CAS No. 56-53-1

Batch: Purity:99.92
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Diethylstilbestrol Chemical Structure
Chemical Structure
Check the Diethylstilbestrol product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.

Chemical Information

IUPAC Name 4-[(E)-4-(4-hydroxyphenyl)hex-3-en-3-yl]phenol
CAS Number 56-53-1
Molecular Formula

C18H20O2
Molecular Weight (MW) 268.35
SMILES CCC(=C(CC)C1=CC=C(C=C1)O)C2=CC=C(C=C2)O
InChIKey RGLYKWWBQGJZGM-ISLYRVAYSA-N

Ordering Information

Biological Activity

Diethylstilbestrol is a synthetic nonsteroidal estrogen that acts as a potent agonist of estrogen receptors. Upon diffusing into target cells within the female reproductive tract, pituitary gland, and hypothalamus, diethylstilbestrol binds estrogen receptors to modulate gene transcription. This activation suppresses follicle-stimulating hormone release from the anterior pituitary and increases hepatic synthesis of sex hormone-binding globulin, altering endocrine signaling and inducing animal models of pituitary adenoma. [1]

How to Prepare Stock Solution?

Concentration Volume Mass
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Solubility

Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
Solvent Solubility & Note
DMSO 100 mg/mL (372.64 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.)
Ethanol 10 mg/mL
Water Insoluble
FAQ
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
  • Preheat media/saline to 37°C.
  • Mix rapidly (pipette/vortex) upon addition.
  • For complex mixes, always add the aqueous phase last.
  • Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).

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Note: Technical data last updated: Sep 1, 2026.