CAS No. 860-79-7

Batch: Purity:99.92
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Cyclovirobuxine D Chemical Structure
Chemical Structure
Check the Cyclovirobuxine D product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.

Chemical Information

CAS Number 860-79-7
Molecular Formula

C26H46N2O
Molecular Weight (MW) 402.66
SMILES CC(C1C(CC2(C1(CCC34C2CCC5C3(C4)CCC(C5(C)C)NC)C)C)O)NC

Ordering Information

Biological Activity

Cyclovirobuxine D is a bioactive steroidal alkaloid derived from Buxus microphylla that exerts cardioprotective activity in acute myocardial ischemia models. It enhances cardiomyocyte viability under oxidative and hypoxic conditions while reducing coronary artery ligation-induced myocardial infarct size in rats through ATP-sensitive potassium channel activation. Additionally, cyclovirobuxine D protects endothelial cells against hypoxia and increases endothelial nitric oxide release, leading to reduced venous thrombus formation.

How to Prepare Stock Solution?

Concentration Volume Mass
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Solubility

Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
Solvent Solubility & Note
Ethanol 20 mg/mL
DMSO Insoluble
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO.)
Water Insoluble
FAQ
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
  • Preheat media/saline to 37°C.
  • Mix rapidly (pipette/vortex) upon addition.
  • For complex mixes, always add the aqueous phase last.
  • Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).

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Note: Technical data last updated: Sep 1, 2026.