CAS No. 104227-87-4
| CAS Number | 104227-87-4 | |
|---|---|---|
| Molecular Formula |
C14H19N5O4 |
|
| Molecular Weight (MW) | 321.33863 | |
| SMILES | CC(=O)OCC(CCN1C=NC2=CN=C(N=C21)N)COC(=O)C |
Famciclovir is an orally bioavailable prodrug of the guanine analogue penciclovir with antiviral activity against herpesviruses. Upon intracellular conversion to penciclovir and subsequent phosphorylation by viral thymidine kinase, penciclovir triphosphate inhibits viral DNA polymerase, thereby blocking viral DNA replication and viral propagation. Treatment with famciclovir reduces the accumulation of latent viral load within neural ganglia in post-exposure prophylaxis models. [1]
|
Concentration
Volume
Mass
|
|---|
| Solvent | Solubility & Note |
|---|---|
| DMSO |
64 mg/mL
(199.16 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Water | 64 mg/mL |
| Ethanol | 48 mg/mL |
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
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