CAS No. 356-12-7
| CAS Number | 356-12-7 | |
|---|---|---|
| Molecular Formula |
C26H32F2O7 |
|
| Molecular Weight (MW) | 494.52 | |
| SMILES | CC(=O)OCC(=O)C12C(CC3C1(CC(C4(C3CC(C5=CC(=O)C=CC54C)F)F)O)C)OC(O2)(C)C |
Fluocinonide is a potent glucocorticoid steroid that acts as a glucocorticoid receptor agonist to mediate anti-inflammatory responses. Upon binding to the glucocorticoid receptor, it promotes receptor nuclear translocation and modulates gene transcription, leading to the inhibition of pro-inflammatory signaling pathways such as NF-κB and AP-1. This transrepression suppresses the production of inflammatory cytokines, attenuating redness, itching, and tissue inflammation. [1]
|
Concentration
Volume
Mass
|
|---|
| Solvent | Solubility & Note |
|---|---|
| DMSO |
20 mg/mL
(40.44 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Water | Insoluble |
| Ethanol | Insoluble |
| DMSO |
69 mg/mL
(139.52 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Water | Insoluble |
| Ethanol | Insoluble |
| DMSO |
99 mg/mL
(200.19 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Water | Insoluble |
| Ethanol | Insoluble |
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
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