CAS No. 304-20-1
Batch:
Purity:99.95
Chemical Structure
Check the
Hydralazine HCl
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
| IUPAC Name | phthalazin-1-ylhydrazine;hydrochloride | |
|---|---|---|
| CAS Number | 304-20-1 | |
| Molecular Formula |
C8H8N4.HCl |
|
| Molecular Weight (MW) | 196.64 | |
| SMILES | C1=CC=C2C(=C1)C=NN=C2NN.Cl | |
| InChIKey | ZUXNZUWOTSUBMN-UHFFFAOYSA-N |
Hydralazine HCl is a direct-acting smooth muscle relaxant and vasodilator that decreases vascular resistance primarily in arteries and arterioles. It acts by elevating intracellular cGMP levels and reducing IP3-mediated calcium release from the sarcoplasmic reticulum. Furthermore, hydralazine functions as a nitric oxide donor and induces hypoxia-inducible factor-1α (HIF-1α) stabilization via reactive oxygen species generation, promoting arterial vasodilation and decreased vascular tone. [1]
|
Concentration
Volume
Mass
|
|---|
Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| Water | 39 mg/mL |
| DMSO |
Insoluble
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO.) |
| Ethanol | Insoluble |
| Water | 1 mg/mL |
| DMSO |
Insoluble
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO.) |
| Ethanol | Insoluble |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Note: Technical data last updated: Sep 1, 2026.