CAS No. 99873-43-5
Batch:
Purity:99.88
Chemical Structure
Check the
Droxinostat
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
| IUPAC Name | 4-(4-chloro-2-methylphenoxy)-N-hydroxybutanamide | |
|---|---|---|
| CAS Number | 99873-43-5 | |
| Molecular Formula |
C11H14ClNO3 |
|
| Molecular Weight (MW) | 243.69 | |
| SMILES | CC1=C(C=CC(=C1)Cl)OCCCC(=O)NO | |
| InChIKey | JHSXDAWGLCZYSM-UHFFFAOYSA-N |
Droxinostat is a selective histone deacetylase (HDAC) inhibitor targeting HDAC8 (IC50 = 1.46 μM), HDAC6 (IC50 = 2.47 μM), and HDAC3 (IC50 = 16.9 μM). By selectively inhibiting these HDAC isoforms, droxinostat enhances caspase activation and sensitizes malignant cell populations to FAS- and Apo2L/TRAIL-induced apoptosis through the extrinsic death receptor signaling pathway.
|
Concentration
Volume
Mass
|
1 mg | 5 mg | 10 mg |
|---|
Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| DMSO |
49 mg/mL
(201.07 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Ethanol | 49 mg/mL |
| Water | Insoluble |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Pre-aliquoted for Longevity: Solid-state aliquots offer significantly longer shelf life compared to stock solutions, ensuring maximum stability for every use.
Looking for a specific aliquot size? Reach out to your local sales representative or contact us at orders@selleckchem.com.
Note: Technical data last updated: Sep 1, 2026.