Cancer Metastatic |
National Cancer Institute, Naples |
2025-03-12 | PHASE2 |
| NCT03773367 | ACTIVE_NOT_RECRUITING | Resectable Gastric and Gastroesophageal Junction Adenocarcinoma |
Lund University Hospital |
2018-12-14 | PHASE2 |
| NCT06219941 | RECRUITING | Gastric Cancer; Gastroesophageal Junction Cancer; Biliary Tract Cancer; Pancreatic Ductal Adenocarcinoma |
AstraZeneca |
2023-12-13 | PHASE2 |
| NCT06894797 | RECRUITING | Locally Advanced Rectal Cancer |
Peking University Cancer Hospital & Institute |
2025-04-01 | |
| NCT07047560 | RECRUITING | Colorectal Cancer (CRC) |
Tianjin Medical University Cancer Institute and Hospital |
2024-09-01 | PHASE2 |
| NCT06514313 | RECRUITING | Soft Tissue Sarcoma |
Yizhuo Zhang |
2024-07-03 | PHASE2 |
| NCT01189643 | ACTIVE_NOT_RECRUITING | Sarcoma; Desmoplastic Small Round Cell Tumor (DSRCT) |
Memorial Sloan Kettering Cancer Center |
2010-08 | EARLY_PHASE1 |
| NCT04725994 | ACTIVE_NOT_RECRUITING | Gastric Cancer |
Idience Co., Ltd. |
2021-06-28 | PHASE1; PHASE2 |
| NCT05457829 | RECRUITING | Rhabdomyosarcoma, Child |
Sun Yat-sen University |
2023-12-30 | PHASE2 |
| NCT06625320 | ACTIVE_NOT_RECRUITING | Pancreatic Cancer; PDAC; PDAC - Pancreatic Ductal Adenocarcinoma |
Revolution Medicines, Inc. |
2024-10-16 | PHASE3 |
| NCT06346392 | ACTIVE_NOT_RECRUITING | Gastric Cancer; Gastroesophageal Junction Cancer |
AstraZeneca |
2024-03-04 | PHASE3 |
| NCT05238831 | WITHDRAWN | Advanced Breast Carcinoma; Advanced Malignant Solid Neoplasm; Advanced Ovarian Carcinoma; Advanced Pancreatic Carcinoma; Advanced Prostate Carcinoma; Advanced Sarcoma; Anatomic Stage III Breast Cancer AJCC v8; Anatomic Stage IV Breast Cancer AJCC v8; Recurrent Adult Soft Tissue Sarcoma; Recurrent Breast Carcinoma; Recurrent Ovarian Carcinoma; Recurrent Prostate Carcinoma; Stage II Pancreatic Cancer AJCC v8; Stage III Ovarian Cancer AJCC v8; Stage III Pancreatic Cancer AJCC v8; Stage IV Ovarian Cancer AJCC v8; Stage IV Pancreatic Cancer AJCC v8 |
OHSU Knight Cancer Institute |
2023-01-30 | EARLY_PHASE1 |
| NCT06697366 | NOT_YET_RECRUITING | Gastric Cancer |
Ruijin Hospital |
2024-11-20 | PHASE2 |
| NCT06405139 | RECRUITING | Colorectal Cancer |
Cancer Institute and Hospital, Chinese Academy of Medical Sciences |
2024-05-01 | PHASE2 |
| NCT06370754 | NOT_YET_RECRUITING | Pancreatic Cancer |
Fudan University |
2024-04-30 | PHASE1; PHASE2 |
| NCT04481204 | WITHDRAWN | Borderline Resectable Pancreatic Adenocarcinoma; Locally Advanced Pancreatic Ductal Adenocarcinoma; Resectable Pancreatic Ductal Adenocarcinoma |
M.D. Anderson Cancer Center |
2023-04-18 | PHASE2 |
| NCT05153239 | COMPLETED | Relapsed Small Cell Lung Cancer |
PharmaMar |
2022-07-22 | PHASE3 |
| NCT06341309 | UNKNOWN | Metastatic Colorectal Cancer |
West China Hospital |
2024-08-09 | PHASE1; PHASE2 |
| NCT04743661 | ACTIVE_NOT_RECRUITING | Recurrent Medulloblastoma; Recurrent Ependymoma |
Pediatric Brain Tumor Consortium |
2022-04-04 | PHASE2 |
| NCT06340204 | RECRUITING | Ewing Sarcoma |
Peking University People's Hospital |
2024-03-25 | PHASE1 |
| NCT06490536 | RECRUITING | Colon Cancer Stage II; Colon Cancer Stage III |
IFOM ETS - The AIRC Institute of Molecular Oncology |
2024-10-22 | PHASE3 |
| NCT06011772 | ACTIVE_NOT_RECRUITING | Colo-rectal Cancer |
Roswell Park Cancer Institute |
2023-12-18 | EARLY_PHASE1 |
| NCT06184698 | RECRUITING | Colorectal Cancer |
Hebei Medical University Fourth Hospital |
2024-01-01 | PHASE2 |
| NCT06512428 | UNKNOWN | Advanced Esophageal Squamous Cell Carcinoma |
Shanghai Runshi Pharmaceutical Technology Co., Ltd |
2024-03-15 | PHASE2 |
| NCT06172036 | NOT_YET_RECRUITING | Neoadjuvant Chemotherapy; Resectable Pancreatic Cancer |
Zhejiang University |
2024-01-20 | PHASE2 |
| NCT05630183 | COMPLETED | Metastatic Pancreatic Ductal Adenocarcinoma |
Agenus Inc. |
2023-03-27 | PHASE2 |
| NCT06225622 | UNKNOWN | Metastatic Colorectal Cancer |
Shanghai Zhongshan Hospital |
2024-03-11 | PHASE1 |
| NCT06700603 | NOT_YET_RECRUITING | Pancreatic Cancer |
Rui-hua Xu, MD, PhD |
2024-11-20 | PHASE2 |
| NCT06463548 | NOT_YET_RECRUITING | Biliary Tract Carcinoma |
Yunpeng Liu |
2024-07-01 | |
| NCT04267978 | RECRUITING | Glioblastoma, Recurrent; Lower Grade Glioma, Recurrent |
Beijing Sanbo Brain Hospital |
2020-02-13 | PHASE2 |
| NCT06816771 | RECRUITING | Rhabdomyosarcoma, Recurrent, Refractory |
Shandong Cancer Hospital and Institute |
2025-02 | PHASE2 |
| NCT06176885 | RECRUITING | Colorectal Cancer |
yue junhan |
2023-12-20 | PHASE2 |
| NCT05342636 | COMPLETED | Esophageal Squamous Cell Carcinoma (ESCC) |
Merck Sharp & Dohme LLC |
2022-07-27 | PHASE1; PHASE2 |
| NCT05990543 | ACTIVE_NOT_RECRUITING | Recurrent or Metastatic Colorectal Cancer |
Korea University Anam Hospital |
2024-01-29 | PHASE1; PHASE2 |
| NCT04861558 | RECRUITING | Colorectal Cancer; Peritoneal Metastases |
Uppsala University |
2021-05-01 | PHASE3 |
| NCT06192680 | NOT_YET_RECRUITING | Colorectal Cancer |
Harbin Medical University |
2024-04-01 | PHASE2 |
| NCT05731518 | UNKNOWN | Small Cell Lung Cancer |
Biocity Biopharmaceutics Co., Ltd. |
2023-02-23 | PHASE1; PHASE2 |
| NCT06467786 | RECRUITING | Small Cell Lung Cancer |
Tang-Du Hospital |
2024-03-15 | PHASE4 |
| NCT06375642 | UNKNOWN | Intrahepatic Cholangiocarcinoma |
Tianjin Medical University Cancer Institute and Hospital |
2024-05-10 | PHASE2 |
| NCT06486545 | UNKNOWN | Advanced Gastric Cancer |
Hunan Cancer Hospital |
2024-08-25 | |
| NCT06021015 | UNKNOWN | Colorectal Cancer Liver Metastasis |
Zhongda Hospital |
2023-09-10 | |
| NCT02967289 | COMPLETED | Colon Cancer (High-risk Stage III: pT4N1 or pT1 to 4 N2) |
UNICANCER |
2017-03-27 | PHASE3 |
| NCT06394713 | NOT_YET_RECRUITING | Advanced Malignant Neoplasm |
Qilu Pharmaceutical Co., Ltd. |
2024-06-15 | PHASE1; PHASE2 |
| NCT06434090 | UNKNOWN | Colorectal Cancer |
Sun Yat-sen University |
2024-06-05 | PHASE1; PHASE2 |
| NCT05859750 | RECRUITING | Pancreatic Cancer |
Akeso |
2023-05-25 | PHASE2 |
| NCT06225999 | COMPLETED | Metastatic Adenocarcinoma of the Pancreas |
Institut de Recherches Internationales Servier |
2024-04-25 | PHASE2 |
| NCT04067115 | COMPLETED | Ewing Sarcoma |
Sarcoma Alliance for Research through Collaboration |
2021-01-05 | PHASE1; PHASE2 |
| NCT06210360 | NOT_YET_RECRUITING | Pancreatic Cancer |
Changhai Hospital |
2024-02-01 | PHASE2 |
| NCT06437678 | UNKNOWN | Gastric Cancer |
Zhejiang Cancer Hospital |
2024-05-27 | PHASE2 |
| NCT04371224 | UNKNOWN | Pancreatic Cancer |
Seoul National University Hospital |
2020-06-23 | PHASE2 |
| NCT04447092 | UNKNOWN | Pancreatic Cancer; Chemotherapy Effect |
Seoul National University Hospital |
2020-07-01 | PHASE2 |
| NCT06430827 | UNKNOWN | Biliary Tract Carcinoma |
Ba Yi |
2024-06-30 | PHASE2 |
| NCT04752696 | COMPLETED | Pancreatic Ductal Adenocarcinoma |
Cardiff Oncology |
2021-05-25 | PHASE2 |
| NCT05546853 | COMPLETED | Pancreatic Ductal Adenocarcinoma |
University Hospital, Grenoble |
2023-03-28 | PHASE1 |
| NCT05049863 | TERMINATED | Small-cell Lung Cancer; Small Cell Lung Carcinoma |
Washington University School of Medicine |
2023-02-27 | PHASE1 |
| NCT05643677 | UNKNOWN | Gastric Cancer |
Fujian Medical University |
2022-12 | PHASE2 |
| NCT04581473 | ACTIVE_NOT_RECRUITING | Gastric Adenocarcinoma; Pancreatic Cancer; Gastroesophageal Junction Adenocarcinoma |
CARsgen Therapeutics Co., Ltd. |
2020-10-23 | PHASE1; PHASE2 |
| NCT05656222 | WITHDRAWN | Objective Response; Overall Survival |
Peking University People's Hospital |
2021-08-01 | |
| NCT06538207 | COMPLETED | Metastatic Pancreatic Cancer |
Ono Pharmaceutical Co., Ltd. |
2021-01-13 | PHASE1 |
| NCT04109924 | COMPLETED | Advanced Colorectal Carcinoma; Metastatic Colon Adenocarcinoma; Metastatic Rectal Adenocarcinoma; Recurrent Colon Adenocarcinoma; Recurrent Colorectal Adenocarcinoma; Recurrent Rectal Adenocarcinoma; Stage III Colon Cancer AJCC v8; Stage III Colorectal Cancer AJCC v8; Stage III Rectal Cancer AJCC v8; Stage IIIA Colon Cancer AJCC v8; Stage IIIA Colorectal Cancer AJCC v8; Stage IIIB Colorectal Cancer AJCC v8; Stage IIIB Rectal Cancer AJCC v8; Stage IIIC Colon Cancer AJCC v8; Stage IIIC Colorectal Cancer AJCC v8; Stage IV Colon Cancer AJCC v8; Stage IVA Colorectal Cancer AJCC v8; Stage IVA Rectal Cancer AJCC v8; Stage IVB Colon Cancer AJCC v8; Stage IVB Colorectal Cancer AJCC v8; Stage IVB Rectal Cancer AJCC v8; Stage IVC Colon Cancer AJCC v8; Stage IVC Colorectal Cancer AJCC v8; Stage IVC Rectal Cancer AJCC v8; Unresectable Colon Adenocarcinoma; Unresectable Colorectal Carcinoma; Unresectable Rectal Adenocarcinoma |
Roswell Park Cancer Institute |
2019-12-27 | PHASE2 |
| NCT05620862 | UNKNOWN | Pediatric Solid Tumor |
Sun Yat-sen University |
2022-10-25 | PHASE1 |
| NCT03709680 | ACTIVE_NOT_RECRUITING | Ewing Sarcoma; Solid Tumors; Rhabdoid Tumor; Rhabdomyosarcoma; Neuroblastoma; Medulloblastoma; Diffuse Intrinsic Pontine Glioma |
Pfizer |
2019-05-24 | PHASE2 |
| NCT04525014 | TERMINATED | Brain Tumor, Recurrent; Brain Tumor, Pediatric; Central Nervous System Neoplasms; Unspecified Childhood Solid Tumor, Protocol Specific |
EpicentRx, Inc. |
2023-01-26 | PHASE1 |
| NCT04641871 | COMPLETED | Metastatic Cancer; Solid Tumor |
Symphogen A/S |
2020-10-12 | PHASE1 |
| NCT05383352 | COMPLETED | Metastatic Pancreatic Adenocarcinoma |
Ipsen |
2022-05-30 | PHASE1 |
| NCT06197438 | UNKNOWN | Gastric Cancer |
Fujian Cancer Hospital |
2024-01-01 | PHASE2 |
| NCT05278351 | UNKNOWN | Colorectal Neoplasms Malignant |
Shanghai Zhongshan Hospital |
2022-07-13 | PHASE2 |
| NCT05839470 | UNKNOWN | Colorectal Cancer |
Fujian Cancer Hospital |
2023-11-19 | PHASE2 |
| NCT04595266 | ACTIVE_NOT_RECRUITING | Colorectal Cancer Metastatic; Liver Metastasis Colon Cancer |
Grupo Espanol Multidisciplinario del Cancer Digestivo |
2021-06-29 | PHASE2 |
| NCT04842526 | UNKNOWN | Refractory or Recurrent Neuroblastoma in Children |
Tianjin Medical University Cancer Institute and Hospital |
2021-04-12 | PHASE2 |
| NCT05004350 | COMPLETED | BRAF V600E; Metastatic Colorectal Cancer |
Pierre Fabre Medicament |
2021-09-14 | PHASE2 |
| NCT04668976 | UNKNOWN | Colorectal Cancer; Cholangiocarcinoma |
Benaroya Research Institute |
2020-11-25 | PHASE2 |
| NCT04034459 | UNKNOWN | Metastatic Colorectal Cancer |
Ludwig-Maximilians - University of Munich |
2016-11-25 | PHASE2 |
| NCT05669807 | UNKNOWN | Second Line Treatment of Gastric Cancer |
Zhejiang Cancer Hospital |
2022-12 | PHASE2 |
| NCT05854498 | Recruiting | Metastatic Colorectal Cancer |
University of Wisconsin Madison|Ipsen |
2023-10-13 | Phase 2 |
| NCT05824455 | TERMINATED | Advanced Solid Tumors |
Shanghai Jun Pai Ying Shi Therapeutics Co., Ltd. |
2023-03-23 | PHASE1; PHASE2 |
| NCT03483038 | ACTIVE_NOT_RECRUITING | Pancreatic Adenocarcinoma |
University of Florida |
2018-12-13 | PHASE2 |
| NCT04117945 | ACTIVE_NOT_RECRUITING | BRAF V600E Negative; KRAS Gene Mutation Negative; Locally Advanced Unresectable Colorectal Adenocarcinoma; Metastatic Colorectal Adenocarcinoma; NRAS Gene Mutation Negative; Stage III Colorectal Cancer AJCC v8; Stage IIIA Colorectal Cancer AJCC v8; Stage IIIB Colorectal Cancer AJCC v8; Stage IIIC Colorectal Cancer AJCC v8; Stage IV Colorectal Cancer AJCC v8; Stage IVA Colorectal Cancer AJCC v8; Stage IVB Colorectal Cancer AJCC v8; Stage IVC Colorectal Cancer AJCC v8 |
Academic and Community Cancer Research United |
2020-03-03 | PHASE2 |
| NCT04486651 | UNKNOWN | Stomach Cancer |
Taizhou Hanzhong biomedical co. LTD |
2020-09-16 | PHASE3 |
| NCT04808791 | COMPLETED | Gastroesophageal Junction Adenocarcinoma; Advanced Gastric Carcinoma |
AHS Cancer Control Alberta |
2021-10-27 | PHASE2 |
| NCT02567435 | ACTIVE_NOT_RECRUITING | Alveolar Rhabdomyosarcoma; Botryoid-Type Embryonal Rhabdomyosarcoma; Embryonal Rhabdomyosarcoma; Rhabdomyosarcoma; Sclerosing Rhabdomyosarcoma; Spindle Cell Rhabdomyosarcoma |
National Cancer Institute (NCI) |
2016-06-01 | PHASE3 |
| NCT04513951 | COMPLETED | Metastatic Colorectal Cancer |
Gruppo Oncologico del Nord-Ovest |
2020-04-01 | PHASE2 |
| NCT03874026 | RECRUITING | Colorectal Cancer; ADCC |
National Cancer Institute, Naples |
2019-09-05 | PHASE2 |
| NCT03879798 | TERMINATED | Small Cell Lung Cancer |
Memorial Sloan Kettering Cancer Center |
2019-03-15 | PHASE1; PHASE2 |
| NCT05322499 | UNKNOWN | Stage IV Esophagus Squamous Cell Carcinoma |
Zhejiang Cancer Hospital |
2022-04-15 | PHASE2 |
| NCT03141034 | COMPLETED | Gastric Adenocarcinoma; Gastro-esophageal Junction Adenocarcinoma |
Washington University School of Medicine |
2017-11-01 | PHASE2 |
| NCT04381910 | COMPLETED | Small Cell Lung Cancer |
Luye Pharma Group Ltd. |
2020-09-28 | PHASE2 |
| NCT05732129 | Not yet recruiting | Homologous Recombination Deficiency Alterations Metastatic Colorectal Cancer |
Fudan University |
2023-03-01 | Phase 2 |
| NCT03279289 | COMPLETED | Metastatic Colorectal Cancer |
Spanish Cooperative Group for the Treatment of Digestive Tumours (TTD) |
2017-10-25 | PHASE2 |
| NCT05731518 | Recruiting | Small Cell Lung Cancer |
Biocity Biopharmaceutics Co. Ltd. |
2023-02-23 | Phase 1|Phase 2 |
| NCT05251038 | WITHDRAWN | Pancreatic Cancer; Unresectable Pancreatic Cancer; Metastatic Pancreatic Cancer; KRAS P.G12C |
Devalingam Mahalingam |
2022-09-13 | PHASE1; PHASE2 |
| NCT03712397 | COMPLETED | Head & Neck Cancer |
National Health Research Institutes, Taiwan |
2018-12-24 | PHASE2 |
| NCT03726021 | COMPLETED | Overall Survival |
Qingdao Central Hospital |
2018-01-26 | PHASE2 |
| NCT02919787 | ACTIVE_NOT_RECRUITING | Pancreatic Cancer |
Oslo University Hospital |
2016-09 | PHASE2; PHASE3 |
| NCT04985201 | UNKNOWN | Small Cell Lung Cancer |
Shanghai Pulmonary Hospital, Shanghai, China |
2021-11-01 | PHASE2 |
| NCT06003998 | Recruiting | Colorectal Cancer|Peritoneal Metastases |
Catharina Ziekenhuis Eindhoven |
2022-12-27 | Phase 2 |
| NCT05027100 | UNKNOWN | Small Cell Lung Cancer (SCLC) |
Haibo Zhang |
2021-09-30 | |
| NCT05277766 | Recruiting | Peritoneal Carcinomatosis|Peritoneal Metastases|Colorectal Cancer|Small Bowel Cancer|Appendix Cancer|Gastric Cancer|Pancreatic Cancer|Bile Duct Cancer |
University Hospital Ghent|Kom Op Tegen Kanker|University Ghent |
2022-11-21 | Phase 1 |
| NCT03535727 | COMPLETED | Adenocarcinoma; Pancreatic Neoplasms; Neoplasm, Glandular; Neoplasms; Neoplasms Pancreatic; Digestive System Neoplasm; Endocrine Gland Neoplasms; Digestive System Disease; Pancreatic Diseases; Endocrine System Diseases |
Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins |
2018-06-21 | PHASE1; PHASE2 |
| NCT04097444 | UNKNOWN | Metastatic Colorectal Cancer |
Chugai Pharmaceutical |
2019-10-11 | PHASE2 |
| NCT04324476 | UNKNOWN | Advanced Colorectal Cancer |
Jiangsu Cancer Institute & Hospital |
2019-09-01 | PHASE2 |
| NCT04358341 | UNKNOWN | Gastric Cancer |
Sixth Affiliated Hospital, Sun Yat-sen University |
2020-06-17 | PHASE2 |
| NCT04929652 | UNKNOWN | Advanced Colorectal Cancer |
Jiangsu Cancer Institute & Hospital |
2021-06-01 | PHASE1; PHASE2 |
| NCT03206151 | COMPLETED | Metastatic Colorectal Cancer |
Taizhou Mabtech Pharmaceutical Co.,Ltd |
2017-12-12 | PHASE3 |
| NCT05379790 | Recruiting | Gastric Cancer|Peritoneal Metastases |
Erasmus Medical Center |
2022-05-25 | Phase 1 |
| NCT04411537 | UNKNOWN | Locally Advanced Rectal Cancer |
Fudan University |
2020-07-01 | PHASE2 |
| NCT04727853 | COMPLETED | Small Cell Lung Cancer (SCLC) |
CSPC Ouyi Pharmaceutical Co., Ltd. |
2021-03-01 | PHASE2 |
| NCT03739801 | WITHDRAWN | Locally Advanced Unresectable Gastric Adenocarcinoma; Metastatic Gastroesophageal Junction Adenocarcinoma; Metastatic Unresectable Gastric Adenocarcinoma; Unresectable Gastroesophageal Junction Adenocarcinoma; Gastric Adenocarcinoma; Gastroesophageal Junction Adenocarcinoma |
University of Southern California |
2020-04-06 | PHASE1; PHASE2 |
| NCT02975882 | COMPLETED | Childhood Solid Neoplasm; Recurrent Malignant Solid Neoplasm; Recurrent Primary Central Nervous System Neoplasm; Refractory Malignant Solid Neoplasm; Refractory Primary Central Nervous System Neoplasm |
Children's Oncology Group |
2017-08-15 | PHASE1 |
| NCT03088813 | COMPLETED | Small Cell Lung Cancer |
Ipsen |
2018-04-25 | PHASE3 |
| NCT02833753 | COMPLETED | Colorectal Cancer; Appendix Cancer; Peritoneal Carcinomatosis |
University of Massachusetts, Worcester |
2016-07 | PHASE1 |
| NCT02539537 | COMPLETED | Pancreatic Cancer; Carcinoma |
UNICANCER |
2015-10-23 | PHASE3 |
| NCT05025033 | COMPLETED | Gastric Cancer |
Tianjin Medical University Cancer Institute and Hospital |
2019-05-30 | PHASE2 |
| NCT03495921 | TERMINATED | Ewing Sarcoma; Ewing Family of Tumors; Ewing's Tumor Metastatic; Ewing's Sarcoma Metastatic; Ewing's Tumor Recurrent; Rare Diseases; Sarcoma; Neoplasms, Connective and Soft Tissue; Neoplasms by Histologic Type; Neoplasms, Bone Tissue; Neoplasms, Connective Tissue; Sarcoma, Ewing; Neoplasms |
Gradalis, Inc. |
2018-08-21 | PHASE3 |
| NCT04627142 | TERMINATED | Metastatic Colorectal Cancer (CRC) |
Boehringer Ingelheim |
2020-11-23 | PHASE1 |
| NCT04789941 | UNKNOWN | Locally Advanced Cervical Carcinoma |
Assiut University |
2021-04-01 | PHASE2 |
| NCT04368507 | COMPLETED | Colorectal Cancer Metastatic; Colorectal Cancer Recurrent |
CellabMED |
2019-08-09 | PHASE1; PHASE2 |
| NCT03387904 | UNKNOWN | Esophageal Squamous Cell Carcinoma |
The First Affiliated Hospital of Zhengzhou University |
2019-01-13 | PHASE2 |
| NCT03528785 | UNKNOWN | Pancreatic Adenocarcinoma |
Centro Ricerche Cliniche di Verona |
2018-03-02 | PHASE2 |
| NCT01897454 | TERMINATED | Pancreatic Adenocarcinoma; Stage IIA Pancreatic Cancer; Stage IIB Pancreatic Cancer; Stage III Pancreatic Cancer |
Albert Einstein College of Medicine |
2012-01-27 | PHASE2 |
| NCT04943627 | WITHDRAWN | Advanced Cancer; Metastatic Cervical Cancer |
Agenus Inc. |
2021-08-02 | PHASE3 |
| NCT03086616 | COMPLETED | Diffuse Intrinsic Pontine Glioma |
Sabine Mueller, MD, PhD |
2017-10-31 | PHASE1 |
| NCT03484195 | UNKNOWN | Colonic Neoplasms; Drug Therapy |
China Medical University, China |
2018-04-01 | PHASE2 |
| NCT01926197 | COMPLETED | Pancreatic Cancer |
Stanford University |
2013-08-14 | PHASE3 |
| NCT03703063 | UNKNOWN | Pancreatic Adenocarcinoma |
Benaroya Research Institute |
2018-09-17 | PHASE1 |
| NCT04753216 | COMPLETED | Platinum-Resistant Fallopian Tube Carcinoma; Platinum-Resistant Ovarian Carcinoma; Platinum-Resistant Primary Peritoneal Carcinoma; Recurrent Fallopian Tube Carcinoma; Recurrent Ovarian Carcinoma; Recurrent Primary Peritoneal Carcinoma; Refractory Fallopian Tube Carcinoma; Refractory Ovarian Carcinoma; Refractory Primary Peritoneal Carcinoma |
Northwestern University |
2021-03-16 | PHASE2 |
| NCT04034173 | TERMINATED | Treatment Related Cancer |
Ludwig-Maximilians - University of Munich |
2019-07-24 | PHASE2 |
| NCT04299880 | COMPLETED | Oncology |
Sumitomo Pharma America, Inc. |
2020-02-24 | PHASE1 |
| NCT03251417 | TERMINATED | Esophageal Squamous Cell Carcinoma |
Peking University |
2017-09-10 | PHASE2 |
| NCT02596828 | COMPLETED | Pineoblastoma |
University of Regensburg |
2016-04 | PHASE2 |
| NCT03337087 | UNKNOWN | Metastatic Biliary Tract Carcinoma; Metastatic Colorectal Carcinoma; Metastatic Gastroesophageal Junction Adenocarcinoma; Metastatic Malignant Digestive System Neoplasm; Metastatic Pancreatic Adenocarcinoma; Stage IV Colorectal Cancer AJCC v7; Stage IV Pancreatic Cancer AJCC v6 and v7; Stage IVA Colorectal Cancer AJCC v7; Stage IVB Colorectal Cancer AJCC v7 |
Academic and Community Cancer Research United |
2018-11-02 | PHASE1; PHASE2 |
| NCT01079780 | COMPLETED | Colorectal Cancer |
Eastern Cooperative Oncology Group |
2011-01-18 | PHASE2 |
| NCT03142516 | COMPLETED | Colorectal Neoplasms; Colorectal Carcinoma; Colorectal Cancer Metastatic; Neoplasm Metastasis |
Grupo Espanol Multidisciplinario del Cancer Digestivo |
2017-10-31 | PHASE2 |
| NCT02022644 | COMPLETED | High Grade Glioma |
University of California, San Francisco |
2014-10-23 | PHASE1 |
| NCT04337879 | UNKNOWN | Advanced Colorectal Cancer |
Chia Tai Tianqing Pharmaceutical Group Co., Ltd. |
2020-07-20 | PHASE1; PHASE2 |
| NCT03493061 | COMPLETED | Colo-rectal Cancer; Liver Metastases |
Sun Yat-sen University |
2018-02-01 | PHASE2 |
| NCT03711240 | UNKNOWN | Colorectal Cancer |
National Cheng-Kung University Hospital |
2019-01-08 | PHASE2 |
| NCT02025881 | TERMINATED | High-risk Medulloblastoma |
Gustave Roussy, Cancer Campus, Grand Paris |
2013-09-14 | PHASE1; PHASE2 |
| NCT02842580 | TERMINATED | Colorectal Neoplasms |
Federation Francophone de Cancerologie Digestive |
2016-09 | PHASE2 |
| NCT03524508 | COMPLETED | Metastatic Biliary Tract Cancer |
Changhoon Yoo |
2018-09-04 | PHASE2 |
| NCT01467986 | COMPLETED | Neuroblastoma Recurrent |
University of Regensburg |
2013-08 | PHASE2 |
| NCT04499586 | UNKNOWN | Recurrent Colorectal Cancer |
Fudan University |
2019-01-01 | PHASE2 |
| NCT02368860 | COMPLETED | Pancreatic Cancer |
National Cancer Centre, Singapore |
2013-09-17 | PHASE1 |
| NCT03464968 | COMPLETED | Biliary Cancer Metastatic |
Seoul National University Bundang Hospital |
2015-07-29 | PHASE2 |
| NCT02747537 | WITHDRAWN | Pediatric Solid Tumors |
Washington University School of Medicine |
2016-06-24 | PHASE2 |
| NCT03562390 | UNKNOWN | Breast Cancer |
Liaoning Cancer Hospital & Institute |
2017-04-01 | PHASE2 |
| NCT03812783 | UNKNOWN | Hepatocellular Carcinoma |
Sun Yat-sen University |
2018-11-05 | PHASE2 |
| NCT02030678 | UNKNOWN | Stage IIIB, IV, Recurrent, and Metastatic Breast Cancer |
Liaoning Cancer Hospital & Institute |
2014-09 | PHASE2 |
| NCT03545711 | UNKNOWN | Colo-rectal Cancer |
Chinese Academy of Medical Sciences |
2018-05-26 | PHASE1; PHASE2 |
| NCT02631733 | COMPLETED | Malignant Solid Neoplasm |
National Cancer Institute (NCI) |
2017-05-31 | PHASE1 |
| NCT03702985 | UNKNOWN | Locally Advanced Rectal Cancer |
Fudan University |
2018-05-28 | PHASE2 |
| NCT03732508 | UNKNOWN | Advanced Esophageal Squamous Cell Cancer |
Jiangsu HengRui Medicine Co., Ltd. |
2018-11 | PHASE2 |
| NCT03139331 | COMPLETED | Sarcoma; Refractory Sarcoma |
University of California, San Francisco |
2017-06-06 | PHASE1 |
| NCT02049593 | COMPLETED | Metastatic Cancer; Unspecified Adult Solid Tumor |
Jonsson Comprehensive Cancer Center |
2014-06-12 | PHASE1 |
| NCT02935764 | UNKNOWN | Colorectal Carcinoma |
Fudan University |
2016-10 | PHASE3 |
| NCT01528046 | COMPLETED | Solid Tumors; Primary Brain Tumors |
H. Lee Moffitt Cancer Center and Research Institute |
2012-09-24 | PHASE1 |
| NCT01896856 | COMPLETED | Previously Treated Metastatic Colorectal Cancer |
Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins |
2013-10-23 | PHASE1; PHASE2 |
| NCT01862003 | COMPLETED | Metastatic Colorectal Cancer; Recurrent Colorectal Cancer |
University College, London |
2014-05 | PHASE2 |
| NCT03069950 | WITHDRAWN | Colorectal Adenocarcinoma Metastatic to the Liver |
Memorial Sloan Kettering Cancer Center |
2017-02-28 | PHASE2 |
| NCT02890355 | COMPLETED | Metastatic Pancreatic Adenocarcinoma; Recurrent Pancreatic Carcinoma; Stage IV Pancreatic Cancer AJCC v6 and v7 |
National Cancer Institute (NCI) |
2016-10-27 | PHASE2 |
| NCT03824899 | UNKNOWN | Locally Advanced Rectal Cancer |
Fudan University |
2018-10-10 | |
| NCT01858649 | COMPLETED | Metastatic Colorectal Cancer |
Cliniques universitaires Saint-Luc- Université Catholique de Louvain |
2013-05 | PHASE2 |
| NCT02292758 | COMPLETED | Colorectal Adenocarcinoma; RAS Wild Type; Stage IV Colorectal Cancer AJCC v7; Stage IVA Colorectal Cancer AJCC v7; Stage IVB Colorectal Cancer AJCC v7 |
Academic and Community Cancer Research United |
2014-12-12 | PHASE2 |
| NCT03329183 | UNKNOWN | Colorectal Cancer |
Shanghai Changzheng Hospital |
2019-03 | PHASE2 |
| NCT02928224 | COMPLETED | BRAF V600E-mutant Metastatic Colorectal Cancer |
Pfizer |
2016-10-13 | PHASE3 |
| NCT02645864 | COMPLETED | Esophageal Squamous Cell Carcinoma |
Peking University |
2016-01 | PHASE1 |
| NCT03061058 | UNKNOWN | Stomach Neoplasms; Chemotherapy Effect; Chemotherapeutic Toxicity |
The Affiliated Nanjing Drum Tower Hospital of Nanjing University Medical School |
2013-04-01 | PHASE3 |
| NCT02688023 | UNKNOWN | Colorectal Cancer |
Chinese Academy of Medical Sciences |
2014-03 | PHASE2 |
| NCT01859728 | UNKNOWN | Biliary Cancer |
Hospital de Cancer de Barretos - Fundacao Pio XII |
2013-01 | PHASE2 |
| NCT01114555 | COMPLETED | Neuroblastoma |
Memorial Sloan Kettering Cancer Center |
2010-04-29 | PHASE2 |
| NCT01992705 | COMPLETED | Resectable Pancreatic Cancer |
University of Maryland, Baltimore |
2014-03 | EARLY_PHASE1 |
| NCT02312622 | COMPLETED | Stage IV Non-small Cell Lung Cancer (NSCLC); Recurrent Non-small Cell Lung Cancer (NSCLC); Extensive-stage Small Cell Lung Cancer (SCLC); Recurrent Small Cell Lung Cancer (SCLC); Tumors Metastatic to Brain; Metastatic Breast Cancer (mBC) |
Joel Neal |
2015-08 | PHASE2 |
| NCT03030937 | UNKNOWN | Advanced Gastric Cancer Adenocarcinoma of Esophagogastric Junction |
Fujian Cancer Hospital |
2017-02-01 | PHASE2 |
| NCT01355445 | COMPLETED | RHABDOMYOSARCOMA |
Centre Oscar Lambret |
2012-01 | PHASE2 |
| NCT03400592 | UNKNOWN | Stomach Neoplasms |
Peking University |
2015-06 | PHASE2 |
| NCT03076957 | UNKNOWN | Colorectal Cancer |
Chong Kun Dang Pharmaceutical |
2016-12 | PHASE1; PHASE2 |
| NCT02096354 | COMPLETED | Colorectal Neoplasms |
EpicentRx, Inc. |
2014-05 | PHASE2 |
| NCT02896907 | COMPLETED | Pancreatic Adenocarcinoma; Recurrent Pancreatic Carcinoma; Stage III Pancreatic Cancer; Stage IV Pancreatic Cancer; Unresectable Pancreatic Carcinoma |
Sidney Kimmel Comprehensive Cancer Center at Thomas Jefferson University |
2016-10-18 | EARLY_PHASE1 |
| NCT01526135 | COMPLETED | Pancreatic Adenocarcinoma (Ductal Adenocarcinoma) |
UNICANCER |
2012-04-16 | PHASE3 |
| NCT01813253 | TERMINATED | Gastric Cancer; Gastroesophageal Junction Cancer |
Kuhnil Pharmaceutical Co., Ltd. |
2013-05-13 | PHASE3 |
| NCT01650428 | COMPLETED | Rectal Cancer |
University College, London |
2013-04 | PHASE2 |
| NCT02331251 | TERMINATED | Advanced Cancer; Breast Cancer; Sarcoma; Pancreatic Cancer; Small Cell Lung Cancer; Ovarian |
Western Regional Medical Center |
2014-12 | PHASE1; PHASE2 |
| NCT01839877 | COMPLETED | Colorectal Cancer With Non Resectable Hepatic Metastasis |
Federation Francophone de Cancerologie Digestive |
2013-05 | PHASE2 |
| NCT02164916 | COMPLETED | Colorectal Cancer |
SWOG Cancer Research Network |
2014-11 | PHASE2 |
| NCT02558868 | COMPLETED | Pancreatic Neoplasms |
Zhejiang University |
2015-09-01 | PHASE2 |
| NCT02275806 | TERMINATED | Lung Neoplasms, Non-Small Cell Lung Cancer |
Leo W. Jenkins Cancer Center |
2014-10 | PHASE2 |
| NCT02625623 | COMPLETED | Unresectable, Recurrent, Locally Advanced or Metastatic Gastric or Gastroesophageal Junction Adenocarcinoma; Gastric Cancer Third Line |
EMD Serono Research & Development Institute, Inc. |
2015-12-28 | PHASE3 |
| NCT02119026 | COMPLETED | Metastatic Colorectal Cancer |
Prof. Dr. Werner Scheithauer |
2011-02 | PHASE2 |
| NCT01653470 | COMPLETED | Cancer |
Bristol-Myers Squibb |
2012-10-12 | PHASE1 |
| NCT02110953 | TERMINATED | Liver Metastases; Mucinous Adenocarcinoma of the Colon; Mucinous Adenocarcinoma of the Rectum; Recurrent Colon Cancer; Recurrent Rectal Cancer; Signet Ring Adenocarcinoma of the Colon; Signet Ring Adenocarcinoma of the Rectum; Stage IVA Colon Cancer; Stage IVA Rectal Cancer; Stage IVB Colon Cancer; Stage IVB Rectal Cancer |
Fox Chase Cancer Center |
2016-01-29 | PHASE1 |
| NCT02086656 | COMPLETED | Colorectal Cancer Liver Metastases |
Fondazione IRCCS Istituto Nazionale dei Tumori, Milano |
2013-06 | PHASE2 |
| NCT02348450 | UNKNOWN | Small Cell Lung Cancer |
Guangdong Association of Clinical Trials |
2015-02 | PHASE4 |
| NCT02694562 | COMPLETED | Colorectal Carcinoma |
Boston Scientific Corporation |
2013-11 | |
| NCT01593228 | COMPLETED | Solid Tumors |
Sanofi |
2012-05 | PHASE3 |
| NCT02527824 | UNKNOWN | Biliary Tract Neoplasm |
Hallym University Medical Center |
2015-03 | PHASE2 |
| NCT02527785 | COMPLETED | Stomach Neoplasm |
Hallym University Medical Center |
2015-02 | PHASE2 |
| NCT00730158 | COMPLETED | Colorectal Neoplasms |
Edward Chu, MD |
2008-12 | PHASE2 |
| NCT01055314 | COMPLETED | Adult Rhabdomyosarcoma; Childhood Alveolar Rhabdomyosarcoma; Childhood Embryonal Rhabdomyosarcoma; Metastatic Childhood Soft Tissue Sarcoma; Stage IV Adult Soft Tissue Sarcoma; Untreated Childhood Rhabdomyosarcoma |
National Cancer Institute (NCI) |
2010-01 | PHASE2 |
| NCT02071069 | UNKNOWN | Incurable Colorectal Cancer; RAS-wild-type |
Tianshu Liu |
2013-07 | PHASE2 |
| NCT01786538 | WITHDRAWN | Metastatic Colorectal Cancer |
Asan Medical Center |
2013-06 | PHASE3 |
| NCT01765582 | TERMINATED | Colorectal Neoplasms |
Hoffmann-La Roche |
2013-01-23 | PHASE2 |
| NCT02046538 | WITHDRAWN | Adenocarcinoma of the Colon; Adenocarcinoma of the Rectum |
Weill Medical College of Cornell University |
2014-02 | PHASE2 |
| NCT01347866 | TERMINATED | Advanced Cancer |
Pfizer |
2011-10 | PHASE1 |
| NCT00952029 | COMPLETED | Colorectal Cancer |
Federation Francophone de Cancerologie Digestive |
2010-03 | PHASE2; PHASE3 |
| NCT02211443 | UNKNOWN | Metastatic Colorectal Cancer |
Sinocelltech Ltd. |
2015-01 | PHASE1 |
| NCT00381797 | COMPLETED | Childhood Cerebral Anaplastic Astrocytoma; Childhood Oligodendroglioma; Childhood Spinal Cord Neoplasm; Recurrent Childhood Brain Stem Glioma; Recurrent Childhood Ependymoma; Recurrent Childhood Medulloblastoma |
National Cancer Institute (NCI) |
2006-08 | PHASE2 |
| NCT00876993 | COMPLETED | Central Nervous System Tumors |
Johns Hopkins All Children's Hospital |
2008-09 | PHASE1 |
| NCT02433392 | TERMINATED | Glioma |
Boston Scientific Corporation |
2011-12 | PHASE1 |
| NCT02015754 | COMPLETED | Colorectal Cancer |
Yale University |
2014-02 | PHASE2 |
| NCT00354679 | COMPLETED | Esophageal Cancer |
Memorial Sloan Kettering Cancer Center |
2006-04 | PHASE2 |
| NCT01670721 | COMPLETED | Colorectal Cancer Metastatic |
Sanofi |
2012-08 | PHASE3 |
| NCT02060955 | TERMINATED | Glioblastoma Multiforme |
CytoVac A/S |
2014-02 | PHASE2 |
| NCT01030042 | COMPLETED | Metastatic Colorectal Cancer |
Gruppo Italiano per lo studio dei Carcinomi dell'Apparato Digerente |
2009-09 | PHASE3 |
| NCT00871169 | COMPLETED | Pancreatic Cancer |
New Mexico Cancer Research Alliance |
2008-10 | PHASE2 |
| NCT00354835 | COMPLETED | Adult Rhabdomyosarcoma; Childhood Alveolar Rhabdomyosarcoma; Childhood Botryoid-Type Embryonal Rhabdomyosarcoma; Childhood Embryonal Rhabdomyosarcoma; Localized Childhood Soft Tissue Sarcoma; Rhabdomyosarcoma; Sarcoma; Stage I Adult Soft Tissue Sarcoma AJCC v7; Stage II Adult Soft Tissue Sarcoma AJCC v7; Stage III Adult Soft Tissue Sarcoma AJCC v7 |
Children's Oncology Group |
2006-12-26 | PHASE3 |
| NCT01631539 | WITHDRAWN | Liver Metastases; Colorectal Cancer |
Universitaire Ziekenhuizen KU Leuven |
2012-09 | |
| NCT01675128 | COMPLETED | Colorectal Neoplasms; Colorectal Carcinoma; Colorectal Tumors |
National Cancer Institute (NCI) |
2012-08 | PHASE1; PHASE2 |
| NCT01086345 | TERMINATED | Glioblastoma; Gliosarcoma; Brain Tumor |
Case Comprehensive Cancer Center |
2010-02 | EARLY_PHASE1 |
| NCT01652482 | COMPLETED | Colorectal Cancer |
Genentech, Inc. |
2012-10 | PHASE2 |
| NCT00952003 | COMPLETED | Gastric Cancer; Unresectable |
Arbeitsgemeinschaft medikamentoese Tumortherapie |
2009-07 | PHASE2 |
| NCT00183872 | COMPLETED | Gastric Cancer; Esophageal Neoplasms |
University of Southern California |
2005-04-14 | PHASE2 |
| NCT01290783 | UNKNOWN | Metastatic Colorectal Cancer |
Alchemia Oncology |
2011-12 | PHASE3 |
| NCT00948935 | COMPLETED | Biliary Cancer; Cholangiocarcinoma |
Abramson Cancer Center at Penn Medicine |
2009-04 | PHASE2 |
| NCT01269216 | COMPLETED | Rectal Cancer |
Yonsei University |
2008-10 | PHASE2 |
| NCT01183780 | COMPLETED | Colorectal Cancer |
Eli Lilly and Company |
2010-12-02 | PHASE3 |
| NCT01313884 | TERMINATED | Bone Cancer; Ewing's Sarcoma |
Stanford University |
2011-05 | PHASE2 |
| NCT01964027 | UNKNOWN | Stage IV Gastric Cancer With Metastasis |
Anhui Medical University |
2013-10 | PHASE2 |
| NCT01941173 | WITHDRAWN | Recurrent Colon Cancer; Recurrent Rectal Cancer; Stage IVA Colon Cancer; Stage IVA Rectal Cancer; Stage IVB Colon Cancer; Stage IVB Rectal Cancer |
City of Hope Medical Center |
2014-01 | |
| NCT00958386 | COMPLETED | Metastatic Colorectal Cancer |
Spanish Cooperative Group for the Treatment of Digestive Tumours (TTD) |
2009-08 | PHASE2 |
| NCT01635400 | UNKNOWN | Small Cell Carcinoma of Lung |
Zhejiang Cancer Hospital |
2012-06 | PHASE2 |
| NCT02055196 | WITHDRAWN | Adult Anaplastic Astrocytoma; Adult Anaplastic Oligodendroglioma; Adult Giant Cell Glioblastoma; Adult Glioblastoma; Adult Gliosarcoma; Recurrent Adult Brain Tumor |
City of Hope Medical Center |
PHASE1 | |
| NCT01091259 | COMPLETED | Ovarian Cancer; Fallopian Tube Cancer; Primary Peritoneal Carcinoma |
NYU Langone Health |
2010-03 | PHASE2 |
| NCT00671801 | TERMINATED | Malignant Gliomas |
M.D. Anderson Cancer Center |
2008-04-29 | PHASE1 |
| NCT01451632 | COMPLETED | Colorectal Cancer; Squamous Cell Head and Neck Cancer; Non-small Cell Lung Cancer; Triple Negative Breast Cancer; Other Tumors With EGFR Dependence |
Merrimack Pharmaceuticals |
2011-10 | PHASE1 |
| NCT01367275 | TERMINATED | Colorectal Cancer; Colorectal Adenocarcinoma |
M.D. Anderson Cancer Center |
2011-08 | PHASE2 |
| NCT01141244 | COMPLETED | Unspecified Childhood Solid Tumor, Protocol Specific |
National Cancer Institute (NCI) |
2010-06 | PHASE1 |
| NCT00045201 | ACTIVE_NOT_RECRUITING | Adult Solid Neoplasm |
National Cancer Institute (NCI) |
2002-06-13 | PHASE1 |
| NCT01138904 | COMPLETED | Gastric Cancer |
Dong-A University Hospital |
2009-09 | PHASE2 |
| NCT00524186 | TERMINATED | Esophageal Cancer; Gastric Cancer |
Roswell Park Cancer Institute |
2007-05 | PHASE1 |
| NCT00762255 | COMPLETED | Glioblastoma |
H. Lee Moffitt Cancer Center and Research Institute |
2008-09 | PHASE1 |
| NCT01322152 | COMPLETED | Colorectal Cancer |
Fudan University |
2011-03 | PHASE2 |
| NCT00967616 | COMPLETED | Colorectal Cancer; Neoplasms, Colorectal |
Daiichi Sankyo |
2009-09 | PHASE2 |
| NCT01607554 | TERMINATED | Non-small Cell Lung Cancer |
New Mexico Cancer Research Alliance |
2012-04 | PHASE1; PHASE2 |
| NCT01282697 | COMPLETED | Refractory Solid Tumors in Children |
University Hospital, Strasbourg, France |
2011-04-22 | PHASE1 |
| NCT01640782 | COMPLETED | Adenocarcinoma of the Stomach; Adenocarcinoma of the Gastroesophageal Junction |
Mario Negri Institute for Pharmacological Research |
2005-02 | PHASE3 |
| NCT00499369 | TERMINATED | Recurrent Colon Cancer; Recurrent Rectal Cancer; Stage IVA Colon Cancer; Stage IVA Rectal Cancer; Stage IVB Colon Cancer; Stage IVB Rectal Cancer |
National Cancer Institute (NCI) |
2007-06 | PHASE3 |
| NCT00079274 | COMPLETED | Adenocarcinoma of the Colon; Stage III Colon Cancer |
National Cancer Institute (NCI) |
2004-02 | PHASE3 |
| NCT01480986 | COMPLETED | Progression Free Survival of the Treatment |
Peking University |
2011-09 | PHASE2 |
| NCT00953121 | COMPLETED | Malignant Glioma |
Annick Desjardins |
2009-09 | PHASE2 |
| NCT00967655 | UNKNOWN | Colorectal Cancer |
Loma Linda Oncology Medical Group, Inc. |
2009-07 | PHASE2 |
| NCT00777478 | UNKNOWN | Colorectal Cancer |
Radboud University Medical Center |
2008-12 | PHASE1 |
| NCT01004159 | TERMINATED | Colorectal Cancer |
Roswell Park Cancer Institute |
2009-09 | PHASE2 |
| NCT00911820 | COMPLETED | Esophageal Cancer; Gastric Cancer; Stomach Cancer |
Dana-Farber Cancer Institute |
2009-07 | PHASE2 |
| NCT00436072 | COMPLETED | Colorectal Cancer |
Dana-Farber Cancer Institute |
2007-02 | PHASE1 |
| NCT01285102 | TERMINATED | Liver Metastases; Mucinous Adenocarcinoma of the Colon; Mucinous Adenocarcinoma of the Rectum; Recurrent Colon Cancer; Recurrent Rectal Cancer; Signet Ring Adenocarcinoma of the Colon; Signet Ring Adenocarcinoma of the Rectum; Stage IV Colon Cancer; Stage IV Rectal Cancer |
Fox Chase Cancer Center |
2010-10 | PHASE1 |
| NCT00544778 | TERMINATED | Sarcoma |
City of Hope Medical Center |
2001-08 | PHASE2 |
| NCT00817284 | COMPLETED | Glioblastoma Multiforme |
Ulrik Lassen |
2008-11 | PHASE2 |
| NCT01017653 | TERMINATED | Malignant Glioma of Brain |
Annick Desjardins |
2010-02 | PHASE2 |
| NCT00144989 | COMPLETED | Small-Cell-Lung Cancer |
Haruhiko Fukuda |
2002-09 | PHASE3 |
| NCT00546130 | UNKNOWN | Small Cell Lung Cancer |
University of Toyama |
2007-11 | PHASE2 |
| NCT01051765 | UNKNOWN | Advanced Esophageal Squamous Carcinoma |
Peking University |
2009-08 | PHASE2 |
| NCT00597402 | COMPLETED | Glioblastoma; Gliosarcoma; Brain Tumor |
Duke University |
2007-07 | PHASE2 |
| NCT00483834 | COMPLETED | Colorectal Cancer |
University Health Network, Toronto |
2006-12 | PHASE2 |
| NCT00062374 | COMPLETED | Gastric Adenocarcinoma; Stage II Gastric Cancer; Stage III Gastric Cancer; Stage IV Gastric Cancer |
National Cancer Institute (NCI) |
2003-06 | PHASE2 |
| NCT01226550 | COMPLETED | Peritoneal Carcinosis (PC) |
Hospices Civils de Lyon |
2007-06 | PHASE1; PHASE2 |
| NCT00639327 | COMPLETED | Gastric Cancer |
Japan Clinical Cancer Research Organization |
2008-03 | PHASE2; PHASE3 |
| NCT00354978 | COMPLETED | Colorectal Cancer |
M.D. Anderson Cancer Center |
2005-01 | PHASE2 |
| NCT00827684 | COMPLETED | Metastatic Colorectal Cancer |
Vejle Hospital |
2009-03 | PHASE2 |
| NCT00689624 | COMPLETED | Metastatic Colorectal Cancer |
University Hospital of Crete |
2007-07 | PHASE2 |
| NCT00792363 | COMPLETED | Metastatic Colorectal Cancer |
Vejle Hospital |
2008-11 | PHASE2 |
| NCT00557102 | COMPLETED | Colorectal Cancer; Metastatic Cancer |
National Cancer Institute, France |
2007-09 | PHASE2 |
| NCT00642577 | COMPLETED | Colorectal Cancer |
Hoffmann-La Roche |
2007-07 | PHASE3 |
| NCT00839111 | UNKNOWN | Colorectal Neoplasms |
Fudan University |
2008-11 | PHASE2 |
| NCT00616785 | UNKNOWN | Lung Cancer |
Yonsei University |
2007-06 | PHASE2 |
| NCT00074321 | COMPLETED | Unspecified Adult Solid Tumor, Protocol Specific |
National Cancer Institute (NCI) |
2003-11 | PHASE1 |
| NCT00813072 | COMPLETED | Stomach Neoplasms; Esophageal Neoplasms |
PharmaEngine |
2007-11 | PHASE2 |
| NCT01022918 | COMPLETED | Naive Unresectable Glioblastoma |
Centre Georges Francois Leclerc |
2009-01 | PHASE2 |
| NCT00806663 | COMPLETED | Metastatic Colorectal Cancer; Liver Metastases |
Central European Society for Anticancer Drug Research |
2008-08 | PHASE2 |
| NCT00614393 | COMPLETED | Metastatic Colorectal Cancer |
Merck Sharp & Dohme LLC |
2007-12-24 | PHASE2 |
| NCT00611728 | COMPLETED | Glioblastoma |
Duke University |
2008-03 | PHASE1 |
| NCT00984438 | WITHDRAWN | Glioblastoma Multiforme |
University of Cincinnati |
2009-06 | PHASE1; PHASE2 |
| NCT01123811 | COMPLETED | Adenocarcinoma of Stomach or Esophagogastric Junction |
Johannes Gutenberg University Mainz |
2006-05 | PHASE2 |
| NCT00588900 | TERMINATED | Colorectal Cancer |
Alliance for Clinical Trials in Oncology |
2008-03 | PHASE2 |
| NCT00467142 | COMPLETED | Colorectal Cancer |
Institut Bergonié |
2007-01-23 | PHASE2 |
| NCT00186979 | COMPLETED | Solid Tumors |
St. Jude Children's Research Hospital |
2003-05 | PHASE1 |
| NCT00457691 | COMPLETED | Metastatic Colorectal Cancer |
Pfizer |
2007-06 | PHASE3 |
| NCT00475293 | COMPLETED | Metastatic Colorectal Cancer |
Spanish Cooperative Group for the Treatment of Digestive Tumours (TTD) |
2007-05 | PHASE2 |
| NCT00979563 | COMPLETED | Advanced Solid Malignancies |
Hanmi Pharmaceutical Company Limited |
2008-07 | PHASE1 |
| NCT00449163 | TERMINATED | Colorectal Cancer |
University of Miami |
2006-03-01 | PHASE2 |
| NCT00569790 | COMPLETED | Colorectal Cancer |
Taiho Pharmaceutical Co., Ltd. |
2007-10 | PHASE2 |
| NCT00614965 | COMPLETED | Non Small Cell Lung Cancer |
Hellenic Oncology Research Group |
2006-11 | PHASE2 |
| NCT00832689 | COMPLETED | Biliary Tract Cancer |
Yonsei University |
2008-06 | PHASE2 |
| NCT00681876 | TERMINATED | Colorectal Cancer |
Hellenic Oncology Research Group |
2008-04 | PHASE2 |
| NCT00433381 | COMPLETED | Adult Glioblastoma; Adult Gliosarcoma; Recurrent Adult Brain Neoplasm |
National Cancer Institute (NCI) |
2007-03-01 | PHASE2 |
| NCT00601692 | COMPLETED | Esophageal Cancer |
Memorial Sloan Kettering Cancer Center |
2003-04 | PHASE1 |
| NCT00590031 | COMPLETED | Esophageal Carcinoma |
Memorial Sloan Kettering Cancer Center |
2002-11 | PHASE2 |
| NCT00545545 | COMPLETED | Recurrent Colorectal Carcinoma; Progressive Colorectal Carcinoma |
HiberCell, Inc. |
2007-10 | PHASE1; PHASE2 |
| NCT00296062 | TERMINATED | Colorectal Cancer; Unspecified Adult Solid Tumor, Protocol Specific |
Case Comprehensive Cancer Center |
2006-03 | PHASE1 |
| NCT00508404 | COMPLETED | Metastatic Colorectal Cancer |
Amgen |
2007-05-09 | PHASE2 |
| NCT00408551 | UNKNOWN | Colorectal Cancer; Metastatic Cancer |
Goshen Health System |
2005-11 | PHASE2 |
| NCT00483080 | COMPLETED | Colorectal Cancer (CRC) |
AGC Biologics S.p.A. |
2006-12 | PHASE2 |
| NCT00183859 | COMPLETED | Adenocarcinoma; Gastric Cancer |
University of Southern California |
1999-09 | PHASE1 |
| NCT00059761 | COMPLETED | Lung Cancer |
Radiation Therapy Oncology Group |
2003-03 | PHASE1 |
| NCT00311584 | COMPLETED | Neuroblastoma |
Children's Oncology Group |
2006-04 | PHASE2 |
| NCT00042874 | COMPLETED | Unspecified Adult Solid Tumor, Protocol Specific |
National Cancer Institute (NCI) |
2002-05 | PHASE1 |
| NCT00718757 | COMPLETED | Non-Hodgkins Lymphoma; Hodgkin's Disease; Acute Lymphoblastic Leukemia |
St. Jude Children's Research Hospital |
2005-01 | PHASE1 |
| NCT00463073 | COMPLETED | Malignant Gliomas |
Rigshospitalet, Denmark |
2006-08 | PHASE2 |
| NCT00361842 | COMPLETED | Colorectal Neoplasms |
Jazz Pharmaceuticals |
2006-07 | PHASE2 |
| NCT00283556 | COMPLETED | Malignant Glioma |
Kentuckiana Cancer Institute |
2001-08 | PHASE1; PHASE2 |
| NCT00084617 | COMPLETED | Adenocarcinoma of the Gastroesophageal Junction; Diffuse Adenocarcinoma of the Stomach; Intestinal Adenocarcinoma of the Stomach; Mixed Adenocarcinoma of the Stomach; Recurrent Gastric Cancer; Stage IIIA Gastric Cancer; Stage IIIB Gastric Cancer; Stage IIIC Gastric Cancer; Stage IV Gastric Cancer |
National Cancer Institute (NCI) |
2004-03 | PHASE2 |
| NCT00423696 | COMPLETED | Colorectal Cancer |
UNICANCER |
2006-03-23 | PHASE2 |
| NCT00193375 | COMPLETED | Lung Cancer |
SCRI Development Innovations, LLC |
2003-08 | PHASE2 |
| NCT00532714 | COMPLETED | Breast Cancer Metastatic |
National Cancer Center, Korea |
2006-08 | PHASE2 |
| NCT00153998 | COMPLETED | Colorectal Cancer; Liver Metastases |
Technische Universität Dresden |
2004-11 | PHASE2 |
| NCT00500292 | COMPLETED | Colorectal; Cancer |
Genzyme, a Sanofi Company |
2007-03 | PHASE2 |
| NCT00381862 | COMPLETED | Colorectal Cancer; Nausea and Vomiting |
OHSU Knight Cancer Institute |
2006-06 | PHASE2 |
| NCT00143403 | COMPLETED | Colorectal Neoplasms; Liver Neoplasms |
Pfizer |
2001-12 | PHASE3 |
| NCT02582970 | COMPLETED | Colorectal Cancer |
Hoffmann-La Roche |
2005-05 | PHASE4 |
| NCT00112892 | COMPLETED | Unspecified Adult Solid Tumor, Protocol Specific |
Roswell Park Cancer Institute |
2004-08 | PHASE1 |
| NCT00509860 | COMPLETED | Sarcoma |
M.D. Anderson Cancer Center |
2003-03 | PHASE2 |
| NCT00215982 | COMPLETED | Colorectal Cancer |
H. Lee Moffitt Cancer Center and Research Institute |
2004-12 | PHASE2 |
| NCT00135135 | COMPLETED | Neuroblastoma |
St. Jude Children's Research Hospital |
2005-08 | PHASE2 |
| NCT00072527 | COMPLETED | Lung Cancer |
Alliance for Clinical Trials in Oncology |
2003-11 | PHASE2 |
| NCT00115765 | COMPLETED | Colorectal Cancer |
Amgen |
2005-06-01 | PHASE3 |
| NCT00294931 | COMPLETED | Carcinoma, Small Cell Lung |
SCRI Development Innovations, LLC |
2006-02 | PHASE2 |
| NCT00308529 | COMPLETED | Carcinoma, Small Cell Lung; Lung Cancer |
SCRI Development Innovations, LLC |
2006-03 | PHASE2 |
| NCT00320320 | TERMINATED | Colorectal Neoplasms; Metastases |
Gachon University Gil Medical Center |
2005-04 | PHASE2 |
| NCT00401128 | COMPLETED | Kidney Cancer |
The Cleveland Clinic |
2004-05 | PHASE2 |
| NCT00275041 | COMPLETED | Breast Cancer |
Alliance for Clinical Trials in Oncology |
2006-02 | PHASE2 |
| NCT00027612 | COMPLETED | Brain and Central Nervous System Tumors |
Alliance for Clinical Trials in Oncology |
2002-07 | PHASE1; PHASE2 |
| NCT00099125 | COMPLETED | Brain and Central Nervous System Tumors |
Radiation Therapy Oncology Group |
2004-11 | PHASE2 |
| NCT00106054 | TERMINATED | Colorectal Neoplasms; Liver Neoplasms |
Pfizer |
2006-01 | PHASE2 |
| NCT00268359 | COMPLETED | Brain and Central Nervous System Tumors |
Duke University |
2005-05 | PHASE2 |
| NCT00213486 | COMPLETED | Esophageal Neoplasms |
University Hospital, Rouen |
2003-01-15 | PHASE2 |
| NCT00507091 | COMPLETED | Metastatic; Colorectal; Adenocarcinoma |
Genzyme, a Sanofi Company |
2005-08 | PHASE1 |
| NCT00021073 | COMPLETED | Unspecified Adult Solid Tumor, Protocol Specific |
National Cancer Institute (NCI) |
2001-05 | PHASE1 |
| NCT00012363 | COMPLETED | Esophageal Cancer; Gastric Cancer |
SWOG Cancer Research Network |
2001-04 | PHASE2 |
| NCT00003995 | COMPLETED | Colorectal Cancer |
National Cancer Institute (NCI) |
1999-09 | PHASE2 |
| NCT00047242 | COMPLETED | Unspecified Adult Solid Tumor, Protocol Specific |
Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins |
2002-08 | PHASE1 |
| NCT00233623 | WITHDRAWN | Metastatic Colorectal Cancer |
AstraZeneca |
2004-07 | PHASE2 |
| NCT00066274 | COMPLETED | Colorectal Cancer |
UNICANCER |
2002-07-23 | PHASE2 |
| NCT00990912 | COMPLETED | Pediatric Solid Tumors |
Bristol-Myers Squibb |
2004-01 | PHASE1; PHASE2 |
| NCT00004005 | COMPLETED | Carcinoma of Unknown Primary; Colorectal Cancer; Unspecified Adult Solid Tumor, Protocol Specific; Unspecified Childhood Solid Tumor, Protocol Specific |
St. Jude Children's Research Hospital |
1998-09 | PHASE2 |
| NCT00048139 | COMPLETED | Colorectal Cancer |
Hoffmann-La Roche |
2001-10 | PHASE2 |
| NCT00062842 | COMPLETED | Cancer |
Baylor College of Medicine |
1998-09-09 | PHASE1 |
| NCT00080951 | COMPLETED | Colorectal Cancer |
Alliance for Clinical Trials in Oncology |
2004-03 | PHASE2 |
| NCT00165464 | COMPLETED | Esophageal Cancer; Gastric Cancer; GE Junction Cancer |
Dana-Farber Cancer Institute |
2001-08 | PHASE2 |
| NCT00083148 | COMPLETED | Breast Cancer |
Roswell Park Cancer Institute |
2002-11 | PHASE1 |
| NCT00003955 | COMPLETED | Sarcoma |
Children's Oncology Group |
1999-09 | PHASE2 |
| NCT00006095 | COMPLETED | Unspecified Childhood Solid Tumor, Protocol Specific |
Children's Oncology Group |
2000-07 | PHASE1 |
| NCT00284817 | COMPLETED | Cancer |
MedImmune LLC |
2001-07 | PHASE1; PHASE2 |
| NCT00048126 | COMPLETED | Colorectal Cancer |
Hoffmann-La Roche |
2001-07 | PHASE2 |
| NCT00022698 | COMPLETED | Colorectal Cancer |
Hoffmann-La Roche |
2001-05 | PHASE2 |
| NCT00020748 | COMPLETED | Unspecified Adult Solid Tumor, Protocol Specific |
Georgetown University |
2000-08 | PHASE1 |
| NCT00003594 | COMPLETED | Colorectal Cancer |
Alliance for Clinical Trials in Oncology |
1998-10 | PHASE3 |
| NCT00025285 | COMPLETED | Lung Cancer |
Wake Forest University Health Sciences |
2001-11-01 | PHASE2 |
| NCT00003245 | COMPLETED | Lymphoma |
M.D. Anderson Cancer Center |
1998-02-18 | PHASE2 |
| NCT00030862 | COMPLETED | Esophageal Cancer |
Memorial Sloan Kettering Cancer Center |
2001-10 | PHASE2 |
| NCT00006366 | COMPLETED | Colorectal Cancer |
Radiation Therapy Oncology Group |
2001-02 | PHASE2 |
| NCT00006465 | COMPLETED | Unspecified Adult Solid Tumor, Protocol Specific |
Case Comprehensive Cancer Center |
2000-12 | PHASE1 |
| NCT00005626 | COMPLETED | Leukemia; Lymphoma |
H. Lee Moffitt Cancer Center and Research Institute |
1998-02 | PHASE2 |
| NCT00024141 | COMPLETED | Unspecified Adult Solid Tumor, Protocol Specific |
Roswell Park Cancer Institute |
2001-05 | PHASE1 |
| NCT00020930 | COMPLETED | Colorectal Cancer |
Memorial Sloan Kettering Cancer Center |
2001-03 | PHASE2 |
| NCT00003463 | COMPLETED | Brain and Central Nervous System Tumors |
Duke University |
1998-07 | PHASE1 |
| NCT00016250 | COMPLETED | Colorectal Cancer |
Memorial Sloan Kettering Cancer Center |
2000-12 | PHASE2 |
| NCT00004922 | COMPLETED | Carcinoma of Unknown Primary; Neuroendocrine Carcinoma; Neuroendocrine Carcinoma of the Skin |
Memorial Sloan Kettering Cancer Center |
1999-06 | PHASE2 |
| NCT00006103 | COMPLETED | Colorectal Cancer |
Alliance for Clinical Trials in Oncology |
2000-07 | PHASE3 |
| NCT00002759 | COMPLETED | Drug/Agent Toxicity by Tissue/Organ; Lymphoma; Neutropenia; Small Intestine Cancer; Unspecified Adult Solid Tumor, Protocol Specific |
National Cancer Institute (NCI) |
1996-06 | PHASE1 |
| NCT00006037 | TERMINATED | Colorectal Cancer |
University of Southern California |
1999-11 | PHASE2 |
| NCT00003134 | COMPLETED | Brain and Central Nervous System Tumors |
Alliance for Clinical Trials in Oncology |
1998-01 | PHASE2 |
| NCT00003742 | COMPLETED | Unspecified Adult Solid Tumor, Protocol Specific |
Memorial Sloan Kettering Cancer Center |
1998-10 | PHASE1 |
| NCT00004885 | COMPLETED | Colorectal Cancer |
European Organisation for Research and Treatment of Cancer - EORTC |
1999-07 | PHASE3 |
| NCT00004051 | COMPLETED | Unspecified Adult Solid Tumor, Protocol Specific |
Memorial Sloan Kettering Cancer Center |
1998-08 | PHASE1 |
| NCT00003710 | COMPLETED | Unspecified Adult Solid Tumor, Protocol Specific |
The University of Texas Health Science Center at San Antonio |
1998-08 | PHASE1 |
| NCT00003276 | COMPLETED | Gallbladder Cancer |
Alliance for Clinical Trials in Oncology |
1998-03 | PHASE2 |
| NCT00002988 | COMPLETED | Brain and Central Nervous System Tumors |
Duke University |
1997-04 | PHASE1 |
| NCT00002933 | COMPLETED | Colorectal Cancer |
Case Comprehensive Cancer Center |
1996-09 | PHASE2 |
| NCT00004182 | COMPLETED | Breast Cancer |
Northwestern University |
1999-10 | PHASE2 |
| NCT00264134 | TERMINATED | Non-small Cell Lung Cancer; Extensive Stage Unresectable |
Kentuckiana Cancer Institute |
2003-06 | PHASE1; PHASE2 |
| NCT00001495 | COMPLETED | Neoplasms |
National Cancer Institute (NCI) |
1995-11 | PHASE1 |
| NCT00313859 | COMPLETED | Colorectal Cancer; Metastasis |
Samsung Medical Center |
2005-09 | PHASE2 |
| NCT00004923 | COMPLETED | Unspecified Adult Solid Tumor, Protocol Specific |
Yale University |
1999-04 | PHASE1; PHASE2 |
| NCT00168896 | UNKNOWN | Small Cell Lung Cancer |
Charite University, Berlin, Germany |
2001-10 | PHASE2; PHASE3 |
| NCT00209664 | SUSPENDED | Gastric Cancer |
Hokkaido Gastrointestinal Cancer Study Group |
2004-01 | PHASE2 |
| NCT00004924 | COMPLETED | Lung Cancer |
Yale University |
1999-03 | PHASE2 |
| NCT00020501 | COMPLETED | Colorectal Cancer; Metastatic Cancer |
National Institutes of Health Clinical Center (CC) |
2001-03 | PHASE3 |
| NCT00087282 | COMPLETED | Liver Cancer |
Memorial Sloan Kettering Cancer Center |
2004-06 | PHASE2 |
| NCT00323011 | TERMINATED | Colorectal Cancer |
University of Southern California |
2006-05 | PHASE2 |
| NCT00003301 | COMPLETED | Brain and Central Nervous System Tumors |
New Approaches to Brain Tumor Therapy Consortium |
1998-07 | PHASE1; PHASE2 |
| NCT00034502 | COMPLETED | Colorectal Cancer |
Eli Lilly and Company |
PHASE1; PHASE2 | |
| NCT00220064 | COMPLETED | Upper Gastrointestinal Tumours |
Royal Marsden NHS Foundation Trust |
2000-07 | PHASE2 |
| NCT00220168 | COMPLETED | Upper Gastrointestinal Tumours |
Royal Marsden NHS Foundation Trust |
2003-01 | PHASE4 |
| NCT00027833 | UNKNOWN | Colorectal Cancer |
Herbert Irving Comprehensive Cancer Center |
2001-12 | PHASE2 |
| NCT00319800 | UNKNOWN | Non-Small Cell Lung Cancer |
Gachon University Gil Medical Center |
2006-02 | PHASE2 |
| NCT00513266 | UNKNOWN | Colorectal Cancer; Metastatic Cancer |
Centre Hospitalier Universitaire Vaudois |
2007-06 | PHASE2 |
| NCT00003260 | UNKNOWN | Colorectal Cancer |
GERCOR - Multidisciplinary Oncology Cooperative Group |
1998-01 | PHASE3 |
| NCT01224652 | UNKNOWN | Gastric Cancer |
Korean Cancer Study Group |
PHASE3 | |
| NCT00047762 | COMPLETED | Colorectal Cancer |
Genentech, Inc. |
2002-10 | PHASE1 |
| NCT00192712 | COMPLETED | Pancreatic Cancer |
Rambam Health Care Campus |
2002-11 | PHASE2; PHASE3 |
| NCT00077987 | COMPLETED | Colorectal Neoplasms |
Pfizer |
2003-12 | PHASE2 |
| NCT00180960 | TERMINATED | Colon Tumors; Rectum Tumors; Appendix Tumors; Peritoneum Tumors; Endocrine Tumors |
Gustave Roussy, Cancer Campus, Grand Paris |
2003-06 | PHASE2 |
| NCT00819728 | COMPLETED | Carcinoma, Non-Small-Cell Lung |
Sanofi |
2000-06 | PHASE2 |
| NCT00006000 | COMPLETED | Unspecified Adult Solid Tumor, Protocol Specific |
Ohio State University Comprehensive Cancer Center |
2000-08 | PHASE1 |
| NCT00020488 | COMPLETED | Unspecified Adult Solid Tumor, Protocol Specific |
National Cancer Institute (NCI) |
2001-02 | PHASE1 |
| NCT00502762 | UNKNOWN | Lung Cancer; Refractory to Chemotherapy |
Gachon University Gil Medical Center |
2004-09 | PHASE2 |
| NCT00506168 | TERMINATED | Colorectal Neoplasms; Secondary; Drug Therapy, Combination |
National Cancer Center, Korea |
2001-11 | PHASE2 |
| NCT00675194 | COMPLETED | Gastric Cancer |
Johannes Gutenberg University Mainz |
2003-10 | PHASE2 |
| NCT00263016 | TERMINATED | Carcinoma, Non-Small-Cell Lung |
Sanofi |
2005-05 | PHASE2 |
| NCT00209651 | UNKNOWN | Colorectal Cancer |
Hokkaido Gastrointestinal Cancer Study Group |
2004-01 | PHASE2 |
| NCT00303745 | UNKNOWN | Colorectal Cancer |
Federation Francophone de Cancerologie Digestive |
2006-06 | PHASE2 |
(data from https://clinicaltrials.gov, updated on 2026-06-18)
Check the
Irinotecan (CPT-11)
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
Mechanism and Biochemical Profile
Appendix RUO and cGMP Quality Standards
| Quality Dimension | RUO (Research Use Only) | cGMP (Current Good Manufacturing Practice) |
|---|---|---|
| Clinical Applicability | Prohibited in human clinical trials or medical diagnostics. | Mandatory for human clinical trials (Phase I–III) and therapies. |
| Regulatory Status | Non-regulated grade; exempt from drug manufacturing laws. | Legally enforced by health authorities (e.g., FDA, EMA, NMPA). |
| Facility Environment | Unclassified analytical or research laboratories. | Validated Cleanrooms (ISO Class 5–8) with continuous monitoring. |
| Quality Control | Basic purity and activity testing. | Rigorous safety release testing (Sterility, Endotoxin, Mycoplasma). |
| Process Validation | Basic equipment calibration; no process validation required. | Full qualification (IQ/OQ/PQ) and complete batch records. |
| Quality Assurance | Vendor self-declared without required formal QMS. | Mandatory QA/QC unit, Change Control, CAPA, and vendor audits. |
| Regulatory Impact | High risk of IND rejection if used as a critical raw material. | Required for IND/NDA filings, supported by Drug Master Files (DMF). |
Footnotes
Regulatory Note: Governed by FDA (21 CFR Parts 210/211/312), EMA (EudraLex Vol 4), ICH Guidelines (E6/Q7/Q9/Q10), and compendial standards (USP <71>/<85>/<1043>).
- Irinotecan (CPT-11) Solubility in DMSO
- Irinotecan (CPT-11) Stock Solution
- Irinotecan (CPT-11) Storage
- Irinotecan (CPT-11) Stability
- Irinotecan (CPT-11) Molecular Weight
- Irinotecan (CPT-11) SMILES
- Irinotecan (CPT-11) CAS Number
- Irinotecan (CPT-11) Chemical Structure (2D and 3D)
- Irinotecan (CPT-11) SDS｜MSDS
Note: Technical data last updated: Sep 1, 2026.