CAS No. 57808-66-9

Batch: Purity:99.92
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Domperidone Chemical Structure
Chemical Structure
Check the Domperidone product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.

Chemical Information

IUPAC Name 6-chloro-3-[1-[3-(2-oxo-3H-benzimidazol-1-yl)propyl]piperidin-4-yl]-1H-benzimidazol-2-one
CAS Number 57808-66-9
Molecular Formula

C22H24ClN5O2
Molecular Weight (MW) 425.91
SMILES C1CN(CCC1N2C3=C(C=C(C=C3)Cl)NC2=O)CCCN4C5=CC=CC=C5NC4=O
InChIKey FGXWKSZFVQUSTL-UHFFFAOYSA-N

Biological Activity

Domperidone is an orally active dopamine receptor antagonist targeting dopamine D2 and D3 receptors. By blocking dopamine receptors in the chemoreceptor trigger zone located in the area postrema outside the blood-brain barrier, it antagonizes peripheral dopaminergic signaling. This inhibition disrupts dopamine-mediated suppression of gastrointestinal motility and emetic pathways, thereby suppressing nausea and vomiting phenotypes. [1]

How to Prepare Stock Solution?

Concentration Volume Mass
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Solubility

Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
Solvent Solubility & Note
DMSO 48 mg/mL (112.69 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.)
Ethanol 1 mg/mL
Water Insoluble
FAQ
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
  • Preheat media/saline to 37°C.
  • Mix rapidly (pipette/vortex) upon addition.
  • For complex mixes, always add the aqueous phase last.
  • Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).

Reference

[1] Brogden RN, et al. Drugs. 1982;24(5):360-400.

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Note: Technical data last updated: Sep 1, 2026.