CAS No. 518-17-2

Batch: Purity:99.87
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Evodiamine Chemical Structure
Chemical Structure
Check the Evodiamine product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.

Chemical Information

IUPAC Name (1S)-21-methyl-3,13,21-triazapentacyclo[11.8.0.02,10.04,9.015,20]henicosa-2(10),4,6,8,15,17,19-heptaen-14-one
CAS Number 518-17-2
Molecular Formula

C19H17N3O
Molecular Weight (MW) 303.36
InChIKey TXDUTHBFYKGSAH-SFHVURJKSA-N

Ordering Information

Biological Activity

Evodiamine is a naturally occurring alkaloid from Evodiae Fructus that acts as an inhibitor of NF-κB signaling. It suppresses IκB kinase activation, blocking constitutive and inducible NF-κB nuclear translocation and downstream transcriptional activity. This pathway inhibition downregulates anti-apoptotic and proliferative gene expression, leading to cell cycle arrest, inhibition of tumor cell proliferation, and induction of apoptosis. [1]

How to Prepare Stock Solution?

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Solubility

Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
Solvent Solubility & Note
DMSO Insoluble
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO.)
Water Insoluble
Ethanol Insoluble
FAQ
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
  • Preheat media/saline to 37°C.
  • Mix rapidly (pipette/vortex) upon addition.
  • For complex mixes, always add the aqueous phase last.
  • Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).

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Note: Technical data last updated: Sep 1, 2026.