CAS No. 130693-82-2

Batch: Purity:99.96
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Dorzolamide HCl Chemical Structure
Chemical Structure
Check the Dorzolamide HCl product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.

Chemical Information

IUPAC Name (4S,6S)-4-(ethylamino)-6-methyl-7,7-dioxo-5,6-dihydro-4H-thieno[2,3-b]thiopyran-2-sulfonamide;hydrochloride
CAS Number 130693-82-2
Molecular Formula

C10H16N2O4S3.HCl
Molecular Weight (MW) 360.9
SMILES CCNC1CC(S(=O)(=O)C2=C1C=C(S2)S(=O)(=O)N)C.Cl
InChIKey OSRUSFPMRGDLAG-QMGYSKNISA-N

Biological Activity

Dorzolamide HCl is a water-soluble, potent inhibitor of human carbonic anhydrase II and carbonic anhydrase IV. By inhibiting carbonic anhydrase activity in the ciliary processes of the eye, it reduces bicarbonate ion formation and decreases aqueous humor secretion. This suppression of fluid transport effectively lowers intraocular pressure, making it a key agent for studying ocular hypertension and fluid homeostasis pathways. [1]

How to Prepare Stock Solution?

Concentration Volume Mass
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Solubility

Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
Solvent Solubility & Note
Water 37 mg/mL
DMSO Insoluble
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO.)
Ethanol Insoluble
FAQ
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
  • Preheat media/saline to 37°C.
  • Mix rapidly (pipette/vortex) upon addition.
  • For complex mixes, always add the aqueous phase last.
  • Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
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Reference

[1] Sugrue MF, et al. J Ocul Pharmacol. 1990;6(1):9-22.

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Note: Technical data last updated: Sep 1, 2026.