CAS No. 65928-58-7

Batch: Purity:99.91
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Dienogest Chemical Structure
Chemical Structure
Check the Dienogest product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.

Chemical Information

IUPAC Name 2-[(8S,13S,14S,17R)-17-hydroxy-13-methyl-3-oxo-1,2,6,7,8,11,12,14,15,16-decahydrocyclopenta[a]phenanthren-17-yl]acetonitrile
CAS Number 65928-58-7
Molecular Formula

C20H25NO2
Molecular Weight (MW) 311.42
SMILES CC12CCC3=C4CCC(=O)C=C4CCC3C1CCC2(CC#N)O
InChIKey AZFLJNIPTRTECV-FUMNGEBKSA-N

Ordering Information

Biological Activity

Dienogest is an orally active synthetic progestin that acts as a progesterone receptor agonist with selective antiandrogenic activity. By binding to progesterone receptors, it modulates downstream steroid receptor signaling pathways to inhibit cell proliferation and attenuate pro-inflammatory cytokine expression, including interleukin-8 and prostaglandin E2. Consequently, dienogest reduces inflammatory mediator secretion and suppresses endometriotic lesion growth and proliferation in cell and tissue models. [1]

How to Prepare Stock Solution?

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Solubility

Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
Solvent Solubility & Note
DMSO 62 mg/mL (199.08 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.)
Water Insoluble
Ethanol Insoluble
FAQ
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
  • Preheat media/saline to 37°C.
  • Mix rapidly (pipette/vortex) upon addition.
  • For complex mixes, always add the aqueous phase last.
  • Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).

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Note: Technical data last updated: Sep 1, 2026.