CAS No. 97682-44-5

Batch: Purity:99.99
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Irinotecan (CPT-11) Chemical Structure
Chemical Structure
Check the Irinotecan (CPT-11) product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.

Chemical Information

IUPAC Name [(19S)-10,19-diethyl-19-hydroxy-14,18-dioxo-17-oxa-3,13-diazapentacyclo[11.8.0.02,11.04,9.015,20]henicosa-1(21),2,4(9),5,7,10,15(20)-heptaen-7-yl] 4-piperidin-1-ylpiperidine-1-carboxylate
CAS Number 97682-44-5
Molecular Formula

C33H38N4O6
Molecular Weight (MW) 586.68
SMILES CCC1=C2CN3C(=CC4=C(C3=O)COC(=O)C4(CC)O)C2=NC5=C1C=C(C=C5)OC(=O)N6CCC(CC6)N7CCCCC7
InChIKey UWKQSNNFCGGAFS-XIFFEERXSA-N

Ordering Information

Biological Activity

Irinotecan (CPT-11) is a topoisomerase I inhibitor that exhibits cytotoxic activity against colon cancer cell lines, including LoVo and HT-29. As a semisynthetic derivative of camptothecin, irinotecan is converted into its active metabolite SN-38, which potently inhibits topoisomerase I. This inhibition stabilizes the topoisomerase I-DNA cleavage complex, preventing DNA replication and transcription and ultimately inducing DNA double-strand breaks and apoptotic cell death. [1][2]

How to Prepare Stock Solution?

Concentration Volume Mass
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Solubility

Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
Solvent Solubility & Note
DMSO 25 mg/mL (42.61 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.)
Water Insoluble
Ethanol Insoluble
FAQ
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
  • Preheat media/saline to 37°C.
  • Mix rapidly (pipette/vortex) upon addition.
  • For complex mixes, always add the aqueous phase last.
  • Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).

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Note: Technical data last updated: Sep 1, 2026.