CAS No. 183319-69-9
Batch:
Purity:99.94
Chemical Structure
Check the
Erlotinib (CP-358774) Hydrochloride
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
| IUPAC Name | N-(3-ethynylphenyl)-6,7-bis(2-methoxyethoxy)quinazolin-4-amine;hydrochloride | |
|---|---|---|
| CAS Number | 183319-69-9 | |
| Molecular Formula |
C22H23N3O4.HCl |
|
| Molecular Weight (MW) | 429.90 | |
| SMILES | COCCOC1=C(C=C2C(=C1)C(=NC=N2)NC3=CC=CC(=C3)C#C)OCCOC.Cl | |
| InChIKey | GTTBEUCJPZQMDZ-UHFFFAOYSA-N |
Erlotinib Hydrochloride is a potent EGFR inhibitor with an IC50 of 2 nM in cell-free assays and shows over 1000-fold selectivity for EGFR over c-Src and v-Abl. It inhibits EGFR autophosphorylation in intact tumor cells with an IC50 of 20 nM. By blocking EGFR kinase activity, erlotinib induces p27 accumulation and downregulates cyclin D1 expression, leading to cell-cycle arrest at the G1 phase and inhibition of cell proliferation. [1]
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Concentration
Volume
Mass
|
|---|
Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| DMSO |
6 mg/mL
(13.95 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Water | Insoluble |
| Ethanol | Insoluble |
| DMSO |
4 mg/mL
(9.3 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO.) |
| Water | Insoluble |
| Ethanol | Insoluble |
| DMSO |
6 mg/mL
(13.95 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Water | Insoluble |
| Ethanol | Insoluble |
| DMSO |
4 mg/mL
(9.3 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO.) |
| Water | Insoluble |
| Ethanol | Insoluble |
| DMSO |
4 mg/mL
(9.3 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO.) |
| Water | Insoluble |
| Ethanol | Insoluble |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Pre-aliquoted for Longevity: Solid-state aliquots offer significantly longer shelf life compared to stock solutions, ensuring maximum stability for every use.
Looking for a specific aliquot size? Reach out to your local sales representative or contact us at orders@selleckchem.com.
- Erlotinib (CP-358774) Hydrochloride Clinical Trials
- Erlotinib (CP-358774) Hydrochloride Solubility in DMSO
- Erlotinib (CP-358774) Hydrochloride Stock Solution
- Erlotinib (CP-358774) Hydrochloride Storage
- Erlotinib (CP-358774) Hydrochloride Stability
- Erlotinib (CP-358774) Hydrochloride Molecular Weight
- Erlotinib (CP-358774) Hydrochloride SMILES
- Erlotinib (CP-358774) Hydrochloride Chemical Structure (2D and 3D)
- Erlotinib (CP-358774) Hydrochloride SDS｜MSDS
Note: Technical data last updated: Sep 1, 2026.