CAS No. 152044-54-7

Batch: Purity:99.93
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Patupilone (Epothilone B) Chemical Structure
Chemical Structure
Check the Patupilone (Epothilone B) product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.

Chemical Information

IUPAC Name (1S,3S,7S,10R,11S,12S,16R)-7,11-dihydroxy-8,8,10,12,16-pentamethyl-3-[(E)-1-(2-methyl-1,3-thiazol-4-yl)prop-1-en-2-yl]-4,17-dioxabicyclo[14.1.0]heptadecane-5,9-dione
CAS Number 152044-54-7
Molecular Formula

C27H41NO6S
Molecular Weight (MW) 507.68
SMILES CC1CCCC2(C(O2)CC(OC(=O)CC(C(C(=O)C(C1O)C)(C)C)O)C(=CC3=CSC(=N3)C)C)C
InChIKey QXRSDHAAWVKZLJ-PVYNADRNSA-N

Ordering Information

Biological Activity

Patupilone (Epothilone B) is a potent microtubule-stabilizing agent and microtubule function inhibitor with an IC50 of. By binding to tubulin, it promotes microtubule assembly and suppresses microtubule dynamics in a concentration-dependent manner. This induction of microtubule stabilization leads to mitotic cell cycle arrest at the G2/M transition, preventing proper cell division and inducing apoptotic cell death in targeted cancer cells. [1]

How to Prepare Stock Solution?

Concentration Volume Mass
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Solubility

Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
Solvent Solubility & Note
DMSO 102 mg/mL (200.91 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.)
Ethanol 102 mg/mL
Water Insoluble
FAQ
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
  • Preheat media/saline to 37°C.
  • Mix rapidly (pipette/vortex) upon addition.
  • For complex mixes, always add the aqueous phase last.
  • Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).

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Note: Technical data last updated: Sep 1, 2026.