CAS No. 107868-30-4
| IUPAC Name | (8R,9S,10R,13S,14S)-10,13-dimethyl-6-methylidene-7,8,9,11,12,14,15,16-octahydrocyclopenta[a]phenanthrene-3,17-dione | |
|---|---|---|
| CAS Number | 107868-30-4 | |
| Molecular Formula |
C20H24O2 |
|
| Molecular Weight (MW) | 296.4 | |
| SMILES | CC12CCC3C(C1CCC2=O)CC(=C)C4=CC(=O)C=CC34C | |
| InChIKey | BFYIZQONLCFLEV-DAELLWKTSA-N |
Exemestane is an irreversible steroidal aromatase inhibitor that targets human placental aromatase (IC50 = and rat ovarian aromatase (IC50 =. Structurally related to the natural substrate androstenedione, it acts as a suicide substrate that covalently inactivates aromatase. This mechanism blocks the conversion of androgens to estrogens, downregulating estrogen signaling pathways and inhibiting estrogen-dependent cell proliferation in breast cancer models. [1]
|
Concentration
Volume
Mass
|
|---|
| Solvent | Solubility & Note |
|---|---|
| DMSO |
54 mg/mL
(182.18 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Ethanol | 15 mg/mL |
| Water | Insoluble |
| DMSO |
59 mg/mL
(199.05 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Ethanol | 41 mg/mL |
| Water | Insoluble |
| DMSO |
54 mg/mL
(182.18 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Ethanol | 21 mg/mL |
| Water | Insoluble |
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
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