CAS No. 112811-59-3
| IUPAC Name | 1-cyclopropyl-6-fluoro-8-methoxy-7-(3-methylpiperazin-1-yl)-4-oxoquinoline-3-carboxylic acid | |
|---|---|---|
| CAS Number | 112811-59-3 | |
| Molecular Formula |
C19H22FN3O4 |
|
| Molecular Weight (MW) | 375.39 | |
| SMILES | CC1CN(CCN1)C2=C(C=C3C(=C2OC)N(C=C(C3=O)C(=O)O)C4CC4)F | |
| InChIKey | XUBOMFCQGDBHNK-UHFFFAOYSA-N |
Gatifloxacin is a synthetic broad-spectrum antibiotic belonging to the fourth-generation fluoroquinolone class that targets bacterial DNA gyrase and topoisomerase IV. By inhibiting these essential type II topoisomerases, gatifloxacin blocks bacterial DNA replication, transcription, and repair processes. This target inhibition leads to double-strand DNA breaks and ultimately induces rapid bactericidal cell death across both Gram-positive and Gram-negative bacterial strains.
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Concentration
Volume
Mass
|
|---|
| Solvent | Solubility & Note |
|---|---|
| DMSO |
7 mg/mL
(18.64 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Water | Insoluble |
| Ethanol | Insoluble |
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
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