CAS No. 120011-70-3

Batch: Purity:99.94
Check CoA
Donepezil HCl Chemical Structure
Chemical Structure
Check the Donepezil HCl product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.

Chemical Information

IUPAC Name 2-[(1-benzylpiperidin-4-yl)methyl]-5,6-dimethoxy-2,3-dihydroinden-1-one;hydrochloride
CAS Number 120011-70-3
Molecular Formula

C24H29NO3.HCl
Molecular Weight (MW) 416
SMILES COC1=C(C=C2C(=C1)CC(C2=O)CC3CCN(CC3)CC4=CC=CC=C4)OC.Cl
InChIKey XWAIAVWHZJNZQQ-UHFFFAOYSA-N

Biological Activity

Donepezil HCl is a potent and reversible acetylcholinesterase (AChE) inhibitor. By selectively inhibiting AChE, it prevents the enzymatic breakdown of acetylcholine, thereby elevating synaptic acetylcholine concentrations in the central nervous system. This enhancement of central cholinergic neurotransmission promotes synaptic plasticity, counteracts cognitive dysfunction, and improves memory and learning performance in animal models of neurodegeneration. [1]

Solubility

Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
Solvent Solubility & Note
Water 5 mg/mL
DMSO Insoluble
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO.)
Ethanol Insoluble
FAQ
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
  • Preheat media/saline to 37°C.
  • Mix rapidly (pipette/vortex) upon addition.
  • For complex mixes, always add the aqueous phase last.
  • Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Free Aliquotting Service

Pre-aliquoted for Longevity: Solid-state aliquots offer longer shelf life compared to stock solutions.

Looking for a specific aliquot size? Contact your local sales representative or orders@selleckchem.com.

Reference

[1] Sugimoto H, et al. J Med Chem. 1995;38(24):4821-9.

Jump to

Note: Technical data last updated: Sep 1, 2026.