CAS No. 4342-03-4
Batch:
Purity:99.89
Chemical Structure
Check the
Dacarbazine
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
Chemical Information
| IUPAC Name | 4-[(E)-dimethylaminodiazenyl]-1H-imidazole-5-carboxamide | |
|---|---|---|
| CAS Number | 4342-03-4 | |
| Molecular Formula |
C6H10N6O |
|
| Molecular Weight (MW) | 182.18 | |
| SMILES | CN(C)N=NC1=C(NC=N1)C(=O)N | |
| InChIKey | FDKXTQMXEQVLRF-ZHACJKMWSA-N |
Biological Activity
Dacarbazine is a triazene derivative and antineoplastic alkylating agent that targets genomic DNA by forming adducts and inducing DNA cross-linking across all cell cycle phases. By impairing normal nucleic acid template function and disrupting DNA replication, dacarbazine triggers robust cell cycle arrest and activates intrinsic apoptotic pathways to inhibit proliferation in various cancer cell types. [1]
How to Prepare Stock Solution?
|
Concentration
Volume
Mass
|
|---|
Solubility
Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| DMSO |
12 mg/mL
(65.86 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Water | 2 mg/mL (超声加热十分钟，60℃) |
| Ethanol | 1 mg/mL |
| DMSO |
3 mg/mL
(16.46 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Water | Insoluble |
| Ethanol | Insoluble |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Pre-aliquoted for Longevity: Solid-state aliquots offer longer shelf life compared to stock solutions.
Looking for a specific aliquot size? Contact your local sales representative or orders@selleckchem.com.
Reference
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Note: Technical data last updated: Sep 1, 2026.