Clinical Trials

Numerous clinical trials evaluate imatinib mesylate across a broad spectrum of oncologic and immunological indications, prominently chronic myeloid leukemia, Philadelphia chromosome-positive acute lymphoblastic leukemia, malignant mesothelioma, and graft-versus-host disease. Encompassing Phase 1 through Phase 4 studies, these investigations examine pharmacokinetic profiles, combination regimens, and disease management strategies sponsored by academic centers, hospital groups, and pharmaceutical entities such as Novartis and Inhibikase Therapeutics Inc. Recruitment statuses across these trials are varied, comprising completed, actively recruiting, terminated, and withdrawn studies.

NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT06119789 RECRUITING
Rare Malignant Neoplasm
Oslo University Hospital
 2025-03-20 PHASE2
NCT04307576 RECRUITING
Leukemia, Acute Lymphoblastic
Mats Heyman
 2020-07-13 PHASE3
NCT07585266 RECRUITING
Gastrointestinal Stromal Neoplasms
GlaxoSmithKline
 2026-07-27 PHASE3
NCT06087263 ACTIVE_NOT_RECRUITING
Gastrointestinal Stromal Tumors
M.D. Anderson Cancer Center
 2024-06-18 PHASE2
NCT01746836 RECRUITING
Chronic Phase Chronic Myelogenous Leukemia, BCR-ABL1 Positive; Philadelphia Chromosome Positive, BCR-ABL1 Positive Chronic Myelogenous Leukemia; Recurrent Chronic Myelogenous Leukemia, BCR-ABL1 Positive
M.D. Anderson Cancer Center
 2013-01-17 PHASE2
NCT04877522 RECRUITING
Chronic Myelogenous Leukemia; Leukemia, Myelogenous, Chronic, BCR-ABL Positive
Novartis Pharmaceuticals
 2022-08-30 PHASE4
NCT07171203 RECRUITING
Gastrointestinal Stromal Tumors
University of California, San Diego
 2026-05-13 PHASE1
NCT05385549 RECRUITING
Gastrointestinal Stromal Tumors
Asan Medical Center
 2022-09-07 PHASE2
NCT04933669 RECRUITING
Progression-free Survival; Gastrointestinal Stromal Tumor; Neoadjuvant
First Affiliated Hospital of Zhejiang University
 2021-09-07 PHASE2
NCT06061094 RECRUITING
Philadelphia Chromosome Positive Acute Lymphoblastic Leukemia
Goethe University
 2023-07-14 PHASE2
NCT05722795 RECRUITING
Breast Cancer; Triple Negative Breast Cancer
Vastra Gotaland Region
 2023-06-01
NCT04070443 ACTIVE_NOT_RECRUITING
Philadelphia Chromosome Positive CML; BCR-ABL Positive Chronic Myelogenous Leukemia
Centre Leon Berard
 2019-11-13 PHASE2
NCT03516279 ACTIVE_NOT_RECRUITING
Chronic Phase Chronic Myelogenous Leukemia, BCR-ABL1 Positive; Minimal Residual Disease
ECOG-ACRIN Cancer Research Group
 2019-06-26 PHASE2
NCT07530367 NOT_YET_RECRUITING
Palmoplantar Pustulosis (PPP)
Second Affiliated Hospital, Zhejiang University, School of Medicine
 2026-08-01 PHASE3
NCT04488081 ACTIVE_NOT_RECRUITING
COVID-19
QuantumLeap Healthcare Collaborative
 2020-07-31 PHASE2
NCT04838041 RECRUITING
Chronic Phase Chronic Myelogenous Leukemia
Medical College of Wisconsin
 2021-11-11 PHASE2
NCT06962254 RECRUITING
Solid Tumor Cancer
China Medical University Hospital
 2025-05-10 PHASE1
NCT07096609 RECRUITING
GIST
Asan Medical Center
 2025-10-29 PHASE1; PHASE2
NCT06692491 NOT_YET_RECRUITING
Rare Tumour
Peking University Shenzhen Hospital
 2025-01-01 PHASE2
NCT07689201 NOT_YET_RECRUITING
Gastrointestinal Neoplasms
GlaxoSmithKline
 2026-08-31 PHASE2
NCT05734105 ACTIVE_NOT_RECRUITING
GIST
Deciphera Pharmaceuticals, LLC
 2023-12-13 PHASE3
NCT06655246 RECRUITING
Gastrointestinal Stromal Tumor (GIST); Gastrointestinal Stromal Cancer; Gastrointestinal Stromal Neoplasm; Gastrointestinal Stromal Tumor, Malignant; Gastrointestinal Stromal Cell Tumors
Kura Oncology, Inc.
 2025-03-27 PHASE1
NCT07406633 RECRUITING
GIST - Gastrointestinal Stromal Tumor; GIST; GIST Metastatic Cancer; Gastro Intestinal Stromal Tumour; Gastrointestinal Tumors
Kumquat Biosciences Inc.
 2026-06-23 PHASE2
NCT05152472 RECRUITING
Unresectable Gastrointestinal Stromal Tumor (GIST); Locally Advanced Gastrointestinal Stromal Tumor (GIST); Metastatic Gastrointestinal Stromal Tumor
Centre Leon Berard
 2022-01-14 PHASE2
NCT04722848 ACTIVE_NOT_RECRUITING
Acute Lymphoblastic Leukemia (Philadelphia Chromosome Positive); ALL, Adult; Philadelphia-Positive ALL
Gruppo Italiano Malattie EMatologiche dell'Adulto
 2021-09-08 PHASE3
NCT05905887 RECRUITING
Gastrointestinal Stromal Tumors
Asan Medical Center
 2023-09-06 PHASE2
NCT07559370 RECRUITING
Malaria (Plasmodium Falciparum)
Victoria Biomedical Research Institute
 2026-01-20 PHASE2
NCT04598009 RECRUITING
Melanoma Stage III; Melanoma Stage IV
University of California, San Francisco
 2021-03-03 PHASE2
NCT05367765 NOT_YET_RECRUITING
CML, Chronic Phase
Jiangsu Hansoh Pharmaceutical Co., Ltd.
 2022-04-30 PHASE4
NCT06326346 RECRUITING
Gastrointestinal Stromal Tumors
Asan Medical Center
 2024-11-20 PHASE2
NCT06889168 RECRUITING
Lymphangioleiomyomatosis (LAM); Lymphangioleiomyomatosis
Columbia University
 2025-10-20 PHASE1
NCT05245968 ACTIVE_NOT_RECRUITING
Gastrointestinal Stromal Tumors
Taiho Pharmaceutical Co., Ltd.
 2021-12-01 PHASE1
NCT01991379 ACTIVE_NOT_RECRUITING
Gastrointestinal Stromal Tumor (GIST)
Memorial Sloan Kettering Cancer Center
 2013-11 PHASE1; PHASE2
NCT06090669 RECRUITING
Inherited Bone Marrow Failure Syndrome; Familial Platelet Disorder With Predisposition to Myeloid Malignancies
National Cancer Institute (NCI)
 2023-12-19 PHASE1
NCT05970900 NOT_YET_RECRUITING
Gastrointestinal Stromal Tumor of Rectum
Fujian Medical University Union Hospital
 2023-10-01 PHASE3
NCT04423185 RECRUITING
Rare Tumor
Cancer Institute and Hospital, Chinese Academy of Medical Sciences
 2020-08-15 PHASE2
NCT07022743 ACTIVE_NOT_RECRUITING
Chronic Myeloid Leukemia (CML)
Obafemi Awolowo University
 2025-07-01 PHASE2
NCT02413736 ACTIVE_NOT_RECRUITING
Sarcoma
Heikki Joensuu
 2015-05 PHASE3
NCT04147533 ACTIVE_NOT_RECRUITING
Chronic Myeloid Leukemia, Chronic Phase; Withdrawal;Drug
Masaryk University
 2020-06-16 PHASE2
NCT01742299 COMPLETED
GIST and CML
Novartis Pharmaceuticals
 2013-03-26 PHASE4
NCT06626984 UNKNOWN
Sepsis; Fluid Overload; Endothelial Dysfunction; Microcirculation
Belfast Health and Social Care Trust
 2024-12-01 PHASE1; PHASE2
NCT02735707 RECRUITING
Community-acquired Pneumonia, Influenza, COVID-19
UMC Utrecht
 2016-04-11 PHASE3
NCT05751733 RECRUITING
Gastrointestinal Stromal Tumors
Xiangya Hospital of Central South University
 2023-02-01
NCT03193281 UNKNOWN
Chronic Myeloid Leukemia
University of Auckland, New Zealand
 2017-07-17 PHASE2
NCT03844360 RECRUITING
Hematological Neoplasms
Wei Zhao
 2016-01-31 PHASE4
NCT05413915 TERMINATED
Chronic Myeloid Leukemia; Chronic Myeloid Leukemia, BCR/ABL-Positive; Chronic Myeloid Leukemia in Remission
Sarit Assouline
 2023-11-01 PHASE3
NCT01316250 COMPLETED
Chronic Myelogenous Leukemia
American University of Beirut Medical Center
 2010-08
NCT04129931 COMPLETED
Asthma
University of North Carolina, Chapel Hill
 2019-12-19 PHASE2
NCT04578847 UNKNOWN
Chronic Myeloid Leukemia; Chronic Myeloid Leukemia in Remission; BCR-ABL Positive Chronic Myelogenous Leukemia
National Research Center for Hematology, Russia
 2020-01-15 PHASE2
NCT03944304 COMPLETED
Gastrointestinal Stromal Tumors
Asan Medical Center
 2019-05-27 PHASE2
NCT05009927 RECRUITING
Metastatic Gastrointestinal Stromal Tumor (GIST); C-KIT Mutation; Advanced Gastrointestinal Stromal Tumor (GIST)
Centre Leon Berard
 2022-01-03 PHASE2
NCT01541709 UNKNOWN
Gastrointestinal Stromal Tumors
Asan Medical Center
 2012-03 PHASE2
NCT05220280 UNKNOWN
Covid19; Coronavirus Disease 2019; SARS-CoV-2 Acute Respiratory Disease
Clinical Urology and Epidemiology Working Group
 2022-02-06 PHASE4
NCT02881086 COMPLETED
Acute Lymphoblastic Leukemia; Lymphoblastic Lymphoma
Goethe University
 2016-08 PHASE3
NCT04709731 UNKNOWN
Chronic Myeloid Leukemia (CML)
Associazione Italiana Pazienti Leucemia Mieloide Cronica
 2021-02-01 PHASE2
NCT04546074 UNKNOWN
Melanoma
Keio University
 2020-09-14 PHASE1; PHASE2
NCT03997903 TERMINATED
Sickle Cell Disease
Indiana University
 2020-02-26 PHASE1; PHASE2
NCT04126681 COMPLETED
Chronic Myeloid Leukemia, Chronic Phase
Ascentage Pharma Group Inc.
 2019-10-21 PHASE2
NCT03469011 TERMINATED
Papillary Thyroid Cancer
AHS Cancer Control Alberta
 2018-09-18 PHASE1
NCT03654768 ACTIVE_NOT_RECRUITING
Chronic Phase Chronic Myelogenous Leukemia, BCR-ABL1 Positive
SWOG Cancer Research Network
 2018-10-24 PHASE2
NCT04416750 UNKNOWN
Pulmonary Arterial Hypertension
Imperial College London
 2021-01-20 PHASE2
NCT04394416 TERMINATED
COVID-19
University of Maryland, Baltimore
 2020-06-02 PHASE3
NCT02852486 COMPLETED
Leukemia, Chronic Myeloid
University of Campinas, Brazil
 2016-06-22 PHASE2
NCT04688983 UNKNOWN
Acute Lymphoblastic Leukemia, Adult
Cardiff University
 2021-01 PHASE2
NCT02365441 UNKNOWN
Gastrointestinal Stromal Tumour
Australasian Gastro-Intestinal Trials Group
 2015-06-30 PHASE2
NCT02326311 COMPLETED
Leukemia, Chronic Myeloid
Azienda Socio Sanitaria Territoriale degli Spedali Civili di Brescia
 2015-06-10 PHASE3
NCT02260505 COMPLETED
Gastrointestinal Stromal Tumors; Resected Gastrointestinal Stromal Tumors; Non-metastatic; High Risk of Recurrence; KIT Gene Mutation
Centre Leon Berard
 2014-12-24 PHASE3
NCT05132738 UNKNOWN
Gastrointestinal Stromal Tumors
RenJi Hospital
 2021-08-01
NCT04971226 ACTIVE_NOT_RECRUITING
Chronic Myeloid Leukemia (CML) Philadelphia Chromosome Positive
Novartis Pharmaceuticals
 2021-10-06 PHASE3
NCT00044304 ACTIVE_NOT_RECRUITING
Eosinophilic Myeloid Neoplasm; Hypereosinophilic Syndrome
National Institute of Allergy and Infectious Diseases (NIAID)
 2002-09-26 PHASE2
NCT04677439 UNKNOWN
Flumatinib; Chronic Myeloid Leukemia, Chronic Phase; Imatinib
Shenzhen Second People's Hospital
 2021-01-01 PHASE4
NCT04933526 UNKNOWN
Chronic Myeloid Leukemia in Chronic Phase
Shenzhen Second People's Hospital
 2021-07-01 PHASE4
NCT04138381 UNKNOWN
Maximum Tolerated Dose; GIST; Metastatic Adult Soft Tissue Sarcoma; Drug Toxicity; Drug Use
Grupo Espanol de Investigacion en Sarcomas
 2019-08-16 PHASE1; PHASE2
NCT03722420 ACTIVE_NOT_RECRUITING
Chronic Myeloid Leukemia, Chronic Phase
Il-Yang Pharm. Co., Ltd.
 2018-12-28 PHASE3
NCT05274438 UNKNOWN
Advanced Melanoma
Peking University Cancer Hospital & Institute
 2021-01-26 PHASE2
NCT02602314 UNKNOWN
Chronyc Myeloid Leukemia
Gruppo Italiano Malattie EMatologiche dell'Adulto
 2016-11-11 PHASE4
NCT05071482 TERMINATED
Acute Leukemia
Institute of Hematology & Blood Diseases Hospital, China
 2021-09-16 PHASE4
NCT03674099 UNKNOWN
Multiple Sclerosis
Tomas Olsson
 2018-10-01 PHASE2
NCT04903730 COMPLETED
Pulmonary Arterial Hypertension
Aerami Therapeutics
 2021-05-24 PHASE1
NCT01491763 UNKNOWN
Acute Lymphoblastic Leukemia Ph Positive
PETHEMA Foundation
 2008-01 PHASE4
NCT05623774 Recruiting
CML
Inhibikase Therapeutics Inc.
 2022-12-16 Phase 1
NCT02924714 SUSPENDED
Gastrointestinal Stromal Tumor
Oslo University Hospital
 2017-01
NCT04041674 WITHDRAWN
HIV Infections
National Institute of Allergy and Infectious Diseases (NIAID)
 2022-03-01 PHASE1
NCT03589326 ACTIVE_NOT_RECRUITING
Philadelphia Chromosome Positive Acute Lymphoblastic Leukemia (Ph+ALL)
Takeda
 2018-10-04 PHASE3
NCT04633122 COMPLETED
Gastrointestinal Stromal Tumor(GIST)
Zai Lab (Shanghai) Co., Ltd.
 2020-11-25 PHASE2
NCT04043676 UNKNOWN
Chronic Myeloid Leukemia
Fundación Teófilo Hernando, Spain
 2019-04-30 PHASE2
NCT04409223 TERMINATED
Gastrointestinal Stromal Tumors
Jiangsu HengRui Medicine Co., Ltd.
 2020-09-12 PHASE3
NCT04794088 TERMINATED
ARDS; Acute Respiratory Distress Syndrome; Covid19; Endothelial Dysfunction; Pulmonary Edema
Dr. Jurjan Aman
 2021-03-14 PHASE2
NCT05224128 UNKNOWN
Liver Fibrosis
Research Institute for Gastroenterology and Liver Diseases (RIGLD)
 2021-02-20 PHASE1; PHASE2
NCT02001818 COMPLETED
Chronic Myeloid Leukaemia
Australasian Leukaemia and Lymphoma Group
 2014-04-11 PHASE2
NCT02638428 UNKNOWN
Relapsed Pediatric Solid Tumor; Refractory Pediatric Solid Tumor; Relapsed Pediatric AML; Refractory Pediatric AML
Samsung Medical Center
 2015-12 PHASE2
NCT03578367 COMPLETED
CML; Chronic Myelogenous Leukemia; Leukemia, Myeloid Chronic; Hematologic Diseases
Novartis Pharmaceuticals
 2018-11-22 PHASE2
NCT04042597 UNKNOWN
Effect of Drugs; Quality of Life; Chordoma; Advanced Cancer
Peking University People's Hospital
 2019-07-18 PHASE2
NCT02081378 COMPLETED
Chronic Myelogenous Leukemia; Philadelphia Chromosome-positive Acute Lymphoblastic Leukemia
Novartis Pharmaceuticals
 2014-04-24 PHASE1
NCT04346147 UNKNOWN
COVID-19 Pneumonia
Hospital Universitario de Fuenlabrada
 2020-05-07 PHASE2
NCT03862768 UNKNOWN
Gastrointestinal Stromal Tumors; Surgery
Shanghai Zhongshan Hospital
 2019-07
NCT03023046 COMPLETED
Acute Lymphoblastic Leukemia; Lymphoblastic Lymphoma
University of Washington
 2017-02-23 PHASE2
NCT02644525 TERMINATED
Loiasis
National Institute of Allergy and Infectious Diseases (NIAID)
 2019-09-16 PHASE2
NCT04357613 UNKNOWN
SARS Virus
Versailles Hospital
 2020-09-01 PHASE2
NCT02363361 UNKNOWN
Cervical Spinal Cord Injury
Professor Mikael Svensson, MD PhD
 2018-04 PHASE2
NCT01694277 COMPLETED
Gastrointestinal Stromal Tumors
AB Science
 2012-04 PHASE3
NCT02398825 TERMINATED
Chronic Myeloid Leukemia; Chronic Phase; Adults
Gruppo Italiano Malattie EMatologiche dell'Adulto
 2016-06-23 PHASE2
NCT01319981 COMPLETED
Leukemia
M.D. Anderson Cancer Center
 2013-03-05 PHASE2
NCT02627677 TERMINATED
Chronic Phase Chronic Myeloid Leukemia
Ariad Pharmaceuticals
 2015-12-31 PHASE3
NCT03688568 WITHDRAWN
Neurofibroma, Plexiform
Indiana University
 2018-09-01 PHASE2
NCT03291054 TERMINATED
Gastrointestinal Stromal Tumors
Columbia University
 2018-02-28 PHASE2
NCT03228303 UNKNOWN
Chronic Myeloid Leukemia
Assiut University
 2017-12-01 EARLY_PHASE1
NCT02538926 WITHDRAWN
B Acute Lymphoblastic Leukemia; B Lymphoblastic Lymphoma; Recurrent Adult Acute Lymphoblastic Leukemia; Recurrent B Lymphoblastic Lymphoma; Recurrent T Lymphoblastic Leukemia/Lymphoma; Refractory B Lymphoblastic Lymphoma; Refractory T Lymphoblastic Lymphoma; T Acute Lymphoblastic Leukemia; T Lymphoblastic Lymphoma
University of Washington
 2018-07-01 PHASE2
NCT02401815 COMPLETED
Gastrointestinal Stromal Tumors
Cogent Biosciences, Inc.
 2015-03-06 PHASE1; PHASE2
NCT03112603 COMPLETED
Graft-versus-host Disease (GVHD)
Incyte Corporation
 2017-06-29 PHASE3
NCT03515018 UNKNOWN
Leukemia, Chronic Myeloid
First Affiliated Hospital of Harbin Medical University
 2018-05-01 PHASE3
NCT02431403 UNKNOWN
Lymphoma, Non-Hodgkin
Pusan National University Hospital
 2015-02 PHASE1; PHASE2
NCT02342600 WITHDRAWN
Gastrointestinal Stromal Tumors
Sarcoma Alliance for Research through Collaboration
 2017-01 PHASE2
NCT03062436 UNKNOWN
Chronic Myeloid Leukemia; Treatment Free Remission
Command Hospital, India
 2017-08-01
NCT03426722 COMPLETED
Gastrointestinal Stromal Tumors (GISTs)
Asan Medical Center
 2018-03-01 PHASE3
NCT03205267 UNKNOWN
Chronic Myelogenous Leukaemia
University of Bonn
 2016-03 PHASE2
NCT02576080 UNKNOWN
Gastrointestinal Stromal Tumor
Assistance Publique Hopitaux De Marseille
 2015-10 PHASE3
NCT01751425 TERMINATED
Chronic Myelogenous Leukemia, BCR-ABL1 Positive; Chronic Myelogenous Leukemia, BCR-ABL1 Positive in Remission; Minimal Residual Disease; Philadelphia Chromosome Positive, BCR-ABL1 Positive Chronic Myelogenous Leukemia
M.D. Anderson Cancer Center
 2013-07-24 PHASE1
NCT03343600 TERMINATED
Patients Who Have Received Allo-HSCT
National Taiwan University Hospital
 2017-11-09 PHASE2
NCT03239886 UNKNOWN
Leukemia, Myeloid, Chronic-Phase
University of Sao Paulo General Hospital
 2016-12-15
NCT03214718 UNKNOWN
Chronic Myeloid Leukemia Patients
Assiut University
 2017-08-05
NCT02712112 COMPLETED
Gastrointestinal Stromal Tumors (GISTs)
Asan Medical Center
 2016-03-16 PHASE2
NCT02216578 COMPLETED
Metastatic Gastrointestinal Stromal Tumor
European Organisation for Research and Treatment of Cancer - EORTC
 2017-02-02 PHASE2
NCT02257541 COMPLETED
Advanced Gastrointestinal Stromal Tumor (GIST)
Memorial Sloan Kettering Cancer Center
 2014-10-02 PHASE1; PHASE2
NCT03131999 COMPLETED
Lymphangioleiomyomatosis
Medical University of South Carolina
 2018-01-23 PHASE1; PHASE2
NCT01762969 UNKNOWN
CML
Rabin Medical Center
 2013-01 PHASE2
NCT03697668 UNKNOWN
Plasmodium Falciparum Malaria (Drug Resistant)
Nurex S.r.l.
 2017-09-17 PHASE2
NCT00928525 COMPLETED
Advanced Desmoid Tumor; Advanced Chondrosarcoma
Italian Sarcoma Group
 2007-05 PHASE2
NCT02174445 TERMINATED
Chronic Myeloid Leukemia
Prof. Dr. Nikolas von Bubnoff
 2014-03 PHASE3
NCT01755325 SUSPENDED
Chronic Myelogenous Leukemia
Junmin Li
 2012-11 PHASE3
NCT00338728 COMPLETED
Anatomic Stage IV Breast Cancer AJCC v8; Estrogen Receptor Positive; KIT Positive; PDGFR Positive; Postmenopausal; Progesterone Receptor Positive; Prognostic Stage IV Breast Cancer AJCC v8
M.D. Anderson Cancer Center
 2003-10-03 PHASE2
NCT01933906 COMPLETED
Chronic Phase Chronic Myeloid Leukemia
Arbeitsgemeinschaft medikamentoese Tumortherapie
 2013-08-30 PHASE1
NCT01735968 COMPLETED
3rd Line GIST
Novartis Pharmaceuticals
 2013-02-27 PHASE1
NCT02894645 UNKNOWN
Acute Lymphoblastic Leukemia (ALL)
National University Hospital, Singapore
 2008-10 PHASE4
NCT03171389 UNKNOWN
GIST, Malignant; KIT Exon 13 Mutation; KIT Gene Mutation
Sebastian Bauer
 2017-03-22 PHASE2
NCT00812240 TERMINATED
Gastrointestinal Stromal Tumors
AB Science
 2009-01 PHASE3
NCT02495519 COMPLETED
Fibromatosis
Yonsei University
 2014-04 PHASE2
NCT01804985 COMPLETED
Chronic Myeloid Leukaemia
University of Liverpool
 2013-12 PHASE2
NCT01460693 COMPLETED
Myeloid Leukemia, Chronic, Chronic Phase
Newcastle University
 2008-08 PHASE3
NCT03328117 COMPLETED
Acute Lung Injury
Exvastat Ltd.
 2017-11-13 PHASE1
NCT01898377 TERMINATED
Chronic Graft-versus-host Disease
Seoul National University Hospital
 2013-08 PHASE2
NCT02949570 UNKNOWN
CML, Chronic Phase
Hybrigenics Corporation
 2014-02 PHASE2
NCT02812693 WITHDRAWN
Stage IIIA Skin Melanoma; Stage IIIB Skin Melanoma; Stage IIIC Skin Melanoma; Stage IV Skin Melanoma
Joanne Jeter
 2016-11-04 PHASE1; PHASE2
NCT01593254 COMPLETED
Chronic Phase Chronic Myeloid Leukemia
Bristol-Myers Squibb
 2012-09-12 PHASE2
NCT02889328 COMPLETED
Gastrointestinal Stromal Tumors (GISTs)
Asan Medical Center
 2016-09 PHASE2
NCT02891395 COMPLETED
Graft Versus Host Disease
University Hospital, Lille
 2012-12-24 PHASE2
NCT02317159 UNKNOWN
Chronic Myeloid Leukemia
Cttq
 2015-02 PHASE4
NCT02204644 COMPLETED
CML, CML-CP,MMR,TKI
Jiangsu Hansoh Pharmaceutical Co., Ltd.
 2014-06 PHASE3
NCT01343173 COMPLETED
Chronic Myeloid Leukaemia
University Hospital, Bordeaux
 2011-04-06
NCT02204722 TERMINATED
Chronic Myeloid Leukemia
Dong-A ST Co., Ltd.
 2014-10-13 PHASE4
NCT02013089 UNKNOWN
Gastrointestinal Cancers
Sun Yat-sen University
 2013-12
NCT01781975 COMPLETED
Diabetes Mellitus, Type I; Diabetes Mellitus, Insulin-Dependent, 1; Type 1 Diabetes Mellitus; Insulin-Dependent Diabetes Mellitus 1; IDDM
University of California, San Francisco
 2014-01 PHASE2
NCT01827930 TERMINATED
Leukemia, Myeloid, Chronic-Phase
Institut Bergonié
 2009-07 PHASE3
NCT00867113 COMPLETED
Gastrointestinal Stromal Tumor (GIST)
Novartis Pharmaceuticals
 2009-07-22 PHASE2
NCT01907607 COMPLETED
Advanced Gastrointestinal Stromal Tumors
Institut Bergonié
 2014-02 PHASE2
NCT01188889 WITHDRAWN
Chronic Myeloid Leukemia
University of Michigan Rogel Cancer Center
 2013-09 PHASE1; PHASE2
NCT02185937 TERMINATED
Gastrointestinal Stromal Tumor; Major Gastrectomy
Radboud University Medical Center
 2014-08 PHASE1
NCT02115672 WITHDRAWN
Chronic Myeloid Leukemia
Sheba Medical Center
 2014-11 PHASE1; PHASE2
NCT02687425 UNKNOWN
Leukemia, Myelogenous, Chronic, BCR-ABL Positive
Meng Li
 2016-02 PHASE2
NCT02115386 TERMINATED
Philadelphia Positive (Ph+) Chronic Myeloid Leukemia
Novartis Pharmaceuticals
 2015-12-17 PHASE3
NCT01771458 COMPLETED
Reccurent/Metastatic Solid Tumor Disease
Institut Curie
 2012-10 PHASE2
NCT00777036 COMPLETED
Leukemia
Bristol-Myers Squibb
 2009-03-20 PHASE2
NCT02130557 COMPLETED
Leukemia, Myelogenous, Chronic, Breakpoint Cluster Region-Abelson Proto-oncogene (BCR-ABL) Positive
Pfizer
 2014-07-15 PHASE3
NCT02086487 TERMINATED
Myeloid Leukemia, Chronic
King Abdullah International Medical Research Center
 2013-03 PHASE4
NCT01468688 COMPLETED
3rd Line GIST
Novartis Pharmaceuticals
 2012-04-20 PHASE1
NCT00764595 COMPLETED
Gastrointestinal Stromal Tumor; Metastatic Cancer
Translational Research Center for Medical Innovation, Kobe, Hyogo, Japan
 2008-10 PHASE2
NCT02687425 Unknown status
Leukemia Myelogenous Chronic BCR-ABL Positive
Meng Li|Tongji Hospital
 2016-02 Phase 2
NCT01025505 COMPLETED
Treatment; Stem Cell Transplantation
Gruppo Italiano Malattie EMatologiche dell'Adulto
 2012-06 PHASE2
NCT02303899 COMPLETED
Mesothelioma, Malignant
Istituto Clinico Humanitas
 2014-11 PHASE2
NCT00891527 COMPLETED
Pulmonary Veno Occlusive Disease
Boston Children's Hospital
 2008-10 PHASE1; PHASE2
NCT01660906 COMPLETED
Chronic Phase Chronic Myeloid Leukemia
Bristol-Myers Squibb
 2012-12 PHASE4
NCT01097694 COMPLETED
Asthma
Brigham and Women's Hospital
 2010-11 PHASE2
NCT01297777 COMPLETED
Systemic Mastocytosis
Hospital Virgen de la Salud
 2011-01 PHASE4
NCT01077544 COMPLETED
Chronic Myeloid Leukemia; Acute Lymphoblastic Leukemia
Novartis Pharmaceuticals
 2011-04-14 PHASE1
NCT00760877 COMPLETED
CHRONIC MYELOGENOUS LEUKEMIA
Novartis Pharmaceuticals
 2009-06 PHASE3
NCT01802450 UNKNOWN
Chronic Myeloid Leukemia
PETHEMA Foundation
 2013-03 PHASE2
NCT01564836 UNKNOWN
Chronic Myeloid Leukemia; Imatinib; Complete Molecular Response
Seoul St. Mary's Hospital
 2010-06
NCT00427999 COMPLETED
Prostate Cancer
Novartis Pharmaceuticals
 2007-02 PHASE2
NCT01389583 UNKNOWN
Gastrointestinal Stromal Tumor
National Health Research Institutes, Taiwan
 2011-10 PHASE2
NCT01490775 TERMINATED
Chronic Phase CML
Rex Cancer Center, Raleigh, NC
 2009-04
NCT01511289 COMPLETED
Leukemia; Leukemia, Myeloid; Leukemia, Myelogenous, Chronic, BCR-ABL Positive; Philadelphia Chromosome; Bone Marrow Diseases; Hematologic Diseases
Il-Yang Pharm. Co., Ltd.
 2011-08 PHASE3
NCT01524848 COMPLETED
Gastrointestinal Stromal Tumors
Scandinavian Sarcoma Group
 2012-02 PHASE2
NCT01309997 COMPLETED
Graft Versus Host Disease; Systemic Scleroderma
Lee, Stephanie
 2011-03 PHASE2
NCT02303899 Completed
Mesothelioma Malignant
Istituto Clinico Humanitas
 2014-11 Phase 2
NCT02129166 WITHDRAWN
Healthy Volunteers
University of Florida
 2014-09 PHASE1
NCT01275196 COMPLETED
Chronic Myeloid Leukemia
Novartis Pharmaceuticals
 2011-04 PHASE3
NCT01267695 COMPLETED
Gastrointestinal Stromal Tumor
Peking University
 2010-05 PHASE2
NCT01289028 COMPLETED
Gastrointestinal Stromal Tumors
Novartis Pharmaceuticals
 2008-11 PHASE3
NCT00038610 COMPLETED
Leukemia
M.D. Anderson Cancer Center
 2001-03 PHASE2
NCT00466726 COMPLETED
Leukemia
Gruppo Italiano Malattie EMatologiche dell'Adulto
 2007-03 PHASE2
NCT01478373 COMPLETED
Gastrointestinal Stromal Tumors
Novartis Pharmaceuticals
 2012-01 PHASE2
NCT00802841 COMPLETED
Chronic Myelogenous Leukemia
Novartis Pharmaceuticals
 2009-05 PHASE3
NCT00036738 COMPLETED
Adult Acute Lymphoblastic Leukemia in Remission; Adult B Acute Lymphoblastic Leukemia With t(9;22)(q34.1;q11.2); BCR-ABL1; Blastic Phase; Childhood Acute Lymphoblastic Leukemia in Remission; Childhood B Acute Lymphoblastic Leukemia With t(9;22)(q34.1;q11.2); BCR-ABL1; Chronic Myelogenous Leukemia, BCR-ABL1 Positive; Chronic Phase of Disease; Recurrent Adult Acute Lymphoblastic Leukemia; Recurrent Childhood Acute Lymphoblastic Leukemia; Recurrent Disease
Fred Hutchinson Cancer Center
 2001-07-13 PHASE2
NCT01400074 UNKNOWN
Chronic Myeloid Leukemia
Seoul St. Mary's Hospital
 2009-01 PHASE3
NCT00509093 COMPLETED
Leukemia
Case Comprehensive Cancer Center
 2008-10 PHASE2
NCT00793871 COMPLETED
Gastrointestinal Neoplasms, Gastrointestinal Stromal Tumors
Pfizer
 2008-11 PHASE4
NCT00327678 COMPLETED
Leukemia, Lymphocytic
Assistance Publique - Hôpitaux de Paris
 2006-05 PHASE3
NCT01117987 TERMINATED
Pulmonary Arterial Hypertension
Novartis Pharmaceuticals
 2010-04 PHASE3
NCT01172548 COMPLETED
Gastrointestinal Stromal Tumors
Novartis Pharmaceuticals
 2008-08 PHASE2
NCT00458848 COMPLETED
Leukemia
Gruppo Italiano Malattie EMatologiche dell'Adulto
 2004-10 PHASE2
NCT02103322 COMPLETED
Chronic Myeloid Leukemia; Gastrointestinal Stromal Tumor
Amneal Pharmaceuticals, LLC
 2014-02 PHASE2; PHASE3
NCT00402766 COMPLETED
Mesothelioma
M.D. Anderson Cancer Center
 2006-08 PHASE1
NCT01175109 UNKNOWN
Chordoma
Deric M Park MD
 2011-10 PHASE1
NCT01043874 COMPLETED
Philadelphia Chromosome Positive; Chronic Myelogenous Leukemia in Chronic Phase
Novartis Pharmaceuticals
 2009-12 PHASE4
NCT00702403 COMPLETED
Accelerated Phase Chronic Myelogenous Leukemia; Adult Acute Lymphoblastic Leukemia in Remission; Blastic Phase Chronic Myelogenous Leukemia; Childhood Acute Lymphoblastic Leukemia in Remission; Childhood Chronic Myelogenous Leukemia; Chronic Myelogenous Leukemia, BCR-ABL1 Positive; Chronic Phase Chronic Myelogenous Leukemia; Philadelphia Positive Adult Acute Lymphoblastic Leukemia; Philadelphia Positive Childhood Acute Lymphoblastic Leukemia; Recurrent Adult Acute Lymphoblastic Leukemia; Recurrent Childhood Acute Lymphoblastic Leukemia; Relapsing Chronic Myelogenous Leukemia; Untreated Adult Acute Lymphoblastic Leukemia; Untreated Childhood Acute Lymphoblastic Leukemia
Fred Hutchinson Cancer Center
 2008-08-14 PHASE1; PHASE2
NCT00470470 COMPLETED
Acral Lentiginous Malignant Melanoma; Recurrent Melanoma; Stage IIIA Melanoma; Stage IIIB Melanoma; Stage IIIC Melanoma; Stage IV Melanoma
National Cancer Institute (NCI)
 2007-04 PHASE2
NCT01782508 UNKNOWN
Melanoma
Peking University Cancer Hospital & Institute
 2012-08 PHASE2
NCT00580281 COMPLETED
Gastric Cancer; Leukemia; Chronic Myelogenous Leukemia
Memorial Sloan Kettering Cancer Center
 2006-11
NCT01281865 COMPLETED
Adult Synovial Sarcoma; Recurrent Adult Soft Tissue Sarcoma; Stage III Adult Soft Tissue Sarcoma; Stage IV Adult Soft Tissue Sarcoma
National Cancer Institute (NCI)
 2011-01 PHASE1; PHASE2
NCT00538109 COMPLETED
Leukemia, Myeloid, Chronic
King Faisal Specialist Hospital & Research Center
 2007-10
NCT01650805 TERMINATED
Chronic Myeloid Leukemia
Ariad Pharmaceuticals
 2012-06 PHASE3
NCT00415857 TERMINATED
Leukemia
M.D. Anderson Cancer Center
 2006-12 PHASE2
NCT00476190 COMPLETED
Acute Lymphoblastic Leukemia
Dana-Farber Cancer Institute
 2007-04 PHASE2
NCT01898377 Terminated
Chronic Graft-versus-host Disease
Seoul National University Hospital
 2013-08 Phase 2
NCT01819389 COMPLETED
Leukemia, Myeloid, Chronic, BCR-ABL Positive
Hospital Universitario Dr. Jose E. Gonzalez
 2012-10 PHASE3
NCT01391611 TERMINATED
Gastrointestinal Stromal Tumor (GIST)
Kristen Ganjoo
 2011-07 PHASE2
NCT00237185 COMPLETED
Unresectable or Metastatic Malignant Gastrointestinal Stromal Tumor (GIST)
Novartis Pharmaceuticals
 2000-06 PHASE2
NCT01221376 UNKNOWN
Chronic Myeloid Leukemia (CML) With Philadelphia Chromosome-positive (Ph+)
Renato Melaragno
 2011-02 PHASE2
NCT01243489 COMPLETED
Chronic Myelogenous Leukemia (CML)
Gesellschaft fur Medizinische Innovation - Hamatologie und Onkologie mbH
 2010-10 PHASE4
NCT01795716 COMPLETED
Chronic Myeloid Leukemia
Chia Tai Tianqing Pharmaceutical Group Co., Ltd.
 2012-09 PHASE1
NCT00415909 TERMINATED
Chronic Myelogenous Leukemia
M.D. Anderson Cancer Center
 2006-12 PHASE2
NCT00171158 COMPLETED
Philadelphia Chromosome Positive CML
Novartis Pharmaceuticals
 1999-07-26 PHASE2
NCT01294202 COMPLETED
Gastrointestinal Stromal Tumor (GIST)
Astex Pharmaceuticals, Inc.
 2011-03 PHASE2
NCT01440959 COMPLETED
Gastrointestinal Stromal Tumors
Asan Medical Center
 2011-09 PHASE2
NCT01404715 COMPLETED
Healthy
University of California, San Francisco
 2011-10 PHASE1
NCT01005914 TERMINATED
Leukemia
OHSU Knight Cancer Institute
 2009-06 PHASE2
NCT01312818 TERMINATED
Acute Lymphoblastic Leukemia
Masonic Cancer Center, University of Minnesota
 2011-06 PHASE2
NCT00882206 TERMINATED
Leukemia; Lymphoma
Masonic Cancer Center, University of Minnesota
 2009-04 PHASE2
NCT02891395 Completed
Graft Versus Host Disease
University Hospital Lille|Novartis
 2012-12-24 Phase 2
NCT00732784 COMPLETED
Healthy
Jan Beumer
 2008-11 PHASE1
NCT00510354 COMPLETED
Progressive Gastrointestinal Stromal Tumor
Novartis Pharmaceuticals
 2006-10 PHASE4
NCT01392469 COMPLETED
Pulmonary Arterial Hypertension
Novartis Pharmaceuticals
 2011-04-20 PHASE3
NCT01206088 COMPLETED
CML; Nilotinib; Imatinib Resistant; Imatinib Intolerant
Novartis Pharmaceuticals
 2009-02 PHASE4
NCT00751036 TERMINATED
Gastrointestinal Stromal Tumors
Novartis Pharmaceuticals
 2009-06 PHASE3
NCT01751919 COMPLETED
Chronic Myeloid Leukemia; Gastrointestinal Stromal Tumor
Dong-A ST Co., Ltd.
 2012-05 PHASE1
NCT00372476 COMPLETED
Breast Cancer
Novartis Pharmaceuticals
 2006-06 PHASE4
NCT01068769 COMPLETED
Gastrointestinal Stromal Tumor
Suzanne George, MD
 2010-02 PHASE2
NCT01503502 UNKNOWN
Myelogenous Leukemia, Chronic
Jiangsu HengRui Medicine Co., Ltd.
 2011-08 PHASE2
NCT00866736 COMPLETED
Chronic Myeloid Leukemia
Kanto CML Study Group
 2009-03 PHASE2
NCT00760981 COMPLETED
Graft vs Host Disease
David Miklos
 2008-09 PHASE1
NCT00039377 COMPLETED
Adult Acute Lymphoblastic Leukemia in Remission
National Cancer Institute (NCI)
 2002-04 PHASE2
NCT01383447 TERMINATED
Philadelphia Chromosome Positive Adult Precursor Acute Lymphoblastic Leukemia; Recurrent Adult Acute Lymphoblastic Leukemia
National Cancer Institute (NCI)
 2010-10 PHASE1; PHASE2
NCT00055874 COMPLETED
Leukemia
Heidelberg University
 2002-06 PHASE3
NCT01227135 UNKNOWN
Leukemia
Lynn McMahon
 2010-03 PHASE2
NCT01926548 COMPLETED
Healthy
HK inno.N Corporation
 2012-02 PHASE1
NCT00333840 COMPLETED
Chronic Myelogenous Leukemia
Novartis Pharmaceuticals
 2000-06 PHASE3
NCT00510653 COMPLETED
Ovarian Cancer
M.D. Anderson Cancer Center
 2002-03 PHASE2
NCT00424385 COMPLETED
Prostate Cancer
Oncology Specialists, S.C.
 2007-01 PHASE1
NCT00786812 COMPLETED
Chronic Myeloid Leukemia
Novartis Pharmaceuticals
 2008-08 PHASE4
NCT01483014 COMPLETED
Gastrointestinal Stromal Tumors
Novartis Pharmaceuticals
 2008-06 PHASE2
NCT00555581 COMPLETED
Systemic Sclerosis
Hospital for Special Surgery, New York
 2007-08 PHASE2
NCT00478985 COMPLETED
Myeloid Leukemia, Chronic
University Hospital, Bordeaux
 2007-06
NCT01673009 COMPLETED
Neurofibromatosis
Indiana University
 2006-05 PHASE2
NCT01039519 COMPLETED
Gastrointestinal Stromal Tumor
Synta Pharmaceuticals Corp.
 2010-01 PHASE2
NCT00845221 COMPLETED
Chronic Myeloid Leukemia
Poitiers University Hospital
 2004-07 PHASE4
NCT01110668 COMPLETED
Gastrointestinal Stromal Tumor
Novartis Pharmaceuticals
 2008-09 PHASE2
NCT01506336 COMPLETED
Gastro Intestinal Stromal Tumor
AB Science
 2008-10 PHASE2
NCT02480608 COMPLETED
Leukemia, Myelogenous, Chronic, BCR-ABL Positive
University of Leipzig
 2004-04 PHASE1; PHASE2
NCT00049127 COMPLETED
Adult Anaplastic Oligodendroglioma; Adult Mixed Glioma; Adult Oligodendroglioma; Recurrent Adult Brain Neoplasm
Alliance for Clinical Trials in Oncology
 2003-06 PHASE1; PHASE2
NCT00268229 COMPLETED
Leukemia
The Cleveland Clinic
 2003-07 PHASE1
NCT01216085 COMPLETED
CML; Imatinib
Novartis Pharmaceuticals
 2010-08 PHASE2
NCT01011075 COMPLETED
Non-small Cell Lung Cancer
New Mexico Cancer Research Alliance
 2009-08 PHASE2
NCT00424515 COMPLETED
Mucosal Melanoma; Acral/Lentiginous Melanoma; Chronically Sun Damaged Melanomas
Dana-Farber Cancer Institute
 2006-07 PHASE2
NCT00500188 COMPLETED
Gastrointestinal Stromal Tumors
M.D. Anderson Cancer Center
 2003-07 PHASE2
NCT01031628 TERMINATED
Gastrointestinal Stromal Tumors
Sarcoma Alliance for Research through Collaboration
 2010-01 PHASE3
NCT00702689 COMPLETED
Sclerotic Graft Versus Host Disease; Imatinib Mesylate
National Cancer Institute (NCI)
 2008-12-15 PHASE2
NCT01131325 TERMINATED
CML; Philadelphia Chromosome Positive (Ph+); Chronic Myelogenous Leukemia Chronic Phase(CML-CP) Patients With Low Imatinib Trough Levels
Novartis Pharmaceuticals
 2010-10-21 PHASE4
NCT00022490 TERMINATED
Leukemia
OHSU Knight Cancer Institute
 2001-06 PHASE2
NCT00902174 COMPLETED
Pulmonary Arterial Hypertension
Novartis Pharmaceuticals
 2009-09 PHASE3
NCT01066468 TERMINATED
Chronic Myeloid Leukemia (CML); Philadelphia Chromosome Positive Acute Lymphoblastic Leukemia (Ph+ ALL); Other Glivec/Gleevec Indicated Hematological Disorders (HES, CEL, MDS/ MPN)
Novartis Pharmaceuticals
 2010-10 PHASE1
NCT01046487 COMPLETED
Cancer
Centre Oscar Lambret
 2009-02-09 PHASE1
NCT00667953 TERMINATED
Melanoma; Advanced Melanoma
Abramson Cancer Center at Penn Medicine
 2003-01 PHASE1; PHASE2
NCT00314873 COMPLETED
Thymic Carcinoma
Indiana University
 2006-04 PHASE1
NCT00852566 COMPLETED
Chronic Myeloid Leukemia
Norwegian University of Science and Technology
 2009-03 PHASE2
NCT00441155 COMPLETED
Gastrointestinal Stromal Tumors
Novartis Pharmaceuticals
 2006-11 PHASE1
NCT00193258 COMPLETED
Clear Cell Renal Cell Carcinoma
SCRI Development Innovations, LLC
 2004-06 PHASE1; PHASE2
NCT00881049 COMPLETED
Metastatic Melanoma
Peking University
 2008-12 PHASE2
NCT00390156 COMPLETED
Unspecified Adult Solid Tumor
University of California, San Francisco
 2006-08 PHASE1
NCT00981942 COMPLETED
Nephrogenic Systemic Fibrosis
University of Aarhus
 2009-09 PHASE3
NCT01743300 COMPLETED
Healthy
Leiden University Medical Center
 2007-07 PHASE1
NCT00858806 COMPLETED
Chronic Myeloid Leukemia
Università degli Studi di Brescia
 2008-04 PHASE2
NCT00744081 COMPLETED
AML
Goethe University
 2004-07 PHASE2
NCT01091207 COMPLETED
Gastrointestinal Stromal Tumors
Samsung Medical Center
 2009-11 PHASE2
NCT01048320 COMPLETED
Advanced Pancreatic Cancer
Royal Marsden NHS Foundation Trust
 2006-07 PHASE1
NCT00455559 COMPLETED
Gastrointestinal Stromal Tumors
AEterna Zentaris
 2006-08 PHASE2
NCT00124748 TERMINATED
Leukemia, Myeloid, Chronic Phase
Novartis Pharmaceuticals
 2005-06 PHASE3
NCT00573378 TERMINATED
Chronic Myeloid Leukemia
University of Michigan Rogel Cancer Center
 2007-09 PHASE2
NCT00161213 COMPLETED
Pancreatic Cancer
University of Medicine and Dentistry of New Jersey
 2005-09 PHASE2
NCT00506831 COMPLETED
Scleroderma, Systemic
Stanford University
 2007-07 PHASE1; PHASE2
NCT00574873 COMPLETED
Chronic Myeloid Leukemia
Pfizer
 2008-02-05 PHASE3
NCT00075400 COMPLETED
Recurrent Uterine Sarcoma; Uterine Carcinosarcoma
National Cancer Institute (NCI)
 2004-01 PHASE2
NCT01316458 COMPLETED
Prostatic Neoplasm; Genital Neoplasms, Male; Neoplasms, Abdominal; Urogenital Neoplasms; Genital Diseases, Male; Prostatic Diseases; Antineoplastic Agents; Imatinib
Novartis Pharmaceuticals
 2003-06 PHASE2
NCT00376467 COMPLETED
Acute Lymphoblastic Leukemia
Gruppo Italiano Malattie EMatologiche dell'Adulto
 2001-12 PHASE2
NCT01011998 WITHDRAWN
Chronic Myelogenous Leukemia
New Mexico Cancer Research Alliance
 2009-09 PHASE2
NCT00573326 UNKNOWN
Systemic Sclerosis
Azienda Ospedaliera Universitaria Policlinico
 2009-02 PHASE2
NCT00101088 TERMINATED
Accelerated Phase Chronic Myelogenous Leukemia; Blastic Phase Chronic Myelogenous Leukemia; Chronic Myelogenous Leukemia, BCR-ABL1 Positive; Chronic Phase Chronic Myelogenous Leukemia; Relapsing Chronic Myelogenous Leukemia
National Cancer Institute (NCI)
 2005-04 PHASE1
NCT00479934 COMPLETED
Scleroderma, Localized; Scleroderma, Systemic
University Hospital, Bordeaux
 2007-12 PHASE2
NCT00861471 TERMINATED
Prostate Cancer; Prostatic Neoplasms
NYU Langone Health
 2005-05 PHASE1; PHASE2
NCT00618319 COMPLETED
GIST
Biogen
 2008-02 PHASE2
NCT00840450 TERMINATED
Ovarian Cancer
NYU Langone Health
 2007-04 PHASE2
NCT01153750 COMPLETED
Advanced or Metastatic Cholangiocellular Carcinoma and Bile Duct
University Hospital Dresden
 2007-04 PHASE2
NCT00068380 COMPLETED
Recurrent Gastric Cancer; Stage IV Gastric Cancer
National Cancer Institute (NCI)
 2004-03 PHASE2
NCT00485485 COMPLETED
Head and Neck Cancer; Squamous Cell Cancer
M.D. Anderson Cancer Center
 2007-01 PHASE2
NCT00265798 ACTIVE_NOT_RECRUITING
Gastrointestinal Stromal Tumor
National Cancer Institute (NCI)
 2005-09-14 PHASE2
NCT00500110 COMPLETED
Prostate Cancer
M.D. Anderson Cancer Center
 2003-06 PHASE2
NCT00320190 TERMINATED
Leukemia, Myeloid, Chronic
Bristol-Myers Squibb
 2006-08 PHASE2
NCT00331409 COMPLETED
Kidney Cancer
OHSU Knight Cancer Institute
 2006-01 PHASE2
NCT00045734 COMPLETED
Adult Grade I Meningioma; Adult Grade II Meningioma; Adult Grade III Meningioma; Adult Meningeal Hemangiopericytoma; Adult Meningioma; Recurrent Adult Brain Tumor
National Cancer Institute (NCI)
 2003-02 PHASE2
NCT00421317 TERMINATED
Melanoma
Centre Oscar Lambret
 2005-12 PHASE2
NCT00430066 COMPLETED
Polycythemia Vera
Niguarda Hospital
 2007-02 PHASE2
NCT00499889 TERMINATED
Leukemia
M.D. Anderson Cancer Center
 2003-02 PHASE2
NCT00372567 TERMINATED
Gastrointestinal Stromal Tumor
Pfizer
 2007-06 PHASE3
NCT00471497 COMPLETED
Myelogenous Leukemia, Chronic
Novartis Pharmaceuticals
 2007-07-31 PHASE3
NCT00316953 COMPLETED
Accelerated Phase Chronic Myelogenous Leukemia; Blastic Phase Chronic Myelogenous Leukemia; Childhood Chronic Myelogenous Leukemia; Chronic Myelogenous Leukemia, BCR-ABL1 Positive; Meningeal Chronic Myelogenous Leukemia; Recurrent Childhood Acute Lymphoblastic Leukemia; Relapsing Chronic Myelogenous Leukemia; Unspecified Childhood Solid Tumor, Protocol Specific
National Cancer Institute (NCI)
 2006-03 PHASE1
NCT00573404 TERMINATED
Gastrointestinal Stromal Tumor
Vanderbilt-Ingram Cancer Center
 2007-07 PHASE1
NCT00243191 COMPLETED
Dermatofibrosarcoma Protuberans
Sarcoma Alliance for Research through Collaboration
 2006-05 PHASE2
NCT01271166 TERMINATED
Advanced Colorectal Cancer
Novartis Pharmaceuticals
 2007-10 PHASE1
NCT00446004 COMPLETED
Healthy
University of Pittsburgh
 2007-04 PHASE1
NCT00074308 COMPLETED
Recurrent Melanoma; Stage III Melanoma; Stage IV Melanoma; Unspecified Adult Solid Tumor, Protocol Specific
National Cancer Institute (NCI)
 2003-10 PHASE1; PHASE2
NCT00585221 TERMINATED
Gastrointestinal Stromal Tumors; Cancer Brain; Solid Tumors
University of Utah
 2007-07 PHASE2
NCT00529763 COMPLETED
Leukemia
Bristol-Myers Squibb
 2007-11-17 PHASE2
NCT00417807 COMPLETED
Refractory Desmoplastic Small Round Cell Tumors
Novartis Pharmaceuticals
 2005-08 PHASE1; PHASE2
NCT00482703 COMPLETED
Myeloid Leukemia, Chronic
Bristol-Myers Squibb
 2007-05 PHASE1; PHASE2
NCT01114087 COMPLETED
Chronic Myeloid Leukemia; Gastrointestinal Stromal Tumors
Assistance Publique - Hôpitaux de Paris
 2008-10
NCT00570635 COMPLETED
Gastrointestinal Stromal Tumors; Gastrointestinal Neoplasms
Exelixis
 2007-12 PHASE2
NCT00688766 TERMINATED
Gastrointestinal Stromal Tumors
Infinity Pharmaceuticals, Inc.
 2008-08 PHASE3
NCT00427583 TERMINATED
Malignant Peripheral Nerve Sheath Tumors
Novartis Pharmaceuticals
 2006-05 PHASE2; PHASE3
NCT00171977 COMPLETED
Gastrointestinal Stromal Tumors
Novartis Pharmaceuticals
 2004-07 PHASE4
NCT00558961 TERMINATED
Chronic Lymphocytic Leukemia
Jewish General Hospital
 2005-10 PHASE1; PHASE2
NCT00354913 COMPLETED
Glioblastoma; Gliosarcoma
Duke University
 2005-05 PHASE2
NCT00251225 COMPLETED
Prostate Cancer
Leonard Appleman
 2005-08 PHASE2
NCT00052494 COMPLETED
Lung Cancer
University Health Network, Toronto
 2003-04 PHASE1
NCT00483366 COMPLETED
Unspecified Adult Solid Tumor, Protocol Specific
University of Nebraska
 2006-08-15 PHASE1
NCT00028002 COMPLETED
Gastrointestinal Stromal Tumor
National Cancer Institute (NCI)
 2002-03-31 PHASE2
NCT00461929 TERMINATED
Chronic Myeloid Leukemia; Gastrointestinal Stromal Cell Tumors; Chromosome Abnormality
University Health Network, Toronto
 2005-02 PHASE4
NCT00618501 COMPLETED
Leukemia
Asan Medical Center
 2005-10 PHASE2
NCT00087152 COMPLETED
Breast Cancer
National Cancer Institute (NCI)
 2004-06 PHASE2
NCT01545427 TERMINATED
Scleroderma
London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's
 2008-04 PHASE2
NCT00594555 WITHDRAWN
Chronic Myeloid Leukemia, Blast Crisis; Acute Myeloid Leukemia
University of Cincinnati
 2007-11 PHASE2
NCT00264160 COMPLETED
Leukemia, Myeloid, Chronic
Novartis Pharmaceuticals
 2006-05 PHASE2; PHASE3
NCT00512902 COMPLETED
Alveolitis; Systemic Sclerosis
University of California, Los Angeles
 2007-08 PHASE1; PHASE2
NCT00103168 COMPLETED
Gastrointestinal Stromal Tumor
European Organisation for Research and Treatment of Cancer - EORTC
 2004-12 PHASE3
NCT00446316 COMPLETED
Healthy
University of Pittsburgh
 2007-04 PHASE1
NCT00519090 TERMINATED
Myelogenous Leukemia
Novartis Pharmaceuticals
 2007-10 PHASE3
NCT00281996 TERMINATED
Pancreatic Cancer
Northwestern University
 2005-03 PHASE1
NCT01275222 COMPLETED
Gastrointestinal Stromal Tumors
Novartis Pharmaceuticals
 2002-11-13 PHASE1; PHASE2
NCT00428909 COMPLETED
Chronic Myeloid Leukemia (CML)
Novartis Pharmaceuticals
 2006-11 PHASE1
NCT00154375 COMPLETED
Glioblastoma Multiforme; Astrocytoma
Novartis Pharmaceuticals
 2004-10 PHASE3
NCT00457743 COMPLETED
Gastrointestinal Stromal Tumors
Pfizer
 2005-01 PHASE1; PHASE2
NCT00021229 TERMINATED
Brain and Central Nervous System Tumors
National Cancer Institute (NCI)
 2001-05 PHASE1; PHASE2
NCT00782834 TERMINATED
Gastrointestinal Stromal Tumors
Fox Chase Cancer Center
 2008-07 PHASE2
NCT00362466 TERMINATED
Leukemia
Bristol-Myers Squibb
 2007-04 PHASE3
NCT00114959 TERMINATED
Myeloid Leukemia, Chronic; Myeloid Leukemia, Chronic, Accelerated-Phase; Blast Phase; Myeloid Leukemia, Chronic, Chronic-Phase
ChemGenex Pharmaceuticals
 2005-10 PHASE2
NCT00385203 COMPLETED
Gastrointestinal Stromal Tumors; Soft Tissue Sarcomas
AstraZeneca
 2006-09 PHASE2
NCT00115739 TERMINATED
Thyroid Cancer
University of Michigan Rogel Cancer Center
 2004-02 PHASE2
NCT00075218 COMPLETED
Gastrointestinal Stromal Tumor
Pfizer
 2003-12 PHASE3
NCT00193180 COMPLETED
Breast Cancer
SCRI Development Innovations, LLC
 2005-05 PHASE2
NCT00352677 COMPLETED
Chronic Myeloid Leukemia; Acute Lymphocytic Leukemia
CytRx
 2006-07 PHASE1
NCT00130195 COMPLETED
Acute Lymphoblastic Leukemia
Japan Adult Leukemia Study Group
 2002-09 PHASE2
NCT00101595 COMPLETED
Chronic Myeloid Leukemia; Leukemia, Lymphoblastic, Acute, Philadelphia-positive
Bristol-Myers Squibb
 2005-01 PHASE2
NCT00193349 COMPLETED
Lung Cancer
SCRI Development Innovations, LLC
 2002-09 PHASE2
NCT00061945 COMPLETED
Acute Undifferentiated Leukemia; B-cell Adult Acute Lymphoblastic Leukemia; B-cell Childhood Acute Lymphoblastic Leukemia; L1 Adult Acute Lymphoblastic Leukemia; L1 Childhood Acute Lymphoblastic Leukemia; L2 Adult Acute Lymphoblastic Leukemia; L2 Childhood Acute Lymphoblastic Leukemia; Philadelphia Chromosome Negative Adult Precursor Acute Lymphoblastic Leukemia; Philadelphia Chromosome Positive Adult Precursor Acute Lymphoblastic Leukemia; Philadelphia Chromosome Positive Childhood Precursor Acute Lymphoblastic Leukemia; T-cell Adult Acute Lymphoblastic Leukemia; T-cell Childhood Acute Lymphoblastic Leukemia; Untreated Adult Acute Lymphoblastic Leukemia; Untreated Childhood Acute Lymphoblastic Leukemia
National Cancer Institute (NCI)
 2003-06 PHASE1; PHASE2
NCT00787384 COMPLETED
Hypereosinophilic Syndrome; Chronic Eosinophilic Leukemia; Chronic Idiopathic Hypereosinophilia
Northern Italy Leukemia Group
 2004-10 PHASE2
NCT00025246 COMPLETED
Gastrointestinal Stromal Tumor
National Cancer Institute (NCI)
 2001-09 PHASE2
NCT00763763 COMPLETED
Leukemia, Lymphocytic, Acute; Philadelphia Chromosome; Blast Crisis; Leukemia, Myeloid, Chronic
Assistance Publique - Hôpitaux de Paris
 2004-12 PHASE2
NCT00030394 COMPLETED
Childhood Chronic Myelogenous Leukemia; Chronic Myelogenous Leukemia, BCR-ABL1 Positive; Chronic Phase Chronic Myelogenous Leukemia
National Cancer Institute (NCI)
 2002-09 PHASE2
NCT01083589 COMPLETED
Non-small Cell Lung Cancer
M.D. Anderson Cancer Center
 2005-01 PHASE2
NCT00210119 TERMINATED
Myeloid Leukemia, Chronic
Institut Bergonié
 2006-07-12 PHASE2
NCT00323791 TERMINATED
Kidney Cancer
University of Medicine and Dentistry of New Jersey
 2006-04 PHASE2
NCT00278876 COMPLETED
Sarcoma; Gastrointestinal Stromal Tumors
Asan Medical Center
 2005-04 PHASE2
NCT00036751 COMPLETED
Primary Peritoneal Cavity Cancer; Recurrent Ovarian Epithelial Cancer; Stage III Ovarian Epithelial Cancer; Stage IV Ovarian Epithelial Cancer
National Cancer Institute (NCI)
 2002-04 PHASE2
NCT00039416 COMPLETED
Chronic Myelomonocytic Leukemia; Essential Thrombocythemia; Polycythemia Vera; Primary Myelofibrosis
National Cancer Institute (NCI)
 2002-04 PHASE2
NCT00084630 COMPLETED
Adult Fibrosarcoma; Dermatofibrosarcoma Protuberans; Recurrent Adult Soft Tissue Sarcoma; Stage IV Adult Soft Tissue Sarcoma
National Cancer Institute (NCI)
 2004-05 PHASE2
NCT00171860 TERMINATED
Hypereosinophilic Syndrome
Novartis Pharmaceuticals
 2002-09 PHASE2
NCT00068783 COMPLETED
Recurrent Neuroendocrine Carcinoma of the Skin; Stage II Neuroendocrine Carcinoma of the Skin; Stage III Neuroendocrine Carcinoma of the Skin
National Cancer Institute (NCI)
 2003-10 PHASE2
NCT00062205 COMPLETED
Sarcoma
City of Hope Medical Center
 2002-06 PHASE2
NCT00171899 COMPLETED
Chronic Myelogenous Leukemia
Novartis Pharmaceuticals
 2005-04 PHASE4
NCT00085475 COMPLETED
Sarcoma
European Organisation for Research and Treatment of Cancer - EORTC
 2004-04 PHASE2
NCT00209079 TERMINATED
Gastric Adenocarcinoma
Emory University
 2004-09 PHASE2
NCT00041197 COMPLETED
Gastrointestinal Stromal Tumor
National Cancer Institute (NCI)
 2002-06 PHASE3
NCT00006343 COMPLETED
Leukemia
Novartis
 2000-06 PHASE3
NCT00245128 TERMINATED
Chronic Myeloproliferative Disorders
OHSU Knight Cancer Institute
 2005-08 PHASE2
NCT00337454 COMPLETED
Chronic Myelogenous Leukemia
Bristol-Myers Squibb
 2005-07 PHASE1; PHASE2
NCT00324077 WITHDRAWN
Myeloid Leukemia, Chronic, Chronic-Phase
Bristol-Myers Squibb
 2006-08 PHASE1
NCT00254267 COMPLETED
Advanced Gastrointestinal Stromal Tumor
Amgen
 2005-11 PHASE2
NCT00080665 COMPLETED
Breast Cancer
Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins
 2003-12 PHASE1
NCT00041041 COMPLETED
Primary Peritoneal Cavity Cancer; Recurrent Ovarian Epithelial Cancer
National Cancer Institute (NCI)
 2002-06 PHASE2
NCT00384228 COMPLETED
Chronic Myelogenous Leukemia; Acute Lymphoblastic Leukemia (Philadelphia Chromosome Positive)
Novartis Pharmaceuticals
 2005-05 PHASE1; PHASE2
NCT00154388 COMPLETED
Life Threatening Diseases
Novartis Pharmaceuticals
 2001-02 PHASE2
NCT00079313 COMPLETED
Chronic Myelomonocytic Leukemia; Chronic Myelogenous Leukemia
National Heart, Lung, and Blood Institute (NHLBI)
 2004-01-14 PHASE2
NCT00230334 TERMINATED
Eosinophilia; Hypereosinophilic Syndrome
Steven E. Coutre
 2003-06-12 PHASE2
NCT00002514 COMPLETED
Leukemia
Eastern Cooperative Oncology Group
 1993-05-07 PHASE3
NCT00123487 COMPLETED
Myeloid Leukemia, Chronic, Accelerated Phase; Leukemia, Lymphoblastic, Acute, Philadelphia-Positive
Bristol-Myers Squibb
 2005-06 PHASE3
NCT00135005 COMPLETED
Gastrointestinal Stromal Tumors
Novartis Pharmaceuticals
 2005-08 PHASE1
NCT00354523 TERMINATED
Solid Tumor; Thyroid Cancer
M.D. Anderson Cancer Center
 2004-12 PHASE1; PHASE2
NCT00390897 COMPLETED
Chronic Myeloid Leukaemia
PETHEMA Foundation
 2003-07 PHASE4
NCT00101660 COMPLETED
Chronic Myeloid Leukemia; Philadelphia-Positive Myeloid Leukemia
Bristol-Myers Squibb
 2005-02 PHASE2
NCT00422825 COMPLETED
Healthy
Novartis Pharmaceuticals
 2006-06 PHASE1
NCT00093639 COMPLETED
Leukemia
Novartis Pharmaceuticals
 2004-08 PHASE1; PHASE2
NCT00101647 COMPLETED
Chronic Myelogenous Leukemia
Bristol-Myers Squibb
 2004-12 PHASE2
NCT00091078 TERMINATED
Gastrointestinal Stromal Tumor
National Cancer Institute (NCI)
 2005-09 PHASE2
NCT00402662 TERMINATED
Metastatic Melanoma
Yale University
 2006-02 PHASE2
NCT00047502 COMPLETED
Chronic Myelogenous Leukemia
M.D. Anderson Cancer Center
 2002-11-01 PHASE1
NCT00049569 COMPLETED
L1 Childhood Acute Lymphoblastic Leukemia; L2 Childhood Acute Lymphoblastic Leukemia; Non-T, Non-B Childhood Acute Lymphoblastic Leukemia; Recurrent Childhood Acute Lymphoblastic Leukemia; T-cell Childhood Acute Lymphoblastic Leukemia
National Cancer Institute (NCI)
 2003-01
NCT00287846 COMPLETED
Desmoid Tumor
UNICANCER
 2004-09 PHASE1; PHASE2
NCT00156286 COMPLETED
Small Cell Lung Cancer
University of Michigan Rogel Cancer Center
 2002-03 PHASE2
NCT00030667 COMPLETED
Childhood Desmoplastic Small Round Cell Tumor; Childhood Synovial Sarcoma; Gastrointestinal Stromal Tumor; Lung Metastases; Recurrent Childhood Soft Tissue Sarcoma; Recurrent Ewing Sarcoma/Peripheral Primitive Neuroectodermal Tumor; Recurrent Neuroblastoma; Recurrent Osteosarcoma
National Cancer Institute (NCI)
 2002-05 PHASE2
NCT00049192 COMPLETED
Chronic Myelogenous Leukemia, BCR-ABL1 Positive; Chronic Phase Chronic Myelogenous Leukemia; Relapsing Chronic Myelogenous Leukemia
National Cancer Institute (NCI)
 2002-11 PHASE2
NCT00216112 COMPLETED
Ovarian Cancer
Daniela Matei, MD
 2003-12 PHASE2
NCT00004932 COMPLETED
Leukemia
Children's Oncology Group
 2002-01 PHASE1
NCT00154336 COMPLETED
Rheumatoid Arthritis
Novartis Pharmaceuticals
 2004-07 PHASE2
NCT00136409 COMPLETED
Myelofibrosis; Myeloid Metaplasia; Agnogenic Myeloid Metaplasia; Chronic Myelomonocytic Leukemia
Dana-Farber Cancer Institute
 2002-05 PHASE2
NCT00080678 COMPLETED
Metastatic Cancer; Prostate Cancer
M.D. Anderson Cancer Center
 2003-05 PHASE2
NCT00237172 COMPLETED
Gastrointestinal Stromal Tumors
Novartis Pharmaceuticals
 2002-09 PHASE2
NCT00053248 COMPLETED
Leukemia
OHSU Knight Cancer Institute
 2002-10 PHASE1; PHASE2
NCT00248482 COMPLETED
Lung Cancer
Barbara Ann Karmanos Cancer Institute
 2002-02 PHASE2
NCT00026169 COMPLETED
Malignant Neoplasm; Unspecified Adult Solid Tumor, Protocol Specific
National Cancer Institute (NCI)
 2001-09 PHASE1
NCT00010049 COMPLETED
Brain and Central Nervous System Tumors
Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins
 2001-02-27 PHASE1; PHASE2
NCT00081133 COMPLETED
Leukemia
Memorial Sloan Kettering Cancer Center
 2003-12 PHASE1; PHASE2
NCT00661180 COMPLETED
Chronic Myelogenous Leukemia
Bayer
 2004-01 PHASE2
NCT00025415 COMPLETED
Accelerated Phase Chronic Myelogenous Leukemia; Acute Undifferentiated Leukemia; AIDS-related Peripheral/Systemic Lymphoma; AIDS-related Primary CNS Lymphoma; Anaplastic Large Cell Lymphoma; Angioimmunoblastic T-cell Lymphoma; Atypical Chronic Myeloid Leukemia, BCR-ABL1 Negative; Blastic Phase Chronic Myelogenous Leukemia; Childhood Myelodysplastic Syndromes; Chronic Eosinophilic Leukemia; Chronic Myelogenous Leukemia, BCR-ABL1 Positive; Chronic Myelomonocytic Leukemia; Chronic Neutrophilic Leukemia; Chronic Phase Chronic Myelogenous Leukemia; de Novo Myelodysplastic Syndromes; Essential Thrombocythemia; Extramedullary Plasmacytoma; Extranodal Marginal Zone B-cell Lymphoma of Mucosa-associated Lymphoid Tissue; Gastrointestinal Stromal Tumor; Intraocular Lymphoma; Isolated Plasmacytoma of Bone; Meningeal Chronic Myelogenous Leukemia; Monoclonal Gammopathy of Undetermined Significance; Myelodysplastic/Myeloproliferative Neoplasm, Unclassifiable; Nodal Marginal Zone B-cell Lymphoma; Polycythemia Vera; Previously Treated Myelodysplastic Syndromes; Primary Central Nervous System Non-Hodgkin Lymphoma; Primary Myelofibrosis; Primary Systemic Amyloidosis; Progressive Hairy Cell Leukemia, Initial Treatment; Prolymphocytic Leukemia; Recurrent Adult Acute Lymphoblastic Leukemia; Recurrent Adult Acute Myeloid Leukemia; Recurrent Adult Burkitt Lymphoma; Recurrent Adult Diffuse Large Cell Lymphoma; Recurrent Adult Diffuse Mixed Cell Lymphoma; Recurrent Adult Diffuse Small Cleaved Cell Lymphoma; Recurrent Adult Hodgkin Lymphoma; Recurrent Adult Immunoblastic Large Cell Lymphoma; Recurrent Adult Lymphoblastic Lymphoma; Recurrent Adult T-cell Leukemia/Lymphoma; Recurrent Cutaneous T-cell Non-Hodgkin Lymphoma; Recurrent Grade 1 Follicular Lymphoma; Recurrent Grade 2 Follicular Lymphoma; Recurrent Grade 3 Follicular Lymphoma; Recurrent Mantle Cell Lymphoma; Recurrent Marginal Zone Lymphoma; Recurrent Mycosis Fungoides/Sezary Syndrome; Recurrent Small Lymphocytic Lymphoma; Refractory Chronic Lymphocytic Leukemia; Refractory Hairy Cell Leukemia; Refractory Multiple Myeloma; Relapsing Chronic Myelogenous Leukemia; Secondary Acute Myeloid Leukemia; Secondary Myelodysplastic Syndromes; Small Intestine Lymphoma; Splenic Marginal Zone Lymphoma; Stage IV Adult Burkitt Lymphoma; Stage IV Adult Diffuse Large Cell Lymphoma; Stage IV Adult Diffuse Mixed Cell Lymphoma; Stage IV Adult Diffuse Small Cleaved Cell Lymphoma; Stage IV Adult Hodgkin Lymphoma; Stage IV Adult Immunoblastic Large Cell Lymphoma; Stage IV Adult Lymphoblastic Lymphoma; Stage IV Adult T-cell Leukemia/Lymphoma; Stage IV Chronic Lymphocytic Leukemia; Stage IV Cutaneous T-cell Non-Hodgkin Lymphoma; Stage IV Grade 1 Follicular Lymphoma; Stage IV Grade 2 Follicular Lymphoma; Stage IV Grade 3 Follicular Lymphoma; Stage IV Mantle Cell Lymphoma; Stage IV Marginal Zone Lymphoma; Stage IV Mycosis Fungoides/Sezary Syndrome; Stage IV Small Lymphocytic Lymphoma; T-cell Large Granular Lymphocyte Leukemia; Unspecified Adult Solid Tumor, Protocol Specific; Untreated Adult Acute Lymphoblastic Leukemia; Untreated Adult Acute Myeloid Leukemia; Untreated Hairy Cell Leukemia; Waldenström Macroglobulinemia
National Cancer Institute (NCI)
 2001-08 PHASE1
NCT00042003 COMPLETED
Chronic Myelogenous Leukemia
Astex Pharmaceuticals, Inc.
 2002-07 PHASE2
NCT00066326 COMPLETED
Leukemia
Barbara Ann Karmanos Cancer Institute
 2003-06 PHASE1
NCT00940563 COMPLETED
Advanced Gastrointestinal Stromal Tumors
Novartis Pharmaceuticals
 2002-03 PHASE2
NCT00039364 COMPLETED
Brain and Central Nervous System Tumors
European Organisation for Research and Treatment of Cancer - EORTC
 2002-03 PHASE2
NCT00045188 COMPLETED
Male Breast Cancer; Recurrent Breast Cancer; Stage IV Breast Cancer
National Cancer Institute (NCI)
 2002-08 PHASE2
NCT00045669 COMPLETED
Head and Neck Cancer
University Health Network, Toronto
 2002-07 PHASE2
NCT00042952 TERMINATED
Ovarian Dysgerminoma; Recurrent Malignant Testicular Germ Cell Tumor; Recurrent Ovarian Germ Cell Tumor; Stage II Malignant Testicular Germ Cell Tumor; Stage II Ovarian Germ Cell Tumor; Stage III Malignant Testicular Germ Cell Tumor; Stage III Ovarian Germ Cell Tumor; Testicular Seminoma
National Cancer Institute (NCI)
 2002-06 PHASE2
NCT00045422 COMPLETED
Leukemia
Memorial Sloan Kettering Cancer Center
 2002-04 PHASE2
NCT00006052 COMPLETED
Leukemia
Novartis
 2000-06 PHASE2
NCT00006053 COMPLETED
Leukemia
Novartis
 2000-06 PHASE2
NCT00685828 UNKNOWN
Gastrointestinal Stromal Tumor
European Organisation for Research and Treatment of Cancer - EORTC
 2001-01 PHASE3
NCT00006357 COMPLETED
Endometrial Cancer; Gastrointestinal Stromal Tumor; Ovarian Cancer; Sarcoma; Small Intestine Cancer
European Organisation for Research and Treatment of Cancer - EORTC
 2000-08 PHASE1; PHASE2
NCT00122473 COMPLETED
Dermatofibrosarcoma
Dermatologic Cooperative Oncology Group
 2004-01 PHASE1; PHASE2
NCT00551252 UNKNOWN
Mesothelioma
Gruppo Italiano MEsotelioma
 2008-01 PHASE2
NCT00064285 COMPLETED
Leukemia
Virginia Commonwealth University
 2003-06 PHASE1
NCT00112775 UNKNOWN
Leukemia
Jonsson Comprehensive Cancer Center
 2005-03 PHASE2
NCT00237120 COMPLETED
Chronic Myelogenous Leukemia in Chronic Phase
Novartis
 2002-11 PHASE3
NCT00904735 UNKNOWN
Brain and Central Nervous System Tumors
Istituto Scientifico H. San Raffaele
 2009-06 PHASE2
NCT00290485 UNKNOWN
Gastrointestinal Stromal Tumors
Maisonneuve-Rosemont Hospital
 2005-08 PHASE2
NCT00510926 COMPLETED
Myeloid Leukemia, Chronic, Chronic-Phase
University of Bologna
 2004-01 PHASE2
NCT00426179 COMPLETED
Seasonal Allergic Rhinitis
Novartis
 2006-12 PHASE1; PHASE2
NCT00219752 COMPLETED
Chronic Myeloid Leukemia
Poitiers University Hospital
 2002-05 PHASE2
NCT00180921 UNKNOWN
Cancer of the Head and Neck; Carcinoma, Adenoid Cystic
Gustave Roussy, Cancer Campus, Grand Paris
 2004-07 PHASE2
NCT00031915 COMPLETED
Childhood Malignant Fibrous Histiocytoma of Bone; Sarcoma
National Cancer Institute (NCI)
 2002-06 PHASE2
NCT00131274 COMPLETED
Idiopathic Pulmonary Fibrosis; Lung Disease; Pulmonary Fibrosis
Daniels, Craig E., M.D.
 2003-04 PHASE2; PHASE3
NCT00244829 COMPLETED
Leukemia
Fred Hutchinson Cancer Center
 2004-01 PHASE1; PHASE2
NCT00219726 COMPLETED
Chronic Myeloid Leukemia
Poitiers University Hospital
 2002-05 PHASE2
NCT00146913 UNKNOWN
Chronic Myeloid Leukemia
Hospices Civils de Lyon
 2004-03 PHASE2
NCT00110058 COMPLETED
Leukemia
Fred Hutchinson Cancer Center
 2005-02 PHASE2
NCT00403156 WITHDRAWN
Choroidal Neovascularization
Vitreous -Retina- Macula Consultants of New York
 2006-11 PHASE1
NCT00514488 COMPLETED
Chronic Myeloid Leukemia
University of Bologna
 2004-06 PHASE3
NCT00042016 COMPLETED
Chronic Myelogenous Leukemia
Astex Pharmaceuticals, Inc.
 2002-07 PHASE2
NCT00327262 UNKNOWN
Chronic Myeloid Leukemia
Central European Leukemia Study Group
 2004-01 PHASE3
NCT01222013 SUSPENDED
Acute Lymphoblastic Leukemia (ALL) Philadelphia Chromosome-positive (Ph+)
Renato Melaragno
 PHASE2
NCT00041990 COMPLETED
Chronic Myelogenous Leukemia
Astex Pharmaceuticals, Inc.
 2002-07 PHASE2
NCT00199186 UNKNOWN
Philadelphia Positive Acute Lymphoblastic Leukemia; Lymphoid Blastic Phase of Chronic Myeloid Leukemia
Johann Wolfgang Goethe University Hospital
 2002-03 PHASE2
NCT00084513 COMPLETED
Unspecified Adult Solid Tumor, Protocol Specific
Fox Chase Cancer Center
 2004-08 PHASE1
NCT00149136 UNKNOWN
Acute Lymphocytic Leukemia
Hospices Civils de Lyon
 2002-08 PHASE2

(data from https://clinicaltrials.gov, updated on 2025-03-26)

Check the Imatinib (STI571) Mesylate product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.

Compliance for Clinical Use

Mechanism and Biochemical Profile

Imatinib mesylate selectively binds to the ATP-binding site of v-Abl, c-Kit, and platelet-derived growth factor receptors (PDGFR), thereby inhibiting autophosphorylation and blocking downstream oncogenic signal transduction cascades to induce cellular autophagy and apoptosis. This multi-kinase blockade effectively suppresses aberrant proliferation, providing the mechanistic rationale for its clinical activity observed in trials studying Philadelphia chromosome-positive leukemias and solid tumor malignancies.

Appendix RUO and cGMP Quality Standards

Quality Dimension RUO (Research Use Only) cGMP (Current Good Manufacturing Practice)
Clinical Applicability Prohibited in human clinical trials or medical diagnostics. Mandatory for human clinical trials (Phase I–III) and therapies.
Regulatory Status Non-regulated grade; exempt from drug manufacturing laws. Legally enforced by health authorities (e.g., FDA, EMA, NMPA).
Facility Environment Unclassified analytical or research laboratories. Validated Cleanrooms (ISO Class 5–8) with continuous monitoring.
Quality Control Basic purity and activity testing. Rigorous safety release testing (Sterility, Endotoxin, Mycoplasma).
Process Validation Basic equipment calibration; no process validation required. Full qualification (IQ/OQ/PQ) and complete batch records.
Quality Assurance Vendor self-declared without required formal QMS. Mandatory QA/QC unit, Change Control, CAPA, and vendor audits.
Regulatory Impact High risk of IND rejection if used as a critical raw material. Required for IND/NDA filings, supported by Drug Master Files (DMF).

Footnotes

Regulatory Note: Governed by FDA (21 CFR Parts 210/211/312), EMA (EudraLex Vol 4), ICH Guidelines (E6/Q7/Q9/Q10), and compendial standards (USP <71>/<85>/<1043>).

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Note: Technical data last updated: Sep 1, 2026.