CAS No. 50-04-4
| CAS Number | 50-04-4 | |
|---|---|---|
| Molecular Formula |
C23H30O6 |
|
| Molecular Weight (MW) | 402.48 | |
| SMILES | CC(=O)OCC(=O)C1(CCC2C1(CC(=O)C3C2CCC4=CC(=O)CCC34C)C)O |
Cortisone acetate is a synthetic glucocorticoid and steroid hormone precursor that acts as a glucocorticoid receptor agonist following enzymatic conversion. Upon bioactivation to cortisol, it binds to glucocorticoid receptors, modulating nuclear transcription and inhibiting pro-inflammatory signaling pathways such as NF-kB. This downstream signaling suppresses immune system activation, reducing the expression of inflammatory cytokines and inhibiting immune-mediated inflammatory responses. [1]
|
Concentration
Volume
Mass
|
|---|
| Solvent | Solubility & Note |
|---|---|
| DMSO |
7 mg/mL
(17.39 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Water | Insoluble |
| Ethanol | Insoluble |
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
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