Fluconazole Clinical Trials

Size	Price	Qty
50mg	USD 147
1g	USD 590

Clinical Trials

Numerous clinical trials spanning Early Phase 1 through Phase 4 have evaluated fluconazole's efficacy, pharmacokinetics, and drug interactions across various recruitment statuses, including active, completed, and terminated studies. Supported by academic and pharmaceutical sponsors such as Radboud University Medical Center and Boehringer Ingelheim, these research protocols primarily investigate invasive fungal infections, cryptococcal meningitis, esophageal and vulvovaginal candidiasis, and prophylaxis in immunocompromised populations, such as those with HIV or organ transplants.

NCT Number	Recruitment	Conditions	Sponsor/Collaborators	Start Date	Phases
NCT07743593	NOT_YET_RECRUITING	Cryptococcal Antigenemia; HIV-1-infection; Cryptococcal Infection; Cryptococcal Meningitis	University of Minnesota	2027-01-05	PHASE3
NCT04930107	ACTIVE_NOT_RECRUITING	Candidiasis, Vulvovaginal	University of Manitoba	2021-12-07	EARLY_PHASE1
NCT06274554	RECRUITING	Crohn's Disease; Inflammatory Bowel Diseases	Weill Medical College of Cornell University	2024-10-04	PHASE3
NCT05421858	RECRUITING	Candidemia; Candidiasis, Invasive	Basilea Pharmaceutica	2024-12-11	PHASE3
NCT03828773	RECRUITING	Candidiasis; Fungal Infection; Acute Myeloid Leukemia; Genetic Predisposition; Aspergillosis	Bochud Pierre-Yves	2019-02-11
NCT07295314	NOT_YET_RECRUITING	Gut Microbiome; Healthy Adult Male; Antifungal Therapy	Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA)	2026-01	EARLY_PHASE1
NCT03945448	RECRUITING	Cryptococcal Meningitis	Makerere University	2019-06-20	PHASE2; PHASE3
NCT06770530	RECRUITING	Cystectomy	Rigshospitalet, Denmark	2024-06-24	PHASE4
NCT07395024	ACTIVE_NOT_RECRUITING	Healthy Volunteer	Astellas Pharma Global Development, Inc.	2026-02-03	PHASE1
NCT07341672	NOT_YET_RECRUITING	Healthy Adult Subject	Sunshine Lake Pharma Co., Ltd.	2026-12-31	PHASE1
NCT06709196	RECRUITING	Cystectomy; Bladder Cancer Requiring Cystectomy; Postoperative Infections; Antibiotic Prophylaxis; Ileal Conduit	Rigshospitalet, Denmark	2025-01-07	PHASE4
NCT07396857	RECRUITING	Cardiovascular	Université de Sherbrooke	2025-11-01
NCT07565441	NOT_YET_RECRUITING	ADPKD (Autosomal Dominant Polycystic Kidney Disease)	Jemincare	2026-05-11	PHASE1
NCT06616168	ACTIVE_NOT_RECRUITING	Bacterial Vaginosis	Danylo Halytsky Lviv National Medical University	2023-09-01	PHASE1
NCT07033962	NOT_YET_RECRUITING	Onychomycosis	Assiut University	2025-06
NCT05367089	RECRUITING	Candidiasis, Vulvovaginal; Recurrent Candidiasis of Vagina	Maastricht University Medical Center	2022-08-22	PHASE3
NCT05895162	COMPLETED	Vulvovaginal Candidiasis; Vaginal Yeast Infections	FEMPHARMA Kft.	2023-06-10
NCT07439250	COMPLETED	Healthy	Eli Lilly and Company	2026-03-02	PHASE1
NCT07342153	RECRUITING	Tinea Corporis; Dermatophytosis	Urooj Fatima	2025-11-01	PHASE4
NCT04368559	COMPLETED	Candidemia; Mycoses; Fungal Infection; Fungemia; Invasive Candidiasis; Pneumocystis; Mold Infection; Invasive Fungal Disease; Prophylaxis of Invasive Fungal Infections; Aspergillus	Mundipharma Research Limited	2020-05-11	PHASE3
NCT06922344	RECRUITING	Pityriasis Versicolor	Khyber Teaching Hospital	2025-03-01	PHASE4
NCT07311759	ACTIVE_NOT_RECRUITING	Chronic Paronychia	Cairo University	2024-08-17	PHASE3
NCT05178862	TERMINATED	Candidiasis, Invasive; Candidemia	Scynexis, Inc.	2022-08-03	PHASE3
NCT07636018	COMPLETED	Healthy Adults	Pfizer	2025-08-26	PHASE1
NCT06771063	RECRUITING	Vaginitis	Cisen Pharmaceutical CO., LTD.	2025-01-13	PHASE2
NCT06847464	COMPLETED	RSV Infection; Drug Drug Interaction (DDI)	Enanta Pharmaceuticals, Inc	2025-01-27	PHASE1
NCT05059145	UNKNOWN	Candidiasis, Vulvovaginal	Karolinska Institutet	2022-04-27	PHASE2
NCT05176379	UNKNOWN	Healthy	University of Oklahoma	2022-02-19	PHASE4
NCT06593457	COMPLETED	Healthy Volunteers	Nurix Therapeutics, Inc.	2024-08-20	PHASE1
NCT04495608	COMPLETED	Nephrolithiasis; Nephrocalcinosis; Hypercalciuria	Hospices Civils de Lyon	2021-01-13	PHASE2
NCT06345794	COMPLETED	Healthy	DICE Therapeutics, Inc., a wholly owned subsidiary of Eli Lilly and Company	2024-04-03	PHASE1
NCT06173596	COMPLETED	Healthy	Alexion Pharmaceuticals, Inc.	2024-01-10	PHASE1
NCT04626258	UNKNOWN	Candidiasis, Vulvovaginal; Recurrent Candidiasis of Vagina	Maastricht University Medical Center	2021-03-01	PHASE4
NCT06822166	COMPLETED	Interaction Drug Food	Ahon Pharmaceutical Co., Ltd.	2023-12-04	PHASE1
NCT05074602	UNKNOWN	Recurrent Vulvovaginal Candidiasis	Jiangsu HengRui Medicine Co., Ltd.	2021-09-14	PHASE3
NCT05657613	COMPLETED	Drug Interactions	CTI BioPharma	2023-01-03	PHASE1
NCT05399641	COMPLETED	Vulvovaginal Candidiasis	Scynexis, Inc.	2022-05-01	PHASE3
NCT05661591	COMPLETED	Malignant Tumor	Jiangsu HengRui Medicine Co., Ltd.	2023-02-28	PHASE1
NCT03939273	UNKNOWN	Systemic Inflammatory Response Syndrome; Postoperative Shock; Coronary Artery Disease; Extracorporeal Circulation; Complications	Radboud University Medical Center	2022-03
NCT05471063	UNKNOWN	Cryptococcal Meningitis	Peking Union Medical College Hospital	2022-08-22
NCT07557966	COMPLETED	Safety; Efficacy; Intrastromal Injection; Fluconazole; Treatment; Fungal Keratitis	Tanta University	2022-01-01
NCT04734405	UNKNOWN	Recurrent Vulvovaginal Candidiasis	ProFem GmbH	2019-10-01	PHASE2; PHASE3
NCT05130723	Recruiting	Invasive Fungal Infections	Radboud University Medical Center	2022-10-18	--
NCT05862714	COMPLETED	Tinea Versicolor	Combined Military Hospital Abbottabad	2022-03-01	PHASE1
NCT04809649	WITHDRAWN	Coccidioidomycosis; Valley Fever	George R Thompson	2021-05-15	PHASE2
NCT05478772	COMPLETED	Health Volunteers	Concert Pharmaceuticals	2022-07-11	PHASE1
NCT05602597	COMPLETED	Relapsed or Refractory Lymphoma	Hutchmed	2022-06-01	PHASE1
NCT05147727	COMPLETED	Tumor	Jiangsu HengRui Medicine Co., Ltd.	2022-03-14	PHASE1
NCT04551963	COMPLETED	B-cell Malignancies	BeiGene	2020-11-15	PHASE1
NCT05076409	COMPLETED	Healthy	Boehringer Ingelheim	2021-10-19	PHASE1
NCT05848492	COMPLETED	Invasive Candidiases	Services Institute of Medical Sciences, Pakistan	2021-05-01	PHASE3
NCT03667690	COMPLETED	Candidemia; Mycoses; Fungal Infection; Invasive Candidiases	Cidara Therapeutics Inc., a subsidiary of Merck & Co., Inc. (Rahway, New Jersey USA)	2018-10-07	PHASE3
NCT04956419	UNKNOWN	Acute Vulvovaginal Candidiasis	Jiangsu HengRui Medicine Co., Ltd.	2021-04-24	PHASE3
NCT04029116	COMPLETED	Recurrent Vulvovaginal Candidiasis	Scynexis, Inc.	2019-10-21	PHASE3
NCT04933682	COMPLETED	Healthy	Alexion Pharmaceuticals, Inc.	2021-06-07	PHASE1
NCT04464577	WITHDRAWN	Healthy Participants	Bristol-Myers Squibb	2021-04-01	PHASE1
NCT04933682	Completed	Healthy	Alexion Pharmaceuticals Inc.	2021-06-23	Phase 1
NCT04850651	COMPLETED	Healthy Subjects	Jiangsu HengRui Medicine Co., Ltd.	2021-04-16	PHASE1
NCT04702464	COMPLETED	Healthy Volunteers	Celgene	2021-01-12	PHASE1
NCT04871724	COMPLETED	RSV Infection	Enanta Pharmaceuticals, Inc	2021-03-12	PHASE1
NCT04122560	COMPLETED	Fluconazole; Candidiasis; Invasive Fungal Infections; Obesity	Radboud University Medical Center	2019-11-30	PHASE4
NCT03476317	COMPLETED	Crohn Disease	Children's Hospital of Philadelphia	2018-07-12	PHASE2
NCT04502277	UNKNOWN	Candidiasis	Sutphin Drugs	2020-09-01	EARLY_PHASE1
NCT03840616	COMPLETED	Recurrent Vulvovaginal Candidiasis	Mycovia Pharmaceuticals Inc.	2019-03-13	PHASE3
NCT03167957	WITHDRAWN	Vulvovaginal Candidiases; Yeast Infection; Vulvovaginitis; Yeast Infection Vaginal; Candidiasis, Vulvovaginal	Matinas BioPharma Nanotechnologies, Inc.	2019-12	PHASE2
NCT05140096	COMPLETED	Healthy Volunteers	Acerta Pharma BV	2020-01-03	PHASE1
NCT01503515	COMPLETED	Fungal Infection; Hematopoietic and Lymphoid Cell Neoplasm	Children's Oncology Group	2013-03-21	PHASE3
NCT03942029	COMPLETED	Healthy	Eli Lilly and Company	2019-06-21	PHASE1
NCT02532192	WITHDRAWN	Lymphoma	M.D. Anderson Cancer Center	2015-12	PHASE1
NCT02222922	COMPLETED	Neoplasms	Pfizer	2014-10-17	PHASE1
NCT03028103	COMPLETED	Diffuse Large B Cell Lymphoma; Primary Mediastinal Lymphoma; Mantle Cell Lymphoma; Advanced Solid Tumor; Marginal Zone Lymphoma	Epizyme, Inc.	2017-03-27	PHASE1
NCT04038008	COMPLETED	Bioequivalence	Pharmtechnology LLC	2019-07-26	PHASE1
NCT04193319	COMPLETED	Advanced Cancer	Jiangsu HengRui Medicine Co., Ltd.	2019-07-19	PHASE1
NCT03159845	COMPLETED	Stem Cell Transplant Complications	Azienda Ospedaliero, Universitaria Pisana	2014-01-01	PHASE2
NCT03621072	COMPLETED	Bioequivalence	Pfizer	2019-06-03	PHASE1
NCT02734862	COMPLETED	Candidemia; Mycoses; Fungal Infection; Fungemia; Invasive Candidiasis	Cidara Therapeutics Inc., a subsidiary of Merck & Co., Inc. (Rahway, New Jersey USA)	2016-07-26	PHASE2
NCT04201054	COMPLETED	Healthy Volunteers	Parc de Salut Mar	2019-03-25	PHASE1
NCT03821480	COMPLETED	Bioequivalence	Pfizer	2019-01-28	PHASE1
NCT03634345	COMPLETED	Dermatitis, Atopic	Pfizer	2018-09-12	PHASE1
NCT02765256	COMPLETED	Crohn's Disease	University of Pennsylvania	2016-08	PHASE2
NCT03610945	COMPLETED	NASH - Nonalcoholic Steatohepatitis	Enanta Pharmaceuticals, Inc	2018-07-19	PHASE1
NCT03112031	COMPLETED	Meningitis Streptococcal; Hiv; Meningitis; Meningoencephalitis	Oxford University Clinical Research Unit, Vietnam	2017-10-10	PHASE2
NCT01307579	COMPLETED	Acute Myeloid Leukemia; Adult Acute Monoblastic Leukemia; Adult Acute Monocytic Leukemia; Adult Acute Myeloid Leukemia in Remission; Adult Acute Myeloid Leukemia With Inv(16)(p13.1q22); CBFB-MYH11; Adult Acute Myeloid Leukemia With Maturation; Adult Acute Myeloid Leukemia With Minimal Differentiation; Adult Acute Myeloid Leukemia With t(16;16)(p13.1;q22); CBFB-MYH11; Adult Acute Myeloid Leukemia With t(8;21); (q22; q22.1); RUNX1-RUNX1T1; Adult Acute Myeloid Leukemia With t(9;11)(p22.3;q23.3); MLLT3-KMT2A; Adult Acute Myeloid Leukemia Without Maturation; Adult Acute Myelomonocytic Leukemia; Alkylating Agent-Related Acute Myeloid Leukemia; Childhood Acute Monoblastic Leukemia; Childhood Acute Monocytic Leukemia; Childhood Acute Myeloid Leukemia in Remission; Childhood Acute Myeloid Leukemia With Maturation; Childhood Acute Myeloid Leukemia With Minimal Differentiation; Childhood Acute Myeloid Leukemia Without Maturation; Childhood Acute Myelomonocytic Leukemia; Fungal Infection; Myeloid Neoplasm; Neutropenia; Recurrent Adult Acute Myeloid Leukemia; Recurrent Childhood Acute Myeloid Leukemia; Secondary Acute Myeloid Leukemia; Untreated Adult Acute Myeloid Leukemia; Untreated Childhood Myeloid Neoplasm	Children's Oncology Group	2011-04-04	PHASE3
NCT02663674	TERMINATED	Coccidioidomycosis	National Institute of Allergy and Infectious Diseases (NIAID)	2015-12-29	PHASE4
NCT01950507	TERMINATED	Stem Cell Transplantation; Graft vs Host Disease	National Institutes of Health Clinical Center (CC)	2014-02-20	PHASE1
NCT03253094	COMPLETED	Candida Vulvovaginitis	Scynexis, Inc.	2017-08-01	PHASE2
NCT03451110	COMPLETED	Healthy Subjects	Eisai Inc.	2018-02-05	PHASE1
NCT03002012	TERMINATED	Cryptococcosis; Cryptococcal Infections; AIDS-Related Opportunistic Infections	University of Minnesota	2017-11-15	PHASE3
NCT02624453	UNKNOWN	Cryptococcal Meningitis	ANRS, Emerging Infectious Diseases	2015-07
NCT00761267	COMPLETED	Candidemia	Pfizer	2009-02	PHASE3
NCT03135106	COMPLETED	Healthy	Janssen Research & Development, LLC	2017-04-14	PHASE1
NCT03036046	WITHDRAWN	Acute Myeloid Leukemia	F2G Ltd	2017-03	PHASE1; PHASE2
NCT02122770	COMPLETED	Advanced Solid Tumors	Millennium Pharmaceuticals, Inc.	2014-04-01	PHASE1
NCT02971007	COMPLETED	Vulvovaginitis; Yeast Infection; Yeast Infection Vaginal; Candidiasis, Vulvovaginal	Matinas BioPharma Nanotechnologies, Inc.	2016-11	PHASE2
NCT00885703	COMPLETED	Cryptococcal Meningitis; HIV Infections	National Institute of Allergy and Infectious Diseases (NIAID)	2010-04-16	PHASE1; PHASE2
NCT02733432	COMPLETED	Candidiasis, Vulvovaginal; Mycoses; Yeast Infection; Moniliasis, Vulvovaginal; Vaginitis, Monilial	Cidara Therapeutics Inc., a subsidiary of Merck & Co., Inc. (Rahway, New Jersey USA)	2016-06-08	PHASE2
NCT02183779	UNKNOWN	Raynaud Disease; Hyperemia; Cold	University Hospital, Grenoble	2014-06
NCT02679456	COMPLETED	Vulvovaginal Candidiasis	Scynexis, Inc.	2015-11	PHASE2
NCT02809768	COMPLETED	Healthy Participants	Eisai Inc.	2016-04	PHASE1
NCT02730442	COMPLETED	Invasive Aspergillosis	F2G Ltd	2016-02	PHASE1
NCT02244606	COMPLETED	Mycoses; Candidiasis, Invasive; Candidemia	Scynexis, Inc.	2014-09	PHASE2
NCT02941068	COMPLETED	Intra-abdominal Perforation	Nanjing PLA General Hospital	2012-03	PHASE2
NCT01354314	COMPLETED	HIV Associated Neurocognitive Disorder	Johns Hopkins University	2010-11	PHASE1; PHASE2
NCT01825031	COMPLETED	Human Immunodeficiency Virus	Anna Griffiths, MRC	2013-06	PHASE3
NCT02136030	UNKNOWN	Cryptococcal Meningitis	TTY Biopharm	2011-02
NCT02145832	COMPLETED	Candidiasis	Institut National de la Santé Et de la Recherche Médicale, France	2014-10	PHASE2; PHASE3
NCT01715922	UNKNOWN	Cryptococcal Meningitis; HIV	ANRS, Emerging Infectious Diseases	2012-05	PHASE2; PHASE3
NCT02079298	COMPLETED	Ductus Arteriosis, Patent; Bacterial Infections and Mycoses	Anders Rane, MD, PhD, Senior professor	2014-04	PHASE4
NCT02180828	COMPLETED	Candidiasis, Vulvovaginal	Peking University Shenzhen Hospital	2014-07	PHASE4
NCT01535469	COMPLETED	Cryptococcal Meningitis; Cryptococcus Neoformans; Cryptococcosis	University of Minnesota	2012-07-01	PHASE4
NCT01953744	TERMINATED	Cutaneous Leishmaniasis	Hospital Universitário Professor Edgard Santos	2014-02	PHASE3
NCT02325011	COMPLETED	Healthy Subjects	Jazz Pharmaceuticals	2014-11	PHASE1
NCT01891331	COMPLETED	Candidiasis, Vulvovaginal	Viamet	2013-08	PHASE2
NCT01683760	COMPLETED	Very Low Birth Weight Infant	Seoul National University Hospital	2012-09	PHASE2
NCT02275975	COMPLETED	Healthy	Kowa Research Institute, Inc.	2014-07	PHASE1
NCT01562132	TERMINATED	Cryptococcal Infection Disseminated	Yale University	2013-09	PHASE2
NCT02093728	COMPLETED	Solid Tumours	AstraZeneca	2014-04	PHASE1
NCT02997059	COMPLETED	Crohn's Disease Aggravated	University Hospital, Lille	2008-07	PHASE2
NCT01974375	UNKNOWN	Liver Transplant Recipient	Asan Medical Center	2012-08	PHASE3
NCT02180100	COMPLETED	Vulvovaginal Candidiasis	Peking University Shenzhen Hospital	2013-08	PHASE4
NCT02093390	COMPLETED	Prostate Cancer; Endometriosis	Millennium Pharmaceuticals, Inc.	2014-03	PHASE1
NCT01806623	COMPLETED	Vulvovaginal Candidiasis	Pfizer	2013-03-05	PHASE3
NCT01924299	COMPLETED	Healthy Volunteers	Eli Lilly and Company	2013-08	PHASE1
NCT00841971	COMPLETED	Mycoses; Fungemia; Central Nervous System Fungal Infections; Lung Diseases, Fungal	University of Pittsburgh	2010-02	PHASE4
NCT01447511	COMPLETED	Healthy	University of Minnesota	2009-05
NCT01772290	COMPLETED	Healthy Volunteer	Genentech, Inc.	2013-02	PHASE1
NCT01497223	COMPLETED	Vulvovaginal Candidiasis	MethylGene Inc.	2011-12	PHASE2
NCT01169402	COMPLETED	Cardiopulmonary Arrest; Fungal Infection	Michael Cohen-Wolkowiez	2010-07	PHASE1
NCT02111629	COMPLETED	Vaginal Discharge	Universidad Nacional de Colombia	2012-05	PHASE3
NCT00166166	TERMINATED	Hyperlipidemia	Emory University	2002-07	PHASE2
NCT03929861	COMPLETED	Pharmacology, Clinical	Bayer	2012-07-31	PHASE1
NCT01058174	COMPLETED	Liver Transplantation; Mycoses	Astellas Pharma Inc	2009-12-15	PHASE3
NCT01290198	COMPLETED	Healthy Volunteers	University Hospital, Grenoble	2011-02
NCT01096706	COMPLETED	Vascular Disease; Heart Disease	University of Edinburgh	2011-07
NCT01386593	COMPLETED	Metabolic Detoxication, Phase I	University Hospital, Basel, Switzerland	2011-05	PHASE1
NCT01392430	COMPLETED	HIV Infection	Chiang Mai University	2009-06
NCT00734539	COMPLETED	Candidiasis	Daniel Benjamin	2008-11	PHASE3
NCT01176058	TERMINATED	Candidemia	Pfizer	2010-12	PHASE3
NCT00964106	COMPLETED	Drug Interactions	GlaxoSmithKline	2009-08-26	PHASE1
NCT01524081	COMPLETED	Acute Appendicitis; Perforated Gastroduodenal Ulcer; Small Bowel Obstruction	The Faculty Hospital Na Bulovce	2008-07	PHASE3
NCT00537888	UNKNOWN	Pulmonary Candidiasis	Capital Medical University	2007-09	PHASE4
NCT01026714	COMPLETED	Healthy Volunteers	University Hospital, Geneva	2009-11	PHASE1; PHASE2
NCT00936182	UNKNOWN	Autism Spectrum Disorder	The Center for Autism and Related Disorders	2009-07
NCT01153724	COMPLETED	Healthy; Pulmonary Disease, Chronic Obstructive	Boehringer Ingelheim	2010-05	PHASE1
NCT00496197	COMPLETED	Candidiasis	Pfizer	2007-07	PHASE4
NCT00811928	COMPLETED	Leukopenia	Merck Sharp & Dohme LLC	2008-11	PHASE3
NCT00689338	COMPLETED	Invasive Candidiasis	Pfizer	2008-07	PHASE3
NCT00935363	WITHDRAWN	Healthy	University of California, San Francisco	2010-02	PHASE1
NCT01060566	COMPLETED	Cystic Fibrosis	Vertex Pharmaceuticals Incorporated	2010-02	PHASE1
NCT00797420	COMPLETED	Candidiasis	Daniel Benjamin	2008-11	PHASE1
NCT00911235	COMPLETED	Overactive Bladder With Symptoms of Frequency, Urgency, and Urge Urinary Incontinence	Pfizer	2009-05	PHASE1
NCT00860275	COMPLETED	Alzheimer Disease	Bristol-Myers Squibb	2009-04	PHASE1
NCT00423267	COMPLETED	Coccidioidomycosis	Merck Sharp & Dohme LLC	2007-05	PHASE3
NCT00740389	COMPLETED	HIV; AIDS; Fungal Infection	Tibotec Pharmaceuticals, Ireland	2008-09	PHASE1
NCT00304772	WITHDRAWN	Candidiasis; Sepsis	Kyoto University	2006-08	PHASE4
NCT00830856	COMPLETED	Cryptococcal Meningitis; HIV Infections	University of Zimbabwe	2006-10
NCT00145249	COMPLETED	Cryptococcal Meningitis	National Institute of Allergy and Infectious Diseases (NIAID)	2005-05	PHASE2
NCT00503542	COMPLETED	Vaginitis	Agency for Healthcare Research and Quality (AHRQ)	2007-02	EARLY_PHASE1
NCT00553137	COMPLETED	Oropharyngeal Candidiasis	Netherlands Organisation for Scientific Research	2006-11	PHASE4
NCT00170430	COMPLETED	Bacterial Diseases; Other Mycoses; Sexually Transmitted Infection	University of Washington	2003-05	PHASE3
NCT00075803	COMPLETED	Lymphoma; Infection; Leukemia	Medical College of Wisconsin	2003-11	PHASE3
NCT00189709	COMPLETED	Invasive Candidiasis; Candidemia	Astellas Pharma Inc	2004-08	PHASE3
NCT00002533	COMPLETED	Head and Neck Cancer; Infection; Oral Complications	University of Miami	1993-02	PHASE2; PHASE3
NCT00353561	COMPLETED	Diabetes Mellitus; Vulvovaginal Candidiasis	Indian Council of Medical Research	2004-06	PHASE3
NCT00666185	COMPLETED	Candidiasis, Oral	Astellas Pharma Inc	2003-08	PHASE3
NCT02195466	COMPLETED	Healthy	Boehringer Ingelheim	2003-06	PHASE1
NCT01511770	COMPLETED	Healthy	Dr. Reddy's Laboratories Limited	2002-08	PHASE1
NCT00003883	COMPLETED	Cancer	Fred Hutchinson Cancer Center	1998-10	PHASE3
NCT01511757	COMPLETED	Healthy	Dr. Reddy's Laboratories Limited	2002-06	PHASE1
NCT02181946	COMPLETED	HIV Infections	Boehringer Ingelheim	2001-05	PHASE4
NCT00001017	COMPLETED	Meningitis, Cryptococcal; HIV Infections	Pfizer		PHASE3
NCT00000708	COMPLETED	Meningitis, Cryptococcal; HIV Infections	National Institute of Allergy and Infectious Diseases (NIAID)
NCT00002446	COMPLETED	Candidiasis, Oral; HIV Infections	Schering-Plough	1998-08	PHASE3
NCT00023530	COMPLETED	Bone Marrow Transplantation; Blood Disease; Hematopoietic Stem Cell Transplantation; Leukemia; Multiple Myeloma; Myelodysplastic Syndromes; Graft vs Host Disease	National Heart, Lung, and Blood Institute (NHLBI)	2001-09
NCT00313131	COMPLETED	Bacterial Vaginosis; Candidiasis; Vaginitis	Université de Sherbrooke	2004-01	PHASE3
NCT00001107	COMPLETED	Candidiasis	National Institute of Allergy and Infectious Diseases (NIAID)		PHASE4
NCT00002074	COMPLETED	Meningitis, Cryptococcal; HIV Infections	Pfizer
NCT00056368	COMPLETED	Candidiasis	Pfizer	2003-03	PHASE3
NCT00002282	COMPLETED	Candidiasis, Oral; HIV Infections	Pfizer
NCT00002277	COMPLETED	Mycoses; HIV Infections	Pfizer		PHASE3
NCT00000951	COMPLETED	Candidiasis, Oral; HIV Infections	National Institute of Allergy and Infectious Diseases (NIAID)		PHASE4
NCT00002113	COMPLETED	Meningitis, Cryptococcal; HIV Infections	Pfizer
NCT00002399	COMPLETED	Candidiasis, Oral; HIV Infections	Schering-Plough		PHASE2
NCT00002112	COMPLETED	Candidiasis, Oral; HIV Infections	Pfizer
NCT00000744	COMPLETED	Candidiasis; Candidiasis, Esophageal; HIV Infections	National Institute of Allergy and Infectious Diseases (NIAID)
NCT00226538	COMPLETED	Healthy Volunteers	Hadassah Medical Organization	1999-08
NCT00002068	COMPLETED	Meningitis, Cryptococcal; HIV Infections	Pfizer
NCT00002038	COMPLETED	Candidiasis; Mycoses; HIV Infections	Pfizer
NCT00000639	COMPLETED	Meningitis, Cryptococcal; HIV Infections	National Institute of Allergy and Infectious Diseases (NIAID)
NCT00012467	COMPLETED	Meningitis, Cryptococcal; HIV Infections	InterMune	2000-01	PHASE2
NCT00002339	COMPLETED	Candidiasis, Esophageal; HIV Infections	Pfizer		PHASE3
NCT00000776	COMPLETED	Meningitis, Cryptococcal; HIV Infections	National Institute of Allergy and Infectious Diseases (NIAID)		PHASE2
NCT00002325	COMPLETED	Mycoses; HIV Infections; Coccidioidomycosis	Pfizer
NCT00002132	COMPLETED	Candidiasis, Esophageal; HIV Infections	Janssen Pharmaceuticals
NCT00002075	COMPLETED	Meningitis, Cryptococcal; HIV Infections	Pfizer
NCT00000676	COMPLETED	Candidiasis; Mycoses; HIV Infections	National Institute of Allergy and Infectious Diseases (NIAID)		PHASE3
NCT00002304	COMPLETED	Candidiasis, Esophageal; HIV Infections	Pfizer
NCT00004808	COMPLETED	Histoplasmosis; Sporotrichosis; Blastomycosis	National Center for Research Resources (NCRR)	1991-09	PHASE2
NCT00000826	COMPLETED	Bacterial Infections; Mycoses; HIV Infections	National Institute of Allergy and Infectious Diseases (NIAID)		PHASE1
NCT00000788	COMPLETED	Candidiasis; HIV Infections	National Institute of Allergy and Infectious Diseases (NIAID)		PHASE1
NCT00163111	COMPLETED	Candidiasis	Pfizer	1998-09	PHASE3
NCT00479947	UNKNOWN	Vaginal Candidiasis	Faith Mediplex	2007-05	PHASE1
NCT00002394	COMPLETED	Candidiasis, Oral; HIV Infections	Novartis
NCT00001065	COMPLETED	Candidiasis, Oral; HIV Infections	National Institute of Allergy and Infectious Diseases (NIAID)		PHASE2
NCT00000627	COMPLETED	HIV Infections; Histoplasmosis	National Institute of Allergy and Infectious Diseases (NIAID)
NCT00002294	COMPLETED	Meningitis, Cryptococcal; HIV Infections	Pfizer
NCT00001937	COMPLETED	Aspergillosis; Candidiasis; Fungemia; Mycoses	National Cancer Institute (NCI)	1999-11	PHASE3
NCT00002306	COMPLETED	Meningitis, Cryptococcal; HIV Infections	Pfizer
NCT00002122	COMPLETED	Mycoses; Mycobacterium Avium-Intracellulare Infection; HIV Infections	Pfizer		PHASE3
NCT00001542	COMPLETED	Acquired Immunodeficiency Syndrome; Candidiasis; Oral Candidiasis	National Institute of Allergy and Infectious Diseases (NIAID)	1996-07	PHASE4
NCT00002076	COMPLETED	Meningitis, Cryptococcal; HIV Infections	Pfizer
NCT00002077	COMPLETED	Meningitis, Cryptococcal; HIV Infections	Pfizer
NCT00002133	COMPLETED	Candidiasis, Oral; HIV Infections	Janssen, LP
NCT00004938	COMPLETED	Sporotrichosis	National Institute of Allergy and Infectious Diseases (NIAID)	1996-08	PHASE2
NCT00058682	COMPLETED	Candida; Candidiasis	National Cancer Institute (NCI)	2003-04	PHASE3
NCT00002305	COMPLETED	Meningitis, Cryptococcal; HIV Infections	Pfizer
NCT00002010	COMPLETED	Meningitis; HIV Infections	Pfizer
NCT00005920	TERMINATED	Candidiasis, Oral; HIV Infections	Merck Sharp & Dohme LLC		PHASE2
NCT00002040	COMPLETED	Meningitis, Cryptococcal; HIV Infections	Pfizer
NCT00002341	COMPLETED	Candidiasis, Oral; HIV Infections	Janssen, LP
NCT00199264	TERMINATED	Candidiasis Vulvaginitis	J. Uriach and Company	2004-06	PHASE2
NCT00645242	COMPLETED	Tinea Capitis	Pfizer	2002-11	PHASE3

(data from https://clinicaltrials.gov, updated on 2026-09-03)

Check the Fluconazole product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.

Compliance for Clinical Use

Mechanism and Biochemical Profile

Fluconazole selectively inhibits fungal lanosterol 14-alpha-demethylase, suppressing the conversion of lanosterol to ergosterol and thereby disrupting fungal cell membrane structure and permeability. This loss of membrane integrity inhibits fungal cell growth and viability, providing clinical relevance in the management and prevention of invasive fungal infections, candidiasis, and cryptococcal meningitis.

Appendix RUO and cGMP Quality Standards

Quality Dimension	RUO (Research Use Only)	cGMP (Current Good Manufacturing Practice)
Clinical Applicability	Prohibited in human clinical trials or medical diagnostics.	Mandatory for human clinical trials (Phase I–III) and therapies.
Regulatory Status	Non-regulated grade; exempt from drug manufacturing laws.	Legally enforced by health authorities (e.g., FDA, EMA, NMPA).
Facility Environment	Unclassified analytical or research laboratories.	Validated Cleanrooms (ISO Class 5–8) with continuous monitoring.
Quality Control	Basic purity and activity testing.	Rigorous safety release testing (Sterility, Endotoxin, Mycoplasma).
Process Validation	Basic equipment calibration; no process validation required.	Full qualification (IQ/OQ/PQ) and complete batch records.
Quality Assurance	Vendor self-declared without required formal QMS.	Mandatory QA/QC unit, Change Control, CAPA, and vendor audits.
Regulatory Impact	High risk of IND rejection if used as a critical raw material.	Required for IND/NDA filings, supported by Drug Master Files (DMF).

Footnotes

Regulatory Note: Governed by FDA (21 CFR Parts 210/211/312), EMA (EudraLex Vol 4), ICH Guidelines (E6/Q7/Q9/Q10), and compendial standards (USP <71>/<85>/<1043>).