CAS No. 162359-56-0
| IUPAC Name | 2-amino-2-[2-(4-octylphenyl)ethyl]propane-1,3-diol;hydrochloride | |
|---|---|---|
| CAS Number | 162359-56-0 | |
| Molecular Formula |
C19H33NO2.HCl |
|
| Molecular Weight (MW) | 343.9 | |
| SMILES | CCCCCCCCC1=CC=C(C=C1)CCC(CO)(CO)N.Cl | |
| InChIKey | SWZTYAVBMYWFGS-UHFFFAOYSA-N |
FTY720 (Fingolimod) Hydrochloride is a potent immunomodulatory agent and sphingosine-1-phosphate receptor agonist upon phosphorylation to FTY720-phosphate. It promotes lymphocyte sequestration within lymph nodes, blocking auto-reactive immune cell trafficking. Additionally, FTY720 activates the tumor suppressor protein phosphatase 2A (PP2A), downregulating downstream oncogenic signaling pathways and suppressing cell proliferation in leukemia and hepatocellular carcinoma models. [1][2]
| Solvent | Solubility & Note |
|---|---|
| DMSO |
69 mg/mL
(200.63 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Water | 69 mg/mL |
| Ethanol | 69 mg/mL |
| DMSO |
69 mg/mL
(200.63 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Water | 69 mg/mL |
| Ethanol | 69 mg/mL |
| DMSO |
69 mg/mL
(200.63 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Water | 69 mg/mL |
| Ethanol | 69 mg/mL |
| DMSO |
69 mg/mL
(200.63 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Water | 69 mg/mL |
| Ethanol | 69 mg/mL |
| DMSO |
69 mg/mL
(200.63 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Water | 69 mg/mL |
| Ethanol | 69 mg/mL |
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Pre-aliquoted for Longevity: Solid-state aliquots offer significantly longer shelf life compared to stock solutions, ensuring maximum stability for every use.
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