Clofarabine Clinical Trials

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10mg	USD 147
50mg	USD 370

Clinical Trials

Clofarabine has been evaluated in numerous clinical trials spanning phase 1 through phase 3, primarily targeting hematologic malignancies such as acute myeloid leukemia, acute lymphocytic leukemia, myelodysplastic syndromes, and non-Hodgkin's lymphoma. Assessing clofarabine as both monotherapy and in combination regimens, this research is supported by academic institutions, consortia, and industry sponsors including Nantes University Hospital, Indiana University, and Genzyme. Across these studies, trial recruitment statuses range from active and recruiting to completed and terminated protocols.

NCT Number	Recruitment	Conditions	Sponsor/Collaborators	Start Date	Phases
NCT06986382	NOT_YET_RECRUITING	Crohn Disease	Stanford University	2025-07	PHASE1; PHASE2
NCT07566377	RECRUITING	Acute Myelogenous Leukemia; Acute Lymphoblastic Leukemia; Myelodysplastic Syndromes; Non-hodgkin Lymphoma; Hodgkin Lymphoma; Leukemia; Lymphoma; Graft-versus-host Disease	Memorial Sloan Kettering Cancer Center	2026-04-28	PHASE2
NCT05477589	RECRUITING	Acute Myeloid Leukemia (AML) in Remission; Stem Cell Transplantation	Vastra Gotaland Region	2022-06-07	PHASE3
NCT07644481	NOT_YET_RECRUITING	AML (Acute Myelogenous Leukemia); Allogeneic Hematopoietic Stem Cell Transplantation Recipient	Institute of Hematology & Blood Diseases Hospital, China	2026-07-20
NCT07034053	RECRUITING	Advanced Urothelial Carcinoma; Metastatic Urothelial Cancer	Ekaterina Laukhtina	2023-10-24	PHASE1; PHASE2
NCT05917405	RECRUITING	Acute Myeloid Leukemia in Remission	Nantes University Hospital	2023-09-14	PHASE2
NCT07022834	RECRUITING	Langerhans Cell Histiocytosis (LCH)	West China Second University Hospital	2025-06-01	PHASE2
NCT06252870	RECRUITING	Graft Versus Host Disease; Hematologic Malignancy	Nantes University Hospital	2024-07-18	PHASE2
NCT03136146	RECRUITING	Recurrent Acute Lymphoblastic Leukemia; Recurrent Adult Lymphoblastic Lymphoma; Recurrent Burkitt Leukemia; Recurrent Burkitt Lymphoma; Recurrent Childhood Lymphoblastic Lymphoma; Recurrent High Grade B-Cell Lymphoma With MYC and BCL2 or BCL6 Rearrangements; Refractory Acute Lymphoblastic Leukemia; Refractory Burkitt Leukemia; Refractory Burkitt Lymphoma; Refractory High Grade B-Cell Lymphoma With MYC and BCL2 or BCL6 Rearrangements; Refractory Lymphoblastic Lymphoma	M.D. Anderson Cancer Center	2017-08-09	PHASE2
NCT02727803	RECRUITING	Accelerated Phase Chronic Myelogenous Leukemia, BCR-ABL1 Positive; Acute Biphenotypic Leukemia; Acute Lymphoblastic Leukemia; Acute Lymphoblastic Leukemia in Remission; Acute Myeloid Leukemia With Myelodysplasia-Related Changes; Acute Myeloid Leukemia With Variant MLL Translocations; B Acute Lymphoblastic Leukemia With t(9;22)(q34.1;q11.2); BCR-ABL1; Chemotherapy-Related Leukemia; Chronic Myelomonocytic Leukemia; Chronic Phase Chronic Myelogenous Leukemia, BCR-ABL1 Positive; High Grade B-Cell Lymphoma With MYC and BCL2 or BCL6 Rearrangements; ISS Stage II Plasma Cell Myeloma; ISS Stage III Plasma Cell Myeloma; Myelodysplastic Syndrome; Myelodysplastic Syndrome With Excess Blasts; Myelodysplastic Syndrome With Gene Mutation; Myelodysplastic/Myeloproliferative Neoplasm; Previously Treated Myelodysplastic Syndrome; Recurrent Acute Myeloid Leukemia; Recurrent Adult Acute Myeloid Leukemia; Recurrent Hodgkin Lymphoma; Recurrent Non-Hodgkin Lymphoma; Refractory Acute Lymphoblastic Leukemia; Refractory Adult Acute Lymphoblastic Leukemia; Secondary Acute Myeloid Leukemia; Therapy-Related Myelodysplastic Syndrome	M.D. Anderson Cancer Center	2016-05-19	PHASE2
NCT07156435	RECRUITING	Relapsed Pediatric AML; Refractory Pediatric AML	Princess Maxima Center for Pediatric Oncology	2020-11-06	PHASE1
NCT04644016	RECRUITING	AML; ALL; MDS; MPD Withou Myelofibrosis; NHL or HL; Inherited Metabolic Disorders; Hemoglobinopathies; Bone Marrow Failure; HLH	Memorial Sloan Kettering Cancer Center	2020-11-20	PHASE2
NCT03117751	ACTIVE_NOT_RECRUITING	Acute Lymphoblastic Leukemia; Acute Lymphoblastic Lymphoma	St. Jude Children's Research Hospital	2017-03-29	PHASE2; PHASE3
NCT04994808	TERMINATED	Acute Myeloid Leukemia; Myelodysplastic Syndrome	Fred Hutchinson Cancer Center	2023-08-11	PHASE2
NCT02211755	COMPLETED	Neoplasms; Myelodysplastic Syndromes; Lymphomas	National Cancer Institute (NCI)	2014-10-06	PHASE1
NCT04989335	UNKNOWN	Myelogenous Leukemia, Acute	Sheba Medical Center	2021-08-02	PHASE2
NCT01701986	COMPLETED	Hematopoietic Cell Transplantation Recipient; Refractory B-Cell Non-Hodgkin Lymphoma; Refractory Hodgkin Lymphoma; Refractory T-Cell Non-Hodgkin Lymphoma	M.D. Anderson Cancer Center	2012-10-25	PHASE1; PHASE2
NCT03615105	TERMINATED	Acute Lymphoid Leukemia (ALL); Acute Myeloid Leukemia (AML); Chronic Myeloid Leukemia (CML); Hodgkin Lymphoma; Non-Hodgkin Lymphoma; Chronic Lymphocytic Leukemia	Memorial Sloan Kettering Cancer Center	2018-07-25	PHASE2
NCT05569512	TERMINATED	Acute Myeloid Leukemia; Pediatric Cancer	Malika Kapadia	2022-10-06	PHASE1
NCT05917405	Recruiting	Acute Myeloid Leukemia in Remission	Nantes University Hospital	2023-09-14	Phase 2
NCT05065736	TERMINATED	Metastatic Cancer; Carcinoma; Adenocarcinoma	Roberto Vargas	2023-03-06	EARLY_PHASE1
NCT02135874	COMPLETED	Acute Bilineal Leukemia; Acute Biphenotypic Leukemia; Acute Leukemia of Ambiguous Lineage; Acute Undifferentiated Leukemia; Mixed Phenotype Acute Leukemia; Mixed Phenotype Acute Leukemia, B/Myeloid, Not Otherwise Specified; Mixed Phenotype Acute Leukemia, T/Myeloid, Not Otherwise Specified; Recurrent Mixed Phenotype Acute Leukemia	M.D. Anderson Cancer Center	2014-10-27	PHASE2
NCT02883049	COMPLETED	B Acute Lymphoblastic Leukemia; B Acute Lymphoblastic Leukemia, BCR-ABL1-Like; Central Nervous System Leukemia; Testicular Leukemia	National Cancer Institute (NCI)	2012-02-29	PHASE3
NCT03096782	COMPLETED	Accelerated Phase Chronic Myelogenous Leukemia, BCR-ABL1 Positive; Acute Biphenotypic Leukemia; Acute Leukemia; Acute Lymphoblastic Leukemia; Acute Lymphoblastic Leukemia in Remission; Acute Myeloid Leukemia; Acute Myeloid Leukemia Arising From Previous Myelodysplastic Syndrome; Chemotherapy-Related Leukemia; Chronic Lymphocytic Leukemia; Chronic Myelogenous Leukemia, BCR-ABL1 Positive; Chronic Myelomonocytic Leukemia; Hodgkin Lymphoma; Langerhans Cell Histiocytosis; Minimal Residual Disease; Myelodysplastic Syndrome; Myelodysplastic Syndrome With Excess Blasts; Non-Hodgkin Lymphoma; Recurrent Hodgkin Lymphoma; Refractory Acute Lymphoblastic Leukemia; Refractory Myelodysplastic Syndrome; Small Lymphocytic Lymphoma; Therapy-Related Myelodysplastic Syndrome	M.D. Anderson Cancer Center	2017-10-13	PHASE2
NCT04002115	TERMINATED	Acute Myeloid Leukemia	Milton S. Hershey Medical Center	2020-06-03	PHASE2
NCT02083250	COMPLETED	Acute Lymphoblastic Leukemia in Remission; Acute Myeloid Leukemia in Remission; Allogeneic Hematopoietic Stem Cell Transplantation Recipient; Myelodysplastic Syndrome; Previously Treated Myelodysplastic Syndrome; Recurrent Acute Lymphoblastic Leukemia; Recurrent Acute Myeloid Leukemia	M.D. Anderson Cancer Center	2014-03-06	PHASE1
NCT04220008	WITHDRAWN	Recurrent Aggressive Non-Hodgkin Lymphoma; Recurrent B-Cell Non-Hodgkin Lymphoma; Recurrent Burkitt Lymphoma; Recurrent Diffuse Large B-Cell Lymphoma; Recurrent High Grade B-Cell Lymphoma; Recurrent T-Cell Non-Hodgkin Lymphoma; Recurrent Transformed B-Cell Non-Hodgkin Lymphoma	M.D. Anderson Cancer Center	2021-10-29	PHASE2
NCT03263767	TERMINATED	Graft Versus Host Disease	Nantes University Hospital	2018-01-15	PHASE2
NCT01842672	COMPLETED	Acute Lymphoblastic Leukemia; Acute Myelogenous Leukemia; Lymphoblastic Lymphoma; Diffuse Large B-cell Lymphoma; Burkitt Lymphoma/Leukemia	New York Medical College	2013-03	PHASE1; PHASE2
NCT01700946	COMPLETED	Recurrent B-Cell Childhood Acute Lymphoblastic Leukemia; Recurrent Childhood B-Lymphoblastic Lymphoma	St. Jude Children's Research Hospital	2013-04-15	PHASE2
NCT00423514	COMPLETED	Graft Versus Host Disease; Leukemia; Myelodysplastic Syndromes	Memorial Sloan Kettering Cancer Center	2006-11-20	PHASE1; PHASE2
NCT01451515	COMPLETED	Lymphoblastic Lymphoma	St. Jude Children's Research Hospital	2012-05-25	PHASE2
NCT01119066	COMPLETED	Acute Lymphoblastic Leukemia; Acute Myelogenous Leukemia; Myelodysplastic Syndrome; Multiple Myeloma	Memorial Sloan Kettering Cancer Center	2010-05-03	PHASE2
NCT00416351	COMPLETED	Leukemia; Lymphoma; Small Intestine Cancer	Memorial Sloan Kettering Cancer Center	2006-06-27	PHASE1; PHASE2
NCT02085408	COMPLETED	Acute Myeloid Leukemia With Multilineage Dysplasia Following Myelodysplastic Syndrome; Adult Acute Megakaryoblastic Leukemia (M7); Adult Acute Minimally Differentiated Myeloid Leukemia (M0); Adult Acute Monoblastic Leukemia (M5a); Adult Acute Monocytic Leukemia (M5b); Adult Acute Myeloblastic Leukemia With Maturation (M2); Adult Acute Myeloblastic Leukemia Without Maturation (M1); Adult Acute Myeloid Leukemia With 11q23 (MLL) Abnormalities; Adult Acute Myeloid Leukemia With Del(5q); Adult Acute Myeloid Leukemia With Inv(16)(p13;q22); Adult Acute Myeloid Leukemia With t(16;16)(p13;q22); Adult Acute Myeloid Leukemia With t(8;21)(q22;q22); Adult Acute Myelomonocytic Leukemia (M4); Adult Erythroleukemia (M6a); Adult Pure Erythroid Leukemia (M6b); Secondary Acute Myeloid Leukemia; Untreated Adult Acute Myeloid Leukemia	ECOG-ACRIN Cancer Research Group	2011-02-04	PHASE3
NCT01471444	COMPLETED	Disorder Related to Bone Marrow Transplantation; Leukemia; Transplantation Infection	M.D. Anderson Cancer Center	2011-11-02	PHASE3
NCT00697684	COMPLETED	Acute Myeloid Leukemia; Myelodysplastic Syndrome; Acute Lymphocytic Leukemia; Relapsed/Refractory Chronic Lymphocytic Leukemia; Relapsed/Refractory Non Hodgkin's Lymphoma; Hodgkins Disease; Relapsed Refractory Multiple Myeloma	Beth Israel Deaconess Medical Center	2008-06	PHASE1
NCT03615144	TERMINATED	Non-Malignant Hematologic Disorders	Memorial Sloan Kettering Cancer Center	2018-07-23	PHASE2
NCT00549848	COMPLETED	Acute Lymphoblastic Leukemia	St. Jude Children's Research Hospital	2007-10-29	PHASE3
NCT02441803	COMPLETED	Leukemia	M.D. Anderson Cancer Center	2015-09-14	PHASE2
NCT02425904	ACTIVE_NOT_RECRUITING	Langerhans Cell Histiocytosis	Dana-Farber Cancer Institute	2015-05	PHASE2
NCT01885689	ACTIVE_NOT_RECRUITING	Adult Acute Lymphoblastic Leukemia in Remission; Acute Myeloid Leukemia Arising From Previous Myelodysplastic Syndrome; Adult Acute Myeloid Leukemia in Remission; Myelodysplastic Syndrome; Secondary Myelodysplastic Syndrome; Chronic Myelomonocytic Leukemia; Therapy-Related Myelodysplastic Syndrome	City of Hope Medical Center	2014-02-10	PHASE2
NCT01228331	COMPLETED	Leukemia	Universitätsklinikum Hamburg-Eppendorf	2010-10	PHASE2; PHASE3
NCT01596699	TERMINATED	Myeloid Malignancy; Bone Marrow Failure Syndrome; Transfusion-dependent Red Blood Cell (RBC) Defect; Congenital Immunodeficiency; Metabolic Disease; Severe Immune Dysregulation	University of California, San Francisco	2012-05-24	PHASE2
NCT00857389	COMPLETED	Stem Cell Transplantation; Leukemia; Lymphoma	M.D. Anderson Cancer Center	2009-03-02	PHASE2
NCT01252667	COMPLETED	Acute Myeloid Leukemia	Fred Hutchinson Cancer Center	2011-01-25	PHASE2
NCT02925351	COMPLETED	Autoimmune Disease; Crohn Disease; Inflammatory Disorder; Rheumatoid Arthritis; Systemic Lupus Erythematosus; Takayasu Arteritis	Jonsson Comprehensive Cancer Center	2016-01-25	EARLY_PHASE1
NCT01629511	TERMINATED	Allogeneic Hematopoietic Stem Cell Transplantation Recipient; Chronic Lymphocytic Leukemia; Prolymphocytic Leukemia; Richter Syndrome	M.D. Anderson Cancer Center	2012-11-21	PHASE1; PHASE2
NCT02686593	COMPLETED	Acute Myeloid Leukemia	The University of Hong Kong	2016-02-01	PHASE2
NCT02518750	TERMINATED	Acute Lymphoblastic Leukemia; Lymphoma, Non-Hodgkin's; Leukemia, T-Cell; Leukemia, B-Cell	St. Jude Children's Research Hospital	2016-11-23	PHASE2
NCT01794702	COMPLETED	Leukemia	M.D. Anderson Cancer Center	2013-02-20	PHASE1; PHASE2
NCT01796405	WITHDRAWN	Langerhans Cell Histiocytosis	Dana-Farber Cancer Institute		PHASE2
NCT01289457	COMPLETED	Leukemia	M.D. Anderson Cancer Center	2011-02-02	PHASE1; PHASE2
NCT01471067	COMPLETED	Blood And Marrow Transplantation; Leukemia; Lymphoma; Transplantation Infection; Transplantation, Bone Marrow	M.D. Anderson Cancer Center	2012-07-13	PHASE1
NCT00703820	COMPLETED	Acute Myeloid Leukemia	St. Jude Children's Research Hospital	2008-08-04	PHASE3
NCT02349178	TERMINATED	Leukemia, Acute Lymphoblastic; Acute Myeloid Leukemia	Medical College of Wisconsin	2014-12-08	PHASE2
NCT01462253	COMPLETED	Acute Lymphoblastic Leukemia	Gruppo Italiano Malattie EMatologiche dell'Adulto	2012-10	PHASE2
NCT01444742	COMPLETED	Leukemia; Myeloproliferative Diseases	M.D. Anderson Cancer Center	2011-11-16	PHASE2
NCT00498316	COMPLETED	Myelodysplastic Syndrome; Leukemia	M.D. Anderson Cancer Center	2007-07-03	PHASE1
NCT01643668	COMPLETED	Acute Myeloid Leukemia; Acute Lymphoblastic Leukemia; Myelodysplastic Syndrome	Massachusetts General Hospital	2012-07	PHASE2
NCT00990249	COMPLETED	Leukemia; Lymphoma; Allogeneic Haematopoietic Stem Cell Transplantation; Acute Lymphoblastic Leukemia	M.D. Anderson Cancer Center	2009-10	PHASE2
NCT01900509	COMPLETED	Hodgkin Lymphoma; Non-Hodgkin Lymphoma; Acute Leukemia	St. Jude Children's Research Hospital	2013-08	PHASE1
NCT00932412	COMPLETED	Acute Myeloid Leukemia	Hospices Civils de Lyon	2009-03	PHASE2
NCT01160354	TERMINATED	Acute Myelogenous Leukemia	M.D. Anderson Cancer Center	2010-08	PHASE1; PHASE2
NCT01677949	WITHDRAWN	Acute Myeloid Leukemia; Acute Lymphoblastic Leukemia	Masonic Cancer Center, University of Minnesota	2013-12	PHASE2
NCT00529360	COMPLETED	Acute Lymphoblastic Leukemia; Acute Myelogenous Leukemia	New York Medical College	2007-06	PHASE1; PHASE2
NCT03609814	Completed	Hematologic Malignancies\|Nonmalignant Diseases\|Immunodeficiencies\|Hemoglobinopathies\|Genetic Inborn Errors of Metabolism\|Fanconi''s Anemia\|Thalassemia\|Sickle Cell Disease	University of California San Francisco	2016-01-26	--
NCT01621477	TERMINATED	Acute Lymphoblastic Leukemia; Acute Myelocytic Leukemia; Chronic Myelocytic Leukemia; Juvenile Myelomonocytic Leukemia; Myelodysplastic Syndrome; Hodgkin or Non-Hodgkin Lymphoma; Sarcoma, Myeloid	St. Jude Children's Research Hospital	2012-08	PHASE2
NCT01629082	COMPLETED	Myeldysplastic Syndrome (MDS); Chronic Myelomonocytic Leukemia; Bone Marrow Diseases; Neutropenia; Acute Myeloid Leukemia (AML)	National Heart, Lung, and Blood Institute (NHLBI)	2012-06-06	PHASE1
NCT00908167	COMPLETED	Acute Myeloid Leukemia; Infantile Leukemia (Both AML and ALL); Myelodysplastic Syndrome; Myelodysplastic/Myeloproliferative Neoplasms; Biphenotypic Leukemia	St. Jude Children's Research Hospital	2009-09	PHASE1
NCT00903760	COMPLETED	Myelodysplastic Syndrome	M.D. Anderson Cancer Center	2010-01	PHASE2
NCT01960387	TERMINATED	Acute Myeloid Leukemia	University of Pittsburgh	2013-10	PHASE2
NCT00295841	COMPLETED	Leukemia	Wake Forest University Health Sciences	2005-02	PHASE1
NCT00778375	COMPLETED	Acute Myeloid Leukemia; Myelodysplastic Syndrome	M.D. Anderson Cancer Center	2008-10	PHASE2
NCT01423175	UNKNOWN	Acute Myeloid Leukemia; MDS	Hannover Medical School	2011-07	PHASE2
NCT01188174	COMPLETED	AML	Nantes University Hospital	2010-07	PHASE2
NCT00973752	COMPLETED	Acute Lymphoblastic Leukemia	Massachusetts General Hospital	2009-08	PHASE2
NCT00708721	TERMINATED	Cancer; Chronic Myelomonocytic Leukemia	University of Utah	2008-03	PHASE1; PHASE2
NCT01457885	COMPLETED	Acute Myeloblastic Leukemia	University of Michigan Rogel Cancer Center	2011-11	PHASE2
NCT00617929	TERMINATED	Cancer	Masonic Cancer Center, University of Minnesota	2008-01	PHASE2
NCT00383448	COMPLETED	Adrenoleukodystrophy; Metachromatic Leukodystrophy; Globoid Cell Leukodystrophy; Tay Sachs Disease; Sandhoffs Disease; Wolman Disease; I-Cell Disease; Sanfilippo Syndrome; GM1 Gangliosidosis	Masonic Cancer Center, University of Minnesota	2006-09	PHASE2
NCT01041508	COMPLETED	Leukemia Lymphoblastic, Acute; Acute Myeloid Leukemia; Neoplasm Recurrent	Therapeutic Advances in Childhood Leukemia Consortium	2010-01-29	PHASE1
NCT01132573	COMPLETED	Acute Leukemias of Ambiguous Lineage; Philadelphia Chromosome Negative Adult Precursor Acute Lymphoblastic Leukemia; Recurrent Adult Acute Lymphoblastic Leukemia; Untreated Adult Acute Lymphoblastic Leukemia	National Cancer Institute (NCI)	2010-04	PHASE1
NCT01422603	COMPLETED	Acute Myeloid Leukaemia; Myelodysplasia	University Hospital Southampton NHS Foundation Trust	2011-02	PHASE1; PHASE2
NCT01063257	COMPLETED	Myelodysplastic Syndrome	Groupe Francophone des Myelodysplasies	2010-04	PHASE1; PHASE2
NCT01983761	UNKNOWN	Blood And Marrow Transplantation; Leukemia; Lymphoma; Transplantation Infection; Myelodysplastic Syndrome (MDS); Non-Hodgkin's Lymphoma (NHL); Hodgkin's Lymphoma	Targazyme, Inc.	2013-11	PHASE1; PHASE2
NCT00644189	COMPLETED	Follicular Lymphoma; Marginal Zone Lymphoma; Mantle Cell Lymphoma; Small Lymphocytic Lymphoma; Lymphoplasmacytic Lymphoma; Low Grade B-cell Lymphoma, Not Otherwise Specified; Diffuse Large B-cell Lymphoma; Peripheral T-cell Lymphoma; Angioimmunoblastic T-cell Lymphoma; Anaplastic Large-cell Lymphoma	Massachusetts General Hospital	2008-06	PHASE1; PHASE2
NCT01626092	COMPLETED	Lysosomal Storage Disease; Peroxisomal Disorder	Masonic Cancer Center, University of Minnesota	2012-07-11
NCT01500161	TERMINATED	Acute Myelogenous Leukemia; Acute Lymphocytic Leukemia; Chronic Lymphocytic Leukemia; Chronic Myelogenous Leukemia; Hodgkins Disease; Non-Hodgkins Lymphoma; Aplastic Anemia; Multiple Myeloma; Myelodysplastic Syndrome	Texas Oncology Cancer Center	2011-11	PHASE2
NCT00462787	COMPLETED	Leukemia	Memorial Sloan Kettering Cancer Center	2007-04	PHASE1
NCT01295307	COMPLETED	Acute Myeloid Leukemia	Technische Universität Dresden	2011-03	PHASE2
NCT00814164	TERMINATED	Leukemia	Roswell Park Cancer Institute	2008-12	PHASE2
NCT01003678	TERMINATED	Myelodysplastic Syndrome	Roswell Park Cancer Institute	2009-10	PHASE1
NCT00067028	COMPLETED	Acute Myeloid Leukemia; Myelodysplastic Syndrome; Chronic Myeloid Leukemia	M.D. Anderson Cancer Center	2003-12	PHASE2
NCT00863148	COMPLETED	MDS; AML; ALL; BAL	Nantes University Hospital	2009-10	PHASE2
NCT01101880	COMPLETED	Adult Acute Myeloid Leukemia With 11q23 (MLL) Abnormalities; Adult Acute Myeloid Leukemia With Del(5q); Adult Acute Myeloid Leukemia With Inv(16)(p13;q22); Adult Acute Myeloid Leukemia With t(15;17)(q22;q12); Adult Acute Myeloid Leukemia With t(16;16)(p13;q22); Adult Acute Myeloid Leukemia With t(8;21)(q22;q22); Chronic Myelomonocytic Leukemia; de Novo Myelodysplastic Syndromes; Refractory Anemia With Excess Blasts; Untreated Adult Acute Myeloid Leukemia; Myeloproliferative Neoplasm With 10% Blasts or Higher	University of Washington	2010-08	PHASE2
NCT01534702	UNKNOWN	Acute Myeloid Leukemia	Hannover Medical School	2012-01	PHASE1; PHASE2
NCT00469014	COMPLETED	Acute Myeloid Leukemia; Myelodysplastic Syndrome; Chronic Myeloid Leukemia	M.D. Anderson Cancer Center	2006-09	PHASE2
NCT00945815	COMPLETED	Leukemia	SWOG Cancer Research Network	2010-09	PHASE2
NCT01025154	COMPLETED	Acute Myeloid Leukemia	M.D. Anderson Cancer Center	2010-01	PHASE2
NCT00697671	COMPLETED	Acute Lymphoblastic Leukemia; Chronic Myelogenous Leukemia; Juvenile Myelomonocytic Leukemia; Myelodysplastic Syndrome; Non-Hodgkin's Lymphoma	St. Jude Children's Research Hospital	2007-03	PHASE1
NCT01025778	COMPLETED	Acute Lymphoblastic Leukemia; Acute Myeloid Leukemia	Lund University Hospital	2009-12	PHASE2
NCT00838240	UNKNOWN	Leukemia; Myelodysplastic Syndromes	European Organisation for Research and Treatment of Cancer - EORTC	2008-11	PHASE1; PHASE2
NCT00839982	COMPLETED	Adult Acute Myeloid Leukemia With 11q23 (MLL) Abnormalities; Adult Acute Myeloid Leukemia With Del(5q); Adult Acute Myeloid Leukemia With Inv(16)(p13;q22); Adult Acute Myeloid Leukemia With t(16;16)(p13;q22); Adult Acute Myeloid Leukemia With t(8;21)(q22;q22); Myelodysplastic Syndrome With Isolated Del(5q); Previously Treated Myelodysplastic Syndromes; Recurrent Adult Acute Myeloid Leukemia	Fred Hutchinson Cancer Center	2008-11	PHASE1; PHASE2
NCT00299156	COMPLETED	Myelodysplastic Syndrome; Chronic Myelomonocytic Leukemia	M.D. Anderson Cancer Center	2006-03	PHASE2
NCT01158885	TERMINATED	Minimal Residual Disease; Leukemia, Lymphoblastic, Acute; Leukemia, Myelogenous, Acute	Therapeutic Advances in Childhood Leukemia Consortium	2010-08	PHASE2
NCT00824135	COMPLETED	Hematologic Malignancies	St. Jude Children's Research Hospital	2009-01	PHASE1
NCT01031368	COMPLETED	Adult Acute Megakaryoblastic Leukemia (M7); Adult Acute Minimally Differentiated Myeloid Leukemia (M0); Adult Acute Monoblastic Leukemia (M5a); Adult Acute Monocytic Leukemia (M5b); Adult Acute Myeloblastic Leukemia With Maturation (M2); Adult Acute Myeloblastic Leukemia Without Maturation (M1); Adult Acute Myeloid Leukemia With 11q23 (MLL) Abnormalities; Adult Acute Myeloid Leukemia With Del(5q); Adult Acute Myeloid Leukemia With Inv(16)(p13;q22); Adult Acute Myeloid Leukemia With t(15;17)(q22;q12); Adult Acute Myeloid Leukemia With t(16;16)(p13;q22); Adult Acute Myeloid Leukemia With t(8;21)(q22;q22); Adult Acute Myelomonocytic Leukemia (M4); Adult Acute Promyelocytic Leukemia (M3); Adult Erythroleukemia (M6a); Adult Pure Erythroid Leukemia (M6b); Recurrent Adult Acute Myeloid Leukemia; Untreated Adult Acute Myeloid Leukemia	Nohla Therapeutics, Inc.	2009-12	PHASE1
NCT00727766	COMPLETED	Leukemia, Myeloid, Acute	Washington University School of Medicine	2009-01	PHASE1
NCT00454480	COMPLETED	Leukemia; Myelodysplastic Syndromes	The University of New South Wales	2006-08	PHASE2; PHASE3
NCT00372619	COMPLETED	Leukemia	Children's Oncology Group	2007-03	PHASE1; PHASE2
NCT00775593	COMPLETED	Leukemia	Gruppo Italiano Malattie EMatologiche dell'Adulto	2008-12	PHASE2
NCT01279096	COMPLETED	Acute Lymphoid Leukemia Relapse; Acute Lymphoid Leukemia Relapse After Bone Marrow Transplant	University Hospital, Lille	2010-01	PHASE1
NCT00412243	COMPLETED	Burkitt's Lymphoma; Lymphoblastic Lymphoma; Acute Lymphoblastic Leukemia	M.D. Anderson Cancer Center	2006-03	PHASE1; PHASE2
NCT01169012	COMPLETED	Myelodysplastic Syndrome; Acute Myeloid Leukemia; Acute Lymphoblastic Leukemia; Chronic Myelomonocytic Leukemia	UNC Lineberger Comprehensive Cancer Center	2010-09	PHASE1
NCT01193400	TERMINATED	Acute Myelogenous Leukemia	PETHEMA Foundation	2010-09	PHASE2
NCT00187096	COMPLETED	Acute Myeloid Leukemia	St. Jude Children's Research Hospital	2005-09
NCT00317642	COMPLETED	Acute Myelogenous Leukemia	Genzyme, a Sanofi Company	2006-08	PHASE3
NCT00422032	COMPLETED	Myelodysplastic Syndrome; Leukemia	M.D. Anderson Cancer Center	2006-01	PHASE2
NCT02544789	COMPLETED	Acute Lymphoblastic Leukemia	Betta Pharmaceuticals Co., Ltd.	2009-06	PHASE2
NCT00983528	TERMINATED	Acute Lymphoblastic Leukemia	University of California, San Diego	2009-09	PHASE1; PHASE2
NCT00852163	COMPLETED	Leukemia; Myelodysplastic Syndrome	Baylor Research Institute	2007-03	PHASE2
NCT00939653	TERMINATED	Relapsed Acute Myelogenous Leukemia	Therapeutic Advances in Childhood Leukemia Consortium	2009-07-10	PHASE2
NCT00556452	COMPLETED	Leukemia; Hodgkin Lymphoma; Non-Hodgkin Lymphoma; Multiple Myeloma; Myelodysplastic Syndrome	University of Michigan Rogel Cancer Center	2007-10	PHASE1; PHASE2
NCT00531232	COMPLETED	Myelodysplastic Syndromes; Secondary Acute Myeloid Leukemia (AML)	Genzyme, a Sanofi Company	2007-05-07	PHASE2
NCT01196013	COMPLETED	Acute Lymphoblastic Leukemia	Genzyme, a Sanofi Company	2010-08	PHASE1
NCT01090167	COMPLETED	Acute Myelogenous Leukemia	Genzyme, a Sanofi Company	2010-02	PHASE1
NCT00991133	COMPLETED	Lymphoblastic Leukemia, Acute, Childhood	Genzyme, a Sanofi Company	2009-10	PHASE1
NCT00943592	COMPLETED	Advanced Hematologic Malignancies; Leukemia; Preleukemia	University of Chicago	2006-03	PHASE1; PHASE2
NCT00882076	TERMINATED	Leukemia	Milton S. Hershey Medical Center	2009-03	PHASE1
NCT00863434	TERMINATED	Adult Acute Myeloid Leukemia in Remission; Adult Acute Myeloid Leukemia With 11q23 (MLL) Abnormalities; Adult Acute Myeloid Leukemia With Inv(16)(p13;q22); Adult Acute Myeloid Leukemia With t(15;17)(q22;q12); Adult Acute Myeloid Leukemia With t(16;16)(p13;q22); Adult Acute Myeloid Leukemia With t(8;21)(q22;q22); Recurrent Adult Acute Myeloid Leukemia	University of Washington	2009-02	PHASE2
NCT00641030	COMPLETED	Leukemia; Myelodysplastic Syndromes	City of Hope Medical Center	2007-07	PHASE1
NCT00477945	COMPLETED	Non Hodgkin's Lymphoma	Indiana University	2007-05	PHASE1
NCT00477542	COMPLETED	Hematologic Malignancies	Indiana University	2007-05	PHASE1
NCT00724009	COMPLETED	Leukemia	University of Chicago	2007-12	PHASE2
NCT00577694	TERMINATED	Leukemia	UNC Lineberger Comprehensive Cancer Center	2007-11	PHASE1
NCT00315705	COMPLETED	Acute Lymphoblastic Leukemia; Acute Myelogenous Leukemia; Relapsed Leukemia	Genzyme, a Sanofi Company	2006-03	PHASE1; PHASE2
NCT00156013	COMPLETED	Lymphoma, B-Cell; Lymphoma, Non-Hodgkin	Oncology Specialists, S.C.	2005-09	PHASE1; PHASE2
NCT00293410	COMPLETED	Chronic Myeloproliferative Disorders; Leukemia; Myelodysplastic/Myeloproliferative Diseases	Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins	2005-11	PHASE1
NCT00338494	COMPLETED	B-Cell Lymphoma	Yale University	2005-10	PHASE1
NCT00700011	TERMINATED	Myelodysplastic Syndromes	Texas Oncology Cancer Center	2008-03	PHASE2
NCT00602225	COMPLETED	Acute Myeloid Leukemia; Adult Acute Myeloid Leukemia With 11q23 (MLL) Abnormalities; Adult Acute Myeloid Leukemia With Inv(16)(p13;q22); Adult Acute Myeloid Leukemia With t(15;17)(q22;q12); Adult Acute Myeloid Leukemia With t(16;16)(p13;q22); Adult Acute Myeloid Leukemia With t(8;21)(q22;q22); Adult Acute Promyelocytic Leukemia (M3); Recurrent Adult Acute Myeloid Leukemia	University of Washington	2007-12	PHASE1; PHASE2
NCT00626626	TERMINATED	Leukemia; Myelodysplastic Syndrome; Chronic Myelogenous Leukemia; Lymphoma; Hodgkin's Lymphoma; Multiple Myeloma	Milton S. Hershey Medical Center	2007-05	PHASE1; PHASE2
NCT01385891	COMPLETED	Acute Leukemia	Istituto Giannina Gaslini	2008-08	PHASE2; PHASE3
NCT00852709	TERMINATED	Myelodysplastic Syndrome; Acute Myeloid Leukemia; Myeloproliferative Disorders; Acute Lymphocytic Leukemia; Acute Promyelocytic Leukemia; Acute Leukemia; Chronic Myelogenous Leukemia; Myelofibrosis; Chronic Myelomonocytic Leukemia; Juvenile Myelomonocytic Leukemia	Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins	2007-09-01	PHASE1
NCT00503880	TERMINATED	Myelodysplastic Syndromes	University of Nebraska	2007-05-07	PHASE1; PHASE2
NCT00081822	COMPLETED	Acute Myeloid Leukemia	University of Alabama at Birmingham	2004-01	PHASE1
NCT00800566	WITHDRAWN	Leukemia; Chronic Lymphocytic Leukemia	M.D. Anderson Cancer Center	2008-11	PHASE1
NCT00691652	TERMINATED	Lymphoma	OHSU Knight Cancer Institute	2008-05	PHASE1; PHASE2
NCT00337168	COMPLETED	Leukemia	SWOG Cancer Research Network	2006-10	PHASE2
NCT00593645	TERMINATED	Myelodysplastic Syndromes; Acute Myeloid Leukemia	Washington University School of Medicine	2007-11	PHASE2
NCT01656031	COMPLETED	Leukemia	Wake Forest University Health Sciences	2005-02	PHASE2
NCT00750334	TERMINATED	Myelodysplastic Syndromes	Genzyme, a Sanofi Company	2008-09	PHASE1
NCT00638820	TERMINATED	Osteopetrosis	Masonic Cancer Center, University of Minnesota	2007-09	PHASE2
NCT00373529	COMPLETED	Acute Myelogenous Leukemia; Acute Myeloid Leukemia	Genzyme, a Sanofi Company	2006-10	PHASE2
NCT00088218	COMPLETED	Acute Myeloid Leukemia; Myelodysplastic Syndrome	M.D. Anderson Cancer Center	2004-07	PHASE2
NCT00081887	TERMINATED	Chronic Lymphocytic Leukemia; Leukemia	M.D. Anderson Cancer Center	2004-05	PHASE1
NCT00334074	COMPLETED	Acute Myelogenous Leukemia; Myelodysplastic Syndromes; Chronic Myelogenous Leukemia	Baylor Research Institute	2005-08	PHASE2
NCT00924443	COMPLETED	Acute Myeloid Leukemia	Genzyme, a Sanofi Company	2004-06	PHASE2
NCT00201669	COMPLETED	Non-Hodgkin's Lymphoma	Ohio State University Comprehensive Cancer Center	2004-10	PHASE2
NCT00065143	COMPLETED	Leukemia, Myeloid; Myelodysplastic Syndromes	M.D. Anderson Cancer Center	2003-06-23	PHASE2
NCT00241371	TERMINATED	Multiple Myeloma	Washington University School of Medicine	2005-03	PHASE2
NCT00125827	COMPLETED	Solid Tumors	Genzyme, a Sanofi Company	2003-10	PHASE1
NCT00028418	COMPLETED	Hematologic Neoplasms; Lymphoproliferative Disorders; Leukemia; Leukemia, Lymphocytic, Chronic	M.D. Anderson Cancer Center	1999-02	PHASE1
NCT00098033	COMPLETED	Acute Myelogenous Leukemia; Acute Lymphocytic Leukemia; Chronic Myelogenous Leukemia	University of Texas	2002-09	PHASE2
NCT01065545	WITHDRAWN	Acute Myeloid Leukemia	Northwestern University	2011-06	PHASE1
NCT01302106	WITHDRAWN	Myelodysplastic Syndromes	Fondazione Italiana Sindromi Mielodisplastiche-ETS		PHASE2
NCT00125840	COMPLETED	Solid Tumors; Leukemia, Lymphocytic, Acute, Pediatric; Leukemia, Lymphocytic, Acute, Adult; Leukemia, Myelocytic, Acute, Pediatric; Leukemia, Myelocytic, Acute, Adult; Myelodysplastic Syndromes, Adult	Genzyme, a Sanofi Company	2002-08	PHASE1
NCT00044889	COMPLETED	Acute Myelogenous Leukemia	Genzyme, a Sanofi Company	2002-05	PHASE2
NCT00042341	COMPLETED	Leukemia, Lymphoblastic, Acute, Pediatric	Genzyme, a Sanofi Company	2002-05	PHASE2
NCT00930098	COMPLETED	Acute Lymphoblastic Leukemia	Genzyme, a Sanofi Company	2003-12	PHASE2
NCT00042354	COMPLETED	Leukemia, Myelocytic, Acute, Pediatric	Genzyme, a Sanofi Company	2002-05	PHASE2

(data from https://clinicaltrials.gov, updated on 2025-05-23)

Check the Clofarabine product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.

Compliance for Clinical Use

Mechanism and Biochemical Profile

Intracellularly phosphorylated clofarabine inhibits ribonucleotide reductase (IC50 = 65 nM) and DNA polymerase, thereby blocking DNA replication and repair while disrupting mitochondrial membrane integrity to trigger pro-apoptotic factor release and cellular apoptosis. By driving apoptotic cell death in rapidly dividing blast cells, this mechanism inhibits neoplastic cell expansion and provides the therapeutic rationale for treating hematologic malignancies such as acute myeloid leukemia and acute lymphocytic leukemia.

Appendix RUO and cGMP Quality Standards

Quality Dimension	RUO (Research Use Only)	cGMP (Current Good Manufacturing Practice)
Clinical Applicability	Prohibited in human clinical trials or medical diagnostics.	Mandatory for human clinical trials (Phase I–III) and therapies.
Regulatory Status	Non-regulated grade; exempt from drug manufacturing laws.	Legally enforced by health authorities (e.g., FDA, EMA, NMPA).
Facility Environment	Unclassified analytical or research laboratories.	Validated Cleanrooms (ISO Class 5–8) with continuous monitoring.
Quality Control	Basic purity and activity testing.	Rigorous safety release testing (Sterility, Endotoxin, Mycoplasma).
Process Validation	Basic equipment calibration; no process validation required.	Full qualification (IQ/OQ/PQ) and complete batch records.
Quality Assurance	Vendor self-declared without required formal QMS.	Mandatory QA/QC unit, Change Control, CAPA, and vendor audits.
Regulatory Impact	High risk of IND rejection if used as a critical raw material.	Required for IND/NDA filings, supported by Drug Master Files (DMF).

Footnotes

Regulatory Note: Governed by FDA (21 CFR Parts 210/211/312), EMA (EudraLex Vol 4), ICH Guidelines (E6/Q7/Q9/Q10), and compendial standards (USP <71>/<85>/<1043>).