CAS No. 317318-70-0

Batch: Purity:99.71
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GW501516 (GSK-516, Cardarine) Chemical Structure
Chemical Structure
Check the GW501516 (GSK-516, Cardarine) product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.

Chemical Information

IUPAC Name 2-[2-methyl-4-[[4-methyl-2-[4-(trifluoromethyl)phenyl]-1,3-thiazol-5-yl]methylsulfanyl]phenoxy]acetic acid
CAS Number 317318-70-0
Molecular Formula

C21H18F3NO3S2
Molecular Weight (MW) 453.50
InChIKey YDBLKRPLXZNVNB-UHFFFAOYSA-N

Ordering Information

Biological Activity

GW501516 is a potent and highly selective PPARβ/δ agonist with an EC50 of 1 nM and 1000-fold selectivity over hPPARα and hPPARγ. Activation of PPARβ/δ by GW501516 stimulates fatty acid oxidation and glucose uptake in skeletal muscle via AMPK pathway regulation. Furthermore, GW501516 enhances exercise endurance and alleviates metabolic abnormalities in animal models. [1][2]

How to Prepare Stock Solution?

Concentration Volume Mass
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Solubility

Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
Solvent Solubility & Note
DMSO 91 mg/mL (200.66 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.)
Ethanol 22 mg/mL
Water Insoluble
FAQ
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
  • Preheat media/saline to 37°C.
  • Mix rapidly (pipette/vortex) upon addition.
  • For complex mixes, always add the aqueous phase last.
  • Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).

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Note: Technical data last updated: Sep 1, 2026.