FTY720 (Fingolimod) Hydrochloride: Selectivity & Specificity

FTY720 (Fingolimod) Hydrochloride is a potent inhibitor of S1PR1 (sub-nanomolar to nanomolar range), S1PR3 (sub-nanomolar to nanomolar range), S1PR4 (sub-nanomolar to nanomolar range), S1PR5 (sub-nanomolar to nanomolar range), S1PR2 (> 10,000 nM), PTGS2, TGFB1, ACTA2, SELP, VCAM1, NFKB, STAT3, Treg cells, NK cells, IL6, TNF, IL10, Leukocyte adhesion, NO, CD4, CD8, Circulating leukocytes, Corticospinal tract, Cingulate, OPCs, BBB permeability, Demyelination, Mature oligodendrocytes, Myelin sheaths, Neuronal cell number, Dendritic spines (~10% increase), NMDAR, AMPAR, Glutamatergic neurotransmission, TMS stimulatory effect, Peripheral blood lymphocytes, Corpus callosum, Superior longitudinal fasciculus, Mitochondrial membrane, CYCS, DIABLO, BAX, CASP8, CASP9, CASP3, ROS, CXCL5, CXCL10, CCL2, Proinflammatory cytokines, Th1 phenotype, IL17, IFNG, TGFB, B cells, Regulatory B cells, IL1B, CNS inflammation, NOS2, nitrotyrosine, Microglia polarization, Remyelination, CNS repair processes, Synaptic transmission, Synaptic degeneration, C. perfringens, B cell trafficking, IgA plasmablast maturation, Intestinal barrier integrity, Microbial dysbiosis, Intestinal immune function, Pancreatic islet immune tolerance, Autoreactive lymphocytes, Flinching behavior, Guarding behavior, Mechanical hypersensitivity, Cold allodynia, ERK, Microglia, Astrocytes, Neuroinflammation, STAT1, ABCB1, Astrogliosis, AIF1, RBFOX3, FJB, Neuronal cell death, Neuronal cell loss, LDHA, Neuronal damage, Seizure score, Neurodegeneration, MTOR, RPS6KB1, AKT, Myelination, Hippocampal myelin staining, Myelin protection, PTPRC, Spontaneous convulsions, Neuronal loss. FTY720 (Fingolimod) Hydrochloride exhibits the greatest inhibitory potency toward S1PR1, S1PR3, S1PR4, and S1PR5 (IC50 = sub-nanomolar to nanomolar range).