Clinical Trials

Erlotinib hydrochloride has been extensively evaluated across numerous clinical trials spanning Phase 1 to Phase 4, primarily targeting non-small cell lung cancer, head and neck squamous cell carcinoma, esophageal cancer, advanced solid tumors, and chemoprevention in liver cirrhosis. Sponsored by industry leaders like Hoffmann-La Roche and Eli Lilly alongside academic centers such as the National Cancer Institute and Fox Chase Cancer Center, these studies span completed, recruiting, active, terminated, and withdrawn statuses. Overall, these trials reflect a broad assessment of erlotinib as both monotherapy and in combination regimens.

NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT06545695 NOT_YET_RECRUITING
Epidermolytic Ichthyosis; Palmoplantar Keratoderma; Pachyonychia Congenita
Northwestern University
 2027-07-01 PHASE1; PHASE2
NCT04172779 NOT_YET_RECRUITING
Cirrhosis, Liver; Advanced Liver Fibrosis
University of Texas Southwestern Medical Center
 2026-12 PHASE2
NCT04341181 RECRUITING
Cancer; Tumors; Neoplasms; Neoplasia
Ulrik Lassen
 2020-08-24 PHASE2
NCT06997068 RECRUITING
Metastatic Oral Cavity Carcinoma; Recurrent Oral Cavity Carcinoma; Stage IVC Lip and Oral Cavity Cancer AJCC v8; Head and Neck Cancer; Hypopharynx Cancer; Oropharynx Cancer; Clinical Stage IV HPV-Mediated (p16-Positive) Oropharyngeal Carcinoma AJCC v8; Metastatic Hypopharyngeal Carcinoma; Metastatic Laryngeal Carcinoma; Metastatic Malignant Head and Neck Neoplasm; Metastatic Oropharyngeal Carcinoma; Recurrent Hypopharyngeal Carcinoma; Recurrent Laryngeal Carcinoma; Recurrent Malignant Head and Neck Neoplasm; Recurrent Oropharyngeal Carcinoma; Stage IVC Hypopharyngeal Carcinoma AJCC v8; Stage IVC Laryngeal Cancer AJCC v8; Stage IVC Oropharyngeal (p16-Negative) Carcinoma AJCC v8
Mayo Clinic
 2025-07-09 PHASE2
NCT07418177 NOT_YET_RECRUITING
AMD - Age-Related Macular Degeneration
The First Affiliated Hospital with Nanjing Medical University
 2026-02-10 PHASE1; PHASE2
NCT04981509 RECRUITING
Hereditary Leiomyomatosis and Renal Cell Carcinoma; Papillary Renal Cell Carcinoma; Renal Cell Carcinoma; Sporadic Papillary Renal Cell Carcinoma; Stage III Renal Cell Cancer AJCC v8; Stage IV Renal Cell Cancer AJCC v8
National Cancer Institute (NCI)
 2022-06-10 PHASE2
NCT04449874 ACTIVE_NOT_RECRUITING
Non-Small Cell Lung Cancer; Colorectal Cancer; Advanced Solid Tumors
Genentech, Inc.
 2020-07-29 PHASE1
NCT02925234 RECRUITING
Cancer; Tumors; Neoplasm; Neoplasia
The Netherlands Cancer Institute
 2016-08 PHASE2
NCT06483555 RECRUITING
Pancreatic Adenocarcinoma; Metastatic Pancreatic Cancer; Basal Cell Neoplasm
UNC Lineberger Comprehensive Cancer Center
 2025-02-06 PHASE1; PHASE2
NCT03297606 RECRUITING
Lymphoma, Non-Hodgkin; Multiple Myeloma; Advanced Solid Tumors
Canadian Cancer Trials Group
 2018-03-23 PHASE2
NCT06071013 RECRUITING
Non-small Cell Lung Cancer; EGFR Gene Mutation; EGFR-TKI Resistant Mutation
China Medical University Hospital
 2024-02-23 PHASE1; PHASE2
NCT02099058 ACTIVE_NOT_RECRUITING
Advanced Solid Tumors Cancer
AbbVie
 2014-01-15 PHASE1
NCT05442060 RECRUITING
Non-small Cell Lung Cancer
OBI Pharma, Inc
 2022-07-27 PHASE2
NCT06161558 WITHDRAWN
Neoplasms
National Cancer Institute (NCI)
 2025-07-15 PHASE1
NCT02991651 TERMINATED
Lung Cancer, Nonsmall Cell
Io Therapeutics
 2016-12-07 PHASE1
NCT00954226 COMPLETED
Recurrent Head and Neck Carcinoma; Recurrent Salivary Gland Carcinoma; Recurrent Skin Carcinoma; Skin Squamous Cell Carcinoma
M.D. Anderson Cancer Center
 2009-08-05 PHASE1
NCT05904457 UNKNOWN
Solid Tumors; Advanced Solid Tumors; Metastatic Cancer
Asan Medical Center
 2023-01-02 PHASE2
NCT01927744 COMPLETED
Head and Neck Cancer
M.D. Anderson Cancer Center
 2013-12-16 PHASE2
NCT04004572 COMPLETED
Natural Killer/T-Cell Lymphoma, Nasal and Nasal-Type
Rong Tao
 2019-07-01 PHASE2
NCT02098954 UNKNOWN
Carcinoma, Non-Small Cell Lung; EGFR Gene Mutation
Hunan Province Tumor Hospital
 2014-07-01 PHASE2
NCT04591431 UNKNOWN
Breast Cancer; Gastrointestinal Cancer; Non Small Cell Lung Cancer; Other Cancer
Fondazione per la Medicina Personalizzata
 2020-10-07 PHASE2
NCT04172779 Not yet recruiting
Cirrhosis Liver
University of Texas Southwestern Medical Center|National Cancer Institute (NCI)
 2024-07 Phase 2
NCT00254384 COMPLETED
Recurrent Lung Non-Small Cell Carcinoma; Stage IA Lung Non-Small Cell Carcinoma AJCC v7; Stage IB Lung Non-Small Cell Carcinoma AJCC v7; Stage IIA Lung Non-Small Cell Carcinoma AJCC v7; Stage IIB Lung Non-Small Cell Carcinoma AJCC v7; Stage IIIA Lung Non-Small Cell Cancer AJCC v7; Stage IIIB Lung Non-Small Cell Cancer AJCC v7
M.D. Anderson Cancer Center
 2005-10-05 PHASE1
NCT06161558 Not yet recruiting
Neoplasms
National Cancer Institute (NCI)|National Institutes of Health Clinical Center (CC)
 2024-05-15 Phase 1
NCT03137771 ACTIVE_NOT_RECRUITING
Recurrent Non-Small Cell Lung Carcinoma; Stage IV Non-Small Cell Lung Cancer
NRG Oncology
 2017-04-07 PHASE2
NCT01013649 COMPLETED
Pancreatic Adenocarcinoma; Pancreatic Ductal Adenocarcinoma; Pancreatic Intraductal Papillary-Mucinous Neoplasm; Stage I Pancreatic Cancer AJCC v6 and v7; Stage II Pancreatic Cancer AJCC v6 and v7
National Cancer Institute (NCI)
 2010-04-05 PHASE3
NCT05081674 COMPLETED
Lung Neoplasm
Hospital Israelita Albert Einstein
 2020-01-01 PHASE2
NCT02091141 COMPLETED
Neoplasms; Solid Tumors; Biliary Cancer; Salivary Cancer; Bladder Cancer
Genentech, Inc.
 2014-04-14 PHASE2
NCT05827614 Recruiting
Non-small Cell Lung Cancer|Non-Small Cell Lung Adenocarcinoma|Non-Small Cell Squamous Lung Cancer|Head and Neck Squamous Cell Carcinoma|Esophageal Cancer|Gastric Cancer|Breast Cancer|Bladder Cancer|Ovarian Cancer|Endometrial Cancer|Liposarcoma
Boundless Bio
 2023-03-24 Phase 1
NCT03498521 COMPLETED
Cancer of Unknown Primary Site
Hoffmann-La Roche
 2018-07-10 PHASE2
NCT04455594 UNKNOWN
Non-Small Cell Lung Cancer Stage IIIA
The First Affiliated Hospital of Guangzhou Medical University
 2020-10 PHASE2
NCT02942095 COMPLETED
Solid Tumors
M.D. Anderson Cancer Center
 2017-03-06 PHASE1
NCT01130519 COMPLETED
HLRCC; Sporadic Papillary Renal Cell Cancer
National Cancer Institute (NCI)
 2010-05-06 PHASE2
NCT01470716 UNKNOWN
NSCLC Stage II; NSCLC, Stage IIIA
National Cancer Center, Korea
 2012-01 PHASE2
NCT02638428 UNKNOWN
Relapsed Pediatric Solid Tumor; Refractory Pediatric Solid Tumor; Relapsed Pediatric AML; Refractory Pediatric AML
Samsung Medical Center
 2015-12 PHASE2
NCT02239952 UNKNOWN
Cancer; High-grade Glioma
Amsterdam UMC, location VUmc
 2014-11
NCT02424617 COMPLETED
Non-Small Cell Lung Cancer
BerGenBio ASA
 2015-04-19 PHASE1; PHASE2
NCT02277457 WITHDRAWN
Non-Small Cell Lung Cancer
University of Michigan Rogel Cancer Center
 2015-09 EARLY_PHASE1
NCT01180959 COMPLETED
Liver Cancer
M.D. Anderson Cancer Center
 2011-04-14 PHASE2
NCT02714530 TERMINATED
Cancer
Oslo University Hospital
 2014-04-01 PHASE2
NCT01248247 COMPLETED
Lung Cancer
M.D. Anderson Cancer Center
 2011-06-02 PHASE2
NCT01064479 COMPLETED
Metastatic Squamous Cell Carcinoma of the Hypopharynx; Metastatic Squamous Cell Carcinoma of the Larynx; Metastatic Squamous Cell Carcinoma of the Oral Cavity; Metastatic Squamous Cell Carcinoma of the Oropharynx; Recurrent Hypopharyngeal Squamous Cell Carcinoma; Recurrent Laryngeal Squamous Cell Carcinoma; Recurrent Oral Cavity Squamous Cell Carcinoma; Recurrent Oropharyngeal Squamous Cell Carcinoma; Stage IV Hypopharyngeal Squamous Cell Carcinoma AJCC v7; Stage IV Laryngeal Squamous Cell Carcinoma AJCC v7; Stage IV Oral Cavity Squamous Cell Carcinoma AJCC v6 and v7; Stage IV Oropharyngeal Squamous Cell Carcinoma AJCC v7; Stage IVA Hypopharyngeal Squamous Cell Carcinoma AJCC v7; Stage IVA Laryngeal Squamous Cell Carcinoma AJCC v7; Stage IVA Oral Cavity Squamous Cell Carcinoma AJCC v6 and v7; Stage IVA Oropharyngeal Squamous Cell Carcinoma AJCC v7; Stage IVB Hypopharyngeal Squamous Cell Carcinoma AJCC v7; Stage IVB Laryngeal Squamous Cell Carcinoma AJCC v7; Stage IVB Oral Cavity Squamous Cell Carcinoma AJCC v6 and v7; Stage IVB Oropharyngeal Squamous Cell Carcinoma AJCC v7; Stage IVC Hypopharyngeal Squamous Cell Carcinoma AJCC v7; Stage IVC Laryngeal Squamous Cell Carcinoma AJCC v7; Stage IVC Oral Cavity Squamous Cell Carcinoma AJCC v6 and v7; Stage IVC Oropharyngeal Squamous Cell Carcinoma AJCC v7
M.D. Anderson Cancer Center
 2010-02-05 PHASE2
NCT04165031 TERMINATED
Advanced Solid Tumor; Non-Small Cell Lung Cancer; Colorectal Cancer
Eli Lilly and Company
 2019-11-28 PHASE1; PHASE2
NCT02154737 COMPLETED
Pancreatic Cancer
Tony Reid, M.D., Ph.D.
 2013-07 PHASE1
NCT00769483 COMPLETED
Pancreatic Cancer; Pancreatic Adenocarcinoma
M.D. Anderson Cancer Center
 2008-11-13 PHASE1; PHASE2
NCT00543504 COMPLETED
Advanced Cancer
M.D. Anderson Cancer Center
 2007-10-10 PHASE1
NCT02574078 COMPLETED
Non-Small Cell Lung Cancer
Bristol-Myers Squibb
 2015-11-23 PHASE1; PHASE2
NCT02416739 UNKNOWN
Non-Small-Cell Lung Carcinoma
Il Yeong Park, Ph.D.
 2015-03 PHASE2; PHASE3
NCT02961374 COMPLETED
Attenuated Familial Adenomatous Polyposis; Familial Adenomatous Polyposis
National Cancer Institute (NCI)
 2017-10-27 PHASE2
NCT03628521 UNKNOWN
Lung Cancer; Advanced Stage
Shanghai Chest Hospital
 2018-07-20 PHASE1
NCT00871923 COMPLETED
Non-small Cell Lung Cancer; Brain Cancer
M.D. Anderson Cancer Center
 2009-03-26 PHASE2
NCT01432119 WITHDRAWN
Advanced Cancers
M.D. Anderson Cancer Center
 2012-12 PHASE1
NCT02689336 WITHDRAWN
Glioma; Rhabdomyosarcoma; Osteosarcoma; Medulloblastoma; Neuroectodermal Tumor; Ependymoma; Ewing's Sarcoma; Wilms Tumor
Washington University School of Medicine
 2016-08-06 PHASE2
NCT07271446 COMPLETED
Non-small Cell Lung Cancer
Precision Biotech Taiwan Corp.
 2018-09-01 PHASE1
NCT02737228 UNKNOWN
Pancreatic Neoplasms
CrystalGenomics, Inc.
 2016-03 PHASE1; PHASE2
NCT00436332 COMPLETED
Lung Cancer
SWOG Cancer Research Network
 2007-07 PHASE2
NCT02886195 UNKNOWN
EGFR Gene Mutation
Fujian Cancer Hospital
 2016-07 PHASE3
NCT03050411 UNKNOWN
Nonsmall Cell Lung Cancer
Peking University Third Hospital
 2016-05 PHASE1
NCT02044601 WITHDRAWN
Lung Cancer
M.D. Anderson Cancer Center
 2014-06 PHASE1; PHASE2
NCT02770014 TERMINATED
Epidermal Growth Factor Receptor; Non-Small Cell Lung Cancer
Dana-Farber Cancer Institute
 2016-06 PHASE2
NCT02556593 TERMINATED
Non-Small Cell Lung Carcinoma
Sun Yat-sen University
 2015-09 PHASE2
NCT03123484 UNKNOWN
Non Small Cell Lung Cancer
China Medical University, China
 2017-04 PHASE2
NCT01683422 TERMINATED
Pancreatic Cancer
Loma Linda University
 2013-01-02
NCT02411448 ACTIVE_NOT_RECRUITING
Metastatic Non-Small Cell Lung Cancer
Eli Lilly and Company
 2015-05-06 PHASE3
NCT01967095 COMPLETED
EGFR-Mutant Lung Cancer
Memorial Sloan Kettering Cancer Center
 2013-10-15 PHASE1
NCT01562028 COMPLETED
Lung Cancer
ETOP IBCSG Partners Foundation
 2012-06 PHASE2
NCT01664897 COMPLETED
Acute Myeloid Leukemia Arising From Previous Myelodysplastic Syndrome; Adult Acute Myeloid Leukemia With Inv(16)(p13.1q22); CBFB-MYH11; Adult Acute Myeloid Leukemia With t(16;16)(p13.1;q22); CBFB-MYH11; Adult Acute Myeloid Leukemia With t(8;21); (q22; q22.1); RUNX1-RUNX1T1; Adult Acute Myeloid Leukemia With t(9;11)(p22.3;q23.3); MLLT3-KMT2A; Adult Acute Promyelocytic Leukemia With PML-RARA; Alkylating Agent-Related Acute Myeloid Leukemia; Chronic Myelomonocytic Leukemia; Myelodysplastic Syndrome; Previously Treated Myelodysplastic Syndrome; Recurrent Adult Acute Myeloid Leukemia
M.D. Anderson Cancer Center
 2013-05-16 PHASE2
NCT01714908 UNKNOWN
Non-small Cell Lung Cancer
Jinming Yu
 2012-12-14 PHASE2
NCT02723578 COMPLETED
Metastatic Colorectal Cancer
Yonsei University
 2015-12-01 PHASE2
NCT01822496 TERMINATED
Stage III Non-Small Cell Lung Cancer AJCC v7; Stage IIIA Non-Small Cell Lung Cancer AJCC v7; Stage IIIB Non-Small Cell Lung Cancer AJCC v7
National Cancer Institute (NCI)
 2013-11-04 PHASE2
NCT00563784 COMPLETED
Non-Small Cell Lung Cancer; Lung Cancer
M.D. Anderson Cancer Center
 2007-11 PHASE2
NCT01556191 COMPLETED
Stage IV Lung Cancer
Intergroupe Francophone de Cancerologie Thoracique
 2012-05-15 PHASE2
NCT01407822 UNKNOWN
Non-small Cell Lung Cancer
Guangdong Association of Clinical Trials
 2011-12-05 PHASE2; PHASE3
NCT02169284 TERMINATED
Bladder Carcinoma; Recurrent Bladder Carcinoma
National Cancer Institute (NCI)
 2014-10-01 PHASE2
NCT01866410 COMPLETED
Recurrent Non-Small Cell Lung Carcinoma; Stage IV Non-Small Cell Lung Cancer AJCC v7
National Cancer Institute (NCI)
 2013-05-20 PHASE2
NCT01532089 COMPLETED
EGFR Exon 19 Deletion Mutation; EGFR NP_005219.2:p.L858R; Lung Non-Squamous Non-Small Cell Carcinoma; Stage IV Lung Non-Small Cell Cancer AJCC v7
Academic and Community Cancer Research United
 2012-03-16 PHASE2
NCT02352948 COMPLETED
Non - Small Cell Lung Cancer NSCLC
AstraZeneca
 2015-01-13 PHASE3
NCT03460678 Terminated
Carcinoma Non-Small-Cell Lung
Hikma Pharmaceuticals LLC
 2018-02-28 Phase 4
NCT01376310 TERMINATED
Cancer
Novartis Pharmaceuticals
 2010-11-02 PHASE2
NCT01636908 COMPLETED
Cancer; Advanced Solid Tumors
Amsterdam UMC, location VUmc
 2011-08
NCT02399566 UNKNOWN
Lung Adenocarcinoma
Hunan Province Tumor Hospital
 2015-05 PHASE4
NCT02588261 TERMINATED
Non-small Cell Lung Cancer (NSCLC)
Astellas Pharma Global Development, Inc.
 2016-02-11 PHASE3
NCT01965275 UNKNOWN
Self Efficacy; Drug Toxicity
Anhui Medical University
 2013-10 PHASE2
NCT01190241 TERMINATED
Advanced Solid Tumors; Inoperable; Metastasis
Amsterdam UMC, location VUmc
 2010-08
NCT00950365 COMPLETED
Bronchioloalveolar Carcinoma; Large Cell Lung Carcinoma; Lung Adenocarcinoma; Recurrent Non-Small Cell Lung Carcinoma; Stage IIIB Non-Small Cell Lung Cancer; Stage IV Non-Small Cell Lung Cancer
Albert Einstein College of Medicine
 2006-04 PHASE2
NCT02468661 TERMINATED
Non-Small Cell Lung Cancer
Novartis Pharmaceuticals
 2015-09-23 PHASE1
NCT02155465 COMPLETED
Lung Cancer
Memorial Sloan Kettering Cancer Center
 2014-06 PHASE1; PHASE2
NCT01260181 COMPLETED
Non-Squamous Non-Small Cell Lung Cancer
Hoffmann-La Roche
 2011-03-31 PHASE2
NCT01667562 COMPLETED
Non-Small Cell Lung Cancer
Hoffmann-La Roche
 2012-01-20 PHASE3
NCT01660971 ACTIVE_NOT_RECRUITING
Metastatic Pancreatic Adenocarcinoma; Recurrent Pancreatic Carcinoma; Stage III Pancreatic Cancer AJCC v6 and v7; Stage IV Pancreatic Cancer AJCC v6 and v7
National Cancer Institute (NCI)
 2012-07-30 PHASE1
NCT00733408 COMPLETED
Estrogen Receptor-negative Breast Cancer; HER2-negative Breast Cancer; Progesterone Receptor-negative Breast Cancer; Recurrent Breast Cancer; Stage IV Breast Cancer; Triple-negative Breast Cancer
University of Washington
 2008-04-23 PHASE2
NCT02186301 TERMINATED
Non-Small Cell Lung Cancer
Clovis Oncology, Inc.
 2014-11 PHASE2; PHASE3
NCT01962896 TERMINATED
Relapsed / Recurrent Germ Cell Tumors
Theodore Laetsch
 2014-01-08 PHASE2
NCT01998126 COMPLETED
Non-small Cell Lung Cancer
University of Utah
 2013-12-02 PHASE1
NCT02013089 UNKNOWN
Gastrointestinal Cancers
Sun Yat-sen University
 2013-12
NCT01688973 COMPLETED
Recurrent Renal Cell Carcinoma; Stage III Renal Cell Cancer; Stage IV Renal Cell Cancer; Type 1 Papillary Renal Cell Carcinoma; Type 2 Papillary Renal Cell Carcinoma
National Cancer Institute (NCI)
 2012-08-20 PHASE2
NCT01472016 COMPLETED
Advanced Solid Tumors
AbbVie (prior sponsor, Abbott)
 2011-10-06 PHASE1
NCT00573989 TERMINATED
Head and Neck Cancer
Wake Forest University Health Sciences
 2008-03 PHASE1; PHASE2
NCT01471964 TERMINATED
Non-small Cell Lung Cancer Metastatic; Non-small Cell Lung Cancer Recurrent
Fox Chase Cancer Center
 2011-10-20 PHASE1; PHASE2
NCT01592383 COMPLETED
Malignant Peritoneal Mesothelioma
University of Chicago
 2012-06 PHASE2
NCT02095782 TERMINATED
Non-small-cell Lung Cancer
Guangdong Association of Clinical Trials
 2014-03 PHASE2
NCT02206763 TERMINATED
EGFR Mutated EGFR TKI Naive Metastatic NSCLC
Sierra Oncology LLC - a GSK company
 2014-10-16 PHASE1
NCT02318368 TERMINATED
Non-small Cell Lung Cancer
AVEO Pharmaceuticals, Inc.
 2014-11 PHASE2
NCT02064491 COMPLETED
Non-small Cell Lung Cancer
Finnish Lung Cancer Group
 2014-02 PHASE2
NCT01174563 COMPLETED
Non-Squamous Non-Small Cell Lung Cancer
Hoffmann-La Roche
 2011-05-23 PHASE2
NCT02006043 UNKNOWN
Non-small Cell Lung Cancer
Li Zhang
 2013-12 PHASE2
NCT02039674 COMPLETED
Non-small Cell Lung Carcinoma
Merck Sharp & Dohme LLC
 2014-02-21 PHASE1; PHASE2
NCT02015728 UNKNOWN
Recurrent Childhood Brain Tumor
Seattle Children's Hospital
 2013-12
NCT01455389 TERMINATED
Lung Cancer
Genprex, Inc.
 2014-02 PHASE1; PHASE2
NCT02057380 COMPLETED
Advanced Solid Tumors
Astellas Pharma Global Development, Inc.
 2014-04-16 PHASE2
NCT01839955 COMPLETED
Recurrent Non-small Cell Lung Cancer; Stage IIIB Non-small Cell Lung Cancer; Stage IV Non-small Cell Lung Cancer
Neelesh Sharma MD PhD
 2013-09 PHASE1
NCT02495233 TERMINATED
Non-Small-Cell Lung Cancer
Astellas Pharma Global Development, Inc.
 2015-09-08 PHASE1; PHASE2
NCT02321293 UNKNOWN
Lung Cancer
Lady Davis Institute
 2015-08 PHASE1
NCT01320501 SUSPENDED
Non-small Cell Lung Cancer Metastatic
National Guard Health Affairs
 2009-10 PHASE4
NCT01395758 COMPLETED
Metastatic Non-Small Cell Lung Cancer
ArQule, Inc., a subsidiary of Merck Sharp & Dohme LLC, a subsidiary of Merck & Co., Inc. (Rahway, NJ USA)
 2011-07 PHASE2
NCT01887795 COMPLETED
Multiple Brain Metastases; Non-small-cell Lung Cancer
Daping Hospital and the Research Institute of Surgery of the Third Military Medical University
 2013-08 PHASE3
NCT01454102 COMPLETED
Non-small Cell Lung Cancer
Bristol-Myers Squibb
 2011-12-16 PHASE1
NCT00547105 COMPLETED
Lung Cancer
University of Texas Southwestern Medical Center
 2007-06-25 PHASE2
NCT00614653 COMPLETED
Pancreatic Cancer
M.D. Anderson Cancer Center
 2008-01 PHASE1
NCT00410059 COMPLETED
Lung Cancer
M.D. Anderson Cancer Center
 2006-11 PHASE2
NCT01217619 COMPLETED
Non Small Cell Lung Cancer
Baohui Han
 2011-03-02 PHASE2
NCT01351415 COMPLETED
Non-Squamous Non-Small Cell Lung Cancer
Hoffmann-La Roche
 2011-06-25 PHASE3
NCT01532011 COMPLETED
Advanced Cancers; Solid Tumors
M.D. Anderson Cancer Center
 2012-03 PHASE1
NCT01650506 COMPLETED
Breast Cancer
Columbia University
 2012-07 PHASE1
NCT01182350 TERMINATED
Diffuse Intrinsic Pontine Glioma
Karen D. Wright MD
 2011-09 PHASE2
NCT01487265 COMPLETED
Non Small Cell Lung Cancer
SCRI Development Innovations, LLC
 2014-03 PHASE2
NCT01763385 UNKNOWN
Non-small-cell Lung Cancer; Brain Metastases
Wu Jieping Medical Foundation
 2012-11 PHASE2
NCT00881751 COMPLETED
Liver Cancer
Medical University of South Carolina
 2009-03 PHASE2
NCT01059305 TERMINATED
Skin Cancer
M.D. Anderson Cancer Center
 2011-02 PHASE2
NCT01482377 COMPLETED
Neoplasms
Hoffmann-La Roche
 2011-12 PHASE1
NCT01555489 TERMINATED
Stage IV Pancreatic Cancer
Thomas Jefferson University
 2011-10 PHASE2
NCT02380625 UNKNOWN
Ebola Virus Disease
Clinical Research Management, Inc.
 2015-04 PHASE1; PHASE2
NCT01328951 COMPLETED
Non-Squamous Non-Small Cell Lung Cancer
Hoffmann-La Roche
 2011-09 PHASE3
NCT01652469 COMPLETED
Carcinoma, Non-Small-Cell Lung
ETOP IBCSG Partners Foundation
 2012-08 PHASE3
NCT00720304 COMPLETED
Head and Neck Cancer
Case Comprehensive Cancer Center
 2007-11-19 PHASE2
NCT01377376 TERMINATED
Non-small-cell Lung Cancer
Kyowa Kirin Co., Ltd.
 2011-07 PHASE3
NCT00733746 COMPLETED
Pancreatic Cancer
Alliance for Clinical Trials in Oncology
 2009-04 PHASE2
NCT01608841 UNKNOWN
Metastatic Pancreatic Cancer
Taipei Veterans General Hospital, Taiwan
 2005-07 PHASE2
NCT01851096 COMPLETED
Cancer
Esanex Inc.
 2013-03 PHASE1
NCT02355431 WITHDRAWN
Solid Tumors and Hematologic Malignancy; NSCLC (Non-small Cell Lung Carcinoma)
Incyte Corporation
 2014-12 PHASE2
NCT02178397 TERMINATED
NSCLC Patients With EGFR Activating Mutation
Centre Francois Baclesse
 2014-06 PHASE3
NCT01708954 ACTIVE_NOT_RECRUITING
Recurrent Lung Non-Small Cell Carcinoma; Stage IV Lung Non-Small Cell Cancer AJCC v7
National Cancer Institute (NCI)
 2013-02-13 PHASE2
NCT01294306 COMPLETED
Adenosquamous Lung Carcinoma; Bronchioloalveolar Carcinoma; Large Cell Lung Carcinoma; Lung Adenocarcinoma; Recurrent Non-Small Cell Lung Carcinoma; Squamous Cell Lung Carcinoma
National Cancer Institute (NCI)
 2011-02 PHASE2
NCT00442455 COMPLETED
Squamous Cell Carcinoma of the Head and Neck
Grupo de Investigación Clínica en Oncología Radioterapia
 2006-01 PHASE3
NCT01153984 COMPLETED
Carcinoma，Non-Small-Cell Lung
Hoffmann-La Roche
 2011-06 PHASE2
NCT01410214 UNKNOWN
Non-small Cell Lung Cancer Stage IIIA
Chinese Lung Cancer Surgical Group
 2011-05 PHASE2
NCT00903734 COMPLETED
Advanced Cancers
M.D. Anderson Cancer Center
 2009-04 PHASE1
NCT01024413 COMPLETED
Thoracic Neoplasms
Chinese Society of Lung Cancer
 2009-07 PHASE3
NCT02001896 UNKNOWN
Non-Small Cell Lung Cancer
Xinjiang Medical University
 2013-12 PHASE3
NCT01303029 COMPLETED
Metastatic Pancreatic Cancer
Spanish Cooperative Group for the Treatment of Digestive Tumours (TTD)
 2011-02 PHASE2
NCT00977470 ACTIVE_NOT_RECRUITING
Non-small Cell Lung Cancer
Massachusetts General Hospital
 2009-10 PHASE2
NCT00997334 COMPLETED
Non-small Cell Lung Cancer
David M. Jackman, MD
 2010-02 PHASE2
NCT01580735 COMPLETED
Non-small-cell Lung Cancer
Kyowa Kirin Co., Ltd.
 2012-05 PHASE2
NCT00620269 UNKNOWN
Lung Cancer; NSCLC
National Cancer Center, Korea
 2008-02 PHASE2
NCT01928160 WITHDRAWN
Recurrent Non-small Cell Lung Cancer; Stage IV Non-small Cell Lung Cancer
Vanderbilt-Ingram Cancer Center
 2014-06 PHASE2
NCT01887886 COMPLETED
Non-Squamous Non-Small Cell Lung Cancer
Hoffmann-La Roche
 2013-12 PHASE3
NCT01932229 UNKNOWN
NSCLC
Sheba Medical Center
 2013-02 PHASE2
NCT01609543 COMPLETED
Non-Squamous Non-Small Cell Lung Cancer
Hoffmann-La Roche
 2012-05 PHASE4
NCT01727869 COMPLETED
Cancer
Regeneron Pharmaceuticals
 2012-10 PHASE1
NCT01545947 COMPLETED
Carcinoma, Non-Small-Cell Lung; Non-Small Cell Lung Cancer
Celgene
 2012-05-01 PHASE1
NCT00570232 COMPLETED
Head and Neck Cancer
University of Alabama at Birmingham
 2007-12 PHASE2
NCT00883779 COMPLETED
Non-Squamous Non-Small Cell Lung Cancer
Hoffmann-La Roche
 2009-04 PHASE3
NCT01302808 COMPLETED
Lung Cancer; Metastatic Cancer
University of Texas Southwestern Medical Center
 2009-09 PHASE1
NCT02747953 COMPLETED
Non-small Cell Lung Cancer
Samsung Medical Center
 2011-07 PHASE2
NCT00491816 UNKNOWN
Breast Cancer
University of Kansas Medical Center
 2007-07 PHASE2
NCT01204307 COMPLETED
Advanced Non-Squamous Non-Small Cell Lung Cancer
Chang Gung Memorial Hospital
 2010-01 PHASE2
NCT00942734 COMPLETED
Head And Neck Cancer
M.D. Anderson Cancer Center
 2009-07 PHASE2
NCT00994123 COMPLETED
Carcinoma, Non-Small-Cell Lung
Merrimack Pharmaceuticals
 2010-02 PHASE1; PHASE2
NCT00257608 COMPLETED
Non-Small Cell Lung Cancer
Genentech, Inc.
 2006-01 PHASE3
NCT01801111 COMPLETED
Non-Small-Cell Lung Carcinoma
Hoffmann-La Roche
 2013-06-20 PHASE1; PHASE2
NCT00283244 COMPLETED
Lung Cancer
UNC Lineberger Comprehensive Cancer Center
 2006-03 PHASE2
NCT00770263 COMPLETED
Solid Tumors
Washington University School of Medicine
 2009-05 PHASE1
NCT02625168 COMPLETED
Lung Cancer
The University of Hong Kong
 2013-01 PHASE2
NCT01515137 COMPLETED
Head and Neck Squamous Cell Carcinoma
University of Pittsburgh
 2005-11 PHASE1
NCT01602289 COMPLETED
Solid Tumors; Lymphoma; Carcinoma, Non-Small-Cell Lung
Eli Lilly and Company
 2012-06 PHASE1
NCT01110876 TERMINATED
Brain Cancer; Glioblastoma Multiforme
M.D. Anderson Cancer Center
 2011-06 PHASE1; PHASE2
NCT00761345 COMPLETED
Pancreatic Carcinoma Non-resectable; Metastatic Pancreatic Cancer
Fox Chase Cancer Center
 2008-09 PHASE1
NCT01116219 COMPLETED
Lung Cancer
Swiss Cancer Institute
 2010-06 PHASE2
NCT01204697 COMPLETED
Non-Squamous Non-Small Cell Lung Cancer
Hoffmann-La Roche
 2010-11 PHASE2
NCT01187901 COMPLETED
Adenomatous Polyposis Coli
University of Utah
 2010-04 PHASE2
NCT01752205 UNKNOWN
Esophageal Squamous Carcinoma
The Affiliated Hospital of the Chinese Academy of Military Medical Sciences
 2012-11 PHASE3
NCT00301418 COMPLETED
Glioblastoma Multiforme; Anaplastic Astrocytoma
Northwell Health
 2006-03 PHASE1; PHASE2
NCT01250119 COMPLETED
Non-Squamous Non-Small Cell Lung Cancer
Hoffmann-La Roche
 2011-03 PHASE2
NCT01116622 COMPLETED
Advanced, Malignant Aerodigestive Tract Tumor (Lung, Head and Neck and Esophagus)
Dartmouth-Hitchcock Medical Center
 2003-04 PHASE1
NCT01027598 COMPLETED
Non Small Cell Lung Cancer
SCRI Development Innovations, LLC
 2010-01 PHASE2
NCT00153803 COMPLETED
Carcinoma, Non-Small-Cell Lung; Non-small Cell Lung Cancer; NSCLC
Dartmouth-Hitchcock Medical Center
 2005-05 PHASE3
NCT01068587 COMPLETED
Lung Cancer
NCIC Clinical Trials Group
 2010-01-21 PHASE1; PHASE2
NCT00125359 COMPLETED
Carcinoma, Non-small-cell Lung
Konstantin Dragnev
 2005-08 PHASE2
NCT01310036 COMPLETED
Non-Squamous Non-Small Cell Lung Cancer
Hoffmann-La Roche
 2011-04-30 PHASE2
NCT01306045 COMPLETED
Carcinoma, Non-Small-Cell Lung; Carcinoma, Small Cell Lung; Carcinoma, Thymic
National Cancer Institute (NCI)
 2011-02-08 PHASE2
NCT00779389 COMPLETED
Head and Neck Cancer; Non Small Cell Lung Cancer
University of Pittsburgh
 2009-01 PHASE1
NCT01372384 COMPLETED
Non-Squamous Non-Small Cell Lung Cancer
Hoffmann-La Roche
 2012-01 PHASE2
NCT00553462 COMPLETED
Lung Cancer
Alliance for Clinical Trials in Oncology
 2008-03 PHASE2
NCT00313560 COMPLETED
Pancreatic Cancer
Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins
 2006-03-16 PHASE2
NCT01505413 COMPLETED
Pancreatic Cancer
Soonchunhyang University Hospital
 2011-01 PHASE2
NCT01504542 WITHDRAWN
Non-small Cell Lung Cancer
Heat Biologics
 2011-12 PHASE2
NCT01593995 COMPLETED
Non-small Cell Lung Cancer; Pancreatic Cancer
Dong-A University Hospital
 2012-05 PHASE2
NCT01229813 COMPLETED
Colorectal Cancer
Lund University Hospital
 2010-10 PHASE3
NCT00543842 COMPLETED
Rectal Cancer
M.D. Anderson Cancer Center
 2007-12 PHASE1
NCT00925769 COMPLETED
Pancreatic Cancer
Hoffmann-La Roche
 2009-01 PHASE1
NCT01287754 COMPLETED
Non-Small Cell Lung Cancer
Hoffmann-La Roche
 2011-10 PHASE4
NCT00711594 COMPLETED
Carcinoma, Non-Small-Cell Lung
Boehringer Ingelheim
 2008-04 PHASE2
NCT01192165 COMPLETED
Cancer
GlaxoSmithKline
 2010-09-14 PHASE1
NCT01211483 COMPLETED
NSCLC (Advanced Non-small Cell Lung Cancer)
Daiichi Sankyo
 2010-09 PHASE1; PHASE2
NCT00656136 COMPLETED
Carcinoma, Non-Small-Cell Lung
Boehringer Ingelheim
 2008-04 PHASE3
NCT01085136 COMPLETED
Carcinoma, Non-Small-Cell Lung
Boehringer Ingelheim
 2010-02 PHASE3
NCT01360554 COMPLETED
Non-Small Cell Lung Cancer
Pfizer
 2011-06-16 PHASE3
NCT00045201 ACTIVE_NOT_RECRUITING
Adult Solid Neoplasm
National Cancer Institute (NCI)
 2002-06-13 PHASE1
NCT00759928 COMPLETED
Refractory Solid Tumors
SCRI Development Innovations, LLC
 2008-10 PHASE1
NCT01230710 COMPLETED
Non-Small Cell Lung Cancer
Hoffmann-La Roche
 2011-03 PHASE4
NCT01465815 WITHDRAWN
Recurrent Skin Cancer; Recurrent Squamous Cell Carcinoma of the Lip and Oral Cavity; Squamous Cell Carcinoma of the Skin; Stage III Squamous Cell Carcinoma of the Lip and Oral Cavity; Stage IVA Squamous Cell Carcinoma of the Lip and Oral Cavity; Stage IVB Squamous Cell Carcinoma of the Lip and Oral Cavity
OHSU Knight Cancer Institute
 2011-12 PHASE1; PHASE2
NCT00445848 COMPLETED
Lung Cancer
SWOG Cancer Research Network
 2007-07 PHASE2
NCT00834678 COMPLETED
Breast Cancer
Ohio State University Comprehensive Cancer Center
 2009-04 PHASE1; PHASE2
NCT00738751 COMPLETED
Lung Cancer; Head and Neck Cancer
H. Lee Moffitt Cancer Center and Research Institute
 2008-11 PHASE1
NCT01487174 TERMINATED
Carcinoma, Non-Small-Cell Lung
Kadmon Corporation, LLC
 2011-12-14 PHASE3
NCT01186861 COMPLETED
Non-Small Cell Lung Cancer (NSCLC) With Nonprogression Following 4 Cycles of Platinum-based Chemotherapy
Astellas Pharma Inc
 2011-03-04 PHASE2
NCT00975767 TERMINATED
Advanced Malignancies, Non-small Cell Lung Cancer
Mirati Therapeutics Inc.
 2009-08 PHASE1
NCT00621049 COMPLETED
Non-Small Cell Lung Cancer
SCRI Development Innovations, LLC
 2007-12 PHASE2
NCT01259089 COMPLETED
Adenocarcinoma of the Lung; Non-small Cell Lung Cancer
Northwestern University
 2011-04-27 PHASE1; PHASE2
NCT01131429 UNKNOWN
Neoplasms, Lung; Carcinoma, Non-Small Cell Lung; Drug Therapy; Genes, EGFR
Chinese PLA General Hospital
 2010-06 PHASE2
NCT00832637 TERMINATED
Hepatocellular Carcinoma; Cholangiocellular Carcinoma; Cholangiocarcinoma of the Extrahepatic Bile Duct; Bile Duct Cancer; Periampullary Adenocarcinoma; Gallbladder Cancer; Extrahepatic Bile Duct Cancer
New Mexico Cancer Research Alliance
 2007-08 PHASE2
NCT00397384 COMPLETED
Adenocarcinoma of the Colon; Adenocarcinoma of the Rectum; Advanced Adult Primary Liver Cancer; Carcinoma of the Appendix; Gastrointestinal Stromal Tumor; Metastatic Gastrointestinal Carcinoid Tumor; Metastatic Squamous Neck Cancer With Occult Primary; Recurrent Adenoid Cystic Carcinoma of the Oral Cavity; Recurrent Adult Primary Liver Cancer; Recurrent Anal Cancer; Recurrent Basal Cell Carcinoma of the Lip; Recurrent Colon Cancer; Recurrent Esophageal Cancer; Recurrent Esthesioneuroblastoma of the Paranasal Sinus and Nasal Cavity; Recurrent Extrahepatic Bile Duct Cancer; Recurrent Gallbladder Cancer; Recurrent Gastric Cancer; Recurrent Gastrointestinal Carcinoid Tumor; Recurrent Inverted Papilloma of the Paranasal Sinus and Nasal Cavity; Recurrent Lymphoepithelioma of the Nasopharynx; Recurrent Lymphoepithelioma of the Oropharynx; Recurrent Metastatic Squamous Neck Cancer With Occult Primary; Recurrent Midline Lethal Granuloma of the Paranasal Sinus and Nasal Cavity; Recurrent Mucoepidermoid Carcinoma of the Oral Cavity; Recurrent Non-small Cell Lung Cancer; Recurrent Pancreatic Cancer; Recurrent Rectal Cancer; Recurrent Salivary Gland Cancer; Recurrent Small Intestine Cancer; Recurrent Squamous Cell Carcinoma of the Hypopharynx; Recurrent Squamous Cell Carcinoma of the Larynx; Recurrent Squamous Cell Carcinoma of the Lip and Oral Cavity; Recurrent Squamous Cell Carcinoma of the Nasopharynx; Recurrent Squamous Cell Carcinoma of the Oropharynx; Recurrent Squamous Cell Carcinoma of the Paranasal Sinus and Nasal Cavity; Recurrent Verrucous Carcinoma of the Larynx; Recurrent Verrucous Carcinoma of the Oral Cavity; Small Intestine Adenocarcinoma; Small Intestine Leiomyosarcoma; Small Intestine Lymphoma; Stage IV Adenoid Cystic Carcinoma of the Oral Cavity; Stage IV Anal Cancer; Stage IV Basal Cell Carcinoma of the Lip; Stage IV Colon Cancer; Stage IV Esophageal Cancer; Stage IV Esthesioneuroblastoma of the Paranasal Sinus and Nasal Cavity; Stage IV Gastric Cancer; Stage IV Inverted Papilloma of the Paranasal Sinus and Nasal Cavity; Stage IV Lymphoepithelioma of the Nasopharynx; Stage IV Lymphoepithelioma of the Oropharynx; Stage IV Midline Lethal Granuloma of the Paranasal Sinus and Nasal Cavity; Stage IV Mucoepidermoid Carcinoma of the Oral Cavity; Stage IV Non-small Cell Lung Cancer; Stage IV Pancreatic Cancer; Stage IV Rectal Cancer; Stage IV Salivary Gland Cancer; Stage IV Squamous Cell Carcinoma of the Hypopharynx; Stage IV Squamous Cell Carcinoma of the Larynx; Stage IV Squamous Cell Carcinoma of the Lip and Oral Cavity; Stage IV Squamous Cell Carcinoma of the Nasopharynx; Stage IV Squamous Cell Carcinoma of the Oropharynx; Stage IV Squamous Cell Carcinoma of the Paranasal Sinus and Nasal Cavity; Stage IV Verrucous Carcinoma of the Larynx; Stage IV Verrucous Carcinoma of the Oral Cavity; Tongue Cancer; Unresectable Extrahepatic Bile Duct Cancer; Unresectable Gallbladder Cancer
National Cancer Institute (NCI)
 2007-01 PHASE1
NCT01158170 UNKNOWN
Non-small Cell Lung Cancer
Zhejiang Cancer Hospital
 2010-06 PHASE3
NCT00585377 COMPLETED
Cancer
University of Utah
 2007-08 PHASE2
NCT01222689 COMPLETED
Adenocarcinoma of the Pancreas; Recurrent Pancreatic Cancer; Stage III Pancreatic Cancer; Stage IV Pancreatic Cancer
National Cancer Institute (NCI)
 2010-11 PHASE2
NCT00373425 COMPLETED
Non-small Cell Lung Cancer
OSI Pharmaceuticals
 2006-09 PHASE3
NCT00660816 COMPLETED
Lung Cancer
Case Comprehensive Cancer Center
 2008-01 PHASE2
NCT01101334 COMPLETED
Advanced Non-small Cell Lung Cancer (NSCLC)
Daiichi Sankyo
 2010-03 PHASE2
NCT00702975 COMPLETED
Locally Advanced Non-Small Cell Lung Cancer; NSCLC
Radboud University Medical Center
 2008-09 PHASE2
NCT00590902 COMPLETED
Bronchioloalveolar Cell Variant of Non-small Cell Lung Cancer
Memorial Sloan Kettering Cancer Center
 2002-03 PHASE2
NCT01515969 TERMINATED
Non-small Cell Lung Cancer (NSCLC), Recurrent; Non-small Cell Lung Cancer (NSCLC), Stage IV
Heather Wakelee
 2012-07 PHASE1
NCT00634725 COMPLETED
Pancreatic Cancer
GERCOR - Multidisciplinary Oncology Cooperative Group
 2008-02 PHASE3
NCT00878163 ACTIVE_NOT_RECRUITING
Adult Solid Neoplasm; Pancreatic Acinar Cell Carcinoma; Pancreatic Ductal Adenocarcinoma; Recurrent Pancreatic Carcinoma; Stage IV Pancreatic Cancer AJCC v6 and v7
National Cancer Institute (NCI)
 2009-03-31 PHASE1
NCT01090011 COMPLETED
Carcinoma, Non-Small-Cell Lung
Boehringer Ingelheim
 2010-03 PHASE1
NCT01103375 TERMINATED
Adult Anaplastic Astrocytoma; Adult Anaplastic Oligodendroglioma; Adult Diffuse Astrocytoma; Adult Giant Cell Glioblastoma; Adult Glioblastoma; Adult Gliosarcoma; Adult Mixed Glioma; Adult Oligodendroglioma; Recurrent Adult Brain Tumor
Wake Forest University Health Sciences
 2010-05 PHASE1
NCT00810719 COMPLETED
Pancreatic Cancer
University of California, Davis
 2009-04 PHASE2
NCT01244191 TERMINATED
Non Squamous, Non-small-cell Lung Cancer
Daiichi Sankyo
 2011-01-11 PHASE3
NCT00400374 COMPLETED
Head and Neck Cancer
Emory University
 2007-08 PHASE1
NCT00473083 COMPLETED
Rash
British Columbia Cancer Agency
 2009-01 PHASE2
NCT01038856 TERMINATED
Polycythemia Vera
University of Oklahoma
 2009-12 PHASE2
NCT00811993 TERMINATED
Neoplasms
Hoffmann-La Roche
 2009-02 PHASE1
NCT00983307 COMPLETED
Carcinoma, Non-small-cell Lung
Sidney Kimmel Comprehensive Cancer Center at Thomas Jefferson University
 2009-08-27 PHASE2
NCT00391248 COMPLETED
Non-small Cell Lung Cancer
Ontario Clinical Oncology Group (OCOG)
 2006-11 PHASE2
NCT01032070 TERMINATED
Recurrent or Refractory Pediatric Ependymoma
OSI Pharmaceuticals
 2010-09-27 PHASE2
NCT00737243 COMPLETED
Carcinoma
SCRI Development Innovations, LLC
 2008-08 PHASE2
NCT00707252 TERMINATED
Non-Small Cell Lung Cancer
Louisiana State University Health Sciences Center Shreveport
 2008-01 PHASE1
NCT00314262 COMPLETED
Precancerous Conditions
Emory University
 2006-10 PHASE1; PHASE2
NCT01026844 TERMINATED
Non-small Cell Lung Cancer
Massachusetts General Hospital
 2007-07 PHASE1
NCT00766636 TERMINATED
Pancreatic Cancer
M.D. Anderson Cancer Center
 2008-09 PHASE2
NCT00800202 COMPLETED
Non-Small Cell Lung Cancer
Hoffmann-La Roche
 2009-04 PHASE2
NCT00495872 COMPLETED
Solid Tumors
M.D. Anderson Cancer Center
 2007-06 PHASE1
NCT01047059 COMPLETED
Non-Small-Cell Lung Carcinoma
University of Cologne
 2010-01 PHASE2
NCT00476476 COMPLETED
Squamous Cell Carcinoma
Dana-Farber Cancer Institute
 2006-12 PHASE2
NCT01192815 TERMINATED
Stage III Squamous Cell Carcinoma of the Hypopharynx; Stage III Squamous Cell Carcinoma of the Larynx; Stage III Squamous Cell Carcinoma of the Lip and Oral Cavity; Stage III Squamous Cell Carcinoma of the Oropharynx; Stage III Verrucous Carcinoma of the Larynx; Stage III Verrucous Carcinoma of the Oral Cavity; Stage IV Squamous Cell Carcinoma of the Hypopharynx; Stage IV Squamous Cell Carcinoma of the Lip and Oral Cavity; Stage IV Squamous Cell Carcinoma of the Nasopharynx; Stage IV Squamous Cell Carcinoma of the Oropharynx; Stage IV Verrucous Carcinoma of the Larynx; Stage IV Verrucous Carcinoma of the Oral Cavity
Case Comprehensive Cancer Center
 2011-01 PHASE2
NCT01284335 TERMINATED
Advanced Solid Tumors
Eli Lilly and Company
 2008-07 PHASE1
NCT00754494 COMPLETED
Adenomatous Polyp; Recurrent Colon Cancer; Recurrent Rectal Cancer; Stage I Colon Cancer; Stage I Rectal Cancer; Stage IIA Colon Cancer; Stage IIA Rectal Cancer; Stage IIB Colon Cancer; Stage IIB Rectal Cancer; Stage IIC Colon Cancer; Stage IIC Rectal Cancer; Stage IIIA Colon Cancer; Stage IIIA Rectal Cancer; Stage IIIB Colon Cancer; Stage IIIB Rectal Cancer; Stage IIIC Colon Cancer; Stage IIIC Rectal Cancer
National Cancer Institute (NCI)
 2008-07 PHASE2
NCT00276575 COMPLETED
Unspecified Adult Solid Tumor, Protocol Specific
Herbert Hurwitz, MD
 2005-03 PHASE1
NCT00617708 COMPLETED
Stage IV Pancreatic Cancer
National Cancer Institute (NCI)
 2008-03 PHASE1; PHASE2
NCT01009203 TERMINATED
Squamous Cell Carcinoma
New Mexico Cancer Research Alliance
 2009-12 PHASE2
NCT01093222 COMPLETED
Extrahepatic Bile Duct Adenocarcinoma; Gallbladder Adenocarcinoma; Gallbladder Adenocarcinoma With Squamous Metaplasia; Hilar Cholangiocarcinoma; Recurrent Extrahepatic Bile Duct Carcinoma; Recurrent Gallbladder Carcinoma; Undifferentiated Gallbladder Carcinoma; Unresectable Extrahepatic Bile Duct Carcinoma; Unresectable Gallbladder Carcinoma
National Cancer Institute (NCI)
 2010-04 PHASE2
NCT00392665 TERMINATED
Squamous Cell Carcinoma of the Head and Neck (SCCHN)
Massachusetts General Hospital
 2006-10 PHASE2
NCT00976677 TERMINATED
Recurrent Non-small Cell Lung Cancer; Stage IIIB Non-small Cell Lung Cancer; Stage IV Non-small Cell Lung Cancer
National Cancer Institute (NCI)
 2010-01 PHASE2
NCT00998036 COMPLETED
Triple Negative Breast Cancer
Columbia University
 2009-09 PHASE1
NCT00977548 COMPLETED
Myelodysplastic Syndrome
H. Lee Moffitt Cancer Center and Research Institute
 2009-09 PHASE2
NCT00556322 COMPLETED
Non-Small Cell Lung Cancer
Hoffmann-La Roche
 2006-03 PHASE3
NCT00778167 COMPLETED
Recurrent Non-small Cell Lung Cancer; Stage IIIA Non-small Cell Lung Cancer; Stage IIIB Non-small Cell Lung Cancer; Stage IV Non-small Cell Lung Cancer
National Cancer Institute (NCI)
 2008-10 PHASE1; PHASE2
NCT01565538 COMPLETED
Lung Cancer
Si-Yu Wang
 2008-12 PHASE2
NCT00901901 COMPLETED
Carcinoma, Hepatocellular
Bayer
 2009-05-21 PHASE3
NCT00446225 COMPLETED
Non-Small Cell Lung Cancer
Spanish Lung Cancer Group
 2007-02-15 PHASE3
NCT00739453 COMPLETED
Advanced Solid Tumors
Astellas Pharma Inc
 2008-10-23 PHASE1
NCT00353301 COMPLETED
Renal Cell Carcinoma
University of Colorado, Denver
 2006-07 PHASE2
NCT00855894 COMPLETED
Non-Small Cell Lung Cancer
Genentech, Inc.
 2009-03 PHASE2
NCT00265824 COMPLETED
Colorectal Cancer
GERCOR - Multidisciplinary Oncology Cooperative Group
 2005-05 PHASE3
NCT00585533 COMPLETED
Lung Cancer
University of Utah
 2004-06 PHASE2
NCT00637910 UNKNOWN
Non Small Cell Lung Cancer (NSCLC)
Fatebenefratelli and Ophthalmic Hospital
 2007-11 PHASE3
NCT01013831 TERMINATED
Dysplasia; Metaplasia; Pulmonary Precancerous Condition
National Cancer Institute (NCI)
 2009-10 PHASE1
NCT00462995 COMPLETED
Non Small Cell Lung Cancer
University Health Network, Toronto
 2006-05 PHASE2
NCT00448240 TERMINATED
Head and Neck Cancer; Carcinoma, Squamous Cell
Henry Ford Health System
 2007-02 PHASE2; PHASE3
NCT00280150 COMPLETED
Lung Cancer
UNC Lineberger Comprehensive Cancer Center
 2006-01 PHASE1; PHASE2
NCT01189435 TERMINATED
Lung Cancer
Memorial Sloan Kettering Cancer Center
 2010-08 PHASE2
NCT01149122 COMPLETED
Unresectable, Metastatic Biliary Tract Carcinoma
Samsung Medical Center
 2009-01 PHASE3
NCT00550173 COMPLETED
Non-Small-Cell Lung Cancer
Eli Lilly and Company
 2007-11 PHASE2
NCT00503971 TERMINATED
Non-small Cell Lung Cancer
Spanish Lung Cancer Group
 2008-05 PHASE1; PHASE2
NCT00577707 COMPLETED
Non Small Cell Lung Cancer; Lung Cancer
Memorial Sloan Kettering Cancer Center
 2007-11 PHASE2
NCT00349219 COMPLETED
Advanced Non-Small Cell Lung Cancer
National Cancer Institute, Naples
 2006-12 PHASE3
NCT00965731 COMPLETED
Non-Small Cell Lung Cancer
Pfizer
 2010-01 PHASE1
NCT00642746 TERMINATED
Metastatic Colorectal Cancer
OHSU Knight Cancer Institute
 2008-03 PHASE2
NCT00509431 COMPLETED
Brain and Central Nervous System Tumors
Jonsson Comprehensive Cancer Center
 2006-08 PHASE1
NCT00033514 COMPLETED
Breast Cancer
Jonsson Comprehensive Cancer Center
 2001-08 PHASE1; PHASE2
NCT00954525 COMPLETED
Metastatic Pancreatic Cancer
Sidney Kimmel Comprehensive Cancer Center at Thomas Jefferson University
 2009-07 PHASE1
NCT01454180 COMPLETED
Advanced Pancreatic Carcinoma
Centro Nacional de Investigaciones Oncologicas CARLOS III
 2011-10 PHASE2
NCT00336700 TERMINATED
Pancreatic Cancer
Herbert J. Zeh, III MD, FACS
 2006-06 PHASE2
NCT01069757 COMPLETED
Non-small-cell Lung Cancer
Kyowa Kirin Co., Ltd.
 2010-02 PHASE1
NCT00940875 TERMINATED
Non-Small Cell Lung Cancer
Hoffmann-La Roche
 2009-06 PHASE2
NCT00570401 COMPLETED
Lung Cancer
Memorial Sloan Kettering Cancer Center
 2006-06 PHASE2
NCT01299220 WITHDRAWN
Skin Rash
University of Pittsburgh
 2010-11 PHASE4
NCT00550537 COMPLETED
Lung Cancer
Vanderbilt-Ingram Cancer Center
 2007-10 PHASE2
NCT00230126 COMPLETED
Carcinoma, Non-Small-Cell Lung
Ohio State University Comprehensive Cancer Center
 2005-10 PHASE2
NCT00147537 COMPLETED
Carcinoma, Non-Small-Cell Lung
Pfizer
 2005-02 PHASE1; PHASE2
NCT00830245 TERMINATED
Leptomeningeal Carcinomatosis; Non-small Cell Lung Cancer
Clinical Research Center for Solid Tumor, Korea
 2009-01 PHASE2
NCT00996515 COMPLETED
Advanced Solid Tumor Malignancies
New Mexico Cancer Research Alliance
 2008-06 PHASE1
NCT01188707 TERMINATED
Non Small Cell Lung Cancer
Herlev Hospital
 2010-10-01 PHASE1; PHASE2
NCT00954512 TERMINATED
Neoplasms
Merck Sharp & Dohme LLC
 2009-09-25 PHASE1; PHASE2
NCT00591123 COMPLETED
Unresectable Adenocarcinoma of the Esophagus; Metastatic Adenocarcinoma of the Esophagus; Unresectable Adenocarcinoma of Gastric Cardia; Metastatic Adenocarcinoma of Gastric Cardia
Translational Oncology Research International
 2007-12 PHASE2
NCT00884845 COMPLETED
Advanced Malignant Solid Tumors
PharmaMar
 2009-01 PHASE1
NCT00848718 COMPLETED
Locally Advanced, Metastatic Solid Tumors
Merck Sharp & Dohme LLC
 2009-03-17 PHASE1
NCT00539617 TERMINATED
Esophageal Cancer
University of California, San Francisco
 2007-10-05 PHASE2
NCT00716456 COMPLETED
Lung Adenocarcinoma
Memorial Sloan Kettering Cancer Center
 2008-07 PHASE1; PHASE2
NCT00391586 TERMINATED
Carcinoma, Non-Small-Cell Lung
New Mexico Cancer Research Alliance
 2006-07 PHASE2
NCT01332279 WITHDRAWN
Recurrent Metastatic Squamous Neck Cancer With Occult Primary; Recurrent Salivary Gland Cancer; Recurrent Squamous Cell Carcinoma of the Hypopharynx; Recurrent Squamous Cell Carcinoma of the Larynx; Recurrent Squamous Cell Carcinoma of the Lip and Oral Cavity; Recurrent Squamous Cell Carcinoma of the Oropharynx; Recurrent Squamous Cell Carcinoma of the Paranasal Sinus and Nasal Cavity; Recurrent Verrucous Carcinoma of the Larynx; Recurrent Verrucous Carcinoma of the Oral Cavity; Salivary Gland Squamous Cell Carcinoma; Tongue Cancer
Fox Chase Cancer Center
 2011-04 PHASE1
NCT00777309 COMPLETED
Non Small Cell Lung Cancer
ArQule, Inc., a subsidiary of Merck Sharp & Dohme LLC, a subsidiary of Merck & Co., Inc. (Rahway, NJ USA)
 2008-09 PHASE2
NCT01104155 COMPLETED
Non-small Cell Lung Cancer
Eisai Inc.
 2010-02-22 PHASE2
NCT00113347 COMPLETED
Head and Neck Cancer
M.D. Anderson Cancer Center
 2005-04 PHASE1
NCT00597597 TERMINATED
Metastatic Breast Cancer
Rush University Medical Center
 2007-04 PHASE2
NCT00663689 UNKNOWN
Non-Small Cell Lung Cancer; Brain Metastases
Guangdong Provincial People's Hospital
 2008-03 PHASE2
NCT00673049 TERMINATED
Carcinoma, Large Cell; Carcinoma, Non-Small-Cell Lung; Carcinoma, Squamous Cell; Carcinoma, Adenosquamous Cell
Pfizer
 2008-05 PHASE3
NCT00300586 COMPLETED
Stage IV Non-small Cell Lung Cancer
Hospices Civils de Lyon
 2006-06 PHASE3
NCT00456833 COMPLETED
Non Small Cell Lung Cancer
Novartis Pharmaceuticals
 2005-06 PHASE1
NCT00278148 COMPLETED
Lung Cancer
Nathan Pennell, MD, PhD
 2005-10 PHASE1; PHASE2
NCT00777699 COMPLETED
Cancer; Non-Small Cell Lung Cancer
Sanofi
 2008-08 PHASE1
NCT00193258 COMPLETED
Clear Cell Renal Cell Carcinoma
SCRI Development Innovations, LLC
 2004-06 PHASE1; PHASE2
NCT01130753 COMPLETED
Lung Neoplasms; Erlotinib; Neoadjuvant Therapy
Samsung Medical Center
 2007-01 PHASE2
NCT00603915 COMPLETED
Nasopharyngeal Cancer
University Health Network, Toronto
 2006-06 PHASE2
NCT00570258 TERMINATED
Metastatic Breast Cancer
University of Arkansas
 2006-09 PHASE2
NCT00725634 COMPLETED
Malignant Solid Tumor; Lymphomas; Multiple Myeloma
AVEO Pharmaceuticals, Inc.
 2008-09 PHASE1
NCT00045110 COMPLETED
Adult Anaplastic Astrocytoma; Adult Anaplastic Oligodendroglioma; Adult Giant Cell Glioblastoma; Adult Glioblastoma; Adult Gliosarcoma; Adult Grade I Meningioma; Adult Grade II Meningioma; Adult Grade III Meningioma; Recurrent Adult Brain Tumor
National Cancer Institute (NCI)
 2002-08 PHASE1; PHASE2
NCT00674973 COMPLETED
Pancreatic Cancer
Hoffmann-La Roche
 2008-06 PHASE2
NCT00281021 TERMINATED
Carcinoma, Non-Small Cell Lung
University of Louisville
 2006-02 PHASE2
NCT01091376 UNKNOWN
Non-small Cell Lung Cancer
Zhejiang Cancer Hospital
 2010-01 PHASE2
NCT00840125 COMPLETED
Non-Small Cell Lung Cancer
Meir Medical Center
 2009-02 PHASE2
NCT00739063 TERMINATED
Breast Cancer
M.D. Anderson Cancer Center
 2008-07 PHASE2
NCT00696696 COMPLETED
Pancreatic Cancer
NYU Langone Health
 2007-09 PHASE2
NCT00461708 COMPLETED
Pancreatic Cancer
Hoffmann-La Roche
 2007-05 PHASE2
NCT00556712 COMPLETED
Non-Small Cell Lung Cancer
Hoffmann-La Roche
 2006-01 PHASE3
NCT00554775 TERMINATED
Lung Cancer; Metastatic Cancer
University College, London
 2008-01 PHASE2
NCT00550836 COMPLETED
Pancreatic Cancer
Alliance for Clinical Trials in Oncology
 2009-03 PHASE2
NCT00970502 COMPLETED
Cancer of the Pharynx; Cancer of the Larynx; Cancer of the Neck; Paranasal Sinus Neoplasms; Cancer of the Head
Johnny Kao
 2007-02 PHASE1; PHASE2
NCT00272038 COMPLETED
Prostate Cancer
Oncology Specialists, S.C.
 2005-12 PHASE2
NCT00769067 COMPLETED
Non-small Cell Lung Cancer
Pfizer
 2008-11 PHASE2
NCT00633529 COMPLETED
Non-Small Cell Lung Cancer
EMD Serono
 2007-11 PHASE1
NCT00520013 COMPLETED
Ovarian Cancer; Fallopian Tube Cancer; Primary Peritoneal Cancer; Papillary Serous Mullerian Tumor; Clear Cell Mullerian Tumor
Dana-Farber Cancer Institute
 2007-08 PHASE2
NCT02013206 COMPLETED
Non-Small Cell Lung Cancer
Hoffmann-La Roche
 2006-09 PHASE2
NCT00287222 COMPLETED
Hepatocellular Carcinoma
University of Arkansas
 2006-02 PHASE2
NCT00749567 TERMINATED
Non-small-cell Lung Cancer
Hellenic Oncology Research Group
 2008-07 PHASE2
NCT00708448 COMPLETED
Cancer; Non Small Cell Lung Cancer
University of Utah
 2008-03-28 PHASE1
NCT00743938 COMPLETED
Non Small Cell Lung Cancer
Bristol-Myers Squibb
 2009-03 PHASE2
NCT01130779 UNKNOWN
Non-small Cell Lung Cancer
Samsung Medical Center
 2009-08 PHASE2
NCT00425386 COMPLETED
Kidney Cancer
OHSU Knight Cancer Institute
 2006-08 PHASE2
NCT00444015 COMPLETED
Non-Small-Cell Lung Carcinoma
H. Lee Moffitt Cancer Center and Research Institute
 2007-03 PHASE1
NCT00908336 UNKNOWN
Non-Small Cell Lung Cancer
Hospital Arnau de Vilanova
 2009-03 PHASE2
NCT00125372 COMPLETED
Carcinoma, Non-small-cell Lung
Dartmouth-Hitchcock Medical Center
 2005-12
NCT00457392 COMPLETED
Carcinoma, Non-Small Cell Lung
Pfizer
 2007-07 PHASE3
NCT00609999 COMPLETED
Glioblastoma; Gliosarcoma
Duke University
 2008-01 PHASE1
NCT00126581 COMPLETED
Lung Adenocarcinoma; Lung Adenosquamous Carcinoma; Malignant Pericardial Effusion; Malignant Pleural Effusion; Minimally Invasive Lung Adenocarcinoma; Stage IIIB Lung Non-Small Cell Cancer AJCC v7; Stage IV Lung Non-Small Cell Cancer AJCC v7
National Cancer Institute (NCI)
 2005-08-15 PHASE2
NCT00760929 TERMINATED
Non-Squamous Non-Small Cell Lung Cancer
Hoffmann-La Roche
 2008-11-10 PHASE2
NCT00652340 COMPLETED
Recurrent Non Small Cell Lung Cancer
Tragara Pharmaceuticals, Inc.
 2008-04 PHASE2
NCT00729742 COMPLETED
Carcinoma, Non-small Cell Lung
Merck Sharp & Dohme LLC
 2009-02 PHASE1
NCT00321815 COMPLETED
Carcinoma, Non-Small-Cell Lung
Pfizer
 2006-08 PHASE2
NCT00524121 COMPLETED
Esophageal Cancer
Roswell Park Cancer Institute
 2006-03 PHASE2
NCT00816868 COMPLETED
Non-small Cell Lung Cancer
Sun Yat-sen University
 2009-01 PHASE2
NCT00783471 TERMINATED
Advanced Non-Small Cell Lung Cancer
Hellenic Cooperative Oncology Group
 2008-11 PHASE2
NCT00947167 TERMINATED
Neuroendocrine Tumors; Carcinoid Tumors; Adrenal Gland Tumors; Neuroblastoma; Pancreatic Neuroendocrine Tumors; Multiple Endocrine Neoplasia
Pamela L. Kunz
 2009-03 PHASE2
NCT00750698 TERMINATED
Non Small Cell Lung Cancer
Syndax Pharmaceuticals
 2008-08 PHASE2
NCT00440414 COMPLETED
Non Small Cell Lung Cancer
Hellenic Oncology Research Group
 2006-04 PHASE3
NCT00903292 UNKNOWN
Non-Small Cell Lung Cancer
National Cheng-Kung University Hospital
 2009-03
NCT00112736 COMPLETED
Adult Anaplastic Astrocytoma; Adult Anaplastic Oligodendroglioma; Adult Diffuse Astrocytoma; Adult Giant Cell Glioblastoma; Adult Glioblastoma; Adult Gliosarcoma; Adult Mixed Glioma; Adult Pilocytic Astrocytoma; Adult Pineal Gland Astrocytoma; Adult Subependymal Giant Cell Astrocytoma; Recurrent Adult Brain Tumor
National Cancer Institute (NCI)
 2005-04 PHASE1; PHASE2
NCT00307736 COMPLETED
Rectal Cancer; Adenocarcinoma of the Rectum
Massachusetts General Hospital
 2006-05 PHASE1; PHASE2
NCT00603356 COMPLETED
Advanced Solid Tumors
Astellas Pharma Inc
 2007-11 PHASE1
NCT00548093 COMPLETED
Carcinoma, Non Small Cell Lung
Pfizer
 2008-04-29 PHASE2
NCT00376948 COMPLETED
Pancreatic Cancer
Barbara Ann Karmanos Cancer Institute
 2005-05 PHASE2
NCT00996502 TERMINATED
Prostate Cancer
Columbia University
 2006-07 PHASE1; PHASE2
NCT00640978 TERMINATED
Pancreatic Cancer
M.D. Anderson Cancer Center
 2008-03 PHASE2
NCT00602030 COMPLETED
Non-Small-Cell Lung Carcinoma; Carcinoma, Non-Small Cell Lung
Syndax Pharmaceuticals
 2008-01-08 PHASE1; PHASE2
NCT00482625 TERMINATED
Intraductal Papillary Mucinous Neoplasm of the Pancreas; Recurrent Pancreatic Cancer; Stage IA Pancreatic Cancer; Stage IB Pancreatic Cancer; Stage IIA Pancreatic Cancer; Stage IIB Pancreatic Cancer; Stage III Pancreatic Cancer
National Cancer Institute (NCI)
 2007-06 PHASE2
NCT00452075 TERMINATED
Non Small Cell Lung Cancer
Rigshospitalet, Denmark
 2007-03 PHASE2
NCT00335764 COMPLETED
Adult Giant Cell Glioblastoma; Adult Glioblastoma; Adult Gliosarcoma; Recurrent Adult Brain Tumor
National Cancer Institute (NCI)
 2006-04 PHASE1; PHASE2
NCT00773383 TERMINATED
Non-Small Cell Lung Cancer
Hoffmann-La Roche
 2008-11 PHASE2
NCT00265317 COMPLETED
Carcinoma, Non-Small-Cell Lung
Pfizer
 2006-06 PHASE2
NCT00531960 COMPLETED
Non-Small Cell Lung Cancer
Hoffmann-La Roche
 2008-01 PHASE2
NCT00784667 UNKNOWN
Metastatic Colorectal Cancer
Austin Health
 2008-10 PHASE2
NCT00568841 UNKNOWN
Carcinoma, Non-Small-Cell Lung
Lung Cancer Group Cologne
 2007-10 PHASE2
NCT00881166 COMPLETED
Malignant Disease
Astex Pharmaceuticals, Inc.
 2007-11 PHASE1
NCT00030576 COMPLETED
Head and Neck Cancer
University Health Network, Toronto
 2001-11 PHASE1; PHASE2
NCT00750555 TERMINATED
Head and Neck Cancer
Geisinger Clinic
 2008-09 PHASE2
NCT01013506 WITHDRAWN
Breast Cancer
Vanderbilt-Ingram Cancer Center
 2009-08 PHASE2
NCT00803842 WITHDRAWN
Non Small Cell Lung Cancer
Northwestern University
 2008-10
NCT00654420 COMPLETED
Carcinoma, Non-small-cell Lung
Merck Sharp & Dohme LLC
 2008-03-19 PHASE2
NCT01066884 COMPLETED
Non-Squamous Non-Small Cell Lung Cancer
Hoffmann-La Roche
 2009-04 PHASE4
NCT00615758 COMPLETED
Non Small Cell Lung Cancer
Hellenic Oncology Research Group
 2006-10 PHASE2
NCT00522145 COMPLETED
Carcinoma, Non-Small-Cell Lung
Kadmon Corporation, LLC
 2007-05 PHASE2
NCT00598156 COMPLETED
Metastatic Colorectal Cancer
Lund University Hospital
 2007-06 PHASE3
NCT00393068 COMPLETED
Esophageal Cancer
SCRI Development Innovations, LLC
 2007-02 PHASE2
NCT00885066 COMPLETED
Pancreatic Cancer
Centre Antoine Lacassagne
 2008-05 PHASE1
NCT00452413 COMPLETED
Non-Small Cell Lung Cancer; Malignant Solid Tumor
Eli Lilly and Company
 2007-05 PHASE1; PHASE2
NCT02774278 COMPLETED
Non-Squamous Non-Small Cell Lung Cancer
Hoffmann-La Roche
 2005-07 PHASE2
NCT00350753 COMPLETED
Cholangiocarcinoma; Gallbladder Cancer
Rigshospitalet, Denmark
 2006-06 PHASE2
NCT00140556 COMPLETED
Head and Neck Cancer; Pharynx Cancer
David M. Brizel, MD
 2005-08 EARLY_PHASE1
NCT00570375 WITHDRAWN
Myelodysplastic Syndrome
University of Cincinnati
 2007-11 PHASE2
NCT00569114 COMPLETED
Non-small Cell Lung Cancer
Tragara Pharmaceuticals, Inc.
 2007-10 PHASE1
NCT00354549 COMPLETED
Lung Cancer
Swiss Cancer Institute
 2006-01 PHASE2
NCT00408499 COMPLETED
Lung Cancer; Unspecified Adult Solid Tumor, Protocol Specific
University of California, Davis
 2006-08 PHASE1; PHASE2
NCT00266097 COMPLETED
Extrahepatic Bile Duct Cancer; Gallbladder Cancer; Pancreatic Cancer
UNC Lineberger Comprehensive Cancer Center
 2004-08 PHASE1
NCT00387894 TERMINATED
Adult Brain Tumors
Michael Prados
 2007-01 PHASE2
NCT00600015 COMPLETED
Non-Small Cell Lung Cancer
SCRI Development Innovations, LLC
 2008-02 PHASE2
NCT00203424 COMPLETED
Prostate Cancer
Translational Oncology Research International
 2006-01 PHASE2
NCT00574366 COMPLETED
Breast Cancer
Vanderbilt-Ingram Cancer Center
 2005-12 PHASE1
NCT00442507 TERMINATED
Esophageal Neoplasms; Esophageal Diseases
Washington University School of Medicine
 2007-03 PHASE2
NCT00088959 COMPLETED
Recurrent Non-small Cell Lung Cancer; Stage IIIB Non-small Cell Lung Cancer; Stage IV Non-small Cell Lung Cancer
National Cancer Institute (NCI)
 2003-12 PHASE1
NCT00470535 TERMINATED
Pancreatic Cancer
Roswell Park Cancer Institute
 2007-01 PHASE2
NCT00497224 COMPLETED
Cancer; Pancreas
University Health Network, Toronto
 2006-11 PHASE2
NCT02507375 COMPLETED
Non-Small Cell Lung Cancer
Hoffmann-La Roche
 2006-09 PHASE1
NCT00042835 TERMINATED
Adenocarcinoma of the Lung; Bronchoalveolar Cell Lung Cancer; Large Cell Lung Cancer; Squamous Cell Lung Cancer; Stage IIIA Non-small Cell Lung Cancer; Stage IIIB Non-small Cell Lung Cancer
National Cancer Institute (NCI)
 2002-05 PHASE1
NCT04145570 COMPLETED
Lung Cancer
Quadras Scientific Solutions
 2008-10-23 PHASE4
NCT00722969 UNKNOWN
Non-Small Cell Lung Cancer
Universitair Ziekenhuis Brussel
 2007-11 PHASE2
NCT00671970 COMPLETED
Glioblastoma; Gliosarcoma
Duke University
 2007-02 PHASE2
NCT01214720 COMPLETED
Pancreatic Cancer
Hoffmann-La Roche
 2005-07 PHASE3
NCT00320073 COMPLETED
Unspecified Adult Solid Tumor, Protocol Specific
UNC Lineberger Comprehensive Cancer Center
 2006-08 PHASE1
NCT00672243 COMPLETED
Glioblastoma; Gliosarcoma
Duke University
 2007-04 PHASE2
NCT00351039 TERMINATED
Non-Small Cell Lung Cancer
H. Lee Moffitt Cancer Center and Research Institute
 2006-07 PHASE1; PHASE2
NCT00392704 COMPLETED
Head and Neck Cancer
SCRI Development Innovations, LLC
 2006-12 PHASE2
NCT00148772 COMPLETED
Prostate Cancer
Endeavor Health
 2005-08 PHASE2
NCT00466687 COMPLETED
Melanoma
Vanderbilt-Ingram Cancer Center
 2004-09 PHASE2
NCT00390429 COMPLETED
Lung Cancer; Unspecified Adult Solid Tumor, Protocol Specific
University of California, Davis
 2002-07 PHASE1; PHASE2
NCT00365391 COMPLETED
Adult Primary Hepatocellular Carcinoma; Advanced Adult Primary Liver Cancer; Localized Unresectable Adult Primary Liver Cancer; Recurrent Adult Primary Liver Cancer
National Cancer Institute (NCI)
 2006-08 PHASE2
NCT00873353 COMPLETED
Metastatic Adenocarcinoma of the Pancreas
Grupo Gallego de Investigaciones Oncologicas
 2008-03 PHASE2
NCT00130728 COMPLETED
Non-Small Cell Lung Cancer
Genentech, Inc.
 2005-06-08 PHASE3
NCT00284141 COMPLETED
Pulmonary Diseases; Neoplasms, Lung
Sanofi
 2006-01 PHASE2
NCT00085553 COMPLETED
Solid Neoplasm
National Cancer Institute (NCI)
 2004-05-20 PHASE1
NCT00367601 COMPLETED
Lung Cancer
Nasser Hanna, M.D.
 2006-08 PHASE2
NCT01235416 COMPLETED
Histologically or Cytologically Documented Solid Tumors
Amgen
 2005-09 PHASE1
NCT00428194 WITHDRAWN
Cervical Cancer
Masonic Cancer Center, University of Minnesota
 2007-01 PHASE1
NCT00522938 TERMINATED
Carcinoma, Non-Small-Cell Lung
Chroma Therapeutics
 2007-12 PHASE1; PHASE2
NCT00049283 COMPLETED
Metastatic Squamous Neck Cancer With Occult Primary Squamous Cell Carcinoma; Stage III Squamous Cell Carcinoma of the Hypopharynx; Stage III Squamous Cell Carcinoma of the Larynx; Stage III Squamous Cell Carcinoma of the Lip and Oral Cavity; Stage III Squamous Cell Carcinoma of the Nasopharynx; Stage III Squamous Cell Carcinoma of the Oropharynx; Stage III Verrucous Carcinoma of the Larynx; Stage III Verrucous Carcinoma of the Oral Cavity; Stage IV Squamous Cell Carcinoma of the Hypopharynx; Stage IV Squamous Cell Carcinoma of the Nasopharynx; Stage IVA Squamous Cell Carcinoma of the Larynx; Stage IVA Squamous Cell Carcinoma of the Lip and Oral Cavity; Stage IVA Squamous Cell Carcinoma of the Oropharynx; Stage IVA Verrucous Carcinoma of the Larynx; Stage IVA Verrucous Carcinoma of the Oral Cavity; Stage IVB Squamous Cell Carcinoma of the Larynx; Stage IVB Squamous Cell Carcinoma of the Lip and Oral Cavity; Stage IVB Squamous Cell Carcinoma of the Oropharynx; Stage IVB Verrucous Carcinoma of the Larynx; Stage IVB Verrucous Carcinoma of the Oral Cavity; Stage IVC Squamous Cell Carcinoma of the Larynx; Stage IVC Squamous Cell Carcinoma of the Lip and Oral Cavity; Stage IVC Squamous Cell Carcinoma of the Oropharynx; Stage IVC Verrucous Carcinoma of the Larynx; Stage IVC Verrucous Carcinoma of the Oral Cavity; Tongue Cancer; Untreated Metastatic Squamous Neck Cancer With Occult Primary
National Cancer Institute (NCI)
 2002-09 PHASE1
NCT00360360 COMPLETED
Neoplasm, Unknown Primary
SCRI Development Innovations, LLC
 2006-07 PHASE2
NCT00227032 TERMINATED
Brain and Central Nervous System Tumors
UNC Lineberger Comprehensive Cancer Center
 2005-09 PHASE1
NCT00536861 COMPLETED
Non-Small Cell Lung Cancer; Brain Metastases
Amsterdam UMC, location VUmc
 2006-05 PHASE1
NCT00387322 COMPLETED
Lung Cancer; Unspecified Adult Solid Tumor, Protocol Specific
University of California, Davis
 2005-03 PHASE1; PHASE2
NCT00101348 COMPLETED
Metastatic Squamous Neck Cancer With Occult Primary Squamous Cell Carcinoma; Recurrent Adenoid Cystic Carcinoma of the Oral Cavity; Recurrent Basal Cell Carcinoma of the Lip; Recurrent Colon Cancer; Recurrent Esthesioneuroblastoma of the Paranasal Sinus and Nasal Cavity; Recurrent Inverted Papilloma of the Paranasal Sinus and Nasal Cavity; Recurrent Lymphoepithelioma of the Nasopharynx; Recurrent Lymphoepithelioma of the Oropharynx; Recurrent Metastatic Squamous Neck Cancer With Occult Primary; Recurrent Midline Lethal Granuloma of the Paranasal Sinus and Nasal Cavity; Recurrent Mucoepidermoid Carcinoma of the Oral Cavity; Recurrent Non-small Cell Lung Cancer; Recurrent Pancreatic Cancer; Recurrent Rectal Cancer; Recurrent Salivary Gland Cancer; Recurrent Squamous Cell Carcinoma of the Hypopharynx; Recurrent Squamous Cell Carcinoma of the Larynx; Recurrent Squamous Cell Carcinoma of the Lip and Oral Cavity; Recurrent Squamous Cell Carcinoma of the Nasopharynx; Recurrent Squamous Cell Carcinoma of the Oropharynx; Recurrent Squamous Cell Carcinoma of the Paranasal Sinus and Nasal Cavity; Recurrent Verrucous Carcinoma of the Larynx; Recurrent Verrucous Carcinoma of the Oral Cavity; Stage III Adenoid Cystic Carcinoma of the Oral Cavity; Stage III Basal Cell Carcinoma of the Lip; Stage III Colon Cancer; Stage III Esthesioneuroblastoma of the Paranasal Sinus and Nasal Cavity; Stage III Inverted Papilloma of the Paranasal Sinus and Nasal Cavity; Stage III Lymphoepithelioma of the Nasopharynx; Stage III Lymphoepithelioma of the Oropharynx; Stage III Midline Lethal Granuloma of the Paranasal Sinus and Nasal Cavity; Stage III Mucoepidermoid Carcinoma of the Oral Cavity; Stage III Pancreatic Cancer; Stage III Rectal Cancer; Stage III Salivary Gland Cancer; Stage III Squamous Cell Carcinoma of the Hypopharynx; Stage III Squamous Cell Carcinoma of the Larynx; Stage III Squamous Cell Carcinoma of the Lip and Oral Cavity; Stage III Squamous Cell Carcinoma of the Nasopharynx; Stage III Squamous Cell Carcinoma of the Oropharynx; Stage III Squamous Cell Carcinoma of the Paranasal Sinus and Nasal Cavity; Stage III Verrucous Carcinoma of the Larynx; Stage III Verrucous Carcinoma of the Oral Cavity; Stage IIIB Non-small Cell Lung Cancer; Stage IV Adenoid Cystic Carcinoma of the Oral Cavity; Stage IV Basal Cell Carcinoma of the Lip; Stage IV Colon Cancer; Stage IV Esthesioneuroblastoma of the Paranasal Sinus and Nasal Cavity; Stage IV Inverted Papilloma of the Paranasal Sinus and Nasal Cavity; Stage IV Lymphoepithelioma of the Nasopharynx; Stage IV Lymphoepithelioma of the Oropharynx; Stage IV Midline Lethal Granuloma of the Paranasal Sinus and Nasal Cavity; Stage IV Mucoepidermoid Carcinoma of the Oral Cavity; Stage IV Non-small Cell Lung Cancer; Stage IV Pancreatic Cancer; Stage IV Rectal Cancer; Stage IV Renal Cell Cancer; Stage IV Salivary Gland Cancer; Stage IV Squamous Cell Carcinoma of the Hypopharynx; Stage IV Squamous Cell Carcinoma of the Larynx; Stage IV Squamous Cell Carcinoma of the Lip and Oral Cavity; Stage IV Squamous Cell Carcinoma of the Nasopharynx; Stage IV Squamous Cell Carcinoma of the Oropharynx; Stage IV Squamous Cell Carcinoma of the Paranasal Sinus and Nasal Cavity; Stage IV Verrucous Carcinoma of the Larynx; Stage IV Verrucous Carcinoma of the Oral Cavity; Untreated Metastatic Squamous Neck Cancer With Occult Primary
National Cancer Institute (NCI)
 2005-01 PHASE1; PHASE2
NCT00274833 COMPLETED
CNS Tumor, Adult
David Peereboom
 2005-10 PHASE2
NCT00055913 COMPLETED
Recurrent Squamous Cell Carcinoma of the Hypopharynx; Recurrent Squamous Cell Carcinoma of the Larynx; Recurrent Squamous Cell Carcinoma of the Lip and Oral Cavity; Recurrent Squamous Cell Carcinoma of the Nasopharynx; Recurrent Squamous Cell Carcinoma of the Oropharynx; Recurrent Squamous Cell Carcinoma of the Paranasal Sinus and Nasal Cavity; Salivary Gland Squamous Cell Carcinoma; Stage IV Squamous Cell Carcinoma of the Hypopharynx; Stage IV Squamous Cell Carcinoma of the Larynx; Stage IV Squamous Cell Carcinoma of the Lip and Oral Cavity; Stage IV Squamous Cell Carcinoma of the Nasopharynx; Stage IV Squamous Cell Carcinoma of the Oropharynx; Stage IV Squamous Cell Carcinoma of the Paranasal Sinus and Nasal Cavity
National Cancer Institute (NCI)
 2003-03 PHASE1; PHASE2
NCT00673569 COMPLETED
Lung Cancer
Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins
 2006-09 PHASE2
NCT00283634 TERMINATED
NSCLC
Millennium Pharmaceuticals, Inc.
 2005-08 PHASE2
NCT00049166 COMPLETED
Stage II Squamous Cell Carcinoma of the Lip and Oral Cavity; Stage II Squamous Cell Carcinoma of the Oropharynx; Stage III Squamous Cell Carcinoma of the Lip and Oral Cavity; Stage III Squamous Cell Carcinoma of the Oropharynx; Stage IV Squamous Cell Carcinoma of the Lip and Oral Cavity; Stage IV Squamous Cell Carcinoma of the Oropharynx
National Cancer Institute (NCI)
 2002-10 PHASE1
NCT00030498 COMPLETED
Adult Anaplastic Astrocytoma; Adult Anaplastic Ependymoma; Adult Anaplastic Oligodendroglioma; Adult Brain Stem Glioma; Adult Diffuse Astrocytoma; Adult Ependymoblastoma; Adult Giant Cell Glioblastoma; Adult Glioblastoma; Adult Gliosarcoma; Adult Mixed Glioma; Adult Myxopapillary Ependymoma; Adult Oligodendroglioma; Adult Pilocytic Astrocytoma; Adult Primary Hepatocellular Carcinoma; Adult Subependymoma; Advanced Adult Primary Liver Cancer; Advanced Malignant Mesothelioma; Male Breast Cancer; Recurrent Adenoid Cystic Carcinoma of the Oral Cavity; Recurrent Adult Brain Tumor; Recurrent Adult Primary Liver Cancer; Recurrent Anal Cancer; Recurrent Basal Cell Carcinoma of the Lip; Recurrent Bladder Cancer; Recurrent Breast Cancer; Recurrent Cervical Cancer; Recurrent Colon Cancer; Recurrent Esophageal Cancer; Recurrent Esthesioneuroblastoma of the Paranasal Sinus and Nasal Cavity; Recurrent Inverted Papilloma of the Paranasal Sinus and Nasal Cavity; Recurrent Lymphoepithelioma of the Nasopharynx; Recurrent Lymphoepithelioma of the Oropharynx; Recurrent Malignant Mesothelioma; Recurrent Metastatic Squamous Neck Cancer With Occult Primary; Recurrent Midline Lethal Granuloma of the Paranasal Sinus and Nasal Cavity; Recurrent Mucoepidermoid Carcinoma of the Oral Cavity; Recurrent Non-small Cell Lung Cancer; Recurrent Ovarian Epithelial Cancer; Recurrent Pancreatic Cancer; Recurrent Prostate Cancer; Recurrent Rectal Cancer; Recurrent Salivary Gland Cancer; Recurrent Squamous Cell Carcinoma of the Hypopharynx; Recurrent Squamous Cell Carcinoma of the Larynx; Recurrent Squamous Cell Carcinoma of the Lip and Oral Cavity; Recurrent Squamous Cell Carcinoma of the Nasopharynx; Recurrent Squamous Cell Carcinoma of the Oropharynx; Recurrent Squamous Cell Carcinoma of the Paranasal Sinus and Nasal Cavity; Recurrent Verrucous Carcinoma of the Larynx; Recurrent Verrucous Carcinoma of the Oral Cavity; Stage II Esophageal Cancer; Stage II Pancreatic Cancer; Stage III Esophageal Cancer; Stage III Pancreatic Cancer; Stage IIIB Non-small Cell Lung Cancer; Stage IV Adenoid Cystic Carcinoma of the Oral Cavity; Stage IV Anal Cancer; Stage IV Basal Cell Carcinoma of the Lip; Stage IV Bladder Cancer; Stage IV Breast Cancer; Stage IV Colon Cancer; Stage IV Esophageal Cancer; Stage IV Esthesioneuroblastoma of the Paranasal Sinus and Nasal Cavity; Stage IV Inverted Papilloma of the Paranasal Sinus and Nasal Cavity; Stage IV Lymphoepithelioma of the Nasopharynx; Stage IV Lymphoepithelioma of the Oropharynx; Stage IV Midline Lethal Granuloma of the Paranasal Sinus and Nasal Cavity; Stage IV Mucoepidermoid Carcinoma of the Oral Cavity; Stage IV Non-small Cell Lung Cancer; Stage IV Ovarian Epithelial Cancer; Stage IV Pancreatic Cancer; Stage IV Prostate Cancer; Stage IV Rectal Cancer; Stage IV Salivary Gland Cancer; Stage IV Squamous Cell Carcinoma of the Hypopharynx; Stage IV Squamous Cell Carcinoma of the Larynx; Stage IV Squamous Cell Carcinoma of the Lip and Oral Cavity; Stage IV Squamous Cell Carcinoma of the Nasopharynx; Stage IV Squamous Cell Carcinoma of the Oropharynx; Stage IV Squamous Cell Carcinoma of the Paranasal Sinus and Nasal Cavity; Stage IV Verrucous Carcinoma of the Larynx; Stage IV Verrucous Carcinoma of the Oral Cavity; Stage IVA Cervical Cancer; Stage IVB Cervical Cancer; Unspecified Adult Solid Tumor, Protocol Specific; Untreated Metastatic Squamous Neck Cancer With Occult Primary
National Cancer Institute (NCI)
 2001-12 PHASE1
NCT00362986 COMPLETED
Dermatologic Complications; Unspecified Adult Solid Tumor, Protocol Specific
Alliance for Clinical Trials in Oncology
 2006-10 PHASE3
NCT00116506 COMPLETED
Colorectal Cancer; Neoplasm Metastasis
Dana-Farber Cancer Institute
 2005-01 PHASE2
NCT00087412 COMPLETED
Adenocarcinoma of the Lung; Large Cell Lung Cancer; Recurrent Non-small Cell Lung Cancer; Squamous Cell Lung Cancer; Stage IIIB Non-small Cell Lung Cancer; Stage IV Non-small Cell Lung Cancer
National Cancer Institute (NCI)
 2004-09 PHASE2
NCT00060307 COMPLETED
Recurrent Renal Cell Cancer; Stage III Renal Cell Cancer; Stage IV Renal Cell Cancer
National Cancer Institute (NCI)
 2003-05 PHASE2
NCT00072631 COMPLETED
Advanced Non Small Cell Lung Cancer; Failed Prior Chemotherapy
OSI Pharmaceuticals
 2003-11-05 PHASE2
NCT00137826 COMPLETED
Mesothelioma
Dana-Farber Cancer Institute
 2004-02 PHASE2
NCT00085839 COMPLETED
Non-Small Cell Lung Cancer
OSI Pharmaceuticals
 2004-02 PHASE2
NCT00126542 COMPLETED
Fallopian Tube Cancer; Primary Peritoneal Cavity Cancer; Recurrent Ovarian Epithelial Cancer; Stage IV Ovarian Epithelial Cancer
National Cancer Institute (NCI)
 2005-04 PHASE2
NCT00055770 COMPLETED
Recurrent Salivary Gland Cancer; Recurrent Squamous Cell Carcinoma of the Hypopharynx; Recurrent Squamous Cell Carcinoma of the Larynx; Recurrent Squamous Cell Carcinoma of the Lip and Oral Cavity; Recurrent Squamous Cell Carcinoma of the Nasopharynx; Recurrent Squamous Cell Carcinoma of the Oropharynx; Recurrent Squamous Cell Carcinoma of the Paranasal Sinus and Nasal Cavity; Salivary Gland Squamous Cell Carcinoma; Stage III Salivary Gland Cancer; Stage III Squamous Cell Carcinoma of the Hypopharynx; Stage III Squamous Cell Carcinoma of the Larynx; Stage III Squamous Cell Carcinoma of the Lip and Oral Cavity; Stage III Squamous Cell Carcinoma of the Nasopharynx; Stage III Squamous Cell Carcinoma of the Oropharynx; Stage III Squamous Cell Carcinoma of the Paranasal Sinus and Nasal Cavity; Stage IV Salivary Gland Cancer; Stage IV Squamous Cell Carcinoma of the Hypopharynx; Stage IV Squamous Cell Carcinoma of the Larynx; Stage IV Squamous Cell Carcinoma of the Lip and Oral Cavity; Stage IV Squamous Cell Carcinoma of the Nasopharynx; Stage IV Squamous Cell Carcinoma of the Oropharynx; Stage IV Squamous Cell Carcinoma of the Paranasal Sinus and Nasal Cavity
National Cancer Institute (NCI)
 2002-10 PHASE1; PHASE2
NCT00033462 COMPLETED
Adult Primary Cholangiocellular Carcinoma; Adult Primary Hepatocellular Carcinoma; Advanced Adult Primary Liver Cancer; Cholangiocarcinoma of the Extrahepatic Bile Duct; Cholangiocarcinoma of the Gallbladder; Localized Unresectable Adult Primary Liver Cancer; Recurrent Adult Primary Liver Cancer; Recurrent Extrahepatic Bile Duct Cancer; Recurrent Gallbladder Cancer; Unresectable Extrahepatic Bile Duct Cancer; Unresectable Gallbladder Cancer
National Cancer Institute (NCI)
 2002-03 PHASE2
NCT00085280 COMPLETED
Recurrent Non-small Cell Lung Cancer; Stage IIIB Non-small Cell Lung Cancer; Stage IV Non-small Cell Lung Cancer
National Cancer Institute (NCI)
 2004-09
NCT00281866 COMPLETED
Head and Neck Cancer
Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins
 2005-07 PHASE2
NCT00088946 COMPLETED
Bladder Cancer
Jonsson Comprehensive Cancer Center
 2004-05 PHASE2
NCT00086879 COMPLETED
Brain and Central Nervous System Tumors
European Organisation for Research and Treatment of Cancer - EORTC
 2004-05 PHASE2
NCT00047333 TERMINATED
Adult Primary Hepatocellular Carcinoma; Advanced Adult Primary Liver Cancer; Localized Unresectable Adult Primary Liver Cancer
National Cancer Institute (NCI)
 2002-08 PHASE2
NCT00047346 COMPLETED
Adult Primary Hepatocellular Carcinoma; Advanced Adult Primary Liver Cancer; Localized Unresectable Adult Primary Liver Cancer; Recurrent Adult Primary Liver Cancer
National Cancer Institute (NCI)
 2002-08 PHASE1
NCT00217529 COMPLETED
Fallopian Tube Cancer; Ovarian Cancer; Peritoneal Cavity Cancer
Fred Hutchinson Cancer Center
 2004-06 PHASE1; PHASE2
NCT00193622 COMPLETED
Neoplasms, Unknown Primary
SCRI Development Innovations, LLC
 2004-04 PHASE2
NCT00030446 COMPLETED
Fallopian Tube Cancer; Ovarian Cancer; Peritoneal Cavity Cancer
NCIC Clinical Trials Group
 2002-01-10 PHASE2
NCT00033241 COMPLETED
Pancreatic Cancer; Unspecified Adult Solid Tumor, Protocol Specific
OSI Pharmaceuticals
 2001-07-23 PHASE1
NCT00040183 COMPLETED
Pancreatic Cancer
OSI Pharmaceuticals
 2001-11-29 PHASE3
NCT00268684 UNKNOWN
Carcinoma, Non-Small-Cell Lung; Neoplasm Metastasis
Tel-Aviv Sourasky Medical Center
 2005-05 PHASE3
NCT00337883 COMPLETED
Glioblastoma
Genentech, Inc.
 2003-07 PHASE2
NCT00091663 COMPLETED
Lung Cancer; Non-small-cell Lung Carcinoma
Genentech, Inc.
 2004-08 PHASE3
NCT00536770 SUSPENDED
Pancreatic Cancer
Novacea
 2007-09 PHASE2
NCT00030537 COMPLETED
Breast Cancer
National Cancer Institute (NCI)
 2001-11 PHASE2
NCT00466284 UNKNOWN
Non-Small Cell Lung Cancer
Grupo Gallego de Cancer de Pulmon
 2006-01 PHASE2
NCT00047736 COMPLETED
Lung Cancer
Genentech, Inc.
 2001-07 PHASE3
NCT00072072 COMPLETED
Lung Cancer
Jonsson Comprehensive Cancer Center
 2003-08 PHASE1
NCT01600807 WITHDRAWN
Pancreatic Cancer, Metastatic
Dana-Farber Cancer Institute
 PHASE1; PHASE2
NCT00081614 COMPLETED
Renal Cell Carcinoma; Metastases
Genentech, Inc.
 2004-03 PHASE2
NCT00109265 COMPLETED
Breast Cancer
Genentech, Inc.
 2001-05 PHASE2
NCT00293436 WITHDRAWN
Liver Cancer
University of California, San Francisco
 2005-01 PHASE1; PHASE2
NCT00047762 COMPLETED
Colorectal Cancer
Genentech, Inc.
 2002-10 PHASE1
NCT00339586 UNKNOWN
Lung Neoplasms; Non-Small Cell Lung Cancer; Adenocarcinoma, Bronchiolo-Alveolar
Universitair Ziekenhuis Brussel
 2006-01 PHASE2
NCT00095225 COMPLETED
Non-Small-Cell Lung Carcinoma; Neoplasm Recurrence, Local
Genentech, Inc.
 2004-07 PHASE2
NCT00955695 UNKNOWN
Lung Cancer
National Cancer Center, Korea
 2009-05 PHASE3
NCT00989690 UNKNOWN
Lung Cancer
Istituto Scientifico H. San Raffaele
 2008-02 PHASE3

(data from https://clinicaltrials.gov, updated on 2026-08-03)

Check the Erlotinib (CP-358774) Hydrochloride product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.

Compliance for Clinical Use

Mechanism and Biochemical Profile

Erlotinib hydrochloride potently binds to the epidermal growth factor receptor (EGFR/HER1) tyrosine kinase, inhibiting receptor autophosphorylation and triggering the upregulation of p27 with concurrent suppression of cyclin D1. This blockade induces G1 phase cell-cycle arrest and suppresses cell proliferation, which directly underlies its therapeutic efficacy in inhibiting tumor growth across EGFR-driven malignancies such as non-small cell lung cancer and head and neck carcinoma.

Appendix RUO and cGMP Quality Standards

Quality Dimension RUO (Research Use Only) cGMP (Current Good Manufacturing Practice)
Clinical Applicability Prohibited in human clinical trials or medical diagnostics. Mandatory for human clinical trials (Phase I–III) and therapies.
Regulatory Status Non-regulated grade; exempt from drug manufacturing laws. Legally enforced by health authorities (e.g., FDA, EMA, NMPA).
Facility Environment Unclassified analytical or research laboratories. Validated Cleanrooms (ISO Class 5–8) with continuous monitoring.
Quality Control Basic purity and activity testing. Rigorous safety release testing (Sterility, Endotoxin, Mycoplasma).
Process Validation Basic equipment calibration; no process validation required. Full qualification (IQ/OQ/PQ) and complete batch records.
Quality Assurance Vendor self-declared without required formal QMS. Mandatory QA/QC unit, Change Control, CAPA, and vendor audits.
Regulatory Impact High risk of IND rejection if used as a critical raw material. Required for IND/NDA filings, supported by Drug Master Files (DMF).

Footnotes

Regulatory Note: Governed by FDA (21 CFR Parts 210/211/312), EMA (EudraLex Vol 4), ICH Guidelines (E6/Q7/Q9/Q10), and compendial standards (USP <71>/<85>/<1043>).

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Note: Technical data last updated: Sep 1, 2026.