CAS No. 21462-39-5

Batch: Purity:97
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Clindamycin HCl Chemical Structure
Chemical Structure
Check the Clindamycin HCl product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.

Chemical Information

IUPAC Name (2S,4R)-N-[(1S,2S)-2-chloro-1-[(2R,3R,4S,5R,6R)-3,4,5-trihydroxy-6-methylsulfanyloxan-2-yl]propyl]-1-methyl-4-propylpyrrolidine-2-carboxamide;hydrochloride
CAS Number 21462-39-5
Molecular Formula

C18H33ClN2O5S.HCl
Molecular Weight (MW) 461.44
SMILES CCCC1CC(N(C1)C)C(=O)NC(C2C(C(C(C(O2)SC)O)O)O)C(C)Cl.Cl
InChIKey AUODDLQVRAJAJM-XJQDNNTCSA-N

Biological Activity

Clindamycin HCl is a semisynthetic lincosamide antibiotic that targets the 50S ribosomal subunit of bacteria to inhibit bacterial protein synthesis. By binding to the 23S rRNA within the peptidyl transferase center, it prevents peptide bond formation and suppresses ribosomal translation. This inhibition disrupts essential protein production and suppresses bacterial growth in anaerobic and Gram-positive microorganisms. [1][2]

How to Prepare Stock Solution?

Concentration Volume Mass
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Solubility

Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
Solvent Solubility & Note
DMSO 92 mg/mL (199.37 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.)
Water 92 mg/mL
Ethanol Insoluble
FAQ
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
  • Preheat media/saline to 37°C.
  • Mix rapidly (pipette/vortex) upon addition.
  • For complex mixes, always add the aqueous phase last.
  • Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
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Reference

[1] Douthwaite S. Nucleic Acids Res. 1992;20(18):4717-20.

[2] SpížekJ, et al. Appl Microbiol Biotechnol. 2004;64(4):455-464.

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Note: Technical data last updated: Sep 1, 2026.