CAS No. 79217-60-0

Batch: Purity:99.87
Check CoA
Cyclosporine Chemical Structure
Chemical Structure
Check the Cyclosporine product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.

Chemical Information

IUPAC Name 30-ethyl-33-[(E,1R,2R)-1-hydroxy-2-methylhex-4-enyl]-1,4,7,10,12,15,19,25,28-nonamethyl-6,9,18,24-tetrakis(2-methylpropyl)-3,21-di(propan-2-yl)-1,4,7,10,13,16,19,22,25,28,31-undecazacyclotritriacontane-2,5,8,11,14,17,20,23,26,29,32-undecone
CAS Number 79217-60-0
Molecular Formula

C62H111N11O12
Molecular Weight (MW) 1202.61
SMILES CCC1C(=O)N(CC(=O)N(C(C(=O)NC(C(=O)N(C(C(=O)NC(C(=O)NC(C(=O)N(C(C(=O)N(C(C(=O)N(C(C(=O)N(C(C(=O)N1)C(C(C)CC=CC)O)C)C(C)C)C)CC(C)C)C)CC(C)C)C)C)C)CC(C)C)C)C(C)C)CC(C)C)C)C
InChIKey PMATZTZNYRCHOR-KMSBSJHKSA-N

Biological Activity

Cyclosporine is an immunosuppressant drug and a potent inhibitor of the calcineurin phosphatase signaling pathway. It binds specifically to the cytosolic protein cyclophilin within immunocompetent T-lymphocytes to form a stable drug-protein complex. This cyclosporine-cyclophilin complex inhibits calcineurin phosphatase activity, thereby blocking NFAT activation and downregulating interleukin-2 transcription to suppress T-cell proliferation and immune signaling responses. [1][2]

How to Prepare Stock Solution?

Concentration Volume Mass
🧮 Molarity Calculator

Solubility

Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
Solvent Solubility & Note
DMSO 100 mg/mL (83.15 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.)
Ethanol 100 mg/mL
Water Insoluble
FAQ
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
  • Preheat media/saline to 37°C.
  • Mix rapidly (pipette/vortex) upon addition.
  • For complex mixes, always add the aqueous phase last.
  • Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).

Reference

[1] Handschumacher RE, et al. Science. 1984;226(4674):544-7.

[2] Liu J, et al. Cell. 1991;66(4):807-15.

Jump to

Note: Technical data last updated: Sep 1, 2026.